Antimutagenic and antioxidant activity of novel 4-substituted phenyl-2,2′-bichalcophenes and aza-analogs

Drug Design, Development and Therapy

Volumn 7, Issue , 2013, Pages 73-81

  El Sayed, Wael M ^a,b   Hussin, Warda A ^c  

^a KING FAISAL UNIVERSITY   (Saudi Arabia)

^b Ain Shams University   (Egypt)

^c Assiut Branch   (Egypt)

Author keywords

Antimutagenicity; Benzo a pyrene; Bichalcophenes; Salmonella typhimurium; Sodium azide

Indexed keywords

2,2' BICHALCOPHENE DERIVATIVE; ANTIMUTAGENIC AGENT; ANTIOXIDANT; ASCORBIC ACID; AZA DERIVATIVE; BACTERIAL DNA; BENZO[A]PYRENE; SODIUM AZIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMUTAGENIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA REPAIR; DRUG ACTIVITY; DRUG CYTOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; SALMONELLA TYPHIMURIUM;

ANTIMUTAGENICITY; BENZO[A]PYRENE; BICHALCOPHENES; SALMONELLA TYPHIMURIUM; SODIUM AZIDE;

ANTIMUTAGENIC AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; AZA COMPOUNDS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; MUTAGENICITY TESTS; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873692024     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S40129     Document Type: Article

References (23)

1. Maron DM, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res. 1983;113(3-4):173-215.
2. Jarak I, Marjanović M, Piantanida I, Kralj M, Karminski-Zamola G. Novel pentamidine derivatives: synthesis, anti-tumor properties and polynucleotide-binding activities. Eur J Med Chem. 2011;46(7):2807-2815.
3. Kobayashi J, Kato A, Ota Y, Ohba R, Komatsu K. Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation. Mol Cancer. 2010;9:34-44.
4. Paliwal SK, Verma AN, Paliwal S. Neglected disease-african sleeping sickness: recent synthetic and modeling advances. Sci Pharm. 2011;79(3):389-428.
5. Youssef MM, Al-Omair MA, Ismail MA. Synthesis, DNA affinity, and antimicrobial activity of 4-substituted phenyl-2,20-bichalcophenes and aza-analogues. Med Chem Res. 2012;21(12):4074-4082.
6. Hussin WA, Ismail MA, El-Sayed WM. Novel 4-Substituted Phenyl-2,2′-Bichalcophenes and Aza-Analogues as Antibacterial Agents: Structural Activity Relationship. Drug Des Devel Ther. In press.
7. El-Sayed WM, Hussin WA, Ismail MA. Efficacy of two novel 2,2′-bifurans to inhibit methicillin-resistant Staphylococcus aureus infection in male mice in comparison to vancomycin. Drug Des Devel Ther. 2012;6:279-287.
8. Luch A, Baird WM. Metabolic activation and detoxification of polycyclic aromatic hydrocarbons. In: Luch AA, editor. The Carcinogenic Effects of Polycyclic Aromatic Hydrocarbons. London: Imperial College Press; 2005:19-96.
9. Yoon JH, Besaratinia A, Feng Z, et al. DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a, l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res. 2004;64(20):7321-7328.
10. Tesfai Y, Davis D, Reinhold D. Chromium can reduce the mutagenic effects of benzo[a]pyrenediolepoxide in normal human fibroblasts via an oxidative stress mechanism. Mutat Res. 1998;416(3):159-168.
11. Katoh Y, Nemoto N, Tanaka M, Takayama S. Inhibition of benzo[a]pyrene-induced mutagenesis in Chinese hamster V79cells by hemin and related compounds. Mutat Res. 1983;121(2):153-157.
12. Neffati A, Limem I, Kilani S, et al. A comparative evaluation of mutagenic, antimutagenic, radical scavenging and antibacterial activities of essential oils of Pituranthos chloranthus (Coss et Dur). Drug Chem Toxicol. 2009;32(4):372-380.
13. Ajith T, Subin JP, Jacob J, Sanjay PS, Babitha NV. Antimutagenic and anti-oxidant activities of the non-steroidal anti-inflammatory drug celecoxib. Clin Exp Pharmacol Physiol. 2005;32(10):888-893.
14. Hong CE, Cho MC, Jang HA, Lyu SY. Mutagenicity and anti-mutagenicity of Acanthopanax divaricatus var albeofructus. J Toxicol Sci. 2011;36(5): 661-668.
15. Prieto P, Pineda M, Aguilar M. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: Specific application to the determination of vitamin E. Anal Biochem. 1999;269(2):337-341.
16. Oyaizu M. Studies on products of browning reaction: Antioxidative activity of product of browning reaction prepared from glucosamine. Jpn J Nutr. 1986;44:307-315.
17. Zeiger E. Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: Premises, promises, and performance. Regul Toxicol Pharmacol. 1998;28:85-95.
18. Stauffert I, Paulini H, Steinmann U, Sippel H, Estler CJ. Investigations on mutagenicity and genotoxicity of pentamidine and some related trypanocidal diamidines. Mutat Res. 1990;245(2):93-98.
19. Connor TH, Trizna Z. Pentamidine isethionate is negative in tests for microbial mutagenicity and chromosomal breakage in vitro. Toxicol Lett. 1992;63(1):69-74.
20. Marnewick JL, Gelderblom WC, Joubert E. An investigation on the antimutagenic properties of South African herbal teas. Mutat Res. 2000;471(1-2):157-166.
21. Collins AR, Azqueta A, Langie SA. Effects of micronutrients on DNA repair. Eur J Nutr. 2012;51(3):261-279.
22. Watanabe M, Kobayashi H, Ohta T. Rapid inactivation of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX), a potent mutagen in chlorinated drinking water, by sulfhydryl compounds. Mutat Res. 1994;312(2):131-138.
23. Schwab CE, Huber WW, Parzefall W, et al. Search for compounds that inhibit the genotoxic and carcinogenic effects of heterocyclic aromatic amines. Crit Rev Toxicol. 2000;30(1):1-69.