A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress

Nucleic Acids Research

Volumn 41, Issue 3, 2013, Pages 1533-1543

  Wei, Pei Chi ^a,b   Wang, Zi Fu ^c,d   Lo, Wen Ting ^b,e   Su, Mei I ^e   Shew, Jin Yuh ^a,b   Chang, Ta Chau ^c,d   Lee, Wen Hwa ^b,f  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c INSTITUTE OF ATOMIC AND MOLECULAR SCIENCES   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE QUADRUPLEX; NONSELENOCYSTEINE CONTAINING PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; NUCLEOLIN; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRESS; CELLULAR SECRETION; CONTROLLED STUDY; DNA STRUCTURE; GENE; GENE CONTROL; GENE EXPRESSION; GENETIC DAMAGE; MOLECULAR DYNAMICS; NONHUMAN; NONSELENOCYSTEINE CONTAINING PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE ANALYSIS; TRANSACTIVATION; UPREGULATION;

BINDING SITES; CELL LINE; G-QUADRUPLEXES; GC RICH SEQUENCE; HUMANS; PEROXIDASES; PHOSPHOPROTEINS; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SP1 TRANSCRIPTION FACTOR; STRESS, PHYSIOLOGICAL; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84873665545     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks1232     Document Type: Article

References (33)

1. Lipps,H.J. and Rhodes,D. (2009) G-quadruplex structures: In vivo evidence and function. Trends Cell Biol., 19, 414-422.
2. Sen,D. and Gilbert,W. (1988) Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature, 334, 364-366.
3. Williamson,J.R., Raghuraman,M.K. and Cech,T.R. (1989) Monovalent cation-induced structure of telomeric DNA: The G-quartet model. Cell, 59, 871-880.
4. Yang,D. and Okamoto,K. Structural insights into G-quadruplexes: Towards new anticancer drugs. Future Med. Chem., 2, 619-646.
5. Shimizu,A. and Honjo,T. (1984) Immunoglobulin class switching. Cell, 36, 801-803.
6. Kilpatrick,M.W., Torri,A., Kang,D.S., Engler,J.A. and Wells,R.D. (1986) Unusual DNA structures in the adenovirus genome. J. Biol. Chem., 261, 11350-11354.
7. Gonzalez,V. and Hurley,L.H. (2010) The C-terminus of nucleolin promotes the formation of the c-MYC G-quadruplex and inhibits c-MYC promoter activity. Biochemistry, 49, 9706-9714.
8. De Armond,R., Wood,S., Sun,D., Hurley,L.H. and Ebbinghaus,S.W. (2005) Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter. Biochemistry, 44, 16341-16350.
9. Sun,D., Guo,K., Rusche,J.J. and Hurley,L.H. (2005) Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents. Nucleic Acids Res., 33, 6070-6080.
10. Cogoi,S. and Xodo,L.E. (2006) G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription. Nucleic Acids Res., 34, 2536-2549.
11. Dai,J., Dexheimer,T.S., Chen,D., Carver,M., Ambrus,A., Jones,R.A. and Yang,D. (2006) An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands ormed in the human BCL-2 promoter region in solution. J. Am. Chem. Soc., 128, 1096-1098.
12. Blackburn,E.H. (1984) The molecular structure of centromeres and telomeres. Annu. Rev. Biochem., 53, 163-194.
13. Burge,S., Parkinson,G.N., Hazel,P., Todd,A.K. and Neidle,S. (2006) Quadruplex DNA: Sequence, topology and structure. Nucleic Acids Res., 34, 5402-5415.
14. Palumbo,S.L., Ebbinghaus,S.W. and Hurley,L.H. (2009) Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands. J. Am. Chem. Soc., 131, 10878-10891.
15. Siebenlist,U., Hennighausen,L., Battey,J. and Leder,P. (1984) Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma. Cell, 37, 381-391.
16. Simonsson,T., Pecinka,P. and Kubista,M. (1998) DNA tetraplex formation in the control region of c-myc. Nucleic Acids Res., 26, 1167-1172.
17. Tomonaga,T. and Levens,D. (1996) Activating transcription from single stranded DNA. Proc. Natl Acad. Sci. USA, 93, 5830-5835.
18. Bossone,S.A., Asselin,C., Patel,A.J. and Marcu,K.B. (1992) MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences regulating transcriptional initiation and termination. Proc. Natl Acad. Sci. USA, 89, 7452-7456.
19. Siddiqui-Jain,A., Grand,C.L., Bearss,D.J. and Hurley,L.H. (2002) Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc. Natl Acad. Sci. USA, 99, 11593-11598.
20. Seenisamy,J., Rezler,E.M., Powell,T.J., Tye,D., Gokhale,V., Joshi,C.S., Siddiqui-Jain,A. and Hurley,L.H. (2004) The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4. J. Am. Chem. Soc., 126, 8702-8709.
21. Gonzalez,V., Guo,K., Hurley,L. and Sun,D. (2009) Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein. J. Biol. Chem., 284, 23622-23635.
22. Uribe,D.J., Guo,K., Shin,Y.J. and Sun,D. (2011) Heterogeneous nuclear ribonucleoprotein K and nucleolin as transcriptional activators of the vascular endothelial growth factor promoter through interaction with secondary DNA structures. Biochemistry, 50, 3796-3806.
23. Tsou,J.H., Chang,K.Y., Wang,W.C., Tseng,J.T., Su,W.C., Hung,L.Y., Chang,W.C. and Chen,B.K. (2008) Nucleolin regulates c-Jun/Sp1-dependent transcriptional activation of PLA2alpha in phorbol ester-treated non-small cell lung cancer A549 cells. Nucleic Acids Res., 36, 217-227.
24. Daniely,Y., Dimitrova,D.D. and Borowiec,J.A. (2002) Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol. Cell Biol., 22, 6014-6022.
25. Kim,K., Dimitrova,D.D., Carta,K.M., Saxena,A., Daras,M. and Borowiec,J.A. (2005) Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation. Mol. Cell Biol., 25, 2463-2474.
26. Wei,P.C., Lo,W.T., Su,M.I., Shew,J.Y. and Lee,W.H. (2011) Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress. Nucleic Acids Res., 40, 323-332.
27. Dignam,J.D., Lebovitz,R.M. and Roeder,R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 11, 1475-1489.
28. Hwang-Verslues,W.W. and Sladek,F.M. (2008) Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter. Mol. Endocrinol., 22, 78-90.
29. Huppert,J.L. and Balasubramanian,S. (2007) G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res., 35, 406-413.
30. Sundquist,W.I. and Klug,A. (1989) Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops. Nature, 342, 825-829.
31. Kypr,J., Kejnovska,I., Renciuk,D. and Vorlickova,M. (2009) Circular dichroism and conformational polymorphism of DNA. Nucleic Acids Res., 37, 1713-1725.
32. Gray,D.M., Wen,J.D., Gray,C.W., Repges,R., Repges,C., Raabe,G. and Fleischhauer,J. (2008) Measured and calculated CD spectra of G-quartets stacked with the same or opposite polarities. Chirality, 20, 431-440.
33. Zhou,G., Seibenhener,M.L. and Wooten,M.W. (1997) Nucleolin is a protein kinase C-zeta substrate. Connection between cell surface signaling and nucleus in PC12 cells. J. Biol. Chem., 272, 31130-31137.