Development of raloxifene-solid dispersion with improved oral bioavailability via spray-drying technique

Archives of Pharmacal Research

Volumn 36, Issue 1, 2013, Pages 86-93

  Tran, Tuan Hiep ^a   Poudel, Bijay Kumar ^a   Marasini, Nirmal ^a   Woo, Jong Soo ^a   Choi, Han Gon ^b   Yong, Chul Soon ^a   Kim, Jong Oh ^a  

^a Yeungnam University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Bioavailability; Raloxifene; Solubility; Spray drying

Indexed keywords

POVIDONE; RALOXIFENE; WATER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; POWDER; RAT; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY POWDER DIFFRACTION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG COMPOUNDING; MALE; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR STRUCTURE; PHASE TRANSITION; RALOXIFENE; RATS; RATS, SPRAGUE-DAWLEY; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SOLUBILITY; SURFACE PROPERTIES; X-RAY DIFFRACTION;

EID: 84873705172     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0012-y     Document Type: Article

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