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Volumn 779, Issue , 2013, Pages 257-266

Current approaches to epigenetic therapy for the treatment of mantle cell lymphoma

Author keywords

5 aza 2 deoxycytidine; AML; B cell lymphoma; Bendamustine; Bortezomib; CD20; CHOP; Cladribine; Cyclin D1; DNA methylation; Epigenetics; HDAC inhibitor; Hypomethylating agent; Immunotherapy; Lenalidomide; Locus control region; Mantle cell lymphoma; MDS; mTOR inhibitors; Oncogenesis; Panobinostat; PET CT; R CHOP; R Hyper CVAD; Rituximab; Romidepsin; Thrombo embolic event; Vorinostat

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; AZACITIDINE; BENDAMUSTINE; BORTEZOMIB; CD19 ANTIGEN; CD20 ANTIGEN; CLADRIBINE; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DOXORUBICIN; FLAVOPIRIDOL; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; IMMUNOTOXIN; KI 67 ANTIGEN; LENALIDOMIDE; MITOXANTRONE; MONOCLONAL ANTIBODY; OFATUMUMAB; PANOBINOSTAT; PREDNISONE; RITUXIMAB; ROMIDEPSIN; THALIDOMIDE; UNINDEXED DRUG; VINCRISTINE; VORINOSTAT;

EID: 84873607850     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-6176-0_11     Document Type: Review
Times cited : (9)

References (37)
  • 1
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002;16(1):6-21.
    • (2002) Genes Dev , vol.16 , Issue.1 , pp. 6-21
    • Bird, A.1
  • 2
    • 21244467166 scopus 로고    scopus 로고
    • Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies
    • Bhalla KN. Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies. J Clin Oncol. 2005;23(17):3971-93.
    • (2005) J Clin Oncol , vol.23 , Issue.17 , pp. 3971-3993
    • Bhalla, K.N.1
  • 3
    • 40849139208 scopus 로고    scopus 로고
    • Molecular origins of cancer: Epigenetics in cancer
    • Esteller M. Molecular origins of cancer: Epigenetics in cancer. New Engl J Med. 2008;358(11): 1148-59.
    • (2008) New Engl J Med , vol.358 , Issue.11 , pp. 1148-1159
    • Esteller, M.1
  • 4
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD. Translating the histone code. Science. 2001;293(5532):1074-80.
    • (2001) Science , vol.293 , Issue.5532 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 5
    • 0033945861 scopus 로고    scopus 로고
    • DNMT1 binds HDAC2 and a new co-repressor, DMAP1, form a complex at replication foci
    • Rountree MR, Bachman KE, Baylin SB. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, form a complex at replication foci. Nat Genet. 2000;25(3):269-77.
    • (2000) Nat Genet , vol.25 , Issue.3 , pp. 269-277
    • Rountree, M.R.1    Bachman, K.E.2    Baylin, S.B.3
  • 6
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with rb e2f1 and hdac1 and represses transcription from e2f-responsive promoters
    • Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet. 2000;25(3):338-42.
    • (2000) Nat Genet , vol.25 , Issue.3 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 8
    • 0028328632 scopus 로고
    • B-cell-specific demethylation - A novel role for the intronic kappa-chain enhancer sequence
    • Lichtenstein M, Keini G, Cedar H, Bergman Y. B-cell-specific demethylation - A novel role for the intronic kappa-chain enhancer sequence. Cell. 1994;76(5):913-23.
    • (1994) Cell , vol.76 , Issue.5 , pp. 913-923
    • Lichtenstein, M.1    Keini, G.2    Cedar, H.3    Bergman, Y.4
  • 9
    • 0031792775 scopus 로고    scopus 로고
    • The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes
    • Madisen L, Krumm A, Hebbes TR, Groudine M. The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes. Mol Cell Biol. 1998;18(11):6281-92.
    • (1998) Mol Cell Biol , vol.18 , Issue.11 , pp. 6281-6292
    • Madisen, L.1    Krumm, A.2    Hebbes, T.R.3    Groudine, M.4
  • 10
    • 0345357773 scopus 로고    scopus 로고
    • Mechanisms of disease: Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB. Mechanisms of disease: Gene silencing in cancer in association with promoter hypermethylation. New Engl J Med. 2003;349(21):2042- 54.
    • (2003) New Engl J Med , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 11
    • 66549111370 scopus 로고    scopus 로고
    • Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: Its prevalence and clinical significance
    • Hiraga J, Tomita A, Sugimoto T, Shimada K, Ito M, Nakamura S, et al. Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: Its prevalence and clinical significance. Blood. 2009;113(20):4885-93.
    • (2009) Blood , vol.113 , Issue.20 , pp. 4885-4893
    • Hiraga, J.1    Tomita, A.2    Sugimoto, T.3    Shimada, K.4    Ito, M.5    Nakamura, S.6
  • 12
    • 8644252736 scopus 로고    scopus 로고
    • Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
    • Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan WC, et al. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. New Engl J Med. 2004;351(21):2159-69.
    • (2004) New Engl J Med , vol.351 , Issue.21 , pp. 2159-2169
    • Dave, S.S.1    Wright, G.2    Tan, B.3    Rosenwald, A.4    Gascoyne, R.D.5    Chan, W.C.6
  • 16
    • 41349106789 scopus 로고    scopus 로고
    • Ki-67 predicts outcome in advanced-stage mantle cell lymphoma patients treated with anti-CD20 immunochemotherapy: Results from randomized trials of the European MCL Network and the German Low Grade lymphoma Study Group
    • Determann O, Hoster E, Ott G, Bernd HW, Loddenkemper C, Hansmann ML, et al. Ki-67 predicts outcome in advanced-stage mantle cell lymphoma patients treated with anti-CD20 immunochemotherapy: Results from randomized trials of the European MCL Network and the German Low Grade lymphoma Study Group. Blood. 2008;111(4):2385-7.
    • (2008) Blood , vol.111 , Issue.4 , pp. 2385-2387
    • Determann, O.1    Hoster, E.2    Ott, G.3    Bernd, H.W.4    Loddenkemper, C.5    Hansmann, M.L.6
  • 17
    • 0036499084 scopus 로고    scopus 로고
    • Rituximab and CHOP induction therapy for newly diagnosed mantle-cell lymphoma: Molecular complete responses are not predictive of progression-free survival
    • Howard OM, Gribben JG, Neuberg DS, Grossbard M, Poor C, Janicek MJ, et al. Rituximab and CHOP induction therapy for newly diagnosed mantle-cell lymphoma: Molecular complete responses are not predictive of progression-free survival. J Clin Oncol. 2002;20(5):1288-94.
    • (2002) J Clin Oncol , vol.20 , Issue.5 , pp. 1288-1294
    • Howard, O.M.1    Gribben, J.G.2    Neuberg, D.S.3    Grossbard, M.4    Poor, C.5    Janicek, M.J.6
  • 18
    • 20144376591 scopus 로고    scopus 로고
    • Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-Term outcome in patients with previously untreated mantle cell lymphoma: Results of a prospective randomized trial of the german low grade lymphoma study group (glsg
    • Lenz G, Dreyling M, Hoster E, Wormann B, Duhrsen U, Metzner B, et al. Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-Term outcome in patients with previously untreated mantle cell lymphoma: Results of a prospective randomized trial of the German Low Grade Lymphoma Study Group (GLSG). J Clin Oncol. 2005;23(9):1984-92.
    • (2005) J Clin Oncol , vol.23 , Issue.9 , pp. 1984-1992
    • Lenz, G.1    Dreyling, M.2    Hoster, E.3    Wormann, B.4    Duhrsen, U.5    Metzner, B.6
  • 19
    • 27244452464 scopus 로고    scopus 로고
    • High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine
    • Romaguera JE, Fayad L, Rodriguez MA, Broglio KR, Hagemeister FB, Pro B, et al. High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. J Clin Oncol. 2005;23(28):7013-23.
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 7013-7023
    • Romaguera, J.E.1    Fayad, L.2    Rodriguez, M.A.3    Broglio, K.R.4    Hagemeister, F.B.5    Pro, B.6
  • 20
    • 46749085905 scopus 로고    scopus 로고
    • A multi center trial of hyperCVAD plus rituxan in patients with newly diagnosed mantle cell lymphoma
    • Epner EM, Unger J, Miller T, Rimza L, Spier C, Leblanc M, et al. A multi center trial of hyperCVAD plus rituxan in patients with newly diagnosed mantle cell lymphoma. Blood. 2007;110(11):121a.
    • (2007) Blood , vol.110 , Issue.11
    • Epner, E.M.1    Unger, J.2    Miller, T.3    Rimza, L.4    Spier, C.5    Leblanc, M.6
  • 21
    • 80053131089 scopus 로고    scopus 로고
    • Mantle cell lymphoma: The promise of new treatment options
    • Goy A, Kahl B. Mantle cell lymphoma: The promise of new treatment options. Crit Rev Oncol Hemat. 2011;80(1):69-86.
    • (2011) Crit Rev Oncol Hemat , vol.80 , Issue.1 , pp. 69-86
    • Goy, A.1    Kahl, B.2
  • 22
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A, et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study. Lancet Oncol. 2009;10(3):223-32.
    • (2009) Lancet Oncol , vol.10 , Issue.3 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Finelli, C.5    Giagounidis, A.6
  • 23
    • 78651270112 scopus 로고    scopus 로고
    • Azacytidine as a novel agent in the treatment of acute lymphoblastic leukemia
    • Paulson K, Kumar R, Ahsanuddin A, Seftel MD. Azacytidine as a novel agent in the treatment of acute lymphoblastic leukemia. Leukemia Lymphoma. 2011;52(1):134-6.
    • (2011) Leukemia Lymphoma , vol.52 , Issue.1 , pp. 134-136
    • Paulson, K.1    Kumar, R.2    Ahsanuddin, A.3    Seftel, M.D.4
  • 24
    • 77954325193 scopus 로고    scopus 로고
    • Phase I trial of low dose decitabine targeting DNA hypermethylation in patients with chronic lymphocytic leukaemia and Non-Hodgkin lymphoma: Dose-limiting myelosuppression without evidence of DNA hypomethylation
    • Blum KA, Liu ZF, Lucas DM, Chen P, Xie ZL, Baiocchi R, et al. Phase I trial of low dose decitabine targeting DNA hypermethylation in patients with chronic lymphocytic leukaemia and Non-Hodgkin lymphoma: Dose-limiting myelosuppression without evidence of DNA hypomethylation. Brit J Haematol. 2010;150(2):189-95.
    • (2010) Brit J Haematol , vol.150 , Issue.2 , pp. 189-195
    • Blum, K.A.1    Liu, Z.F.2    Lucas, D.M.3    Chen, P.4    Xie, Z.L.5    Baiocchi, R.6
  • 26
    • 0036024588 scopus 로고    scopus 로고
    • Reduceddose cladribine (2-CdA) plus mitoxantrone is effective in the treatment of mantle-cell and low-grade Non-Hodgkin's lymphoma
    • Rummel MJ, Chow KU, Karakas T, Jaager E, Mezger J, Von Grunhagen U, et al. Reduceddose cladribine (2-CdA) plus mitoxantrone is effective in the treatment of mantle-cell and low-grade Non-Hodgkin's lymphoma. Eur J Cancer. 2002;38(13):1739-46.
    • (2002) Eur J Cancer , vol.38 , Issue.13 , pp. 1739-1746
    • Rummel, M.J.1    Chow, K.U.2    Karakas, T.3    Jaager, E.4    Mezger, J.5    Von Grunhagen, U.6
  • 27
    • 33749600951 scopus 로고    scopus 로고
    • Rituximab combined with cladribine or with cladribine and cyclophosphamide in heavily pretreated patients with indolent lymphoproliferative disorders and mantle cell lymphoma
    • Robak T, Smolewski P, Cebula B, Szmigielska-Kaplon A, Chojnowski K, Blonski JZ. Rituximab combined with cladribine or with cladribine and cyclophosphamide in heavily pretreated patients with indolent lymphoproliferative disorders and mantle cell lymphoma. Cancer. 2006;107(7):1542-50.
    • (2006) Cancer , vol.107 , Issue.7 , pp. 1542-1550
    • Robak, T.1    Smolewski, P.2    Cebula, B.3    Szmigielska-Kaplon, A.4    Chojnowski, K.5    Blonski, J.Z.6
  • 28
    • 47249112184 scopus 로고    scopus 로고
    • Long-Term Results Of The Treatment Of Patients With Mantle Cell Lymphoma With Cladribine (2-CDA) Alone (95-80-53) Or 2-CDA And Rituximab
    • N0189) in the North Central Cancer Treatment Group
    • Inwards DJ, Fishkin PAS, Hillman DW, Brown DW, Ansell SM, Kurtin PJ, et al. Long-Term results of the treatment of patients with mantle cell lymphoma with cladribine (2-CDA) alone (95-80-53) or 2-CDA and rituximab (N0189) in the North Central Cancer Treatment Group. Cancer. 2008;113(1):108-16.
    • (2008) Cancer , vol.113 , Issue.1 , pp. 108-116
    • Inwards, D.J.1    Fishkin, P.A.S.2    Hillman, D.W.3    Brown, D.W.4    Ansell, S.M.5    Kurtin, P.J.6
  • 29
    • 79960400013 scopus 로고    scopus 로고
    • Cladribine plus rituximab is an effective therapy for newly diagnosed mantle cell lymphoma
    • Spurgeon SE, Pindyck T, Okada C, Chen YY, Chen ZQ, Mater E, et al. Cladribine plus rituximab is an effective therapy for newly diagnosed mantle cell lymphoma. Leukemia Lymphoma. 2011;52(8):1488-94.
    • (2011) Leukemia Lymphoma , vol.52 , Issue.8 , pp. 1488-1494
    • Spurgeon, S.E.1    Pindyck, T.2    Okada, C.3    Chen, Y.Y.4    Chen, Z.Q.5    Mater, E.6
  • 30
    • 67349190247 scopus 로고    scopus 로고
    • Linking DNA methylation and histone modification: Patterns and paradigms
    • Cedar H, Bergman Y. Linking DNA methylation and histone modification: Patterns and paradigms. Nat Rev Genet. 2009;10(5):295-304.
    • (2009) Nat Rev Genet , vol.10 , Issue.5 , pp. 295-304
    • Cedar, H.1    Bergman, Y.2
  • 31
    • 44349131472 scopus 로고    scopus 로고
    • Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
    • Kondo Y, Shen L, Cheng AS, Ahmed S, Boumber Y, Charo C, et al. Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet. 2008;40(6):741-50.
    • (2008) Nat Genet , vol.40 , Issue.6 , pp. 741-750
    • Kondo, Y.1    Shen, L.2    Cheng, A.S.3    Ahmed, S.4    Boumber, Y.5    Charo, C.6
  • 32
    • 33845996135 scopus 로고    scopus 로고
    • Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma, CTCL
    • Duvic M, Talpur R, Ni X, Zhang CL, Hazarika P, Kelly C, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma, (CTCL). Blood. 2007;109(1):31-9.
    • (2007) Blood , vol.109 , Issue.1 , pp. 31-39
    • Duvic, M.1    Talpur, R.2    Ni, X.3    Zhang, C.L.4    Hazarika, P.5    Kelly, C.6
  • 33
    • 79952773321 scopus 로고    scopus 로고
    • Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphoma
    • Kirschbaum M, Frankel P, Popplewell L, Zain J, Delioukina M, Pullarkat V, et al. Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphoma. J Clin Oncol. 2011;29(9):1198-203.
    • (2011) J Clin Oncol , vol.29 , Issue.9 , pp. 1198-1203
    • Kirschbaum, M.1    Frankel, P.2    Popplewell, L.3    Zain, J.4    Delioukina, M.5    Pullarkat, V.6
  • 37
    • 84873604100 scopus 로고    scopus 로고
    • A Phase I/II Study of vorinostat (SAHA), cladribine (2-CdA), and rituximab shows significant activity in previously untreated mantle cell lymphoma
    • Spurgeon S, Chen AI, Okada C, Parekh S, Leshchenko VV, Palmbach G, et al. A Phase I/II Study of vorinostat (SAHA), cladribine (2-CdA), and rituximab shows significant activity in previously untreated mantle cell lymphoma. Blood. 2011;118(21):203.
    • (2011) Blood , vol.118 , Issue.21 , pp. 203
    • Spurgeon, S.1    Chen, A.I.2    Okada, C.3    Parekh, S.4    Leshchenko, V.V.5    Palmbach, G.6


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