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Stellbrink HJ, Reynes J, Lazzarin A, et al. Dolutegravir in combination therapy exhibits rapid and sustained antiviral response in ARV-naïve adults: 96-week results from SPRING-1 (ING112276). Abstract 102LB presented at the Nineteenth Conference on Retroviruses and Opportunistic Infections, Seattle, WA, March 5-8, 2012.
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(2012)
Dolutegravir in combination therapy exhibits rapid and sustained antiviral response in ARV-naïve adults: 96-week results from SPRING-1 (ING112276)
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Stellbrink, H.J.1
Reynes, J.2
Lazzarin, A.3
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47
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Abstract THLBB04 presented at the Nineteenth International AIDS Conference, Washington, DC, July 22-27
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Raffi F, Rachlis A, Stellbrink HJ, et al. Once-daily dolutegravir (DTG; S/GSK1349572) is non-inferior to raltegravir (RAL) in antiretroviral-naive adults: 48-week results from SPRING-2 (ING113086). Abstract THLBB04 presented at the Nineteenth International AIDS Conference, Washington, DC, July 22-27, 2012.
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(2012)
Once-daily dolutegravir (DTG; S/GSK1349572) is non-inferior to raltegravir (RAL) in antiretroviral-naive adults: 48-week results from SPRING-2 (ING113086)
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Raffi, F.1
Rachlis, A.2
Stellbrink, H.J.3
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48
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Abstract H-556b presented at the Fifty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, September 9-12
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Walmsley S, Antela A, Clumeck N, et al. Dolutegravir (DTG; S/GSK1349572) + abacavir/lamivudine once daily statistically superior to tenofovir/emtricitabine/efavirenz: 48-week results-SINGLE (ING114467). Abstract H-556b presented at the Fifty-second Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, CA, September 9-12, 2012.
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(2012)
Dolutegravir (DTG; S/GSK1349572) + abacavir/lamivudine once daily statistically superior to tenofovir/emtricitabine/efavirenz: 48-week results-SINGLE (ING114467)
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Walmsley, S.1
Antela, A.2
Clumeck, N.3
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49
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Abstract MOAB0105 presented at the Eighteenth International AIDS Conference, Vienna, Austria, July 18-23
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Eron J, Durant J, Poizot-Martin I, et al. Activity of next generation integrase inhibitor (INI) S/GSK1349572in subjects with HIV exhibiting raltegravir resistance: initial results of VIKING study (ING112961). Abstract MOAB0105 presented at the Eighteenth International AIDS Conference, Vienna, Austria, July 18-23, 2010.
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(2010)
Activity of next generation integrase inhibitor (INI) S/GSK1349572in subjects with HIV exhibiting raltegravir resistance: Initial results of VIKING study (ING112961)
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Eron, J.1
Durant, J.2
Poizot-Martin, I.3
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50
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Abstract 151LB presented at the Eighteenth Conference on Retroviruses and Opportunistic Infections, Boston, MA, February 27-March 2
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Eron J, Kumar P, Lazzarin A, et al. DTG in subjects with HIV exhibiting RAL resistance: functional monotherapy results of VIKING study cohort II. Abstract 151LB presented at the Eighteenth Conference on Retroviruses and Opportunistic Infections, Boston, MA, February 27-March 2, 2011.
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(2011)
DTG in subjects with HIV exhibiting RAL resistance: Functional monotherapy results of VIKING study cohort II
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Eron, J.1
Kumar, P.2
Lazzarin, A.3
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52
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Antiviral activity of dolutegravir in subjects with failure on an integrase inhibitor-based regimen: Week 24 phase 3 results from VIKING-3. Abstracts of the Eleventh International Congress on Drug Therapy in HIV Infection
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Nichols G, Mills A, Grossberg R, et al. Antiviral activity of dolutegravir in subjects with failure on an integrase inhibitor-based regimen: week 24 phase 3 results from VIKING-3. Abstracts of the Eleventh International Congress on Drug Therapy in HIV Infection. J Int AIDS Soc. 2012;15 Suppl 4:18112.
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(2012)
J Int AIDS Soc
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, Issue.SUPPL. 4
, pp. 18112
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Nichols, G.1
Mills, A.2
Grossberg, R.3
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53
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Resistance to HIV-1integrase inhibitors: A structural perspective
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Mouscadet JF, Delelis O, Marcelin AG, Tchertanov L. Resistance to HIV-1integrase inhibitors: a structural perspective. Drug Resist Updat. 2010;13(4-5):139-150.
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(2010)
Drug Resist Updat
, vol.13
, Issue.4-5
, pp. 139-150
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Mouscadet, J.F.1
Delelis, O.2
Marcelin, A.G.3
Tchertanov, L.4
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54
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Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143
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Métifiot M, Vandegraaff N, Maddali K, et al. Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143. AIDS. 2011;25(9):1175-1178.
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(2011)
AIDS
, vol.25
, Issue.9
, pp. 1175-1178
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Métifiot, M.1
Vandegraaff, N.2
Maddali, K.3
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55
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Cross-resistance profile determination of two second-generation HIV-1integrase inhibitors using a panel of recombinant viruses derived from raltegravir-treated clinical isolates
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Van Wesenbeeck L, Rondelez E, Feyaerts M, et al. Cross-resistance profile determination of two second-generation HIV-1integrase inhibitors using a panel of recombinant viruses derived from raltegravir-treated clinical isolates. Antimicrob Agents Chemother. 2011;55(1):321-325.
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(2011)
Antimicrob Agents Chemother
, vol.55
, Issue.1
, pp. 321-325
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Van Wesenbeeck, L.1
Rondelez, E.2
Feyaerts, M.3
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Abstract 555 presented at the Seventeenth Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, February 16-19
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Seki T, Kobayashi M, Wakasa-Morimoto C, et al. S/GSK1349572 is a potent next generation HIV integrase inhibitor and demonstrates a superior resistance profile substantiated with 60integrase mutant molecular clones. Abstract 555 presented at the Seventeenth Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, February 16-19, 2010.
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(2010)
S/GSK1349572 is a potent next generation HIV integrase inhibitor and demonstrates a superior resistance profile substantiated with 60integrase mutant molecular clones
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Seki, T.1
Kobayashi, M.2
Wakasa-Morimoto, C.3
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57
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Abstract H-935 presented at the Fiftieth Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, MA, September 12-15
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Vavro C, Underwood M, Madsen H, et al. Polymorphisms at position 101 and 124in the HIV-1integrase gene: lack of effects on susceptibility to S/GSK1349572. Abstract H-935 presented at the Fiftieth Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, MA, September 12-15, 2010.
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(2010)
Polymorphisms at position 101 and 124in the HIV-1integrase gene: Lack of effects on susceptibility to S/GSK1349572
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Vavro, C.1
Underwood, M.2
Madsen, H.3
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58
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Characterization of the R263K mutation in HIV-1integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir
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Quashie PK, Mesplède T, Han YS, et al. Characterization of the R263K mutation in HIV-1integrase that confers low-level resistance to the second-generation integrase strand transfer inhibitor dolutegravir. J Virol. 2012;86(5):2696-2705.
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(2012)
J Virol
, vol.86
, Issue.5
, pp. 2696-2705
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Quashie, P.K.1
Mesplède, T.2
Han, Y.S.3
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59
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Selection in culture of HIV resistance to dolutegravir by mutations at integrase positions R263K and H51Y that diminish viral replication fitness. Abstracts of the Eleventh International Congress on Drug Therapy in HIV Infection
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Mesplede T, Quashie P, Oliveira M, et al. Selection in culture of HIV resistance to dolutegravir by mutations at integrase positions R263K and H51Y that diminish viral replication fitness. Abstracts of the Eleventh International Congress on Drug Therapy in HIV Infection. J Int AIDS Soc. 2012;15 Suppl 4:18113.
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(2012)
J Int AIDS Soc
, vol.15
, Issue.SUPPL. 4
, pp. 18113
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Mesplede, T.1
Quashie, P.2
Oliveira, M.3
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60
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Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1integrase-DNA complexes
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Hightower KE, Wang R, Deanda F, et al. Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1integrase-DNA complexes. Antimicrob Agents Chemother. 2011;55(10):4552-4559.
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(2011)
Antimicrob Agents Chemother
, vol.55
, Issue.10
, pp. 4552-4559
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Hightower, K.E.1
Wang, R.2
Deanda, F.3
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Prevalence of HIV-1integrase mutations related to resistance to dolutegravir in raltegravir naïve and pretreated patients
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for the ARCA Collaborative Group
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Saladini F, Meini G, Bianco C, etal; for the ARCA Collaborative Group. Prevalence of HIV-1integrase mutations related to resistance to dolutegravir in raltegravir naïve and pretreated patients. Clin Microbiol Infect. 2012;18(10):E428-E430.
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(2012)
Clin Microbiol Infect
, vol.18
, Issue.10
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Saladini, F.1
Meini, G.2
Bianco, C.3
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Abstract PS1/2 presented at the Thirteenth European AIDS Conference, Belgrade, Serbia, October 12-15
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Soriano V, Cox J, Eron JJ, et al. Dolutegravir (DTG, S/GSK1349572) treatment of HIV suppression at week 24in the VIKING study. Abstract PS1/2 presented at the Thirteenth European AIDS Conference, Belgrade, Serbia, October 12-15, 2011.
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(2011)
Dolutegravir (DTG, S/GSK1349572) treatment of HIV suppression at week 24in the VIKING study
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Soriano, V.1
Cox, J.2
Eron, J.J.3
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63
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The activity of the integrase inhibitor dolutegravir against HIV-1 variants isolated from raltegravir-treated adults
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Underwood MR, Johns BA, Sato A, Martin JN, Deeks SG, Fujiwara T. The activity of the integrase inhibitor dolutegravir against HIV-1 variants isolated from raltegravir-treated adults. J Acquir Immune Defic Syndr. 2012;61(3):297-301.
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J Acquir Immune Defic Syndr
, vol.61
, Issue.3
, pp. 297-301
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Underwood, M.R.1
Johns, B.A.2
Sato, A.3
Martin, J.N.4
Deeks, S.G.5
Fujiwara, T.6
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Implications of integrase inhibitors for HIV-infected transplantation recipients: Raltegravir and dolutegravir (S/GSK 1349572)
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Waki K, Sugawara Y. Implications of integrase inhibitors for HIV-infected transplantation recipients: raltegravir and dolutegravir (S/GSK 1349572). Biosci Trends. 2011;5(5):189-191.
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(2011)
Biosci Trends
, vol.5
, Issue.5
, pp. 189-191
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Waki, K.1
Sugawara, Y.2
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