The pH sensitivity of murine heat shock protein 47 (HSP47) binding to collagen is affected by mutations in the breach histidine cluster

Journal of Biological Chemistry

Volumn 288, Issue 6, 2013, Pages 4452-4461

  Abdul Wahab, Mohd Firdaus ^a,b   Homma, Takayuki ^a   Wright, Michael ^a,c   Olerenshaw, Dee ^a   Dafforn, Timothy R ^d   Nagata, Kazuhiro ^e   Miller, Andrew D ^a,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITI TEKNOLOGI MALAYSIA   (Malaysia)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROL RELEASE; CONTROLLED RELEASE; ENDOPLASMIC RETICULUM; HEAT SHOCK PROTEIN; HISTIDINE RESIDUES; MOLECULAR CHAPERONES; MOLECULAR MECHANISM; NEUTRAL PH; PH SENSITIVITY; PH SWITCHES; PH-DEPENDENT; PROCOLLAGEN; RELATIVE CONTRIBUTION; RELEASE CHARACTERISTICS; SIDE-CHAINS; TRIPLE-HELICES;

BIOCHEMISTRY; CELL MEMBRANES; COLLAGEN;

AMINO ACIDS;

CHAPERONE; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 7; HEAT SHOCK PROTEIN 47; HISTIDINE; HISTIDINE 191; HISTIDINE 197; HISTIDINE 198; PROCOLLAGEN; UNCLASSIFIED DRUG;

ARTICLE; COLLAGEN SYNTHESIS; CONFORMATIONAL TRANSITION; ENDOPLASMIC RETICULUM; GENE CLUSTER; GENE MUTATION; GOLGI COMPLEX; MOLECULAR MECHANICS; MOUSE; MUTAGENESIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANIMALS; HISTIDINE; HSP47 HEAT-SHOCK PROTEINS; HYDROGEN-ION CONCENTRATION; MICE; MUTATION, MISSENSE; PEPTIDE MAPPING; PROCOLLAGEN; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY;

EID: 84873635071     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.409029     Document Type: Article

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