메뉴 건너뛰기




Volumn 24, Issue 1, 2012, Pages 8-13

Bevacizumab and ovarian cancer

Author keywords

angiogenesis; bevacizumab; molecular targeted therapy; ovarian cancer; vascular endothelial growth factor

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; PACLITAXEL; VASCULOTROPIN;

EID: 84855809821     PISSN: 1040872X     EISSN: 1473656X     Source Type: Journal    
DOI: 10.1097/GCO.0b013e32834daeed     Document Type: Review
Times cited : (28)

References (45)
  • 1
    • 42949171158 scopus 로고    scopus 로고
    • Global Cancer Facts & Figures 2007. Available from http://www.cancer.org/Research/CancerFactsFigures/GlobalCancerFactsFigures/ global-cancerfacts- figures-2007.
    • (2007) Global Cancer Facts & Figures
  • 2
    • 33845212719 scopus 로고    scopus 로고
    • Carcinoma of the ovary. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer
    • Heintz AP, Odicino F, Maisonneuve P, et al. Carcinoma of the ovary. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynaecol Obstet 2006; 95 (Suppl. 1):S161-S192.
    • (2006) Int J Gynaecol Obstet , vol.95 , Issue.SUPPL. 1
    • Heintz, A.P.1    Odicino, F.2    Maisonneuve, P.3
  • 3
    • 0036498788 scopus 로고    scopus 로고
    • Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: A meta-analysis
    • DOI 10.1200/JCO.20.5.1248
    • Bristow RE, Tomacruz RS, Armstrong DK, et al. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol 2002; 20:1248-1259. (Pubitemid 34177431)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.5 , pp. 1248-1259
    • Bristow, R.E.1    Tomacruz, R.S.2    Armstrong, D.K.3    Trimble, E.L.4    Montz, F.J.5
  • 4
    • 63049115790 scopus 로고    scopus 로고
    • Evaluation of new platinumbased treatment regimens in advanced-stage ovarian cancer: A Phase III Trial of the Gynecologic Cancer Intergroup
    • Bookman MA, Brady MF, McGuire WP, et al. Evaluation of new platinumbased treatment regimens in advanced-stage ovarian cancer: a Phase III Trial of the Gynecologic Cancer Intergroup. J Clin Oncol 2009; 27:1419-1425.
    • (2009) J Clin Oncol , vol.27 , pp. 1419-1425
    • Bookman, M.A.1    Brady, M.F.2    McGuire, W.P.3
  • 5
    • 77950349922 scopus 로고    scopus 로고
    • Changing the paradigm in the treatment of platinumsensitive recurrent ovarian cancer: From platinum doublets to nonplatinum doublets and adding antiangiogenesis compounds
    • Monk BJ, Coleman RL. Changing the paradigm in the treatment of platinumsensitive recurrent ovarian cancer: from platinum doublets to nonplatinum doublets and adding antiangiogenesis compounds. Int J Gynecol Cancer 2009; 19 (Suppl. 2):S63-S67.
    • (2009) Int J Gynecol Cancer , vol.19 , Issue.SUPPL. 2
    • Monk, B.J.1    Coleman, R.L.2
  • 6
    • 0043240182 scopus 로고    scopus 로고
    • Ovarian cancer: Strategies for overcoming resistance to chemotherapy
    • Agarwal R, Kaye SB. Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nat Rev Cancer 2003; 3:502-516. (Pubitemid 37328838)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.7 , pp. 502-516
    • Agarwal, R.1    Kaye, S.B.2
  • 7
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of antitumour activity
    • Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of antitumour activity. Nat Rev Cancer 2008; 8:579-591.
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 8
    • 79960420158 scopus 로고    scopus 로고
    • Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action
    • Itamochi H. Targeted therapies in epithelial ovarian cancer: molecular mechanisms of action. World J Biol Chem 2010; 1:209-220.
    • (2010) World J Biol Chem , vol.1 , pp. 209-220
    • Itamochi, H.1
  • 9
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • DOI 10.1038/339058a0
    • Folkman J, Watson K, Ingber D, et al. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989; 339:58-61. (Pubitemid 19115892)
    • (1989) Nature , vol.339 , Issue.6219 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 10
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • DOI 10.1016/S0092-8674(00)80108-7
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86:353-364. (Pubitemid 26272076)
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 11
    • 34447499062 scopus 로고    scopus 로고
    • Novel approaches in advancing the treatment of epithelial ovarian cancer: The role of angiogenesis inhibition
    • DOI 10.1200/JCO.2007.11.1088
    • Martin L, Schilder R. Novel approaches in advancing the treatment of epithelial ovarian cancer: the role of angiogenesis inhibition. J Clin Oncol 2007; 25:2894-2901. (Pubitemid 47123153)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.20 , pp. 2894-2901
    • Martin, L.1    Schilder, R.2
  • 12
    • 63749125392 scopus 로고    scopus 로고
    • VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
    • Lohela M, Bry M, Tammela T, et al. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 2009; 21: 154-165.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 154-165
    • Lohela, M.1    Bry, M.2    Tammela, T.3
  • 13
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • DOI 10.1038/nature04483, PII NATURE04483
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005; 438:967-974. (Pubitemid 43093963)
    • (2005) Nature , vol.438 , Issue.7070 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 14
    • 80052015813 scopus 로고    scopus 로고
    • Molecular control of endothelial cell behaviour during blood vessel morphogenesis
    • Herbert SP, Stainier DY. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. Nat Rev Mol Cell Biol 2011; 12: 551-564.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 551-564
    • Herbert, S.P.1    Stainier, D.Y.2
  • 15
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • DOI 10.1056/NEJMra0706596
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008; 358:2039-2049. (Pubitemid 351656458)
    • (2008) New England Journal of Medicine , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 17
    • 0032742909 scopus 로고    scopus 로고
    • Tumor angiogenesis and recurrence in stage I non-small cell lung cancer
    • DOI 10.1016/S0003-4975(99)00611-6, PII S0003497599006116
    • Ohta Y, Tomita Y, Oda M, et al. Tumor angiogenesis and recurrence in stage I nonsmall cell lung cancer. Ann Thorac Surg 1999; 68:1034-1038. (Pubitemid 29526880)
    • (1999) Annals of Thoracic Surgery , vol.68 , Issue.3 , pp. 1034-1038
    • Ohta, Y.1    Tomita, Y.2    Oda, M.3    Watanabe, S.4    Murakami, S.5    Watanabe, Y.6
  • 19
    • 79957947131 scopus 로고    scopus 로고
    • Clinical significance of VEGFR-2 and VEGFR-3 expression in ovarian cancer patients
    • Klasa-Mazurkiewicz D, Jarzab M, Milczek T, et al. Clinical significance of VEGFR-2 and VEGFR-3 expression in ovarian cancer patients. Pol J Pathol 2011; 62:31-40.
    • (2011) Pol J Pathol , vol.62 , pp. 31-40
    • Klasa-Mazurkiewicz, D.1    Jarzab, M.2    Milczek, T.3
  • 20
    • 77952511940 scopus 로고    scopus 로고
    • Prognostic significance of intratumoral vascular endothelial growth factor as a marker of tumour angiogenesis in epithelial ovarian cancer
    • Siddiqui GK, Elmasry K, Wong Te Fong AC, et al. Prognostic significance of intratumoral vascular endothelial growth factor as a marker of tumour angiogenesis in epithelial ovarian cancer. Eur J Gynaecol Oncol 2010; 31:156-159.
    • (2010) Eur J Gynaecol Oncol , vol.31 , pp. 156-159
    • Siddiqui, G.K.1    Elmasry, K.2    Wong Te Fong, A.C.3
  • 21
    • 4444324696 scopus 로고    scopus 로고
    • VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma
    • DOI 10.1016/j.ygyno.2004.05.056, PII S0090825804003488
    • Chen H, Ye D, Xie X, et al. VEGF, VEGFRs expressions and activated STATs in ovarian epithelial carcinoma. Gynecol Oncol 2004; 94:630-635. (Pubitemid 39194453)
    • (2004) Gynecologic Oncology , vol.94 , Issue.3 , pp. 630-635
    • Chen, H.1    Ye, D.2    Xie, X.3    Chen, B.4    Lu, W.5
  • 24
    • 79959999859 scopus 로고    scopus 로고
    • Immunohistochemical expression of VEGF predicts response to platinum based chemotherapy in patients with epithelial ovarian cancer
    • Siddiqui GK, Maclean AB, Elmasry K, et al. Immunohistochemical expression of VEGF predicts response to platinum based chemotherapy in patients with epithelial ovarian cancer. Angiogenesis 2011; 14:155-161.
    • (2011) Angiogenesis , vol.14 , pp. 155-161
    • Siddiqui, G.K.1    MacLean, A.B.2    Elmasry, K.3
  • 25
    • 0028904030 scopus 로고
    • Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma
    • Boocock CA, Charnock-Jones DS, Sharkey AM, et al. Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst 1995; 87:506-516.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 506-516
    • Boocock, C.A.1    Charnock-Jones, D.S.2    Sharkey, A.M.3
  • 26
    • 58149314571 scopus 로고    scopus 로고
    • AutocrineVEGF-A/KDRloop protects epithelial ovarian carcinoma cells from anoikis
    • Sher I, Adham SA, Petrik J, et al. AutocrineVEGF-A/KDRloop protects epithelial ovarian carcinoma cells from anoikis. Int J Cancer 2009; 124:553-561.
    • (2009) Int J Cancer , vol.124 , pp. 553-561
    • Sher, I.1    Adham, S.A.2    Petrik, J.3
  • 27
    • 58749097443 scopus 로고    scopus 로고
    • Functional significance of VEGFR-2 on ovarian cancer cells
    • Spannuth WA, Nick AM, Jennings NB, et al. Functional significance of VEGFR-2 on ovarian cancer cells. Int J Cancer 2009; 124:1045-1053.
    • (2009) Int J Cancer , vol.124 , pp. 1045-1053
    • Spannuth, W.A.1    Nick, A.M.2    Jennings, N.B.3
  • 28
    • 77955541508 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by EZH2
    • Lu C, Han HD, Mangala LS, et al. Regulation of tumor angiogenesis by EZH2. Cancer Cell 2010; 18:185-197.
    • (2010) Cancer Cell , vol.18 , pp. 185-197
    • Lu, C.1    Han, H.D.2    Mangala, L.S.3
  • 29
    • 0026708632 scopus 로고
    • The vascular endothelial growth factor proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
    • Kim KJ, Li B, Houck K, et al. The vascular endothelial growth factor proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors 1992; 7:53-64.
    • (1992) Growth Factors , vol.7 , pp. 53-64
    • Kim, K.J.1    Li, B.2    Houck, K.3
  • 30
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • DOI 10.1038/362841a0
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factorinduced angiogenesis suppresses tumour growth in vivo. Nature 1993; 362:841-844. (Pubitemid 23132159)
    • (1993) Nature , vol.362 , Issue.6423 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 31
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • DOI 10.1126/science.1104819
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307:58-62. (Pubitemid 40093472)
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 32
    • 36849019301 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group study
    • DOI 10.1200/JCO.2007.11.5345
    • Burger RA, Sill MW, Monk BJ, et al. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: a Gynecologic Oncology Group Study. J Clin Oncol 2007; 25: 5165-5171. (Pubitemid 350237599)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.33 , pp. 5165-5171
    • Burger, R.A.1    Sill, M.W.2    Monk, B.J.3    Greer, B.E.4    Sorosky, J.I.5
  • 34
    • 35348904080 scopus 로고    scopus 로고
    • Bevacizumab plus cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer
    • DOI 10.1016/j.ygyno.2007.07.017, PII S0090825807004635
    • Chura JC, Van Iseghem K, Downs LS Jr, et al. Bevacizumab plus cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer. Gynecol Oncol 2007; 107:326-330. (Pubitemid 47575735)
    • (2007) Gynecologic Oncology , vol.107 , Issue.2 , pp. 326-330
    • Chura, J.C.1    Van Iseghem, K.2    Downs Jr., L.S.3    Carson, L.F.4    Judson, P.L.5
  • 35
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital phase II consortia
    • Garcia AA, Hirte H, Fleming G, et al. Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia. J Clin Oncol 2008; 26:76-82.
    • (2008) J Clin Oncol , vol.26 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3
  • 36
    • 80051549914 scopus 로고    scopus 로고
    • Combined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer: Results of a Phase 2 Study
    • McGonigle KF, Muntz HG, Vuky J, et al. Combined weekly topotecan and biweekly bevacizumab in women with platinum-resistant ovarian, peritoneal, or fallopian tube cancer: results of a Phase 2 Study. Cancer 2010; 117:3731-3740.
    • (2010) Cancer , vol.117 , pp. 3731-3740
    • McGonigle, K.F.1    Muntz, H.G.2    Vuky, J.3
  • 37
    • 73949092398 scopus 로고    scopus 로고
    • Phase II study of carboplatin, paclitaxel, and bevacizumab with maintenance bevacizumab as first-line chemotherapy for advanced mullerian tumors
    • Penson RT, Dizon DS, Cannistra SA, et al. Phase II study of carboplatin, paclitaxel, and bevacizumab with maintenance bevacizumab as first-line chemotherapy for advanced mullerian tumors. J Clin Oncol 2010; 28:154-159.
    • (2010) J Clin Oncol , vol.28 , pp. 154-159
    • Penson, R.T.1    Dizon, D.S.2    Cannistra, S.A.3
  • 38
    • 77954499682 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC): A gynecologic oncology study
    • abstr LBA1
    • Burger RA, Brady MF, Bookman MA, et al. Phase III trial of bevacizumab (BEV) in the primary treatment of advanced epithelial ovarian cancer (EOC), primary peritoneal cancer (PPC), or fallopian tube cancer (FTC): a gynecologic oncology study. J Clin Oncol 2010; 28(Suppl.):abstr LBA1.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Burger, R.A.1    Brady, M.F.2    Bookman, M.A.3
  • 39
    • 80054003628 scopus 로고    scopus 로고
    • Result of interim analysis of overall survival in the GCIG ICON7 phase III randomized trial of bevacizumab in women with newly diagnosed ovarian cancer
    • abstr LBA5006
    • Kristensen G, Perren T, Qian W, et al. Result of interim analysis of overall survival in the GCIG ICON7 phase III randomized trial of bevacizumab in women with newly diagnosed ovarian cancer. J Clin Oncol 2011; 29(Suppl.): abstr LBA5006.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Kristensen, G.1    Perren, T.2    Qian, W.3
  • 40
    • 80053229517 scopus 로고    scopus 로고
    • OCEANS: A randomized, doubleblinded, placebo-controlled phase III trial of chemotherapy with or without bevacizumab (BEV) in patients with platinum-sensitive recurrent epithelial ovarian (EOC), primary peritoneal (PPC), or fallopian tube cancer (FTC)
    • abstr LBA5007
    • Aghajanian C, Finkler NJ, Rutherford T, et al. OCEANS: a randomized, doubleblinded, placebo-controlled phase III trial of chemotherapy with or without bevacizumab (BEV) in patients with platinum-sensitive recurrent epithelial ovarian (EOC), primary peritoneal (PPC), or fallopian tube cancer (FTC). J Clin Oncol 2011; 29(Suppl.):abstr LBA5007.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Aghajanian, C.1    Finkler, N.J.2    Rutherford, T.3
  • 41
    • 33947311852 scopus 로고    scopus 로고
    • What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer?
    • DOI 10.1016/j.ygyno.2007.01.038, PII S0090825807000959
    • Han ES, Monk BJ. What is the risk of bowel perforation associated with bevacizumab therapy in ovarian cancer? Gynecol Oncol 2007; 105:3-6. (Pubitemid 46441477)
    • (2007) Gynecologic Oncology , vol.105 , Issue.1 , pp. 3-6
    • Han, E.S.1    Monk, B.J.2
  • 42
    • 79551520348 scopus 로고    scopus 로고
    • Treatment-related mortality with bevacizumab in cancer patients: A meta-analysis
    • Ranpura V, Hapani S, Wu S. Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis. JAMA 2011; 305:487-494.
    • (2011) JAMA , vol.305 , pp. 487-494
    • Ranpura, V.1    Hapani, S.2    Wu, S.3
  • 43
    • 79953893326 scopus 로고    scopus 로고
    • At what cost does a potential survival advantage of bevacizumab make sense for the primary treatment of ovarian cancer? A cost-effectiveness analysis
    • Cohn DE, Kim KH, Resnick KE, et al. At what cost does a potential survival advantage of bevacizumab make sense for the primary treatment of ovarian cancer? A cost-effectiveness analysis. J Clin Oncol 2011; 29:1247-1251.
    • (2011) J Clin Oncol , vol.29 , pp. 1247-1251
    • Cohn, D.E.1    Kim, K.H.2    Resnick, K.E.3
  • 44
    • 0038690538 scopus 로고    scopus 로고
    • Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: A Southwest Oncology Group and Gynecologic Oncology Group Trial
    • DOI 10.1200/JCO.2003.07.013
    • Markman M, Liu PY, Wilczynski S, et al. Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: a Southwest Oncology Group and Gynecologic Oncology Group trial. J Clin Oncol 2003; 21:2460-2465. (Pubitemid 46606325)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.13 , pp. 2460-2465
    • Markman, M.1    Liu, P.Y.2    Wilczynski, S.3    Monk, B.4    Copeland, L.J.5    Alvarez, R.D.6    Jiang, C.7    Alberts, D.8
  • 45
    • 80051552827 scopus 로고    scopus 로고
    • Consolidation paclitaxel is more costeffective than bevacizumab following upfront treatment of advanced epithelial ovarian cancer
    • Lesnock JL, Farris C, Krivak TC, et al. Consolidation paclitaxel is more costeffective than bevacizumab following upfront treatment of advanced epithelial ovarian cancer. Gynecol Oncol 2011; 122:473-478.
    • (2011) Gynecol Oncol , vol.122 , pp. 473-478
    • Lesnock, J.L.1    Farris, C.2    Krivak, T.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.