Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease

Organic Letters

Volumn 12, Issue 4, 2010, Pages 756-759

  Stowe, G Neil ^a   Šilhár, Peter ^a   Hixon, Mark S ^b   Silvaggi, Nicholas R ^c   Allen, Karen N ^c   Moe, Scott T ^d   Jacobson, Alan R ^d   Barbieri, Joseph T ^e   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Takeda San Diego Inc   (United States)

^c Boston University   (United States)

^d Absolute Science Inc   (United States)

^e MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A; HYDROXAMIC ACID; NEUROTOXIN; PROTEINASE INHIBITOR;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CLOSTRIDIUM; DRUG ANTAGONISM; HUMAN; METABOLISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BOTULINUM TOXIN TYPE A; CATALYSIS; CLOSTRIDIUM; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROXAMIC ACIDS; MOLECULAR STRUCTURE; NEUROTOXINS; PROTEASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76849114940     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol902820z     Document Type: Article

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