Effects of Thymus serpyllum extract on cell proliferation, apoptosis and epigenetic events in human breast cancer Cells

Nutrition and Cancer

Volumn 64, Issue 8, 2012, Pages 1245-1250

  Bozkurt, Emir ^a   Atmaca, Harika ^a   Kisim, Asli ^a   Uzunoglu, Selim ^a   Uslu, Ruchan ^b   Karaca, Burcak ^b,c  

^a CELAL BAYAR UNIVERSITY   (Turkey)

^b EGE UNIVERSITY   (Turkey)

^c University School of Medicine   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; DNA METHYLTRANSFERASE; HISTONE DEACETYLASE; PLANT EXTRACT; THYMUS SERPYLLUM EXTRACT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG INHIBITION; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIGENETICS; HUMAN; HUMAN CELL; MEDICINAL PLANT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYMUS (PLANT); THYMUS SERPYLLUM;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL PROLIFERATION; DNA FRAGMENTATION; DNA METHYLATION; EPIGENESIS, GENETIC; HISTONE DEACETYLASES; HUMANS; MCF-7 CELLS; PLANT EXTRACTS; THYMUS PLANT;

EID: 84873619763     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2012.719658     Document Type: Article

References (21)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al.: Global cancer statistics. CA Cancer J Clin 61(2), 69-90, 2011.
2. Mulero NS and Esteller M: Epigenetic biomarkers for human cancer: the time is now. Crit Rev Oncol Hemat 68(1), 1-11, 2008.
3. Xiao DY and Sheng ZG: Epigenetic drugs for cancer treatment and prevention: mechanisms of action. Biomol Concepts 1, 239-251, 2010.
4. Ganesan A, Nolan L, Crabb SJ, and Packham G: Epigenetic therapy: histone acetylation, DNAmethylation and anti-cancer drug discovery. Curr Cancer Drug Targets 9, 963-981, 2009.
5. Ateeq-ur R, Abdul M, Samia I, Akhtar MZ, Mazhar Q, et al. : Biological evaluation of wild thyme (Thymus serpyllum). Pharmaceutical Biology 47, 628-633, 2009.
6. Javad SG, Mohammad HM, Shabnam S, Meysam H, and Abbas H: Chemichal characterization of bioactive volatile molecules of four Thymus species using nanoscale injection method. Dig J Nanomater Bios 4, 835-841, 2009.
7. Elisabeth SB and Francisco S: Thyme. London: Taylor & Francis, 2002.
8. Raal A, Paaver U, Arak E, and Orav A: Content and composition of the essential oil of Thymus serpyllum L. growing wild in Estonia. Medicina (Kaunas) 40(8), 795-800, 2004.
9. Veeck J and Esteller M: Breast cancer epigenetics: from DNA methylation to microRNAs. J Mammary Gland Biol Neoplasia 15(1), 5-17, 2010.
10. Xu X, Jin H, Liu Y, Liu L, Wu Q, et al.: The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas. Diagn Pathol 7(33), 2012.
11. Sporn MB and Suh N: Chemoprevention of cancer. Carcinogenesis 21, 525-530, 2000.
12. Badisa RB, Tzakou O, Couladis M, and Pilarinou E: Cytotoxic activities of some greek labiatae herbs. Phytother Res 17, 472-476, 2003.
13. Kaileh M, Vanden Berghe W, Boone E, Essawi T, and Haegeman G: Screening of indigenous Palestinian medicinal plants for potential antiinflammatory and cytotoxic activity. J Ethnopharmacol 113, 510-516, 2007.
14. Mustafa T, Atalay S, Kursat K, Zubeyde AP, and Metin S: Antineoplastic properties of some plant extracts which are endemic in sivas. CMJ 32, 9-18, 2010.
15. Chaouki W, Leger DY, Eljastimi J, Beneytout JL, and Hmamouchi M: Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7. Pharmaceutical Biology 48, 269-274, 2010.
16. Yang X, Yan L, and Davidson NE: DNA methylation in breast cancer. Endocr Relat Cancer 8(2), 115-127, 2001.
17. Gao L, Cueto MA, Asselbergs F, and Atadja P: Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J Biol Chem 277, 25748-25755, 2002.
18. Ozdag H, Teschendorff AE, Ahmed AA, Hyland SJ, Blenkiron C, et al.: Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics 7(90), 2006.
19. Ropero S and Esteller M: The role of histone deacetylases (HDACs) in human cancer. Molecular Oncology 1, 19-25, 2007.
20. Butler KV and Kozikowski AP: Chemical origins of isoform selectivity in histone deacetylase inhibitors. Curr Pharm Design 14, 505-528, 2008.
21. Cai FF, Kohler C, Zhang B, Wang MH, Chen WJ, et al.: Epigenetic therapy for breast cancer. Int J Mol Sci 12, 4465-4476, 2011.