메뉴 건너뛰기




Volumn 52, Issue 3, 2013, Pages 268-272

Preparation and In-Vitro Properties of mPEG/PLA Microspheres Loaded 5-Fluorouracil for Controlled Release

Author keywords

5 Fluorouracil; Controlled release; Methoxy polyethylene glycol; Microspheres; Poly(D, L lactide)

Indexed keywords

5-FLUOROURACIL; 5-FLUOROURACIL (5-FU); ANTICANCER DRUG; CONTROLLED RELEASE; DOUBLE EMULSIONS; DRUG LOADING; ENCAPSULATION EFFICIENCY; ENTRAPMENT EFFICIENCY; FICKIAN DIFFUSION; FOURIER TRANSFORM INFRA RED (FTIR) SPECTROSCOPY; HT-29 CELLS; IN-VITRO; METHOXYPOLYETHYLENE GLYCOL; POLY (D ,L-LACTIDE); RELEASE BEHAVIORS; RELEASE KINETICS; RING-OPENING POLYMERIZATION METHODS; SMOOTH SURFACE; SPHERICAL SHAPE;

EID: 84873653982     PISSN: 03602559     EISSN: 15256111     Source Type: Journal    
DOI: 10.1080/03602559.2012.747207     Document Type: Article
Times cited : (17)

References (24)
  • 1
    • 4444246813 scopus 로고    scopus 로고
    • Polymer microspheres for controlled drug release
    • Freiberg, S.; Zhu, X.X. Polymer microspheres for controlled drug release. Int. J. Pharm. 2004, 282, 1-18.
    • (2004) Int. J. Pharm. , vol.282 , pp. 1-18
    • Freiberg, S.1    Zhu, X.X.2
  • 2
    • 79960982395 scopus 로고    scopus 로고
    • Fabrication of poly(D,L-lactide-co-glycolide) microspheres and degradation characteristics in vitro
    • He, Z.Q.; Xiong, L.Z. Fabrication of poly(D,L-lactide-co-glycolide) microspheres and degradation characteristics in vitro. J. Macromol. Sci. B 2011, 50, 1682-1690.
    • (2011) J. Macromol. Sci. B , vol.50 , pp. 1682-1690
    • He, Z.Q.1    Xiong, L.Z.2
  • 3
    • 84860913966 scopus 로고    scopus 로고
    • Fabrication of gelatin/chitosan microspheres with different morphologies and study on biological properties
    • Peng, Z.Y.; Li, Z.P.; Shen, Y.Q.; Zhang, F.; Peng, C.X. Fabrication of gelatin/chitosan microspheres with different morphologies and study on biological properties. Polym.-Plast. Technol. 2012, 51, 739-743.
    • (2012) Polym.-Plast. Technol. , vol.51 , pp. 739-743
    • Peng, Z.Y.1    Li, Z.P.2    Shen, Y.Q.3    Zhang, F.4    Peng, C.X.5
  • 4
    • 0037039862 scopus 로고    scopus 로고
    • Third-generation biomedical materials
    • Hench, L.L.; Polak, J.M. Third-generation biomedical materials. Science 2002, 295, 1014-1017.
    • (2002) Science , vol.295 , pp. 1014-1017
    • Hench, L.L.1    Polak, J.M.2
  • 5
    • 0034580476 scopus 로고    scopus 로고
    • Biomaterials development for bone tissue engineering
    • Burg, K.J.; Porter, S.; Kellam, J.F. Biomaterials development for bone tissue engineering. Biomaterials 2000, 21, 2347-2359.
    • (2000) Biomaterials , vol.21 , pp. 2347-2359
    • Burg, K.J.1    Porter, S.2    Kellam, J.F.3
  • 6
    • 0036118352 scopus 로고    scopus 로고
    • Degradable polymer microspheres for controlled drug delivery
    • Edlund, U.; Albertsson, A.C. Degradable polymer microspheres for controlled drug delivery. Adv. Polym. Sci. 2002, 157, 67-112.
    • (2002) Adv. Polym. Sci. , vol.157 , pp. 67-112
    • Edlund, U.1    Albertsson, A.C.2
  • 7
    • 15044344886 scopus 로고    scopus 로고
    • Bulk and surface modifications of polylactide
    • Wang, S.; Cui, W.; Bei, J. Bulk and surface modifications of polylactide. Anal. Bioanal. Chem. 2005, 381, 547-556.
    • (2005) Anal. Bioanal. Chem. , vol.381 , pp. 547-556
    • Wang, S.1    Cui, W.2    Bei, J.3
  • 8
    • 33750489388 scopus 로고    scopus 로고
    • Degradation behaviour of microspheres prepared by spray-drying poly(d,l-lactide) and poly(d,l-lactide-co-glycolide) polymers
    • Blanco, M.D.; Sastre, R.L.; Teijón, C.; Olmo, R.; Teijón, J.M. Degradation behaviour of microspheres prepared by spray-drying poly(d,l-lactide) and poly(d,l-lactide-co-glycolide) polymers. Int. J. Pharm. 2006, 326, 139-147.
    • (2006) Int. J. Pharm. , vol.326 , pp. 139-147
    • Blanco, M.D.1    Sastre, R.L.2    Teijón, C.3    Olmo, R.4    Teijón, J.M.5
  • 10
    • 52049125437 scopus 로고    scopus 로고
    • Degradation mechanism of poly(lactic-co-glycolic) acid block copolymer cast films in phosphate buffer solution
    • Vey, E.; Roger, C.; Meehan, L.; Booth, J.; Claybourn, M.; Miller, A.F.; Saiani, A. Degradation mechanism of poly(lactic-co-glycolic) acid block copolymer cast films in phosphate buffer solution. Polym. Degrad. Stabil. 2008, 93, 1869-1876.
    • (2008) Polym. Degrad. Stabil. , vol.93 , pp. 1869-1876
    • Vey, E.1    Roger, C.2    Meehan, L.3    Booth, J.4    Claybourn, M.5    Miller, A.F.6    Saiani, A.7
  • 11
    • 79957483528 scopus 로고    scopus 로고
    • Synthesis and application for porous scaffold materials of mono-methoxy polyethylene glycol/polylactide diblock copolymer
    • He, Z.Q.; Xiong, L.Z. Synthesis and application for porous scaffold materials of mono-methoxy polyethylene glycol/polylactide diblock copolymer. J. Macromol. Sci. B 2011, 50, 1226-1233.
    • (2011) J. Macromol. Sci. B , vol.50 , pp. 1226-1233
    • He, Z.Q.1    Xiong, L.Z.2
  • 12
    • 0742287165 scopus 로고    scopus 로고
    • Thermo-oxidative degradation of poly(ethylene glycol)/poly(L-lactic acid) blends
    • Lai, W.C.; Liau, W.B. Thermo-oxidative degradation of poly(ethylene glycol)/poly(L-lactic acid) blends. Polymer 2003, 44, 8103-8109.
    • (2003) Polymer , vol.44 , pp. 8103-8109
    • Lai, W.C.1    Liau, W.B.2
  • 13
    • 6344236904 scopus 로고    scopus 로고
    • Crystallization behavior of poly(L-lactide)-poly(ethylene glycol) multiblock copolymers
    • Lee, S.Y.; Chin, I.J.; Jung, J.S. Crystallization behavior of poly(L-lactide)-poly(ethylene glycol) multiblock copolymers. Eur. Polym. J. 1999, 35, 2147-2153.
    • (1999) Eur. Polym. J. , vol.35 , pp. 2147-2153
    • Lee, S.Y.1    Chin, I.J.2    Jung, J.S.3
  • 14
    • 77955054853 scopus 로고    scopus 로고
    • Development of cell-penetrating peptide-modified MPEG-PCL diblock copolymeric nanoparticles for systemic gene delivery
    • Tanaka, K.; Kanazawa, T.; Shibata, Y.; Suda, Y.; Fukuda, T.; Takashima, Y.; Okada, H. Development of cell-penetrating peptide-modified MPEG-PCL diblock copolymeric nanoparticles for systemic gene delivery. Int. J. Pharm. 2010, 396, 229-238.
    • (2010) Int. J. Pharm. , vol.396 , pp. 229-238
    • Tanaka, K.1    Kanazawa, T.2    Shibata, Y.3    Suda, Y.4    Fukuda, T.5    Takashima, Y.6    Okada, H.7
  • 15
    • 77956686589 scopus 로고    scopus 로고
    • The biological evaluation of the PEG/PLA amphiphilic diblock copolymer
    • He, Z.Q.; Xiong, L.Z. The biological evaluation of the PEG/PLA amphiphilic diblock copolymer. Polym.-Plast. Technol. 2010, 49, 1201-1206.
    • (2010) Polym.-Plast. Technol. , vol.49 , pp. 1201-1206
    • He, Z.Q.1    Xiong, L.Z.2
  • 16
    • 84860911018 scopus 로고    scopus 로고
    • Release behavior and cytotoxicity of poly(vinyl alcohol)/chitosan blend microspheres containing 2,4-dihydroxy-5-fluoropyrimidine
    • He, Z.Q.; Xiong, L.Z. Release behavior and cytotoxicity of poly(vinyl alcohol)/chitosan blend microspheres containing 2,4-dihydroxy-5-fluoropyrimidine. Polym.-Plast. Technol. 2012, 51, 729-733.
    • (2012) Polym.-Plast. Technol. , vol.51 , pp. 729-733
    • He, Z.Q.1    Xiong, L.Z.2
  • 17
    • 1442310888 scopus 로고    scopus 로고
    • Development of novel 5-FU-loaded poly(methylidene malonate 2.1.2)-based microspheres for the treatment of brain cancers
    • Fournier, E.; Passirani, C.; Colin, N.; Bretona, P.; Sagodiraa, S.; Benoitb, J.P. Development of novel 5-FU-loaded poly(methylidene malonate 2.1.2)-based microspheres for the treatment of brain cancers. Eur. J. Pharm. Biopharm. 2004, 57, 189-197.
    • (2004) Eur. J. Pharm. Biopharm. , vol.57 , pp. 189-197
    • Fournier, E.1    Passirani, C.2    Colin, N.3    Bretona, P.4    Sagodiraa, S.5    Benoitb, J.P.6
  • 19
    • 3042543355 scopus 로고    scopus 로고
    • Cytotoxicity of 5-fluorouracil entrapped in gelatin microspheres
    • Muvaffak, A.; Gurhan, I.; Hasirci, N. Cytotoxicity of 5-fluorouracil entrapped in gelatin microspheres. J. Microencapsul. 2004, 21, 293-306.
    • (2004) J. Microencapsul. , vol.21 , pp. 293-306
    • Muvaffak, A.1    Gurhan, I.2    Hasirci, N.3
  • 20
    • 0020451764 scopus 로고
    • Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography
    • Sommadossi, J.P.; Gewirtz, D.A.; Diasio, R.B.; Aubert, C.; Cano, J.P.; Goldman, I.D. Rapid catabolism of 5-fluorouracil in freshly isolated rat hepatocytes as analyzed by high performance liquid chromatography. J. Biol. Chem. 1982, 257, 8171-8176.
    • (1982) J. Biol. Chem. , vol.257 , pp. 8171-8176
    • Sommadossi, J.P.1    Gewirtz, D.A.2    Diasio, R.B.3    Aubert, C.4    Cano, J.P.5    Goldman, I.D.6
  • 21
    • 46749118002 scopus 로고    scopus 로고
    • Study on colon-specific 5-Fu pH-enzyme di-dependent chitosan microspheres
    • Zhao, X.L.; Li, K.X.; Zhao, X.F.; Pang, D.H.; Chen, D.W. Study on colon-specific 5-Fu pH-enzyme di-dependent chitosan microspheres. Chem. Pharm. Bull. 2008, 56, 963-968.
    • (2008) Chem. Pharm. Bull. , vol.56 , pp. 963-968
    • Zhao, X.L.1    Li, K.X.2    Zhao, X.F.3    Pang, D.H.4    Chen, D.W.5
  • 22
    • 0023196815 scopus 로고
    • A simple equation for description of solute release II: Fickian and anomalous release from swellable devices
    • Ritger, P.L.; Peppas, N.A. A simple equation for description of solute release II: Fickian and anomalous release from swellable devices. J. Control. Rel. 1987, 5, 37-42.
    • (1987) J. Control. Rel. , vol.5 , pp. 37-42
    • Ritger, P.L.1    Peppas, N.A.2
  • 23
    • 84873691185 scopus 로고    scopus 로고
    • Chitosan/guargum-g-acrylamide semi IPN microspheres for controlled release studies of 5-fluorouracil
    • Sekhar, E.C.; Rao, K.S.V.K.; Raju, R.R. Chitosan/guargum-g-acrylamide semi IPN microspheres for controlled release studies of 5-fluorouracil. J. Appl. Pharm. Sci. 2011, 8, 199-204.
    • (2011) J. Appl. Pharm. Sci. , vol.8 , pp. 199-204
    • Sekhar, E.C.1    Rao, K.S.V.K.2    Raju, R.R.3
  • 24
    • 84861031203 scopus 로고    scopus 로고
    • Morphological and functional expression of fibroblast on poly(lactide-coglycolide)/β-tricalcium phosphate/nature bone
    • Zhou, Z.H.; Yi, Q.F.; Liu, L.H.; Zhao, Y.M.; Zeng, W.N.; Ou, B.L.; Liu, Q.Q.; Liu, X.P. Morphological and functional expression of fibroblast on poly(lactide-coglycolide)/β-tricalcium phosphate/nature bone. Int. J. Polym. Mater. 2012, 61, 643-653.
    • (2012) Int. J. Polym. Mater. , vol.61 , pp. 643-653
    • Zhou, Z.H.1    Yi, Q.F.2    Liu, L.H.3    Zhao, Y.M.4    Zeng, W.N.5    Ou, B.L.6    Liu, Q.Q.7    Liu, X.P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.