Fabrication of gelatin/chitosan microspheres with different morphologies and study on biological properties

Polymer - Plastics Technology and Engineering

Volumn 51, Issue 7, 2012, Pages 739-743

  Peng, Zhiyuan ^a   Li, Zhiping ^a   Shen, Yongqiang ^a   Zhang, Fan ^a   Peng, Xiaochun ^a  

^a JISHOU UNIVERSITY   (China)

Author keywords

Biological properties; Chitosan; Gelatin; Microspheres; Morphology

Indexed keywords

ACETONE/WATER SOLUTIONS; BIOLOGICAL PROPERTIES; CROSSLINKER; CYTOTOXICITY TEST; FREEZE DRYING METHOD; GELATIN; GLUTARALDEHYDES; HEMOLYTIC REACTION; MOUSE-FIBROBLASTS; POROUS STRUCTURES; TREATMENT METHODS; VOLUME RATIO;

ACETONE; ALDEHYDES; CELL CULTURE; CHEMICAL WATER TREATMENT; CHITOSAN; COAGULATION; CYTOTOXICITY; EMULSIFICATION; LOW TEMPERATURE DRYING; MORPHOLOGY;

MICROSPHERES;

EID: 84860913966     PISSN: 03602559     EISSN: 15256111     Source Type: Journal    
DOI: 10.1080/03602559.2012.663037     Document Type: Article

References (18)

1. Lu, B.; Zhang, J.Q.; Yang.H. Lung-targeting microspheres of carboplatin. Int. J. Pharm. 2003, 265, 1-11.
2. Sato, T., Kanke, M.; Schroeder, G.; Deluca, P. Porous biodegradable microspheres for controlled drug delivery. Pharm. Res. 1988, 5, 21-30.
3. Peng, Z.Y.; Shen, Y.Q. Study on biological safety of polyvinyl alcohol/collagen hydrogel as tissue substitute (I). Polym. Plast. Technol. Eng. 2011, 50, 245-250.
4. Brime, B.; Ballesteros, M.P.; Frutos, P. Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration. J. Microencap. 2000, 17, 777-784.
5. Tabata, Y.; Uno, K.; Ikada, Y.; Muramatsus, S. Synthesis of gelatin microspheres containing interferon. Pharm. Res. 1989, 6, 422-427.
6. Patel, M.; Jain, S.K.; Yadav, A.K.; Gogna, D.; Agrawal, G.P. Preparation and characterization of oxybenzone-loaded gelatin microspheres for enhancement of sunscreening efficacy. Drug Deliv. 2006, 13, 323-330.
7. Maria, A.V.; Marcello, R.; Alessandra, M.; Manuela, G.; Paolo, G.; Francesco, R.; Flavio, F. Microwave-treated gelatin microspheres as drug delivery system. J. Cont. Rel. 2004, 96, 67-84.
8. Peng, Z.Y.; Peng, Z.P.; Shen, Y.Q. Fabrication and properties of gelatin/chitosan composite hydrogel. Polym. Plast. Technol. Eng. 2011, 50, 1160-1164.
9. Adhirajan, N.; Shanmugasundaram, N.; Babu, M. Gelatin microspheres cross-linked with EDC as a drug delivery system for doxycyline: development and characterization. J. Microencapsul. 2007, 24, 647-659.
10. Ugwoke, M.I.; Kinget, R. Influence of processing variables on the properties of gelatin microspheres prepared by the emulsification solvent extraction technique. J. Microencapsul. 1998, 15, 273-281.
11. Sinha, V.R.; Singla, A.K.; Wadhawan, S.; Kaushik, R.; Kumria, R.; Bansal, K.; Dhawan, S.Review: Chitosan microspheres as a potential carrier for drugs. Int. J. Pharm.2004, 274, 1-33.
12. Yuan, Y.; Chesnutt, B.M.; Utturkar, G. The effect of cross-linking of chitosan microspheres with genipin on protein release. Carbohyd. Polym. 2007, 68, 561-567.
13. Jameela, S.R.; Misra, A.; Jayakrishnan, A. Cross-linked chitosan microspheres as carries for prolonged delivery of macromolecular drugs. J. Biomater. Sci. Polym. Ed. 1994, 6, 621-632.
14. Denkbas, E.B.; Mehmet, O. Chitosan microspheres and sponges: preparation and characterization. J. Appl. Polym. Sci. 2000, 76, 1637-1643.
15. Agnihotri, S.A.; Aminabhavi, T.M.; Controlled release of clozapine through chitosan microparticles prepared by a novel method. J. Contr. Rel. 2004, 96, 245-259.
16. Shu, X.Z.; Zhu, K.J. Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation. J. Microencapsul. 2001, 18, 237-245.
17. Mosmann, T. Rapid colorimetric assay of cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 1983, 65, 55-63.
18. ISO 10993, Part 4. Selection of tests for interaction with blood. International Standard Organization, Geneva, Switzerland; 1992.