Evaluating MISER chromatography for a rapid formulation screen

Journal of Pharmaceutical and Biomedical Analysis

Volumn 77, Issue , 2013, Pages 94-99

  Papp, Robert ^a   Andersson, Ulrika ^b   Cantin, Louis David ^a  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Discovery formulations; Dosing vehicles; MISER chromatography; Poorly soluble drugs; Solubility screening

Indexed keywords

ALBENDAZOLE; INDOMETACIN; PHENACETIN;

ARTICLE; CHROMATOGRAPHY; DATA PROCESSING; DRUG FORMULATION; DRUG SOLUBILITY; MISER CHROMATOGRAPHY; PRIORITY JOURNAL; SCIENTIST;

CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY;

EID: 84873615344     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2013.01.016     Document Type: Article

References (19)

1. Chen H., Zhang Z., McNulty C., Olbert C., Yoon H.J., Lee J.W., Kim S.C., Seo M.H., Oh H.S., Lemmo A.V., Ellis S.J., Heimlich K. A high-throughput combinatorial approach for the discovery of a cremophor EL-free paclitaxel formulation. Pharm. Res. 2003, 20:1302-1308.
2. Kwong E., Higgins J., Templeton A.C. Strategies for bringing drug delivery tools into discovery. Int. J. Pharm. 2011, 412:1-7.
3. DeWitte R.S., Kolovanov E. Predicting molecular physical properties. Pharmaceutical Profiling in Drug Discovery for Lead Selection 2004, 27-52. AAPS Press, Arlington, VA. R.T. Borchardt, E.H. Kerns, C.A. Lipinski, D.R. Thakker, B. Wang (Eds.).
4. Palucki M., Higgins J.D., Kwong E., Templeton A.C. Strategies at the interface of drug discovery and development: early optimization of the solid state phase and preclinical toxicology formulation for potential drug candidates. J. Med. Chem. 2010, 53:5897-5905.
5. Dai W.-G., Pollock-Dove C., Dong L.C., Li S. Advanced screening assays to rapidly identify solubility-enhancing formulations: high-throughput, miniaturization and automation. Adv. Drug Delivery Rev. 2008, 60:657-672.
6. Mansky P., Dai W.-G., Li S., Pollock-Dove C., Daehne K., Dong L., Eichenbaum G. Screening method to identify preclinical liquid and semi-solid formulations for low solubility compounds: miniaturization and automation of solvent casting and dissolution testing. J. Pharm. Sci. 2007, 96:1548-1563.
7. Espada A., Molina-Martin M., Dage J., Kuo M.-S. Application of LC/MS and related techniques to high-throughput drug discovery. Drug Discovery Today 2008, 13:417-423.
8. Welch C.J., Gong X., Schafer W., Pratt E.C., Brkovic T., Pirzada Z., Cuff J.F., Kosjek B. MISER chromatography (multiple injections in a single experimental run): the chromatogram is the graph. Tetrahedron: Asymmetry 2010, 21:1674-1681.
9. Alelyunas Y.W., Liu R., Pelosi-Kilby L., Shen C. Application of a dried-DMSO rapid throughput 24-h equilibrium solubility in advancing discovery candidates. Eur. J. Pharm. Sci. 2009, 37:172-183.
10. Li P., Zhao L. Developing early formulations: practice and perspective. Int. J. Pharm. 2007, 341:1-19.
11. Maas J., Kamm W., Hauck G. An integrated early formulation strategy - from hit evaluation to preclinical candidate profiling. Eur. J. Pharm. Biopharm. 2007, 66:1-10.
12. Tong X.S., Wang J., Zheng S., Pivnichny J.V., Griffin P.R., Shen X., Donnelly M., Vakerich K., Nunes C., Fenyk-Melody J. Effect of signal interference from dosing excipients on pharmacokinetic screening of drug candidates by liquid chromatography/mass spectrometry. Anal. Chem. 2002, 74:6305-6313.
13. Chang M., Li Y., Angeles R., Khan S., Chen L., Kaplan J., Yang L. Development of methods to monitor ionization modification from dosing vehicles and phospholipids in study samples. Bioanalysis 2011, 3:1719-1739.
14. Hopfgartner G., Bourgogne E. Quantitative high-throughput analysis of drugs in biological matrices by mass spectrometry. Mass Spectrom. Rev. 2003, 22:195-214.
15. Alsenz J., Kansy M. High throughput solubility measurement in drug discovery and development. Adv. Drug Delivery Rev. 2007, 59:546-567.
16. Dai W.-G., Dong L.C., Li S., Pollock-Dove C., Chen J., Mansky P., Eichenbaum G. Parallel screening approach to identify solubility-enhancing formulations for improved bioavailability of a poorly water-soluble compound using milligram quantities of material. Int. J. Pharm. 2007, 336:1-11.
17. Luippold A.H., Arnhold T., Jörg W., Krüger B., Süssmuth R.D. Application of a rapid and integrated analysis system (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/tandem mass spectrometry. J. Biomol. Screen. 2011, 16:370-377.
18. Archontaki H.A. Kinetic study on the degradation of indomethacin in alkaline aqueous solutions by derivative ultraviolet spectrophotometry. Analyst 1995, 120:2627-2634.
19. Backensfeld T., Müller B.W., Wiese M., Seydel J.K. Effect of cyclodextrin derivatives on indomethacin stability in aqueous solution. Pharm. Res. 1990, 7:484-490.