In vitro cytotoxicity and cellular uptake of curcumin-loaded Pluronic/Polycaprolactone micelles in colorectal adenocarcinoma cells

Journal of Biomaterials Applications

Volumn 27, Issue 7, 2013, Pages 811-827

  Raveendran, Radhika ^a   Bhuvaneshwar, G S ^a   Sharma, Chandra P ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

cellular uptake; curcumin; cytotoxicity; Micelles; Pluronic

Indexed keywords

AMPHIPHILIC POLYMERS; AMPHIPHILICS; AQUEOUS SOLUBILITY; BLOOD COMPATIBILITY; CANCER CELLS; CELLULAR UPTAKE; CLINICAL APPLICATION; COLORECTAL ADENOCARCINOMA; CRITICAL MICELLE CONCENTRATION (CMC); CURCUMIN; FLUORESCENT PROBES; IN-VITRO; PLASMA PROTEIN; PLURONICS; SODIUM DODECYL SULPHATE;

BIOCHEMISTRY; BLOCK COPOLYMERS; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; ELECTROPHORESIS; PLASMA STABILITY; SOLUBILITY; TRANSMISSION ELECTRON MICROSCOPY;

MICELLES;

ANTINEOPLASTIC AGENT; CURCUMIN; DRUG CARRIER; POLOXAMER;

ADENOCARCINOMA; ARTICLE; CELL STRAIN CACO 2; CHEMISTRY; COLORECTAL TUMOR; CYTOLOGY; DRUG EFFECT; ERYTHROCYTE; HEMOLYSIS; HUMAN; METABOLISM; MICELLE; PARTICLE SIZE; THROMBOCYTE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; BLOOD PLATELETS; CACO-2 CELLS; COLORECTAL NEOPLASMS; CURCUMIN; DRUG CARRIERS; ERYTHROCYTES; HEMOLYSIS; HUMANS; MICELLES; PARTICLE SIZE; POLOXAMER;

MLCS; MLOWN;

EID: 84873634556     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328211427473     Document Type: Article

References (58)

1. Allen TM, Cullis PR. Drug delivery systems: entering the mainstream. Science. 2004 ; 303: 1818-1822
2. Farokhzad OC, Langer R. Impact of nanotechnology on drug delivery. ACS Nano. 2009 ; 3: 16-20
3. Tatiana B. Multifunctional polymeric carriers for gene and drug delivery. Pharm Res. 2010 ; 27: 2257-2259
4. Younghoon K, Paul D, David AC, Dennis ED. Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology. 2005 ; 16: 484-491
5. Torchilin VP. Structure and design of polymeric surfactant-based drug delivery systems. J Contr Release. 2001 ; 73: 137-172
6. Sutton D, Nasongkla N, Blanco E, Gao J. Functionalized micellar systems for cancer targeted drug delivery. Pharm Res. 2007 ; 24: 1029-1046
7. Danson S, Ferry D, Alakhov V, Margison J, Kerr D, Jowle D, et al. Phase I dose escalation and pharmacokinetic study of pluronic polymerbound doxorubicin (SP1049C) in patients with advanced cancer. Br J Cancer. 2004 ; 90: 2085-2091
8. Matsumura Y, Hamaguchi T, Ura T, Muro K, Yamada Y, Shimada Y, et al. Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin. Br J Cancer. 2004 ; 91: 1775-1781
9. Kim TY, Kim DW, Chung JY, Shin SG, Kim SC, Heo DS, et al. Phase I and pharmacokinetic study of Genexol-PM a cremophor-free, polymeric micelle formulated paclitaxel, in patients with advanced malignancies. Clin Cancer Res. 2004 ; 10: 3708-3716
10. Maeda H, Greish K, Fang J. The EPR effect and polymeric drugs: a paradigm shift for cancer chemotherapy in the 21st century. Adv Polym Sci. 2006 ; 193: 103-121
11. Weir NM, Selvendiran K, Kutala VK, Tong L, Vishwanath S, Rajaram M, et al. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer Biol Ther. 2007 ; 6: 178-184
12. Kuttan R, Bhanumathy P, Nirmala K, George MC. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett. 1998 ; 29: 197-202
13. Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane). J Biol Chem. 1995 ; 270: 4995-5000
14. Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008 ; 269: 199-225
15. Liu JY, Lin SJ, Lin JK. Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells. Carcinogenesis. 1993 ; 14: 857-861
16. Sahu A, Kasoju N, Bora U. Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells. Biomacromolecules. 2008 ; 9: 2905-2912
17. Sahu A, Bora U, Kasoju N, Goswami P. Self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomater. 2008 ; 4: 1752-1761
18. Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, et al. Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy. J Nanobiotechnol. 2007 ; 5: 3-3
19. So YK, Jung CH, Young ML. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(e-caprolactone) (PCL) amphiphilic block copolymeric nanospheres II-thermo-responsive drug release behaviors. J Contr Release. 2000 ; 65: 345-358
20. Ma G, Song C. PCL/Poloxamer 188 blend microsphere for paclitaxel delivery: influence of Poloxamer 188 on morphology and drug release. J Appl Polym Sci. 2007 ; 104: 1895-1899
21. Chandana M, Sanjeeb KS. The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials. 2010 ; 31: 6597-6611
22. Sahu A, Kasoju N, Goswami P, Bora U. Encapsulation of curcumin in Pluronic block copolymer micelles for drug delivery applications. J Biomater Appl. 2011 ; 25: 619-639
23. Chang X, Macdonald DA, Goosen MFA, Mcauley KB. Mechanism of polymerization in the presence of stannous octoate: the effect of hydroxy and carboxylic acid substances. J Polym Sci: Part A: Polym Chem. 1994 ; 32: 2965-2970
24. Jung CH, So YK, Young ML. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (Pluronic)/poly(ε-caprolactone) (PCL) amphiphilic block copolymeric nanospheres I - preparation and characterization. J Contr Release. 1999 ; 62: 381-392
25. Das RK, Kasoju N, Bora U. Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells. Nanomedicine: Nanotech Biol Med. 2010 ; 6: 153-160
26. Lee DW, Powers K, Baney R. Physicochemical properties and blood compatibility of acylated chitosan nanoparticles. Carb Polym. 2004 ; 58: 371-377
27. Kainthan RK, Gnanamani M, Ganguli M, Ghosh T, Brooks DE, Maiti S, et al. Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA. Biomaterials. 2006 ; 27: 5377-5390
28. Yen FL, Wu TH, Tzeng CW, Lin LT, Lin CC. Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. J Agric Food Chem. 2010 ; 58: 7376-7382
29. Lü F, Fang Y, and Blanchard GJ. Probing the microenvironment of surface-attached pyrene formed by a thermo-responsive oligomer. Spectrochim Acta A Mol Biomol Spectrosc. 2009 ; 74: 991-999
30. Xiong XY, Tam KC, Gan LH. Synthesis and thermally responsive properties properties of novel Pluronic F87/Polycaprolactone (PCL) block copolymers with short PCL blocks. J Appl Polym Sci. 2006 ; 100: 4163-4172
31. Mohanty A, Mohanty D, Sahoo K. Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy. Nanomedicine. 2010 ; 5: 433-449
32. Feng SS. Nanoparticles of biodegradable polymers for new concept chemotherapy. Expert Rev Med Devices. 2004 ; 1: 115-125
33. Mohanraj VJ, Chen Y. Nanoparticles - a review. Trop J Pharm Res. 2006 ; 5: 561-573
34. Pignatello R, Francesco CF. Calorimetric techniques to study the interaction of drugs with biomembrane models. J Pharm Bioallied Sci. 2011 ; 3: 1-2
35. Vinogradov S, Batrakova E, Kabanov A. Effect of copolymer composition on the physicochemical characteristics, in vitro stability, and biodistribution of PLGA-mPEG nanoparticles. Int J Pharm. 2003 ; 259: 115-127
36. Acharya S, Dilnawaz F, Sahoo SK. Targeted epidermal growth factor receptor nanoparticle bioconjugates for breast cancer therapy. Biomaterials. 2009 ; 30: 5737-5750
37. Mohanty C, Sahoo K. The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials. 2010 ; 1: 6597-6611
38. Horbett TA, Brash JL Proteins at interfaces. Horbett TA Brash JL, ed. Washington, DC: American Chemical Society ; 1987: 1-33.
39. Horbett TA. Principles underlying the role of adsorbed plasma proteins in blood interactions with foreign materials. Cardiovasc Pathol. 1993 ; 2: 137-148
40. Jeon SI, Lee JH, Andrade JD, De Gennes PG. Protein-surface interactions in the presence of polyethylene oxide: I. Simplified theory. J Colloid Interface Sci. 1991 ; 142: 149-158
41. Yokoyama M Biorelated polymers and gels. Okano T, ed. San Diego, CA: Academic Press ; 1998: 193-229.
42. Richard AM. Plasma hemoglobin measurement techniques for the in vitro evaluation of blood damage caused by medical devices. Artif Organs. 1997 ; 21: 1255-1267
43. Rekha MR, Sharma CP. Hemocompatible pullulan-polyethyleneimine conjugates for liver cell gene delivery: in vitro evaluation of cellular uptake, intracellular trafficking and transfection efficiency. Acta Biomater. 2011 ; 7: 370-379
44. Choudhuri T, Pal S, Agwarwal ML, Das T, Sa G. Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction. FEBS Lett. 2002 ; 512: 334-340
45. Joshy KS, Paul W, Sharma CP. Copper complexed polymer carriers for IgG adsorption. J Colloid Interface Sci. 2010 ; 352: 178-185
46. Mao C, Liang CX, Mao YQ, Li L, Hou XM, Shen J. Modification of polyethylene with Pluronics F127 for improvement of blood compatibility. Colloids Surf B: Biointerfaces. 2009 ; 74: 362-365
47. Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY, et al. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal. 1997 ; 15: 1867-1876
48. Leung MHM, Colangelo H, Kee TW. Encapsulation of curcumin in cationic micellae suppresses alkaline hydrolysis. Langmuir. 2008 ; 24: 5672-5675
49. Lev-Ari S, Strier L, Kazanov D. Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. Clin Cancer Res. 2005 ; 11: 6738-6744
50. Ma Z, Haddadi A, Molavi O, Lavasanifar A, Lai R, Samuel J. Micelles of poly(ethylene oxide)-b-poly(e-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed Mater Res A. 2008 ; 86: 300-310
51. Lev-Ari S, Strier L, Kazanov D. Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology. 2006 ; 45: 171-177
52. Lev-Ari S, Vexler A, Starr A. Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines. Cancer Invest. 2007 ; 25: 411-418
53. Yan F, Zhang C, Zheng Y. The effect of Poloxamer 188 on nanoparticle morphology, size, cancer cell uptake and cytotoxicity. Nanomedicine: NBM. 2010 ; 6: 170-178
54. Mei L, Zhang Y, Zheng Y. A novel docetaxel-loaded poly(ε- caprolactone)/Pluronic F68 nanoparticle overcoming multidrug resistance for breast cancer treatment. Nanoscale Res Lett. 2009 ; 4: 1530-1539
55. Batrakova EV, Li S, Vinogradov SV, Alakhov VY, Miller DW, Kabanov AV. Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization. J Pharmacol Exp Ther. 2001 ; 299: 483-493
56. Sahay G, Batrakova EV, Kabanov AV. Different internalization pathways of polymeric micelles and unimers and their effects on vesicular transport. Bioconjugate Chem. 2008 ; 19: 2023-2029
57. Shin IG, Kim SY, Lee YM, Cho CS, Sung YK. Methoxy poly (ethylene glycol)/ε-caprolactone amphiphilic block copolymeric micelle containing indomethacin: I. Preparation and characterization. J Contr Release. 1998 ; 51: 1-11
58. Kim SY, Shin IG, Lee YM. Preparation and characterization of biodegradable nanospheres composed of methoxy poly(ethylene glycol) and DL-lactide block copolymer as novel drug carriers. J Contr Release. 1998 ; 56: 197-208