Regulation of P21-activated kinase-4 by progesterone and tumor necrosis factor-α in human endometrium and its increased expression in advanced-stage endometriosis

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 2, 2013, Pages

  Kim, Sung Hoon ^a   Kim, So Ra ^a   Ihm, Hyo Jin ^a   Oh, Young Sang ^a   Chae, Hee Dong ^a   Kim, Chung Hoon ^a   Kang, Byung Moon ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

P21 ACTIVATED KINASE 4; PROGESTERONE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL ASSAY; CELL INVASION; CELL VIABILITY; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; ENDOMETRIOSIS; ENDOMETRIUM CELL; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SECRETORY PATHWAY; STROMA CELL; UPREGULATION; WESTERN BLOTTING;

ADULT; CELL LINE; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; HUMANS; MIDDLE AGED; OVARIAN DISEASES; P21-ACTIVATED KINASES; PROGESTERONE; STROMAL CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84873682154     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-2969     Document Type: Article

References (33)

1. Kumar R, Gururaj AE, Barnes CJ. p21-activated kinases in cancer. Nat Rev Cancer. 2006;6:459-471.
2. Bokoch GM. Biology of the p21-activated kinases. Annu Rev Biochem. 2003;72:743-781.
3. Osada S, Izawa M, Koyama T, Hirai S, Ohno S. A domain containing the Cdc42/Rac interactive binding (CRIB) region of p65PAK inhibits transcriptional activation and cell transformation mediated by the Ras-Rac pathway. FEBS Lett. 1997;404:227-233.
4. Tang Y, Chen Z, Ambrose D, et al. Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol. 1997; 17:4454-4464.
5. Vadlamudi RK, Adam L, Wang RA, et al. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem. 2000;275:36238-36244.
6. Eswaran J, Soundararajan M, Kumar R, Knapp S. UnPAKing the class differences among p21-activated kinases. Trends Biochem Sci. 2008;33:394-403.
7. Arias-Romero LE, Chernoff J. A tale of two Paks. Biol Cell. 2008; 100:97-108.
8. Eswaran J, Soundararajan M, Knapp S. Targeting group II PAKs in cancer and metastasis. Cancer Metastasis Rev. 2009;28:209-217.
9. Wells CM, Jones GE. The emerging importance of group II PAKs. Biochem J. 2010;425:465-473.
10. Gnesutta N, Qu J, Minden A. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J Biol Chem. 2001;276:14414-14419.
11. Li X, Minden A. PAK4 functions in tumor necrosis factor (TNF) α-induced survival pathways by facilitating TRADD binding to the TNF receptor. J Biol Chem. 2005;280:41192-41200.
12. Callow MG, Clairvoyant F, Zhu S, et al. Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem. 2002;277:550-558.
13. Qu J, Cammarano MS, Shi Q, Ha KC, de Lanerolle P, Minden A. Activated PAK4 regulates cell adhesion and anchorage-independent growth. Mol Cell Biol. 2001;21:3523-3533.
14. Zhang H, Li Z, Viklund EK, Strö mblad S. P21-activated kinase 4 interacts with integrin αvβ5 and regulates αvβ5-mediated cell migration. J Cell Biol. 2002;158:1287-1297.
15. Chen S, Auletta T, Dovirak O, et al. Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification. Cancer Biol Ther. 2008;7:1793-1802.
16. Kim SH, Lee HW, Kim YH, et al. Down-regulation of p21-activated kinase 1 by progestin and its increased expression in the eutopic endometrium of women with endometriosis. Hum Reprod. 2009; 24:1133-1141.
17. Lee MY, Kim SH, Ihm HJ, Chae HD, Kim CH, Kang BM. Upregulation of p21-activated kinase 1 by in vitro treatment with interleukin 1-β and its increased expression in ovarian endometriotic cysts. Fertil Steril. 2011;96:508-511.
18. American Society for Reproductive Medicine. 1997 Revised American Society for Reproductive Medicine classification of endometriosis: Fertil Steril. 1996;67:817-821.
19. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. AmJ Obstet Gynecol. 1975;122:262-263.
20. Arici A, Head JR, MacDonald PC, Casey ML. Regulation of interleukin-8 gene expression in human endometrial cells in culture. Mol Cell Endocrinol. 1993;94:195-204.
21. Lee SR, Kim SH, Lee HW, et al. Increased expression of glutathione by estradiol, tumor necrosis factor-β, and interleukin 1-β in endometrial stromal cells. Am J Reprod Immunol. 2009;62:352-356.
22. Osteen KG, Bruner-Tran KL, Eisenberg E. Reduced progesterone action during endometrial maturation: a potential risk factor for the development of endometriosis. Fertil Steril. 2005;83:529-537.
23. Kao LC, Germeyer A, Tulac S, et al. Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. Endocrinology. 2003;144:2870-2881.
24. Bulun SE, Cheng YH, Yin P, et al. Progesterone resistance in endometriosis: link to failure to metabolize estradiol. Mol Cell Endocrinol. 2006;248:94-103.
25. Eisermann J, Gast MJ, Pineda J, Odem RR, Collins JL. 1988 Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery. Fertil Steril. 1988;50:573-579.
26. Hill JA, Anderson DJ. Lymphocyte activity in the presence of peritoneal fluid from fertile women and infertile women with and without endometriosis. Am J Obstet Gynecol. 1989;161:861-864.
27. Fakih H, Baggett B, Holtz G, Tsang KY, Lee J, Williamson HO. Interleukin-1: a possible role in the infertility associated with endometriosis. Fertil Steril. 1987;47:213-217.
28. Mori H, Sawairim M, Nakagawa M. Peritoneal fluid interleukin-1α and tumor necrosis factor in patients with benign gynecologic disease. Am J Reprod Immunol. 1991;26:62-67.
29. Chen D, Yang Z, Hilsenrath R. Stimulation of prostaglandin (PG) F2β and PGE2 release by tumor necrosis factor-α and interleukin-1α in cultured human luteal phase endometrial cells. Hum Reprod. 1995;10:2773-2780.
30. Zhang RJ, Wild RA, Ojago J. Effect of tumor necrosis factor-β on adhesion of human endometrial stromal cells to peritoneal mesothelial cells: an in vitro system. Fertil Steril. 1993;59:1196-1201.
31. Falconer H, Mwenda JM, Chai DC, et al. Treatment with anti-TNF monoclonal antibody (c5N) reduces the extent of induced endometriosis in the baboon. Hum Reprod. 2006;21:1856-1862.
32. Zhou L, Yan C, Gieling RG, et al. Tumor necrosis factor-β induced expression of matrix metalloproteinase-9 through p21-activated kinase-1. BMC Immunol. 2009;10:15.
33. Kalkhoven E, Wissink S, van der Saag PT, van der Burg B. Negative interaction between the RelA(p65) subunit of NF-κB and the progesterone receptor. J Biol Chem. 1996;271:6217-6224.