Synthesis and biological evaluation of new heteroaryl carboxylic acid derivatives as anti-inflammatory-analgesic agents

Chemical and Pharmaceutical Bulletin

Volumn 61, Issue 2, 2013, Pages 222-228

  Abouzid, Khaled Abouzid Mohamed ^a   Khalil, Nadia Abdalla ^b   Ahmed, Eman Mohamed ^b   Zaitone, Sawsan Abo Bakr ^c  

^a Ain Shams University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c Suez Canal University   (Egypt)

Author keywords

Analgesic; Anti inflammatory; Nicotinic acid; Niflumic acid; Pyridazine

Indexed keywords

2 (2 CARBAMOYLPHENOXY)NICOTINIC ACID; 2 (2 CARBAMOYLPHENOXYAMINO)NICOTINIC ACID; 2 [(1H BENZ[D]IMIDAZOL 2 YL)AMINO]NICOTINIC ACID; 2 [(2 BROMOPHENYL)AMINO]NICOTINIC ACID; 2 [(2 CHLOROPYRIDIN 3 YL)AMINO]NICOTINIC ACID; 2 [(2,4 DICHLOROPHENYL)AMINO]NICOTINIC ACID; 2 [(4,5 DIHYDROTHIAZOL 2 YL)AMINO]NICOTINIC ACID; 3 [(6 CHLOROPYRIDAZIN 3 YL)AMINO]BENZOIC ACID; 3 [(6 ETHOXYPYRIDAZIN 3 YL)AMINO]BENZOIC ACID; 3 [(6 OXO 1,6 DIHYDROPYRIDAZIN 3 YL)AMINO]BENZOIC ACID; 3 [(6 SULPHANYLPYRIDAZIN 3 YL)AMINO]BENZOIC ACID; 4 [(6 CHLOROPYRIDAZIN 3 YL)AMINO]BENZOIC ACID; 4 [(6 ETHOXYPYRIDAZIN 3 YL)AMINO]BENZOIC ACID; 4 [(6 OXO 1,6 DIHYDROPYRIDAZIN 3 YL)AMINO]BENZOIC ACID; 4 [(6 SULPHANYLPYRIDAZIN 3 YL)AMINO]BENZOIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CARBOXYLIC ACID DERIVATIVE; CYCLOOXYGENASE 2; INTERLEUKIN 6; MEFENAMIC ACID; NICOTINIC ACID DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE 2; DRUG EVALUATION, PRECLINICAL; EDEMA; INTERLEUKIN-6; MICE; NICOTINIC ACIDS; NIFLUMIC ACID; PYRIDAZINES; RATS; TUMOR NECROSIS FACTOR-ALPHA; ULCER;

EID: 84873602235     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-00949     Document Type: Article

References (23)

1. Meade E. A., Smith W. L., DeWitt D. L., J. Biol. Chem., 268, 6610-6614 (1993).
2. Abbott J. D., Moreland L. W., Expert Opin. Investig. Drugs, 13, 1007-1018 (2004).
3. Bombardieri S., Cattani P., Ciabattoni G., Di Munno O., Pasero G., Patrono C., Pinca E., Pugliese F., Br. J. Pharmacol., 73, 893-901 (1981).
4. Davies P., Bailey P. J., Goldenberg M. M., Ford-Hutchinson A. W., Annu. Rev. Immunol., 2, 335-357 (1984).
5. Lanas A., García-Rodríguez L. A., Arroyo M. T., Gomollón F., Feu F., González-Pérez A., Zapata E., Bástida G., Rodrigo L., Santolaria S., Güell M., de Argila C. M., Quintero E., Borda F., Piqué J. M., Asociación Española de Gastroenterología, Gut, 55, 1731-1738 (2006).
6. Feldmann M., Brennan F. M., Maini R. N., Annu. Rev. Immunol., 14, 397-440 (1996).
7. Maini R. N., Taylor P. C., Annu. Rev. Med., 51, 207-229 (2000).
8. Koch A. E., Arthritis Rheum., 41, 951-962 (1998).
9. Masferrer J. L., Zweifel B. S., Manning P. T., Hauser S. D., Leahy K. M., Smith W. G., Isakson P. C., Seibert K., Proc. Natl. Acad. Sci. U.S.A., 91, 3228-3232 (1994).
10. Seibert K., Zhang Y., Leahy K., Hauser S., Masferrer J., Perkins W., Lee L., Isakson P. C., Proc. Natl. Acad. Sci. U.S.A., 91, 12013-12017 (1994).
11. Dogne J. M., Supuran C. T., Pratico D., J. Med. Chem., 48, 2251-2257 (2005).
12. Hsiao F.-Y., Tsai Y.-W., Huang W.-F., Clin. Ther., 31, 2618-2627 (2009).
13. Gökçe M., Utku S., Küpeli E., Eur. J. Med. Chem., 44, 3760-3764 (2009).
14. Abouzid K., Bekhit S. A., Bioorg. Med. Chem., 16, 5547-5556 (2008).
15. Moradi A., Navidpour L., Amini M., Sadeghian H., Shadnia H., Firouzi O., Miri R., Ebrahimi S. E. S., Abdollahi M., Zahmatkesh M. H., Shafiee A., Arch. Pharm. Chem. Life Sci., 343, 509-518 (2010).
16. Cocco M. T., Congiu C., Onnis V., Morelli M., Felipo V., Cauli O., Bioorg. Med. Chem., 12, 4169-4177 (2004).
17. Chintakunta V. K., Akella V., Vedula M. S., Mamnoor P. K., Mishra P., Casturi S. R., Vangoori A., Rajagopalan R., Eur. J. Med. Chem., 37, 339-347 (2002).
18. Süküroglu M., Caliskan Ergün B., Unlü S., Sahin M. F., Küpeli E., Yesilada E., Banoglu E., Arch. Pharm. Res., 28, 509-517 (2005).
19. Abouzid K. A. M., Khalil N. A., Ahmed E. M., Esmat A. A., Al-Abd A. M., Med. Chem. Res., 21, 3581-3590 (2012).
20. Badran M. M., Abouzid K. A., Hussein M. H., Arch. Pharm. Res., 26, 107-113 (2003).
21. Seigmund E., Cadmus R., Lu G., Proc. Soc. Exp. Biol. Med., 95, 729-731 (1957).
22. Winter C. A., Risley E. A., Nuss G. W., Proc. Soc. Exp. Biol. Med., 111, 544-547 (1962).
23. Cioli V., Putzolu S., Rossi V., Scorza Barcellona P., Corradino C., Toxicol. Appl. Pharmacol., 50, 283-289 (1979).