3-hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry

Journal of Antimicrobial Chemotherapy

Volumn 68, Issue 3, 2013, Pages 573-576

  Li, Lin ^a   Qiu, Jiayin ^a   Lu, Lu ^b,c   An, Shengli ^a   Qiao, Pengyuan ^c   Jiang, Shibo ^b,c   Liu, Shuwen ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c NEW YORK BLOOD CENTER   (United States)

Author keywords

Antiviral activity; HIV 1 entry inhibitor; HIV 1 sexual transmission

Indexed keywords

3 HYDROXYPHTHALIC ANHYDRIDE MODIFIED HUMAN SERUM ALBUMIN; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIGEN P24; GAMMA INTERFERON; LUCIFERASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; MONONUCLEAR CELL; NONHUMAN; TARGET CELL; UTERINE CERVIX EPITHELIUM; VAGINA EPITHELIUM; VIRUS ENTRY;

ANTI-INFECTIVE AGENTS; CELL PROLIFERATION; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; HIV FUSION INHIBITORS; HIV-1; HUMANS; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; PHTHALIC ANHYDRIDES; SERUM ALBUMIN; VIRUS INTERNALIZATION;

EID: 84873592041     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks458     Document Type: Article

References (13)

1. Abdool KQ, Abdool Karim SS, Frohlich JA et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329: 1168-74.
2. Cutler B, Justman J. Vaginal microbicides and the prevention of HIV transmission. Lancet Infect Dis 2008; 8: 685-97.
3. Ketas TJ, Schader SM, Zurita J et al. Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes. Virology 2007; 364: 431-40.
4. Li L, He L, Tan S et al. 3-Hydroxyphthalic anhydride-modified chicken ovalbumin exhibits potent and broad anti-HIV-1 activity: a potential microbicide for preventing sexual transmission of HIV-1. Antimicrob Agents Chemother 2010; 54: 1700-11.
5. Li L, Qiao P, Yang J et al. Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission. Retrovirology 2010; 7: 37.
6. Li L, Tan S, Lu H et al. Combinations of 3-hydroxyphthalic anhydride-modified ovalbumin with antiretroviral drug-based microbicide candidates display synergistic and complementary effects against HIV-1 infection. J Acquir Immune Defic Syndr 2011; 56: 384-92.
7. Mine Y, Yang M. Recent advances in the understanding of egg allergens: basic, industrial, and clinical perspectives. J Agric Food Chem 2008; 56: 4874-900.
8. SF162P3 maps to envelope gp120. J Virol 2003; 77: 989-98.
9. Chou TC, Hayball MP. CalcuSyn: Windows Software for Dose Effect Analysis. Ferguson, MO, USA: BIOSOFT, 1991.
10. Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984; 22: 27-55.
11. Boscolo P, del SA, Sabbioni E et al. Effects of resveratrol on lymphocyte proliferation and cytokine release. Ann Clin Lab Sci 2003; 33: 226-31.
12. Shattock RJ, Doms RW. AIDS models: microbicides could learn from vaccines. Nat Med 2002; 8: 425.
13. Van DL, Govinden R, Mirembe FM et al. Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission. N Engl J Med 2008; 359: 463-72.