메뉴 건너뛰기




Volumn 22, Issue 3, 2013, Pages 317-328

Vascular-disrupting agents in oncology

Author keywords

Angiogenesis inhibitors; Cancer; Vascular disrupting agents; VEGF

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; CISPLATIN; COMBRETASTATIN A4 PHOSPHATE; DOCETAXEL; OMBRABULIN; PACLITAXEL; PLINABULIN; VADIMEZAN; VERUBULIN;

EID: 84873680173     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2013.759557     Document Type: Review
Times cited : (57)

References (85)
  • 1
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356:125-34
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 2
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus Interferon Alfa in metastatic renal cellcarcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al. Sunitinib versus Interferon Alfa in metastatic renal cellcarcinoma. N Engl J Med 2007;356:115-24
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 3
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 4
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer. N Engl J Med 2006;355:2542-50
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 5
    • 33744812137 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients
    • Ramaswamy B, Elias AD, Kelbick NT, et al. Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients. Clin Cancer Res 2006;10:3124-9
    • (2006) Clin Cancer Res , vol.10 , pp. 3124-3129
    • Ramaswamy, B.1    Elias, A.D.2    Kelbick, N.T.3
  • 6
    • 75449088610 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme
    • Cohen MH, Shen YL, Keegan P, Pazdur R. FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiforme. Oncologist 2009;14(11):1131-8
    • (2009) Oncologist , vol.14 , Issue.11 , pp. 1131-1138
    • Cohen, M.H.1    Shen, Y.L.2    Keegan, P.3    Pazdur, R.4
  • 7
    • 60749109735 scopus 로고    scopus 로고
    • A phase i study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors
    • abstract 3550
    • Nathan PD, Judson I, Padhani A, et al. A phase I study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors. J Clin Oncol 2008;26(Suppl): abstract 3550
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Nathan, P.D.1    Judson, I.2    Padhani, A.3
  • 8
    • 49049086508 scopus 로고    scopus 로고
    • Dual targeting of tumor vasculature: Combining Avastin and vascular disrupting agents (CA4P or OXi4503
    • Siemann DW, Shi W. Dual targeting of tumor vasculature: combining Avastin and vascular disrupting agents (CA4P or OXi4503). Anticancer Res 2008;28:2027-31
    • (2008) Anticancer Res , vol.28 , pp. 2027-2031
    • Siemann, D.W.1    Shi, W.2
  • 9
    • 27744553032 scopus 로고    scopus 로고
    • Targeting the tumor vasculature: Enhancing antitumor efficacy through combination treatment with ZD6126 and ZD6474
    • Shi W, Siemann DW. Targeting the tumor vasculature: enhancing antitumor efficacy through combination treatment with ZD6126 and ZD6474. In Vivo 2005;19:1045-50
    • (2005) In Vivo , vol.19 , pp. 1045-1050
    • Shi, W.1    Siemann, D.W.2
  • 10
    • 57449103348 scopus 로고    scopus 로고
    • Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, Von Pawel J, Reck M, et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Br J Cancer 2008;99:2006-12
    • (2008) Br J Cancer , vol.99 , pp. 2006-2012
    • McKeage, M.J.1    Von Pawel, J.2    Reck, M.3
  • 11
    • 0042386700 scopus 로고    scopus 로고
    • Phase i clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
    • Rustin GJS, Galbraith SM, Anderson H, et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol 2003;21:2815-22
    • (2003) J Clin Oncol , vol.21 , pp. 2815-2822
    • Gjs, R.1    Galbraith, S.M.2    Anderson, H.3
  • 12
    • 33645732100 scopus 로고    scopus 로고
    • Phase i clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors
    • Beerepoot LV, Radema SA, Witteveen EO, et al. Phase I clinical evaluation of weekly administration of the novel vascular-targeting agent, ZD6126, in patients with solid tumors. J Clin Oncol 2006;24:1491-8
    • (2006) J Clin Oncol , vol.24 , pp. 1491-1498
    • Beerepoot, L.V.1    Radema, S.A.2    Witteveen, E.O.3
  • 13
    • 79961017301 scopus 로고    scopus 로고
    • Modeling of angioadaptation: Insights for vascular development
    • Pries AR, Reglin B, Secomb TW. Modeling of angioadaptation: insights for vascular development. Int J Dev Biol 2011;55:399-405
    • (2011) Int J Dev Biol , vol.55 , pp. 399-405
    • Pries, A.R.1    Reglin, B.2    Secomb, T.W.3
  • 14
    • 0025093973 scopus 로고
    • Vascular attack as a therapeutic strategy for cancer
    • Denekamp J. Vascular attack as a therapeutic strategy for cancer. Cancer Metastasis Rev 1990;9:267-82
    • (1990) Cancer Metastasis Rev , vol.9 , pp. 267-282
    • Denekamp, J.1
  • 16
    • 68049108414 scopus 로고    scopus 로고
    • Vascular disrupting agents: A novel mechanism of action in the battle against non-small cell lung cancer
    • Gridelli C, Rossi A, Maione P, et al. Vascular disrupting agents: a novel mechanism of action in the battle against non-small cell lung cancer. Oncologist 2009;14:612-20
    • (2009) Oncologist , vol.14 , pp. 612-620
    • Gridelli, C.1    Rossi, A.2    Maione, P.3
  • 17
    • 33751583518 scopus 로고    scopus 로고
    • Drug insight: Vascular disrupting agents and angiogenesis-novel approaches for drug delivery
    • Cooney MM, Heckeren W, Bhakta S. Drug insight: vascular disrupting agents and angiogenesis-novel approaches for drug delivery. Nat Clin Pract Oncology 2006;3:682-92
    • (2006) Nat Clin Pract Oncology , vol.3 , pp. 682-692
    • Cooney, M.M.1    Heckeren, W.2    Bhakta, S.3
  • 18
    • 63049122188 scopus 로고    scopus 로고
    • Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab
    • Sander A, Schiller J, Gray R, et al. Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab. J Clin Oncol 2009;27:1405-12
    • (2009) J Clin Oncol , vol.27 , pp. 1405-1412
    • Sander, A.1    Schiller, J.2    Gray, R.3
  • 19
    • 60749109735 scopus 로고    scopus 로고
    • A phase i study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors
    • abstract 3550
    • Nathan PD, Judson I, Padhani A, et al. A phase I study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors. J Clin Oncol 2008;26(Suppl):abstract 3550
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Nathan, P.D.1    Judson, I.2    Padhani, A.3
  • 20
    • 49049086508 scopus 로고    scopus 로고
    • Dual targeting of tumor vasculature: Combining Avastin and vascular disrupting agents (CA4P or OXi4503
    • Siemann DW, Shi W. Dual targeting of tumor vasculature: combining Avastin and vascular disrupting agents (CA4P or OXi4503). Anticancer Res 2008;28:2027-31
    • (2008) Anticancer Res , vol.28 , pp. 2027-2031
    • Siemann, D.W.1    Shi, W.2
  • 21
    • 27744553032 scopus 로고    scopus 로고
    • Targeting the tumor vasculature: Enhancing antitumor efficacy through combination treatment with ZD6126 and ZD6474
    • Shi W, Siemann DW. Targeting the tumor vasculature: enhancing antitumor efficacy through combination treatment with ZD6126 and ZD6474. In Vivo 2005;19:1045-50
    • (2005) In Vivo , vol.19 , pp. 1045-1050
    • Shi, W.1    Siemann, D.W.2
  • 22
    • 80054760369 scopus 로고    scopus 로고
    • Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors
    • Marysael T, Ni Y, Lerut E, de Witte P. Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors. J Cancer Res Clin Oncol 2011;137:1619-27
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1619-1627
    • Marysael, T.1    Ni, Y.2    Lerut, E.3    De Witte, P.4
  • 23
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
    • Siemann DW, Mercer E, Lepler S, Rojiani AM. Vascular Targeting Agents Enhance Chemotherapeutic Agent Activities in Solid Tumor Therapy. Int J Cancer 2002;99:1-6
    • (2002) Int J Cancer , vol.99 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rojiani, A.M.4
  • 24
    • 0037222218 scopus 로고    scopus 로고
    • Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Siim BG, Lee AE, Shalal-Zwain S, et al. Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemother Pharmacol 2003;51:43-52
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 43-52
    • Siim, B.G.1    Lee, A.E.2    Shalal-Zwain, S.3
  • 25
    • 60749109735 scopus 로고    scopus 로고
    • A phase i study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors
    • abstract 3550
    • Nathan PD, Judson I, Padhani A, et al. A phase I study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors. J Clin Oncol 2008;26(Suppl):abstract 3550
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Nathan, P.D.1    Judson, I.2    Padhani, A.3
  • 26
    • 84873675615 scopus 로고    scopus 로고
    • A study to assess the effectiveness of the combination of carboplatin, paclitaxel, bevacizumab and combretastatin (CA4P)
    • Available from
    • A Study to Assess the Effectiveness of the Combination of Carboplatin, Paclitaxel, Bevacizumab and Combretastatin (CA4P) in Patients With Chemotherapy Na?̈ve Lung Cancer. Available from: http://www.clinicaltrials.gov/ct2/show/ NCT00653939
    • Patients with Chemotherapy Na?̈ve Lung Cancer
  • 27
    • 79959586755 scopus 로고    scopus 로고
    • AS1404-201 Study Group Investigators Comparative outcomes of squamous and non-squamous non-small cell lung cancer (NSCLC) patients in phase II studies of ASA404 (DMXAA)-retrospective analysis of pooled data
    • McKeage MJ, Jameson MB. AS1404-201 Study Group Investigators Comparative outcomes of squamous and non-squamous non-small cell lung cancer (NSCLC) patients in phase II studies of ASA404 (DMXAA)-retrospective analysis of pooled data. J Thorac Dis 2010;2:199-204
    • (2010) J Thorac Dis , vol.2 , pp. 199-204
    • McKeage, M.J.1    Jameson, M.B.2
  • 28
    • 57449103348 scopus 로고    scopus 로고
    • Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, Von Pawel J, Reck M, et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Br J Cancer 2008;99:2006-12
    • (2008) Br J Cancer , vol.99 , pp. 2006-2012
    • McKeage, M.J.1    Von Pawel, J.2    Reck, M.3
  • 29
    • 67449123059 scopus 로고    scopus 로고
    • Phase II study of ASA 404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/DMXAA) 1800mg/m2 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, Reck M, Jameson MB, et al. Phase II study of ASA404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/DMXAA) 1800mg/m2 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Lung Cancer 2009;65:192-7
    • (2009) Lung Cancer , vol.65 , pp. 192-197
    • McKeage, M.J.1    Reck, M.2    Jameson, M.B.3
  • 30
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004;22:2184-91
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 31
    • 54249138858 scopus 로고    scopus 로고
    • Sorafenib plus carboplatin/paclitaxel in chemonaive patients with stage IIIb-IV nonsmall cell lung cancer (NSCLC): Interim analysis (IA) results from the phase III randomized doubleblind placebo-controlled ESCAPE (evaluation of sorafenib carboplatin and paclitaxel efficacy in NSCLC) trial
    • Scagliotti G, von Pawel J, Reck M, et al. Sorafenib plus carboplatin/paclitaxel in chemonaive patients with stage IIIb-IV nonsmall cell lung cancer (NSCLC): interim analysis (IA) results from the phase III, randomized, doubleblind, placebo-controlled, ESCAPE (evaluation of sorafenib, carboplatin, and paclitaxel efficacy in NSCLC) trial. Late breaking abstract presented at 1st European Lung Cancer Conference; 2008
    • (2008) Late Breaking Abstract Presented at 1st European Lung Cancer Conference
    • Scagliotti, G.1    Von Pawel, J.2    Reck, M.3
  • 32
    • 0029063213 scopus 로고
    • Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid
    • Philpott M, Baguley BC, Ching LM. Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother Pharmacol 1995;36:143-8
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 143-148
    • Philpott, M.1    Baguley, B.C.2    Ching, L.M.3
  • 33
    • 0022971018 scopus 로고
    • Activity of flavone acetic acid (NSC-347512) against solid tumors of mice
    • Corbett TH, Bissery MC, Wozniak A, et al. Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. Invest New Drugs 1986;4:207-20
    • (1986) Invest New Drugs , vol.4 , pp. 207-220
    • Corbett, T.H.1    Bissery, M.C.2    Wozniak, A.3
  • 34
    • 80051638135 scopus 로고    scopus 로고
    • Randomized Phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan(ASA404) in advanced non-small-cell lung cancer
    • Lara Jr PN, Douillard J-Y, Nakagawa K, et al. Randomized Phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. J Clin Oncol 2011;29:2965-71
    • (2011) J Clin Oncol , vol.29 , pp. 2965-2971
    • Lara Jr., P.N.1    Douillard, J.-Y.2    Nakagawa, K.3
  • 35
    • 33645659565 scopus 로고    scopus 로고
    • 5,6-dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: A Phase i safety study of a vascular disrupting agent
    • McKeage MJ, Fong P, Jeffery M, et al. 5,6-dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: a Phase I safety study of a vascular disrupting agent. Clin Cancer Res 2006;12:1776-84
    • (2006) Clin Cancer Res , Issue.12 , pp. 1776-1784
    • McKeage, M.J.1    Fong, P.2    Jeffery, M.3
  • 36
    • 34247254358 scopus 로고    scopus 로고
    • AS1404-202 Study Group Investigators. Phase II study of vadimezan combined with carboplatin and paclitaxel in recurrent ovarian cancer
    • Gabra H; AS1404-202 Study Group Investigators. Phase II study of vadimezan combined with carboplatin and paclitaxel in recurrent ovarian cancer. J Clin Oncol 2006;24(Suppl):5032
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. , pp. 5032
    • Gabra, H.1
  • 37
    • 71949103916 scopus 로고    scopus 로고
    • AS1404-203 study group investigators. Addition of vadimezan (ASA404) to docetaxel in patients with hormone-refractory metastatic prostate cancer (HRMPC): Update from a randomized, phase II study
    • Pili R, Rosenthal M. AS1404-203 study group investigators. Addition of vadimezan (ASA404) to docetaxel in patients with hormone-refractory metastatic prostate cancer (HRMPC): update from a randomized, phase II study. J Clin Oncol 2008;26(Suppl):5007
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. , pp. 5007
    • Pili, R.1    Rosenthal, M.2
  • 38
    • 70450216884 scopus 로고    scopus 로고
    • Comparison of safety and efficacy between squaomous and non-squamous non-small cell lung cancer patients in a Phase II study of vadimezan ASA 404
    • McKeage MJ, Jameson MB. Comparison of safety and efficacy between squaomous and non-squamous non-small cell lung cancer patients in a Phase II study of vadimezan (ASA404). J Clin Oncol 2008;26(Suppl 15):441s
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. 15
    • McKeage, M.J.1    Jameson, M.B.2
  • 39
    • 67449123059 scopus 로고    scopus 로고
    • Phase II study of ASA 404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/vadimezan) 1800mg/m(2) combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
    • McKeage MJ, Reck M, Jameson MB, et al. Phase II study of ASA404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/vadimezan) 1800mg/m(2) combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Lung Cancer 2009;65(2):192-7
    • (2009) Lung Cancer , vol.65 , Issue.2 , pp. 192-197
    • McKeage, M.J.1    Reck, M.2    Jameson, M.B.3
  • 40
    • 84873695612 scopus 로고    scopus 로고
    • ASA 404 or Placebo in Combination With Paclitaxel and Carboplatin as First-Line Treatment for Stage IIIb/IV Non-Small Cell Lung Cancer Available from
    • ASA404 or Placebo in Combination With Paclitaxel and Carboplatin as First-Line Treatment for Stage IIIb/IV Non-Small Cell Lung Cancer. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00662597
  • 41
    • 84873676900 scopus 로고    scopus 로고
    • A Study of ASA 404 or Placebo in Combination With Docetaxel in Second-Line Treatment for (Stage IIIb/IV Non-Small Cell Lung Cancer (ATTRACT-2) Available from
    • A Study of ASA404 or Placebo in Combination With Docetaxel in Second-Line Treatment for (Stage IIIb/IV) Non-Small Cell Lung Cancer (ATTRACT-2). Available from: http://www.clinicaltrials.gov/ct2/show/NCT00738387
  • 42
    • 80051638135 scopus 로고    scopus 로고
    • Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan
    • ASA404) in advanced non-small-cell lung cancer
    • Lara P, Douillard J, Nakagawa K, et al. Randomized phase III placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (ASA404) in advanced non-small-cell lung cancer. J Clin Oncol 2011;29:2965-71
    • (2011) J Clin Oncol , vol.29 , pp. 2965-2971
    • Lara, P.1    Douillard, J.2    Nakagawa, K.3
  • 43
    • 80051612685 scopus 로고    scopus 로고
    • Clinical Development of vascular disrupting agents: What lessions can we learn from ASA 404?
    • LoRusso PM, Boerner SA. Clinical Development of vascular disrupting agents: what lessions can we learn from ASA404? J Clin Oncol 2011;29:2952-5
    • (2011) J Clin Oncol , vol.29 , pp. 2952-2955
    • Lorusso, P.M.1    Boerner, S.A.2
  • 44
    • 0036282385 scopus 로고    scopus 로고
    • The biology of the combretastatins as tumor vascular targeting agents
    • Tozer GM, Kanthou C, Parkins CS, Hill SA. The biology of the combretastatins as tumor vascular targeting agents. Int J of Exp Pathol 2002;83:21-38
    • (2002) Int J of Exp Pathol , vol.83 , pp. 21-38
    • Tozer, G.M.1    Kanthou, C.2    Parkins, C.S.3    Hill, S.A.4
  • 45
    • 84855855270 scopus 로고
    • The tumor vascular targeting agent combretastatin A-4 phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing
    • Kanthou C, Tozer GM. The tumor vascular targeting agent combretastatin A-4 phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing. Anticancer Drugs 1993;4:3-17
    • (1993) Anticancer Drugs , vol.4 , pp. 3-17
    • Kanthou, C.1    Tozer, G.M.2
  • 46
    • 27644466314 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelis-cadherin signaling
    • Vincent L, Kermani P, Young LM, et al. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelis-cadherin signaling. J Clin Invest 2005;115:2992-3006
    • (2005) J Clin Invest , vol.115 , pp. 2992-3006
    • Vincent, L.1    Kermani, P.2    Young, L.M.3
  • 47
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
    • Tozer GM, Prise VE, Wilson J, et al. Combretastatin A4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res 1999;59:1626-34
    • (1999) Cancer Res , vol.59 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 48
    • 41549126681 scopus 로고    scopus 로고
    • Distinct signaling pathways of microtubule inhibitors-vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively
    • Kolomeichuk SN, Terrano DT, Lyle CS, et al. Distinct signaling pathways of microtubule inhibitors-vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively. FEBS J 2008;275:1889-99
    • (2008) FEBS J , vol.275 , pp. 1889-1899
    • Kolomeichuk, S.N.1    Terrano, D.T.2    Lyle, C.S.3
  • 49
    • 34547730849 scopus 로고    scopus 로고
    • Combination chemotherapy including combretastatin A4 Phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model
    • Yeung S-CJ, She M, Yang H, et al. Combination chemotherapy including combretastatin A4 Phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model. J Clin Endocrinol Metab 2007;92:2902-9
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2902-2909
    • S-Cj, Y.1    She, M.2    Yang, H.3
  • 51
    • 1642494772 scopus 로고    scopus 로고
    • Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose Phase i study in patients with advanced cancer
    • Cooney MM, Radivoyevitch T, Dowlati A, et al. Cardiovascular safety profile of combretastatin a4 phosphate in a single-dose Phase I study in patients with advanced cancer. Clin Cancer Res 2004;10(1 Pt 1):96-100
    • (2004) Clin Cancer Res , vol.10 , Issue.1 PART 1 , pp. 96-100
    • Cooney, M.M.1    Radivoyevitch, T.2    Dowlati, A.3
  • 52
    • 0642307227 scopus 로고    scopus 로고
    • Phase i trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow
    • Stevenson JP, Rosen M, Sun W, et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol 2003;21:4428-38
    • (2003) J Clin Oncol , vol.21 , pp. 4428-4438
    • Stevenson, J.P.1    Rosen, M.2    Sun, W.3
  • 53
    • 0042386700 scopus 로고    scopus 로고
    • Phase i clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
    • Rustin GJ, Galbraith SM, Anderson H, et al. Phase I clinical trial of weekly combretastatin A4 phosphate: clinical and pharmacokinetic results. J Clin Oncol 2003;21(15):2815-22
    • (2003) J Clin Oncol , vol.21 , Issue.15 , pp. 2815-2822
    • Rustin, G.J.1    Galbraith, S.M.2    Anderson, H.3
  • 54
    • 20044395276 scopus 로고    scopus 로고
    • Phase i Trial of Combretastatin A-4 Phosphate with Carboplatin
    • Bilenker JH, Flaherty KT, Rosen M, et al. Phase I Trial of Combretastatin A-4 Phosphate with Carboplatin. Clin Cancer Res 2005;11:1527-33
    • (2005) Clin Cancer Res , vol.11 , pp. 1527-1533
    • Bilenker, J.H.1    Flaherty, K.T.2    Rosen, M.3
  • 55
    • 0036959614 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate has primary antineoplastic activity against human anaplastic thyroid carcinoma cell lines and xenograft tumors
    • Dziba JM, Marcinek R, Venkataraman G, et al. Combretastatin A4 phosphate has primary antineoplastic activity against human anaplastic thyroid carcinoma cell lines and xenograft tumors. Thyroid 2002;12(12):1063-70
    • (2002) Thyroid , vol.12 , Issue.12 , pp. 1063-1070
    • Dziba, J.M.1    Marcinek, R.2    Venkataraman, G.3
  • 56
    • 84860183520 scopus 로고    scopus 로고
    • A randomized phase II/III trial of a tumor vascular disrupting agent fosbretabulin tromethamine (CA4P) with carboplatin and paclitaxel in anaplastic thyroid cancer: Final survival analysis for FACT trial
    • abstract 5502
    • Sosa JA, Elisei R, Jarzab B, et al. A randomized phase II/III trial of a tumor vascular disrupting agent fosbretabulin tromethamine (CA4P) with carboplatin and paclitaxel in anaplastic thyroid cancer: final survival analysis for FACT trial. J Clin Oncol 2011;29(Suppl):abstract 5502
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Sosa, J.A.1    Elisei, R.2    Jarzab, B.3
  • 57
    • 79953648492 scopus 로고    scopus 로고
    • Phase II trial of combretastatin A-4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer
    • Zweifel M, Jayson GC, Reed NS, et al. Phase II trial of combretastatin A-4 phosphate, carboplatin, and paclitaxel in patients with platinum-resistant ovarian cancer. Ann Oncol 2011;22:2036-41
    • (2011) Ann Oncol , vol.22 , pp. 2036-2041
    • Zweifel, M.1    Jayson, G.C.2    Reed, N.S.3
  • 58
    • 60749109735 scopus 로고    scopus 로고
    • A phase i study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors
    • Nathan PD, Judson I, Padhani A, et al. A phase I study of combretastatin A4 phosphate (CA4P) and bevacizumab in subjects with advanced solid tumors. J Clin Oncol 2008;26(Suppl):3550
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. , pp. 3550
    • Nathan, P.D.1    Judson, I.2    Padhani, A.3
  • 59
    • 84859606443 scopus 로고    scopus 로고
    • A randomized phase II trial of a vascular disrupting agent (VDA) fosbretabulin tromethamine (CA4P) with carboplatin, paclitaxel and bevacizumab in stage 3B/4 nonsquamous non-small cell lung cancer (NSCLC): Analysis of safety and activity of the FALCON trial
    • abstract 7559
    • Garon EB, Kabbinavar FF, Neidhart JA, et al. A randomized phase II trial of a vascular disrupting agent (VDA) fosbretabulin tromethamine (CA4P) with carboplatin, paclitaxel and bevacizumab in stage 3B/4 nonsquamous non-small cell lung cancer (NSCLC): analysis of safety and activity of the FALCON trial. J Clin Oncol 2011;29(Suppl):abstract 7559
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Garon, E.B.1    Kabbinavar, F.F.2    Neidhart, J.A.3
  • 61
    • 33646118484 scopus 로고    scopus 로고
    • NPI-2358 is a tubulin-depolymerizing agent: In-vitro evidence for activity as a tumor vascular-disrupting agent
    • Nicholson B, Lloyd GK, Miller BR, et al. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs 2006;17:25-31
    • (2006) Anticancer Drugs , vol.17 , pp. 25-31
    • Nicholson, B.1    Lloyd, G.K.2    Miller, B.R.3
  • 62
    • 78650376933 scopus 로고    scopus 로고
    • Phase 1 first-in-human trial of the vascular disrupting agent plinabulin (NPI-2358) in patients with solid tumors or lymphomas
    • Mita M, Spear MA, Yee LK, et al. Phase 1 first-in-human trial of the vascular disrupting agent plinabulin (NPI-2358) in patients with solid tumors or lymphomas. Clin Cancer Res 2010;16(23):5892-9
    • (2010) Clin Cancer Res , vol.16 , Issue.23 , pp. 5892-5899
    • Mita, M.1    Spear, M.A.2    Yee, L.K.3
  • 64
    • 84873662626 scopus 로고    scopus 로고
    • NPI-2358, A novel tumor vascular disrupting agent potentiates the anti-tumor activity of docetaxel in the non small cell lung cancer model MV52 [abstract 141]
    • Neuteboom STC, Medina E, Palladino MA, et al. NPI-2358, A novel tumor vascular disrupting agent potentiates the anti-tumor activity of docetaxel in the non small cell lung cancer model MV52 [abstract 141]. Eur J Cancer 2008;6(Suppl):40-0
    • (2008) Eur J Cancer , vol.6 , Issue.SUPPL. , pp. 40-41
    • Stc, N.1    Medina, E.2    Palladino, M.A.3
  • 65
    • 84864349509 scopus 로고    scopus 로고
    • Phase 1 Study of the Novel Vascular Disrupting Agent Plinabulin (NPI-2358) and Docetaxel
    • Millward M, Mainwaring P, Mita A, et al. Phase 1 Study of the Novel Vascular Disrupting Agent Plinabulin (NPI-2358) and Docetaxel. Invest New Drugs 2012;30:1065-73
    • (2012) Invest New Drugs , vol.30 , pp. 1065-1073
    • Millward, M.1    Mainwaring, P.2    Mita, A.3
  • 66
    • 0034069620 scopus 로고    scopus 로고
    • Prospective randomized trial of docetaxel versus best supportive care in patients with non-small cell lung cancer previously treated with platinum-based chemotherapy
    • Shepherd FA, Dancey J, Ramlau R, et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol 2000;18:2095-103
    • (2000) J Clin Oncol , vol.18 , pp. 2095-2103
    • Shepherd, F.A.1    Dancey, J.2    Ramlau, R.3
  • 67
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N, Shepherd FA, Fossella FV, et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004;22158997
    • (2004) J Clin Oncol , vol.2215 , pp. 89-97
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 68
    • 78049454954 scopus 로고    scopus 로고
    • Phase II study of docetaxel with or without plinabulin (NPI-2358) in patients with non-small cell lung cancer (NSCLC) [abstract 7592]
    • Mita AC, Heist RS, Aren O, et al. Phase II study of docetaxel with or without plinabulin (NPI-2358) in patients with non-small cell lung cancer (NSCLC) [abstract 7592]. J Clin Oncol 2010;28(Suppl)):15s
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Mita, A.C.1    Heist, R.S.2    Aren, O.3
  • 69
    • 33750569421 scopus 로고    scopus 로고
    • A pharmacokinetic and DCE-MRI-dynamic phase i study of the antivascular combretastatin analogue AVE8062A administered every 3 weeks
    • Sessa C, Lorusso P, Tolcher AW, et al. A pharmacokinetic and DCE-MRI-dynamic phase I study of the antivascular combretastatin analogue AVE8062A administered every 3 weeks. Proc Amer Assoc Cancer Res 2005;46
    • (2005) Proc Amer Assoc Cancer Res , vol.46
    • Sessa, C.1    Lorusso, P.2    Tolcher, A.W.3
  • 70
    • 84855851144 scopus 로고    scopus 로고
    • Interest of DCE-US with quantification to demonstrate the VDA effect on vascularization in patients with advanced solid tumors treated with AVE8062
    • Chebil M, Soria J, Chami L, et al. Interest of DCE-US with quantification to demonstrate the VDA effect on vascularization in patients with advanced solid tumors treated with AVE8062. J Clin Oncol 2009;27(Suppl):e14522
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Chebil, M.1    Soria, J.2    Chami, L.3
  • 73
    • 70349338935 scopus 로고    scopus 로고
    • AVE8062: A new combretastatin derivative vascular disrupting agent
    • Delmonte A, Sessa C. AVE8062: a new combretastatin derivative vascular disrupting agent. Expert Opin Investig Drugs 2009;18(10):1541-8
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.10 , pp. 1541-1548
    • Delmonte, A.1    Sessa, C.2
  • 74
    • 84873651666 scopus 로고    scopus 로고
    • A phase i study of ombrabulin combined with bevacizumab in patients with advanced solid tumors-preliminary results [abstract L6.5]
    • Ong M, del Conte G, Bahleda R, et al. A phase I study of ombrabulin combined with bevacizumab in patients with advanced solid tumors-preliminary results [abstract L6.5]. Anals Oncology 2012;23(Suppl):i15-25
    • (2012) Anals Oncology , vol.23 , Issue.SUPPL.
    • Ong, M.1    Del Conte, G.2    Bahleda, R.3
  • 75
    • 45349105034 scopus 로고    scopus 로고
    • Two Phase 1 studies of MPC-6827, a novel vascular disrupting agents (VDA), in patients with advanced solid tumors and CNS metastasis
    • Kurzrock R, Akerley W, Hong D, et al. Two Phase 1 studies of MPC-6827, a novel vascular disrupting agents (VDA), in patients with advanced solid tumors and CNS metastasis. J Clin Oncol 2007;25(20 Suppl):3604
    • (2007) J Clin Oncol , vol.25 , Issue.20 SUPPL. , pp. 3604
    • Kurzrock, R.1    Akerley, W.2    Hong, D.3
  • 76
    • 78650450212 scopus 로고    scopus 로고
    • Phase i Clinical Trial of MPC-6827 (Azixa), A Microtubule Destabilizing Agent, in Patients with Advanced Cancer
    • Tsimberidou AM, Akerley W, Schabel MC, et al. Phase I Clinical Trial of MPC-6827 (Azixa), A Microtubule Destabilizing Agent, in Patients with Advanced Cancer. Mol Cancer Ther 2010;9:3410-19
    • (2010) Mol Cancer Ther , vol.9 , pp. 3410-3419
    • Tsimberidou, A.M.1    Akerley, W.2    Schabel, M.C.3
  • 77
    • 84873675194 scopus 로고    scopus 로고
    • Phase 2 study of Azixa (MPC-6827) for the treatment of glioblastoma after bevacizumab failure
    • Phase 2 study of Azixa (MPC-6827) for the treatment of glioblastoma after bevacizumab failure. Society for Neuro-Oncology Scientific Meeting; 2010
    • (2010) Society for Neuro-Oncology Scientific Meeting
  • 78
    • 84873671850 scopus 로고    scopus 로고
    • Phase II study using the response assessment in neuro-oncology (RANO) criteria to evaluate the efficacy of verubulin with radiation therapy and temozolomide in subjects newly diagnosed with glioblastoma multiforme: Part a safety and tolerability results [abstract OT-08]
    • Zhu J-J, Recht LD, Colman H, et al. Phase II study using the response assessment in neuro-oncology (RANO) criteria to evaluate the efficacy of verubulin with radiation therapy and temozolomide in subjects newly diagnosed with glioblastoma multiforme: part a safety and tolerability results [abstract OT-08]. Neuro-Oncology 2011;13:iii85-91
    • (2011) Neuro-Oncology , vol.13
    • Zhu, J.-J.1    Recht, L.D.2    Colman, H.3
  • 79
    • 84866493383 scopus 로고    scopus 로고
    • AURELIA: A randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC)
    • abstract LBA5002
    • Pujade-Lauraine E, Hilpert F, Weber B, et al. AURELIA: a randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC). J Clin Oncol 2012;30(Suppl): abstract LBA5002
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Pujade-Lauraine, E.1    Hilpert, F.2    Weber, B.3
  • 80
    • 66149121478 scopus 로고    scopus 로고
    • Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: A meta-analysis
    • Hapani S, Chu D, Wu S. Risk of gastrointestinal perforation in patients with cancer treated with bevacizumab: a meta-analysis. Lancet Oncol 2009;10(6):559-68
    • (2009) Lancet Oncol , vol.10 , Issue.6 , pp. 559-568
    • Hapani, S.1    Chu, D.2    Wu, S.3
  • 81
    • 36849056497 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
    • Cannistra SA, Matulonis UA, Penson RT, et al. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol 2007;25:5180-6
    • (2007) J Clin Oncol , vol.25 , pp. 5180-5186
    • Cannistra, S.A.1    Matulonis, U.A.2    Penson, R.T.3
  • 83
    • 84860449805 scopus 로고    scopus 로고
    • Gastrointestinal perforation associated with bevacizumab use in metastatic colorectal cancer: Results from a large treatment observational cohort study
    • Kabbinavar FF, Flynn PJ, Kozloff M, et al. Gastrointestinal perforation associated with bevacizumab use in metastatic colorectal cancer: results from a large treatment observational cohort study. Eur J Cancer 2012;48:1126-32
    • (2012) Eur J Cancer , vol.48 , pp. 1126-1132
    • Kabbinavar, F.F.1    Flynn, P.J.2    Kozloff, M.3
  • 84
    • 84873633789 scopus 로고    scopus 로고
    • The vascular disrupting agent ombrabulin (AVE8062) enhances the efficacy of standard therapies in head and neck squamous cell carcinoma xenograft models
    • Epub ahead of print
    • Clemenson C, Jouannot E, Merino-Trigo A, et al. The vascular disrupting agent ombrabulin (AVE8062) enhances the efficacy of standard therapies in head and neck squamous cell carcinoma xenograft models. Invest New Drugs 2012; [Epub ahead of print]
    • (2012) Invest New Drugs
    • Clemenson, C.1    Jouannot, E.2    Merino-Trigo, A.3
  • 85
    • 60549118166 scopus 로고    scopus 로고
    • Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab
    • Scartozzi M, Galizia E, Chiorrini S, et al. Arterial hypertension correlates with clinical outcome in colorectal cancer patients treated with first-line bevacizumab. Ann Oncol 2009;20(2):227-30
    • (2009) Ann Oncol , vol.20 , Issue.2 , pp. 227-230
    • Scartozzi, M.1    Galizia, E.2    Chiorrini, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.