Antimutagenic and anti-oxidant activities of the non-steroidal anti-inflammatory drug celecoxib

Clinical and Experimental Pharmacology and Physiology

Volumn 32, Issue 10, 2005, Pages 888-893

  Ajith, T A ^a   Subin, J P ^b   Jacob, J ^a   Sanjay, P S ^a   Babitha, N V ^a  

^a AMALA INSTITUTE OF MEDICAL SCIENCES   (India)

^b Kurinji College of Arts and Science   (India)

Author keywords

Anti oxidant; Antimutagenic; Celecoxib; Chemoprevention

Indexed keywords

4 NITRO 1,2 PHENYLENEDIAMINE; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTIMUTAGENIC AGENT; ANTIOXIDANT; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DOXORUBICIN; HYDROXYL RADICAL; METHYLNITRONITROSOGUANIDINE; N (2 FLUORENYL)ACETAMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; SODIUM AZIDE; SUPEROXIDE; 1,2-DIAMINO-4-NITROBENZENE; MUTAGENIC AGENT; PHENYLENEDIAMINE DERIVATIVE; PYRAZOLE DERIVATIVE; SCAVENGER; SULFONAMIDE;

ANIMAL TISSUE; ARTICLE; BACTERIAL MUTATION; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG ACTIVITY; IC 50; LIPID PEROXIDATION; MALE; NONHUMAN; RAT; SALMONELLA TYPHIMURIUM; STATISTICAL SIGNIFICANCE; ANIMAL; DOSE RESPONSE; DRUG EFFECT; GENETICS; LIVER MICROSOME; METABOLISM; MUTATION; SPRAGUE DAWLEY RAT;

2-ACETYLAMINOFLUORENE; 9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIMUTAGENIC AGENTS; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; MALE; METHYLNITRONITROSOGUANIDINE; MICROSOMES, LIVER; MUTAGENS; MUTATION; PHENYLENEDIAMINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM; SODIUM AZIDE; SULFONAMIDES; SUPEROXIDES;

EID: 33644683661     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2010.04280.x     Document Type: Article

References (32)

1. Harris CC. Chemical and physical carcinogenesis. Advances and perspective for the 1990s. Cancer Res. 1990 51 : 5023 44.
2. Gray DA. Insertional mutagenesis: Neoplasia arising from retroviral integration. Cancer Invest. 1991 9 : 295 304.
3. Fearon ER Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990 61 : 759 67.
4. Wright PA Williams GT. Molecular biology and gastric carcinoma. Gut 1993 34 : 145 7.
5. Tahara E. Growth factors and oncogenes in human gastrointestinal carcinomas. J. Cancer Res. Clin. Oncol. 1990 116 : 121 31.
6. Bos JL. Ras oncogene in human cancer: A review. Cancer Res. 1989 49 : 4682 9.
7. Mao L Sidransky D. Cancer screening based on genetic alterations in human tumors. Cancer Res. 1994 54 : 1939 40.
8. 53 gene mutational hotspot in human cancers by etiologically designed carcinogens. Cancer Res. 1991 51 : 6185 9.
9. Goyette MC Cho K Fasching CL et al. Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol. Cell. Biol. 1992 12 : 1387 95.
10. Okada F. Inflammation and free radicals in tumour development and progression. Redox. Rep. 2002 7 : 357 68.
11. Rosin MP Anwar WA Ward AJ. Inflammation, chromosomal instability and cancer: The schistosomiasis model. Cancer Res. 1994 54 ( Suppl. S1929 33.
12. Kawamori T Rao CV Seibert K et al. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. Cancer Res. 1998 58 : 401 12.
13. Steele VE Hawk ET Viner JL et al. Mechanisms and application of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer. Mutat. Res. 2003 523 : 137 44.
14. Penning TD Talky JJ Bertenshaw JR et al. Synthesis and biological evaluation of the 1,5-dioxy pyrazol class of cyclooxygenase inhibitors: Identification of 4-[5-1,4-methyl phenyl 3-trifluromethyl-III-pyrazole-1-yl] benzene sulfonimide (SC-56635 celecoxib). J. Med. Chem. 1997 40 : 1347 65.
15. Simon LS Laza FL Lipsky PE et al. Preliminary study of the safety and efficacy of sc-56635, a novel cyclooxygenase 2 inhibitor. Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects. Arthritis Rheum. 1998 41 : 1591 02.
16. Giardiello FM Hamilton SR Krush AJ et al. Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N. Engl. J. Med. 1993 328 : 1313 16.
17. Swamy MV Cooma I Patlolla JMR et al. Chemoprevention of colon cancer by modulation of cox-2 expression and activity. Development of novel chemoprevention regimens. Proc. Am. Assoc. Cancer Res. 2003 44 : 974 5.
18. Maron DM Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983 113 : 173 15.
19. Ajith TA Janardhanan KK. Antioxidant and antihepatotoxic activities of Phellinus rimosus, (Berk) Pilat. J. Ethnopharmacol. 2002 81 : 387 91.
20. Bishayee S Balasubramanian AS. Lipid peroxide formation in rat brain. J. Neurochem. 1971 18 : 909 20.
21. Ohkawa H Ohishi N Yagi K. Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979 95 : 351 8.
22. Halliwell B. Free radical, antioxidant and human disease: Curiosity, cause or consequence? Lancet 1994 344 : 721 4.
23. Hirose M Imaida K Tamano S et al. Cancer chemoprevention by antioxidants. In: Ho CT, Osawa T, Huang MT, Resen RT (eds). Food Phytochemicals II. Teas, Spices and Herbs. American Chemical Society, Washington D.C. 1994 122 32.
24. Chang H Yen JH Yin CL. Celecoxib stimulates reparatory burst through pertussis toxin-sensitive G-protein, a possible signal for beta 2-integrin expression on human neutrophils. Eur. J. Pharmacol. 2004 484 : 29 39.
25. Horsfall MJ Gordon AJ Burns PA et al. Mutational specificity of alkylating agents and the influence of DNA repair. Environ. Mol. Mutagen. 1990 15 : 107 22.
26. Pietro MD Marra G Cejka P et al. Mismatch repair-dependent transciptance changes in human cells treated with the methylating agent N-methyl-N′- nitro-N-nitrosoguanidine. Cancer Res. 2003 63 : 8158 66.
27. Tang MS Vulimiri SV Viaje A et al. Both (±)syn(±)anti-7,12- dimethyl benz[a]anthracene-3,4-diol-1,2 epoxides initiate tumors in mouse skin that posses CAA to CTA-mutations at codon 61 of C-H-ras. Cancer Res. 2000 60 : 5688 95.
28. Chaudhary AK. Detection of endogenous MDA-deoxyguanosine adducts in human liver. Science 1994 265 : 1580 2.
29. Bartsch H. Formation, detection and role in carcinogenesis of ethenobases in DNA. Drug Metab. Rev. 1994 26 : 349 51.
30. Uchida K Shiraishi M Naito Y et al. Activation of stress signaling pathways by the end product of lipid peroxidation-4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J. Biol. Chem. 1999 274 : 2234 7.
31. Sporn MB. Chemoprevention of cancer. Lancet 1993 342 : 1211 13.
32. Jaiswal M La Rurso NF Gores GJ. Nitric oxide in gastrointestinal epithelial cell carcinogenesis: Linking inflammation to oncogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 2001 281 : G626 34.