Protective Effects of d-Limonene on Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin-Induced Diabetic Rats

Basic and Clinical Pharmacology and Toxicology

Volumn 112, Issue 3, 2013, Pages 175-181

  Murali, Ramakrishnan ^a   Karthikeyan, Arumugam ^a   Saravanan, Ramalingam ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIMONENE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; VITAMIN BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; CYCLOHEXENES; DIABETES MELLITUS, EXPERIMENTAL; INSULIN; KIDNEY; LIPID PEROXIDATION; LIPID PEROXIDES; LIVER; MALE; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; STREPTOZOCIN; TERPENES;

RATTUS;

EID: 84873716832     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/bcpt.12010     Document Type: Article

References (42)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetic care 2011;34:62-9.
2. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 2011;94:311-21.
3. Bogdanov VY, Osterud B. Cardiovascular complications of diabetes mellitus: the tissue factor perspective. Thromb Res 2009;125:112-8.
4. Kwon DY, Daily JW III, Kim HJ, Park S. Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutr Res 2010;30:1-13.
5. Rajasekaran S, Sivagnanam K, Subramanian S. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol Rep 2005;57:90-6.
6. Henriksen EJ, Diamond-Stanic MK, Marchionne EM. Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radic Biol Med 2011;51:993-9.
7. Zhang F, Ye C, Li G, Ding W, Zhou W, Zhu H et al. The rat model of type 2 diabetic mellitus and its glycometabolism characters. Exp Anim 2003;52:401-7.
8. Gupta RK, Kesari AN, Murthy PS, Chandra R, Tandon V, Watal G. Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. J Ethnopharmacol 2005;99:75-81.
9. Theis N, Lerdau M. The evolution of function in plant secondary metabolites. Int J Plant Sci 2003;164:S93-103.
10. Sun J. d-Limonene: safety and clinical applications. Altern Med Rev 2007;12:259-64.
11. Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. J Nutr 1999;129:S775-8.
12. Kodama R, Yano T, Furukawa K, Noda K, Ide H. Studies on the metabolism of d-limonene (p-mentha-l, 8-diene), IV. Isolation and characterization of new metabolites and species differences in metabolism. Xenobiotica 1979;6:377-89.
13. Kangralkar VA, Gavimath CC, Jadhav NA, Burli SC. Potential hypoglycemic effect of essential oil of citrus reticulata in wistar rats. Int J Pharm Appl 2010;1:6-9.
14. Peng CH, Ker YB, Weng CF, Peng CC, Huang CN, Lin LY et al. Insulin Secretagogue bioactivity of finger citron fruit (Citrus medica L. var. Sarcodactylis Hort, Rutaceae). J Agric Food Chem 2009;57:8812-9.
15. Murali R, Saravanan R. Antidiabetic effect of d-limonene, a monoterpene on streptozotocin-induced diabetic rats. Biomed Preve Nutr 2012 (Accepted manuscript) http://dx.doi.org/10.1016/j.bionut.2012.08.008 [last accessed on12 August 2012].
16. Yoshino G, Iwai M, Kazumi T, Matsushita M, Morita M, Matsuba K et al. Effect of dietary fructose on triglyceride turnover in streptozotocin-diabetic rats. Atherosclerosis 1989;79:41-6.
17. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 1969;6:24.
18. Berg JM, Tymoczko JL, Stryer L. Glycolysis and glyconeogensis. In: Berg JM, Tymoczko JL, Stryer L (eds). Biochemistry. WH Freeman and Company, New York, 2001;425-64.
19. Niehaus WG, Samuelsson JRB. Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem 1968;6:126-30.
20. Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxides in low density lipoprotein. Anal Biochem 1992;202:384-9.
21. Klein RA. The detection of oxidation in liposome preparation. Biochim Biophys Acta 1979;210:486-9.
22. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of SOD. Indian J Biochem Biophys 1984;21:130-2.
23. Sinha KA. Colorimetric assay of catalase. Anal Biochem 1972;47:389-94.
24. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical roles as a component of glutathione peroxidase. Science 1973;179:588-90.
25. Habig WH, Pabst MJ, Jakoby WB. Glutathion-S-transferase: the first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-9.
26. Ellman GL. Tissue sulphydryl. Arch Biochem Biophys 1959;82:70-7.
27. Roe JH, Kuether CA. The determination of ascorbic acid in whole blood and urine through the 2, 4-dinitrophenylhydrazine derivative of dehydroascorbic acid. J Biol Chem 1943;11:145-64.
28. Baker H, Frankel O, DeAngelis B, Feingold S. Plasma tocopherol in man at various times after ingestion of free or acetylated tocopherol. Nutr Res 1980;21:531-6.
29. Hoa NK, Norberg A, Sillard R, Van Phan D, Thuan ND, Dzung DT et al. The possible mechanisms by which phanoside stimulates insulin secretion from rat islets. J Endocrinol 2007;192:389-94.
30. +-channel activity. Metabolism 2000;49:208-14.
31. Conforti F, Statti GA, Tundis R, Loizzo MR, Menichini F. In vitro Activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease. Phytother Res 2007;21:427-33.
32. Lery V, Zaltzber H, Ben-Amotz A, Kanter Y, Aviram M. β-Carotene affects antioxidant status in non-insulin dependent diabetes mellitus. Pathophysiology 1999;6:157-62.
33. Alfy A, Ahmed A, Fatani A. Protective effect of red grape seeds proanthocyanidins against induction of diabetes by alloxan in rats. Pharmacol Res 2005;52:264-70.
34. Gokce G, Haznedaroglu MZ. Evaluation of antidiabetic, antioxidant and vasoprotective effects of Posidonia oceania extract. J Ethnopharmacol 2008;115:22-130.
35. Halliwell B, Gutteridge JMC. Oxygen toxicity, oxygen radical transition metals and disease. Biochem J 1984;219:1-14.
36. Sindhu RK, Koo JR, Roberts CK, Vaziri ND. Dysregulation of hepatic superoxide dismutase, catalase and glutathione peroxidase in diabetes response to insulin and antioxidant therapies. Clin Exp Hypertens 2004;26:43-53.
37. Anwar MM, Meki AR. Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp Biochem Physiol A Mol Integr Physiol 2003;135:539-47.
38. Zhang XF, Tan BK. Antihyperglycaemic and antioxidant properties of Andrographis particulate in normal and diabetic rats. Clin Exp Pharmacol Physiol 2000;27:358-63.
39. Özbek H, Bayram I, Uǧras S, Cengiz N. Investigation of hepatoprotective effect of Foeniculum vulgare fixed oil in rats. Res J Med Med Sci 2006;1:72-6.
40. Inefers H, Sies H. The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E. Eur J Biochem 1988;174:353-7.
41. Townsend DM, Tew KD, Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother 2003;57:145-55.
42. Opara EC. Oxidative stress, micronutrients, diabetes mellitus and its complications. J R Soc Promot Health 2002;122:28-34.