Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Park, Deric M ^a   Jung, Jinkyu ^a   Masjkur, Jimmy ^b   Makrogkikas, Stylianos ^b   Ebermann, Doreen ^b   Saha, Sarama ^b   Rogliano, Roberta ^c   Paolillo, Nicoletta ^c   Pacioni, Simone ^c   McKay, Ron D ^d   Poser, Steve ^b   Androutsellis Theotokis, Andreas ^b,e  

^a UNIVERSITY OF VIRGINIA   (United States)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c EUROPEAN BRAIN RESEARCH INSTITUTE   (Italy)

^d LIEBER INSTITUTE FOR BRAIN DEVELOPMENT   (United States)

^e CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; BIOLOGICAL MARKER; DNA BINDING PROTEIN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; HES3 PROTEIN, HUMAN; JANUS KINASE 1; SMALL INTERFERING RNA; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CANCER STEM CELL; CENTRAL NERVOUS SYSTEM TUMOR; EMBRYONIC STEM CELL; GENETICS; GLIOBLASTOMA; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL CULTURE;

ANGIOPOIETIN-2; ANIMALS; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM NEOPLASMS; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GLIOBLASTOMA; JANUS KINASE 1; MICE; NEOPLASTIC STEM CELLS; PHOSPHORYLATION; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

MLCS; MLOWN;

EID: 84873694623     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep01095     Document Type: Article

References (32)

1. Deorah, S., Lynch, C. F., Sibenaller, Z. A. & Ryken, T. C. Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus 20, E1 (2006).
2. Stupp, R. et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10, 459-66 (2009).
3. Ignatova, T. N. et al. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 39, 193-206 (2002).
4. Singh, S. K. et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 63, 5821-8 (2003). (Pubitemid 37187480)
5. Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396-401 (2004). (Pubitemid 39551674)
6. Galli, R. et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64, 7011-21 (2004). (Pubitemid 39331011)
7. Hemmati, H. D. et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 100, 15178-83 (2003). (Pubitemid 37518036)
8. Li, Z., Wang, H., Eyler, C. E., Hjelmeland, A. B. & Rich, J. N. Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. J Biol Chem 284, 16705-9 (2009).
9. Hirata, H., Tomita, K., Bessho, Y. & Kageyama, R. Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. Embo J 20, 4454-66 (2001). (Pubitemid 32772040)
10. Lobe, C. G. Expression of the helix-loop-helix factor, Hes3, during embryo development suggests a role in early midbrain-hindbrain patterning. Mech Dev 62, 227-37 (1997). (Pubitemid 27215790)
11. Hatakeyama, J. et al.Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development 131, 5539-50 (2004). (Pubitemid 39625198)
12. Androutsellis-Theotokis, A. et al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442, 823-6 (2006). (Pubitemid 44258913)
13. Androutsellis-Theotokis, A., Rueger, M. A., Mkhikian, H., Korb, E. & McKay, R. D. Signaling pathways controlling neural stem cells slow progressive brain disease. Cold Spring Harb Symp Quant Biol 73, 403-10 (2008).
14. Androutsellis-Theotokis, A. et al. Angiogenic factors stimulate growth of adult neural stem cells. PLoS One 5, e9414 (2010).
15. Androutsellis-Theotokis, A. et al. Targeting neural precursors in the adult brain rescues injured dopamine neurons. Proc Natl Acad Sci USA 106, 13570-5 (2009).
16. Androutsellis-Theotokis, A., Walbridge, S., Park, D. M., Lonser, R. R. & McKay, R. D. Cholera toxin regulates a signaling pathway critical for the expansion of neural stem cell cultures from the fetal and adult rodent brains. PLoS One 5, e10841 (2010).
17. Miraglia, S. et al. A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood 90, 5013-21 (1997). (Pubitemid 28007218)
18. Weigmann, A., Corbeil, D., Hellwig, A. & Huttner, W. B. Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci USA 94, 12425-30 (1997). (Pubitemid 27492544)
19. Johe, K. K., Hazel, T. G., Muller, T., Dugich-Djordjevic, M. M. & McKay, R. D. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev 10, 3129-40 (1996). (Pubitemid 27020541)
20. Androutsellis-Theotokis, A. et al. Generating neurons from stem cells. Methods Mol Biol 438, 31-8 (2008).
21. Soeda, A. et al. Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene 28, 3949-59 (2009).
22. Soeda, A. et al. Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells. J Biol Chem 283, 10958-66 (2008).
23. Levy, D. E. & Darnell, J. E., Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3, 651-62 (2002). (Pubitemid 34987786)
24. Ravin, R. et al. Potency and fate specification in CNS stem cell populations in vitro. Cell Stem Cell 3, 670-80 (2008).
25. Bonni, A. et al. Regulation of gliogenesis in the central nervous system by the JAKSTAT signaling pathway. Science 278, 477-83 (1997). (Pubitemid 27454434)
26. Rajan, P. &McKay, R. D. Multiple routes to astrocytic differentiation in the CNS. J Neurosci 18, 3620-9 (1998). (Pubitemid 28225670)
27. Kamakura, S. et al. Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol 6, 547-54 (2004). (Pubitemid 38786598)
28. Al-Hajj, M.,Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 100, 3983-8 (2003). (Pubitemid 36418143)
29. Dalerba, P. et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA 104, 10158-63 (2007). (Pubitemid 47175279)
30. O'Brien, C. A., Pollett, A., Gallinger, S. & Dick, J. E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106-10 (2007). (Pubitemid 46067310)
31. Ricci-Vitiani, L. et al. Identification and expansion of human colon-cancerinitiating cells. Nature 445, 111-5 (2007). (Pubitemid 46067311)
32. Li, C. et al. Identification of pancreatic cancer stem cells. Cancer Res 67, 1030-7 (2007).