-
2
-
-
14944385553
-
Global cancer statistics 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74-108.
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
3
-
-
33847323129
-
Epidermal growth factor receptor mutations in lung cancer
-
Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat Rev. 2007;7:169-81.
-
(2007)
Nat Rev
, vol.7
, pp. 169-181
-
-
Sharma, S.V.1
Bell, D.W.2
Settleman, J.3
Haber, D.A.4
-
4
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected
-
Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, Nishiwaki Y, Vansteenkiste J, Kudoh S, Rischin D, Eek R, Horai T, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]. J Clin Oncol. 2003;21:2237-46.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
Nishiwaki, Y.7
Vansteenkiste, J.8
Kudoh, S.9
Rischin, D.10
Eek, R.11
Horai, T.12
-
5
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris MG, Natale RB, Herbst RS, Lynch Jr. TJ, Prager D, Belani CP, Schiller JH, Kelly K, Spiridonidis H, Sandler A, Albain KS, Cella D, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial. JAMA. 2003;290:2149-58.
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, H.9
Sandler, A.10
Albain, K.S.11
Cella, D.12
-
6
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (iressa survival evaluation in lung cancer
-
Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J, Thongprasert S, Tan EH, Pemberton K, Archer V, Carroll K. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-37.
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Rodrigues Pereira, J.4
Ciuleanu, T.5
Von Pawel, J.6
Thongprasert, S.7
Tan, E.H.8
Pemberton, K.9
Archer, V.10
Carroll, K.11
-
7
-
-
56249109644
-
Gefitinib versus docetaxel in previously treated non-smallcell lung cancer (INTEREST): A randomised phase III trial
-
Kim ES, Hirsh V, Mok T, Socinski MA, Gervais R, Wu YL, Li LY, Watkins CL, Sellers MV, Lowe ES, Sun Y, Liao ML, et al. Gefitinib versus docetaxel in previously treated non-smallcell lung cancer (INTEREST): A randomised phase III trial. Lancet. 2008;372:1809-18.
-
(2008)
Lancet
, vol.372
, pp. 1809-1818
-
-
Kim, E.S.1
Hirsh, V.2
Mok, T.3
Socinski, M.A.4
Gervais, R.5
Wu, Y.L.6
Li, L.Y.7
Watkins, C.L.8
Sellers, M.V.9
Lowe, E.S.10
Sun, Y.11
Liao, M.L.12
-
8
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1
-
Giaccone G, Herbst RS, Manegold C, Scagliotti G, Rosell R, Miller V, Natale RB, Schiller JH, Von Pawel J, Pluzanska A, Gatzemeier U, Grous J, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1. J Clin Oncol. 2004;22:777-84.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
Natale, R.B.7
Schiller, J.H.8
Von Pawel, J.9
Pluzanska, A.10
Gatzemeier, U.11
Grous, J.12
-
9
-
-
1542713370
-
Carboplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 2
-
Gefitinib in combination with paclitaxel and 160 N. Lamparella et al
-
Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C, Scagliotti G, Rosell R, Oliff I, Reeves JA, Wolf MK, Krebs AD, et al. Gefitinib in combination with paclitaxel and 160 N. Lamparella et al. carboplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 2. J Clin Oncol. 2004;22:785-94.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
Scagliotti, G.7
Rosell, R.8
Oliff, I.9
Reeves, J.A.10
Wolf, M.K.11
Krebs, A.D.12
-
10
-
-
17144385106
-
Gefitinib as afirst-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers
-
Lee DH, Han JY, Lee HG, Lee JJ, Lee EK, Kim HY, Kim HK, Hong EK, Lee JS. Gefitinib as afirst-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers. Clin Cancer Res. 2005;11:3032-7.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3032-3037
-
-
Lee, D.H.1
Han, J.Y.2
Lee, H.G.3
Lee, J.J.4
Lee, E.K.5
Kim, H.Y.6
Kim, H.K.7
Hong, E.K.8
Lee, J.S.9
-
11
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, Nishiwaki Y, Ohe Y, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:947-57.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
Sunpaweravong, P.7
Han, B.8
Margono, B.9
Ichinose, Y.10
Nishiwaki, Y.11
Ohe, Y.12
-
12
-
-
79960702788
-
Biomarker analyses andfinal overall survival results from a phase III, randomized, open-label,first-line study of gefitinib versus carboplatin/ paclitaxel in clinically selected patients with advanced non-smallcell lung cancer in Asia (IPASS
-
Fukuoka M, Wu YL, Thongprasert S, Sunpaweravong P, Leong SS, Sriuranpong V, Chao TY, Nakagawa K, Chu DT, Saijo N, Duffield EL, Rukazenkov Y, et al. Biomarker analyses andfinal overall survival results from a phase III, randomized, open-label,first-line study of gefitinib versus carboplatin/ paclitaxel in clinically selected patients with advanced non-smallcell lung cancer in Asia (IPASS). J Clin Oncol. 2011;29:2866-74.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2866-2874
-
-
Fukuoka, M.1
Wu, Y.L.2
Thongprasert, S.3
Sunpaweravong, P.4
Leong, S.S.5
Sriuranpong, V.6
Chao, T.Y.7
Nakagawa, K.8
Chu, D.T.9
Saijo, N.10
Duffield, E.L.11
Rukazenkov, Y.12
-
13
-
-
77953930730
-
Gefitinib or chemotherapy for non-smallcell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, et al. Gefitinib or chemotherapy for non-smallcell lung cancer with mutated EGFR. N Engl J Med. 2010;362:2380-8.
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
Gemma, A.7
Harada, M.8
Yoshizawa, H.9
Kinoshita, I.10
Fujita, Y.11
Okinaga, S.12
-
14
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, Seto T, Satouchi M, Tada H, Hirashima T, Asami K, Katakami N, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol. 2010;11:121-8.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
Negoro, S.4
Okamoto, I.5
Tsurutani, J.6
Seto, T.7
Satouchi, M.8
Tada, H.9
Hirashima, T.10
Asami, K.11
Katakami, N.12
-
15
-
-
4344646459
-
Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer
-
Perez-Soler R, Chachoua A, Hammond LA, Rowinsky EK, Huberman M, Karp D, Rigas J, Clark GM, Santabarbara P, Bonomi P. Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. J Clin Oncol. 2004;22:3238-47.
-
(2004)
J Clin Oncol
, vol.22
, pp. 3238-3247
-
-
Perez-Soler, R.1
Chachoua, A.2
Hammond, L.A.3
Rowinsky, E.K.4
Huberman, M.5
Karp, D.6
Rigas, J.7
Clark, G.M.8
Santabarbara, P.9
Bonomi, P.10
-
16
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Thongprasert S, Campos D, Maoleekoonpiroj S, Smylie M, Martins R, van Kooten M, Dediu M, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005;353:123-32.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
Tan, E.H.4
Thongprasert, S.5
Campos, D.6
Maoleekoonpiroj, S.7
Smylie, M.8
Martins, R.9
Van Kooten, M.10
Dediu, M.11
-
17
-
-
33748445361
-
Symptom improvement in lung cancer patients treated with erlotinib: Quality of life analysis of the national cancer institute of canada clinical trials group study br.21
-
Bezjak A, Tu D, Seymour L, Clark G, Trajkovic A, Zukin M, Ayoub J, Lago S, de Albuquerque Ribeiro R, Gerogianni A, Cyjon A, Noble J, et al. Symptom improvement in lung cancer patients treated with erlotinib: Quality of life analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol 2006; 24:3831-7.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3831-3837
-
-
Bezjak, A.1
Tu, D.2
Seymour, L.3
Clark, G.4
Trajkovic, A.5
Zukin, M.6
Ayoub, J.7
Lago, S.8
De Albuquerque Ribeiro, R.9
Gerogianni, A.10
Cyjon, A.11
Noble, J.12
-
18
-
-
84857501696
-
Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study
-
Ciuleanu T, Stelmakh L, Cicenas S, Miliauskas S, Grigorescu AC, Hillenbach C, Johannsdottir HK, Klughammer B, Gonzalez EE. Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study. Lancet Oncol. 2012;13(3):300-8.
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 300-308
-
-
Ciuleanu, T.1
Stelmakh, L.2
Cicenas, S.3
Miliauskas, S.4
Grigorescu, A.C.5
Hillenbach, C.6
Johannsdottir, H.K.7
Klughammer, B.8
Gonzalez, E.E.9
-
19
-
-
24944440830
-
TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced nonsmall-cell lung cancer
-
Herbst RS, Prager D, Hermann R, Fehrenbacher L, Johnson BE, Sandler A, Kris MG, Tran HT, Klein P, Li X, Ramies D, Johnson DH, et al. TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced nonsmall-cell lung cancer. J Clin Oncol. 2005;23:5892-9.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5892-5899
-
-
Herbst, R.S.1
Prager, D.2
Hermann, R.3
Fehrenbacher, L.4
Johnson, B.E.5
Sandler, A.6
Kris, M.G.7
Tran, H.T.8
Klein, P.9
Li, X.10
Ramies, D.11
Johnson, D.H.12
-
20
-
-
34248140107
-
Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva Lung Cancer Investigation Trial
-
Gatzemeier U, Pluzanska A, Szczesna A, Kaukel E, Roubec J, De Rosa F, Milanowski J, Karnicka-Mlodkowski H, Pesek M, Serwatowski P, Ramlau R, Janaskova T, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The Tarceva Lung Cancer Investigation Trial. J Clin Oncol. 2007;25:1545-52.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1545-1552
-
-
Gatzemeier, U.1
Pluzanska, A.2
Szczesna, A.3
Kaukel, E.4
Roubec, J.5
De Rosa, F.6
Milanowski, J.7
Karnicka-Mlodkowski, H.8
Pesek, M.9
Serwatowski, P.10
Ramlau, R.11
Janaskova, T.12
-
21
-
-
79960889662
-
Erlotinib versus chemotherapy asfirst-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, openlabel, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, Zhou S, Ren S, Lu S, Zhang L, et al. Erlotinib versus chemotherapy asfirst-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, openlabel, randomised, phase 3 study. Lancet Oncol. 2012;12(8):735-42.
-
(2012)
Lancet Oncol
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
Feng, J.4
Liu, X.Q.5
Wang, C.6
Zhou, S.7
Ren, S.8
Lu, S.9
Zhang, L.10
-
22
-
-
85099426891
-
Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial
-
R. Rosell RG, Vergnenegre A, Massuti B, Felip E, Cardenal F, Garcia Gomez R, Pallares C, Sanchez JM, Porta R, Cobo M, Di Seri M, Garrido Lopez P, Insa A, De Marinis F, Corre R, Carreras M, Carcereny E, Taron M, Paz-Ares LG. Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial. Lancet Oncolo. 2102; 13(3):239-46.
-
Lancet Oncolo
, vol.13
, Issue.3
, pp. 239-246
-
-
R. Rosell, R.G.1
Vergnenegre, A.2
Massuti, B.3
Felip, E.4
Cardenal, F.5
Garcia Gomez, R.6
Pallares, C.7
Sanchez, J.M.8
Porta, R.9
Cobo, M.10
Di Seri, M.11
Garrido Lopez, P.12
Insa, A.13
De Marinis, F.14
Corre, R.15
Carreras, M.16
Carcereny, E.17
Taron, M.18
Paz-Ares, L.G.19
-
23
-
-
70349477817
-
-
for the ATLAS Investigators; Memorial Sloan-Kettering Cancer Center, New York, NY; Genentech, Inc., South San Francisco, CA; University Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer 161 of California, Los Angeles, Los Angeles, CA. A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B forfirst-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC. suppl; abstr LBA8002
-
Miller VA, O'Connor P, Soh C, Kabbinavar F, for the ATLAS Investigators; Memorial Sloan-Kettering Cancer Center, New York, NY; Genentech, Inc., South San Francisco, CA; University Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer 161 of California, Los Angeles, Los Angeles, CA. A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B forfirst-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27:18s. suppl; abstr LBA8002.
-
(2009)
J Clin Oncol
, vol.27
-
-
Miller, V.A.1
O'Connor, P.2
Soh, C.3
Kabbinavar, F.4
-
24
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS medicine. 2005;2:e73.
-
(2005)
PLoS medicine
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
Riely, G.J.4
Somwar, R.5
Zakowski, M.F.6
Kris, M.G.7
Varmus, H.8
-
25
-
-
49649127657
-
Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
-
Engelman JA, Janne PA. Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res. 2008;14:2895-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 2895-2899
-
-
Engelman, J.A.1
Janne, P.A.2
-
26
-
-
40049099220
-
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
-
Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Nat Acad Sci USA. 2008;105:2070-5.
-
(2008)
Proc Nat Acad Sci USA
, vol.105
, pp. 2070-2075
-
-
Yun, C.H.1
Mengwasser, K.E.2
Toms, A.V.3
Woo, M.S.4
Greulich, H.5
Wong, K.K.6
Meyerson, M.7
Eck, M.J.8
-
27
-
-
33748074447
-
Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer
-
Inukai M, Toyooka S, Ito S, Asano H, Ichihara S, Soh J, Suehisa H, Ouchida M, Aoe K, Aoe M, Kiura K, Shimizu N, et al. Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res. 2006;66:7854-8.
-
(2006)
Cancer Res
, vol.66
, pp. 7854-7858
-
-
Inukai, M.1
Toyooka, S.2
Ito, S.3
Asano, H.4
Ichihara, S.5
Soh, J.6
Suehisa, H.7
Ouchida, M.8
Aoe, K.9
Aoe, M.10
Kiura, K.11
Shimizu, N.12
-
28
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, Bergethon K, Shaw AT, Gettinger S, Cosper AK, Akhavanfard S, Heist RS, et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med. 2011;3:75ra26.
-
(2011)
Sci Transl Med
, pp. 375
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
Digumarthy, S.4
Turke, A.B.5
Fidias, P.6
Bergethon, K.7
Shaw, A.T.8
Gettinger, S.9
Cosper, A.K.10
Akhavanfard, S.11
Heist, R.S.12
-
29
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D, Ambrogio L, Shimamura T, Kubo S, Takahashi M, Chirieac LR, Padera RF, Shapiro GI, Baum A, Himmelsbach F, Rettig WJ, Meyerson M, et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008;27:4702-11.
-
(2008)
Oncogene
, vol.27
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
Kubo, S.4
Takahashi, M.5
Chirieac, L.R.6
Padera, R.F.7
Shapiro, G.I.8
Baum, A.9
Himmelsbach, F.10
Rettig, W.J.11
Meyerson, M.12
-
30
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic nonsmall-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
-
Miller VA, Hirsh V, Cadranel J, Chen YM, Park K, Kim SW, Zhou C, Su WC, Wang M, Sun Y, Heo DS, Crino L, et al. Afatinib versus placebo for patients with advanced, metastatic nonsmall-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial. Lancet Oncol. 2012;13:528-38.
-
(2012)
Lancet Oncol
, vol.13
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
Chen, Y.M.4
Park, K.5
Kim, S.W.6
Zhou, C.7
Su, W.C.8
Wang, M.9
Sun, Y.10
Heo, D.S.11
Crino, L.12
-
31
-
-
84862819699
-
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
-
Yang JC, Shih JY, Su WC, Hsia TC, Tsai CM, Ou SH, Yu CJ, Chang GC, Ho CL, Sequist LV, Dudek AZ, Shahidi M, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial. Lancet Oncol. 2012;13:539-48.
-
(2012)
Lancet Oncol
, vol.13
, pp. 539-548
-
-
Yang, J.C.1
Shih, J.Y.2
Su, W.C.3
Hsia, T.C.4
Tsai, C.M.5
Ou, S.H.6
Yu, C.J.7
Chang, G.C.8
Ho, C.L.9
Sequist, L.V.10
Dudek, A.Z.11
Shahidi, M.12
-
32
-
-
84867074465
-
LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin asfirstline treatment for patients with advanced adenocarcinoma of the lung harboring EGFRactivating mutations
-
suppl; abstr LBA7500
-
James Chih-Hsin Yang MHS, Yamamoto N, O'Byrne KJ, Hirsh V, Mok T, Geater SL, Orlov SV, Tsai C-M, Boyer MJ, Su W-C, Bennouna J, Kato T, Gorbunova V, Lecia V. LUX-Lung 3: A randomized, open-label, phase III study of afatinib versus pemetrexed and cisplatin asfirstline treatment for patients with advanced adenocarcinoma of the lung harboring EGFRactivating mutations. J Clin Oncol. 2012;30 (suppl; abstr LBA7500).
-
(2012)
J Clin Oncol
, vol.30
-
-
James Chih-Hsin Yang, M.H.S.1
Yamamoto, N.2
O'Byrne, K.J.3
Hirsh, V.4
Mok, T.5
Geater, S.L.6
Orlov, S.V.7
Tsai, C.-M.8
Boyer, M.J.9
Su, W.-C.10
Bennouna, J.11
Kato, T.12
Gorbunova, V.13
Lecia, V.14
-
33
-
-
37649022615
-
Randomized phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, asfirst-line therapy for patients with advanced or metastatic non small-cell lung cancer
-
Butts CA, Bodkin D, Middleman EL, Englund CW, Ellison D, Alam Y, Kreisman H, Graze P, Maher J, Ross HJ, Ellis PM, McNulty W, et al. Randomized phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, asfirst-line therapy for patients with advanced or metastatic non small-cell lung cancer. J Clin Oncol. 2007;25:5777-84.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5777-5784
-
-
Butts, C.A.1
Bodkin, D.2
Middleman, E.L.3
Englund, C.W.4
Ellison, D.5
Alam, Y.6
Kreisman, H.7
Graze, P.8
Maher, J.9
Ross, H.J.10
Ellis, P.M.11
McNulty, W.12
-
34
-
-
38849114239
-
Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone asfirst-line therapy in EGFR-expressing advanced non-small-cell lung cancer
-
Rosell R, Robinet G, Szczesna A, Ramlau R, Constenla M, Mennecier BC, Pfeifer W, O'Byrne KJ, Welte T, Kolb R, Pirker R, Chemaissani A, et al. Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone asfirst-line therapy in EGFR-expressing advanced non-small-cell lung cancer. Ann Oncol. 2008;19:362-9.
-
(2008)
Ann Oncol
, vol.19
, pp. 362-369
-
-
Rosell, R.1
Robinet, G.2
Szczesna, A.3
Ramlau, R.4
Constenla, M.5
Mennecier, B.C.6
Pfeifer, W.7
O'Byrne, K.J.8
Welte, T.9
Kolb, R.10
Pirker, R.11
Chemaissani, A.12
-
35
-
-
77949891126
-
Cetuximab andfirst-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: Results of the randomized multicenter phase III trial BMS099
-
Lynch TJ, Patel T, Dreisbach L, McCleod M, Heim WJ, Hermann RC, Paschold E, Iannotti NO, Dakhil S, Gorton S, Pautret V, Weber MR, et al. Cetuximab andfirst-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: Results of the randomized multicenter phase III trial BMS099. J Clin Oncol. 2010;28:911-7.
-
(2010)
J Clin Oncol
, vol.28
, pp. 911-917
-
-
Lynch, T.J.1
Patel, T.2
Dreisbach, L.3
McCleod, M.4
Heim, W.J.5
Hermann, R.C.6
Paschold, E.7
Iannotti, N.O.8
Dakhil, S.9
Gorton, S.10
Pautret, V.11
Weber, M.R.12
-
36
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
-
Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, Vynnychenko I, Park K, Yu CT, Ganul V, Roh JK, Bajetta E, et al. Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial. Lancet. 2009;373:1525-31.
-
(2009)
Lancet
, vol.373
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
Von Pawel, J.4
Krzakowski, M.5
Ramlau, R.6
Vynnychenko, I.7
Park, K.8
Yu, C.T.9
Ganul, V.10
Roh, J.K.11
Bajetta, E.12
-
37
-
-
84855311144
-
EGFR expression as a predictor of survival forfirst-line chemotherapy plus cetuximab in patients with advanced 162 N Lamparella et al non-small-cell lung cancer: Analysis of data from the phase 3 FLEX study
-
Pirker R, Pereira JR, von Pawel J, Krzakowski M, Ramlau R, Park K, de Marinis F, Eberhardt WE, Paz-Ares L, Storkel S, Schumacher KM, von Heydebreck A, et al. EGFR expression as a predictor of survival forfirst-line chemotherapy plus cetuximab in patients with advanced 162 N. Lamparella et al. non-small-cell lung cancer: Analysis of data from the phase 3 FLEX study. Lancet Oncol. 2012;13:33-42.
-
(2012)
Lancet Oncol
, vol.13
, pp. 33-42
-
-
Pirker, R.1
Pereira, J.R.2
Von Pawel, J.3
Krzakowski, M.4
Ramlau, R.5
Park, K.6
De Marinis, F.7
Eberhardt, W.E.8
Paz-Ares, L.9
Storkel, S.10
Schumacher, K.M.11
Von Heydebreck, A.12
-
38
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara S, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448:561-6.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
Bando, M.11
Ohno, S.12
-
39
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, Settleman J, Kobayashi S, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27:4247-53.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
Digumarthy, S.R.4
Costa, D.B.5
Heist, R.S.6
Solomon, B.7
Stubbs, H.8
Admane, S.9
McDermott, U.10
Settleman, J.11
Kobayashi, S.12
-
40
-
-
58149382583
-
A mouse model for EML4-ALK-positive lung cancer
-
Soda M, Takada S, Takeuchi K, Choi YL, Enomoto M, Ueno T, Haruta H, Hamada T, Yamashita Y, Ishikawa Y, Sugiyama Y, Mano H. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci USA. 2008;105:19893-7.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19893-19897
-
-
Soda, M.1
Takada, S.2
Takeuchi, K.3
Choi, Y.L.4
Enomoto, M.5
Ueno, T.6
Haruta, H.7
Hamada, T.8
Yamashita, Y.9
Ishikawa, Y.10
Sugiyama, Y.11
Mano, H.12
-
41
-
-
64849101672
-
Cell culture modeling of genotype-directed sensitivity to selective kinase inhibitors: Targeting the anaplastic lymphoma kinase (ALK
-
Settleman J. Cell culture modeling of genotype-directed sensitivity to selective kinase inhibitors: Targeting the anaplastic lymphoma kinase (ALK). Semin Oncol. 2009;36:S36-41.
-
(2009)
Semin Oncol
, vol.36
-
-
Settleman, J.1
-
42
-
-
44849126091
-
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
-
McDermott U, Iafrate AJ, Gray NS, Shioda T, Classon M, Maheswaran S, Zhou W, Choi HG, Smith SL, Dowell L, Ulkus LE, Kuhlmann G, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res. 2008;68:3389-95.
-
(2008)
Cancer Res
, vol.68
, pp. 3389-3395
-
-
McDermott, U.1
Iafrate, A.J.2
Gray, N.S.3
Shioda, T.4
Classon, M.5
Maheswaran, S.6
Zhou, W.7
Choi, H.G.8
Smith, S.L.9
Dowell, L.10
Ulkus, L.E.11
Kuhlmann, G.12
-
43
-
-
70350140489
-
Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
-
suppl; abstr 3509
-
Kwak DRC EL, Clark J, Shapiro GI, Maki RG, Ratain MJ, Solomon B, Bang Y, S.Ou R, et al. Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol. 2009;27:15s (suppl; abstr 3509).
-
(2009)
J Clin Oncol
, vol.27
-
-
Kwak, D.R.C.E.L.1
Clark, J.2
Shapiro, G.I.3
Maki, R.G.4
Ratain, M.J.5
Solomon, B.6
Bang, Y.7
Ou, R.8
-
44
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SH, Dezube BJ, Janne PA, Costa DB, Varella-Garcia M, Kim WH, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010;363:1693-703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
Shaw, A.T.4
Solomon, B.5
Maki, R.G.6
Ou, S.H.7
Dezube, B.J.8
Janne, P.A.9
Costa, D.B.10
Varella-Garcia, M.11
Kim, W.H.12
-
45
-
-
84873608067
-
Impact of crizotinib on survival in patients with advanced, ALKpositive NSCLC compared with historical controls
-
suppl; abstr 7507
-
AT Shaw BYY, Solomon BJ, Riely GJ, Iafrate AJ, Shapiro G, Costa DB, Butaney M, Ou SI, Maki RG, Bang Y, Varella-Garcia M, Salgia R, Wilner KD, Kulig K, Selaru P, Tang Y, Kwak EL, Clark JW, Camidge DR. Impact of crizotinib on survival in patients with advanced, ALKpositive NSCLC compared with historical controls. J Clin Oncol. 2011;29 (suppl; abstr 7507).
-
(2011)
J Clin Oncol
, vol.29
-
-
At Shaw, B.Y.Y.1
Solomon, B.J.2
Riely, G.J.3
Iafrate, A.J.4
Shapiro, G.5
Costa, D.B.6
Butaney, M.7
Ou, S.I.8
Maki, R.G.9
Bang, Y.10
Varella-Garcia, M.11
Salgia, R.12
Wilner, K.D.13
Kulig, K.14
Selaru, P.15
Tang, Y.16
Kwak, E.L.17
Clark, J.W.18
Camidge, D.R.19
-
46
-
-
80052492099
-
Progression-free survival (PFS) from a phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC
-
suppl; abstr 2501).CED
-
DR Camidge YB, Kwak EL, Shaw AT, Iafrate AJ, Maki RG, Solomon BJ, Ou SI, Salgia R, Wilner KD, Costa DB, Shapiro G, LoRusso P, Stephenson P, Tang Y, Ruffner K, Clark JW. Progression-free survival (PFS) from a phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol. 2011;29 (suppl; abstr 2501).CED.
-
(2011)
J Clin Oncol
, pp. 29
-
-
Dr. Camidge, Y.B.1
Kwak, E.L.2
Shaw, A.T.3
Iafrate, A.J.4
Maki, R.G.5
Solomon, B.J.6
Ou, S.I.7
Salgia, R.8
Wilner, K.D.9
Costa, D.B.10
Shapiro, G.11
LoRusso, P.12
Stephenson, P.13
Tang, Y.14
Ruffner, K.15
Clark, J.W.16
-
47
-
-
80051780280
-
Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): PROFILE 1005
-
suppl; abstr 7514
-
Crinò DK, Riely GJ, Janne PA, Blackhall FH, Camidge DR, Hirsh V, Mok T, Solomon BJ, Park K, Gadgeel SM, Martins R, Han J, De Pas TM, Bottomley A, Polli A, Petersen J, Tassell VR, Shaw AT. Initial phase II results with crizotinib in advanced ALK-positive non-small cell lung cancer (NSCLC): PROFILE 1005. J Clin Oncol. 2011;29 (suppl; abstr 7514).
-
(2011)
J Clin Oncol
, pp. 29
-
-
Crinò, D.K.1
Riely, G.J.2
Janne, P.A.3
Blackhall, F.H.4
Camidge, D.R.5
Hirsh, V.6
Mok, T.7
Solomon, B.J.8
Park, K.9
Gadgeel, S.M.10
Martins, R.11
Han, J.12
De Pas, T.M.13
Bottomley, A.14
Polli, A.15
Petersen, J.16
Tassell, V.R.17
Shaw, A.T.18
-
48
-
-
79956318797
-
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK
-
Katayama R, Khan TM, Benes C, Lifshits E, Ebi H, Rivera VM, Shakespeare WC, Iafrate AJ, Engelman JA, Shaw AT. Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK. Proc Natl Acad Sci USA. 2011;108:7535-40.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 7535-7540
-
-
Katayama, R.1
Khan, T.M.2
Benes, C.3
Lifshits, E.4
Ebi, H.5
Rivera, V.M.6
Shakespeare, W.C.7
Iafrate, A.J.8
Engelman, J.A.9
Shaw, A.T.10
-
49
-
-
82555180241
-
An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC
-
suppl; abstr 7500
-
Wong K, Koczywas M, Goldman JW, Paschold EH, Horn L, Lufkin JM, Blackman F, Teofilovici G, Shapiro M. An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2011;29 (suppl; abstr 7500).
-
(2011)
J Clin Oncol
, pp. 29
-
-
Wong, K.1
Koczywas, M.2
Goldman, J.W.3
Paschold, E.H.4
Horn, L.5
Lufkin, J.M.6
Blackman, F.7
Teofilovici, G.8
Shapiro, M.9
-
50
-
-
84856990335
-
Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
-
Doebele RC, Pilling AB, Aisner DL, Kutateladze TG, Le AT, Weickhardt AJ, Kondo KL, Linderman DJ, Heasley LE, Franklin WA, Varella-Garcia M, Camidge DR. Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clin Cancer Res. 2012;18:1472-82.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1472-1482
-
-
Doebele, R.C.1
Pilling, A.B.2
Aisner, D.L.3
Kutateladze, T.G.4
Le, A.T.5
Weickhardt, A.J.6
Kondo, K.L.7
Linderman, D.J.8
Heasley, L.E.9
Franklin, W.A.10
Varella-Garcia, M.11
Camidge, D.R.12
-
51
-
-
38549115197
-
The met tyrosine kinase receptor in development and cancer
-
Gentile A, Trusolino L, Comoglio PM. The met tyrosine kinase receptor in development and cancer. Cancer Metast Rev. 2008;27:85-94.
-
(2008)
Cancer Metast Rev
, vol.27
, pp. 85-94
-
-
Gentile, A.1
Trusolino, L.2
Comoglio, P.M.3
-
52
-
-
13944276728
-
Functional expression and Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer 163 mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer
-
Ma PC, Jagadeeswaran R, Jagadeesh S, Tretiakova MS, Nallasura V, Fox EA, Hansen M, Schaefer E, Naoki K, Lader A, Richards W, Sugarbaker D, et al. Functional expression and Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer 163 mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res. 2005;65:1479-88.
-
(2005)
Cancer Res
, vol.65
, pp. 1479-1488
-
-
Ma, P.C.1
Jagadeeswaran, R.2
Jagadeesh, S.3
Tretiakova, M.S.4
Nallasura, V.5
Fox, E.A.6
Hansen, M.7
Schaefer, E.8
Naoki, K.9
Lader, A.10
Richards, W.11
Sugarbaker, D.12
-
53
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang WC, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Nat Acad Sci USA. 2007;104:20932-7.
-
(2007)
Proc Nat Acad Sci USA
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
Riely, G.4
Viale, A.5
Wang, L.6
Chitale, D.7
Motoi, N.8
Szoke, J.9
Broderick, S.10
Balak, M.11
Chang, W.C.12
-
54
-
-
76749168413
-
Phase I dose escalation trial (ARQ 197-111) evaluating combination of selective c-Met inhibitor ARQ 197 and erlotinib
-
suppl; abstr 3549
-
I Laux JG, Just R, Brady K, Li J, Schwartz B, Savage R, et al. Phase I dose escalation trial (ARQ 197-111) evaluating combination of selective c-Met inhibitor ARQ 197 and erlotinib. J Clin Oncol. 2009;27:15s (suppl; abstr 3549).
-
(2009)
J Clin Oncol
, vol.27
-
-
I Laux, J.G.1
Just, R.2
Brady, K.3
Li, J.4
Schwartz, B.5
Savage, R.6
-
55
-
-
80051974548
-
Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
-
Sequist LV, von Pawel J, Garmey EG, Akerley WL, Brugger W, Ferrari D, et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol. 2011;29(24):3307-15.
-
(2011)
J Clin Oncol
, vol.29
, Issue.24
, pp. 3307-3315
-
-
Sequist, L.V.1
Von Pawel, J.2
Garmey, E.G.3
Akerley, W.L.4
Brugger, W.5
Ferrari, D.6
-
56
-
-
80052511675
-
Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
-
suppl; abstr 7505
-
Spigel DR, Ervin TJ, Ramlau R, Daniel DB, Goldschmidt JH, Blumenschein GR, et al. Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J Clin Oncol. 2011;29 (suppl; abstr 7505).
-
(2011)
J Clin Oncol
, pp. 29
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.3
Daniel, D.B.4
Goldschmidt, J.H.5
Blumenschein, G.R.6
-
57
-
-
0037402509
-
Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del (6)(q21q21)
-
Charest A, Lane K, McMahon K, Park J, Preisinger E, Conroy H, Housman D. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Gene Chromosome Canc. 2003;37:58-71.
-
(2003)
Gene Chromosome Canc
, vol.37
, pp. 58-71
-
-
Charest, A.1
Lane, K.2
McMahon, K.3
Park, J.4
Preisinger, E.5
Conroy, H.6
Housman, D.7
-
58
-
-
33747887175
-
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice
-
Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006;66:7473-81.
-
(2006)
Cancer Res
, vol.66
, pp. 7473-7481
-
-
Charest, A.1
Wilker, E.W.2
McLaughlin, M.E.3
Lane, K.4
Gowda, R.5
Coven, S.6
McMahon, K.7
Kovach, S.8
Feng, Y.9
Yaffe, M.B.10
Jacks, T.11
Housman, D.12
-
59
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007;131:1190-203.
-
(2007)
Cell
, vol.131
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
Possemato, A.4
Yu, J.5
Haack, H.6
Nardone, J.7
Lee, K.8
Reeves, C.9
Li, Y.10
Hu, Y.11
Tan, Z.12
-
60
-
-
84863338079
-
ROS1 rearrangements define a unique molecular class of lung cancers
-
Bergethon K, Shaw AT, Ou SH, Katayama R, Lovly CM, McDonald NT, Massion PP, Siwak-Tapp C, Gonzalez A, Fang R, Mark EJ, Batten JM, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012;30:863-70.
-
(2012)
J Clin Oncol
, vol.30
, pp. 863-870
-
-
Bergethon, K.1
Shaw, A.T.2
Ou, S.H.3
Katayama, R.4
Lovly, C.M.5
McDonald, N.T.6
Massion, P.P.7
Siwak-Tapp, C.8
Gonzalez, A.9
Fang, R.10
Mark, E.J.11
Batten, J.M.12
-
61
-
-
0024384470
-
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
-
Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Bioph Res Co. 1989;161:851-8.
-
(1989)
Biochem Bioph Res Co
, vol.161
, pp. 851-858
-
-
Ferrara, N.1
Henzel, W.J.2
-
62
-
-
0031942430
-
High pre-Treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer
-
Salven P, Ruotsalainen T, Mattson K, Joensuu H. High pre-Treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer. Int J Cancer. 1998;79:144-6.
-
(1998)
Int J Cancer
, vol.79
, pp. 144-146
-
-
Salven, P.1
Ruotsalainen, T.2
Mattson, K.3
Joensuu, H.4
-
63
-
-
39749096242
-
VEGF polymorphisms and survival in early-stage non-small-cell lung cancer
-
Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol. 2008;26:856-62.
-
(2008)
J Clin Oncol
, vol.26
, pp. 856-862
-
-
Heist, R.S.1
Zhai, R.2
Liu, G.3
Zhou, W.4
Lin, X.5
Su, L.6
Asomaning, K.7
Lynch, T.J.8
Wain, J.C.9
Christiani, D.C.10
-
64
-
-
2942657615
-
Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
-
Johnson DH, Fehrenbacher L, Novotny WF, Herbst RS, Nemunaitis JJ, Jablons DM, Langer CJ, De Vore III RF, Gaudreault J, Damico LA, Holmgren E, Kabbinavar F. Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol. 2004;22:2184-91.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2184-2191
-
-
Johnson, D.H.1
Fehrenbacher, L.2
Novotny, W.F.3
Herbst, R.S.4
Nemunaitis, J.J.5
Jablons, D.M.6
Langer, C.J.7
De Vore III, R.F.8
Gaudreault, J.9
Damico, L.A.10
Holmgren, E.11
Kabbinavar, F.12
-
65
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 2006;355:2542-50.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
66
-
-
77951473661
-
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo asfirst-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL
-
Reck M, Von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Moore N, Manegold C. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo asfirst-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL). Ann Oncol. 2010;21:1804-9.
-
(2010)
Ann Oncol
, vol.21
, pp. 1804-1809
-
-
Reck, M.1
Von Pawel, J.2
Zatloukal, P.3
Ramlau, R.4
Gorbounova, V.5
Hirsh, V.6
Leighl, N.7
Mezger, J.8
Archer, V.9
Moore, N.10
Manegold, C.11
-
67
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat Rev. 2007;7:95-106.
-
(2007)
Nat Rev
, vol.7
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
68
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, Van Den Eertwegh AJ, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363:711-23
-
(2010)
N Engl J Med
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
Weber, R.W.4
Sosman, J.A.5
Haanen, J.B.6
Gonzalez, R.7
Robert, C.8
Schadendorf, D.9
Hassel, J.C.10
Akerley, W.11
Van Den Eertwegh, A.J.12
-
69
-
-
84863911486
-
Ipilimumab in combination with paclitaxel and carboplatin asfirstline treatment in stage IIIb/IV non-small-cell lung cancer: Results from a randomized, doubleblind, multicenter phase II study
-
Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, Reck M. Ipilimumab in combination with paclitaxel and carboplatin asfirstline treatment in stage IIIb/IV non-small-cell lung cancer: Results from a randomized, doubleblind, multicenter phase II study. J Clin Oncol. 2012;30:2046-54.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2046-2054
-
-
Lynch, T.J.1
Bondarenko, I.2
Luft, A.3
Serwatowski, P.4
Barlesi, F.5
Chacko, R.6
Sebastian, M.7
Neal, J.8
Lu, H.9
Cuillerot, J.M.10
Reck, M.11
-
70
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366:2455-65.
-
(2012)
N Engl J Med
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
Hwu, W.J.4
Topalian, S.L.5
Hwu, P.6
Drake, C.G.7
Camacho, L.H.8
Kauh, J.9
Odunsi, K.10
Pitot, H.C.11
Hamid, O.12
-
71
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDermott, D.F.6
Powderly, J.D.7
Carvajal, R.D.8
Sosman, J.A.9
Atkins, M.B.10
Leming, P.D.11
Spigel, D.R.12
-
72
-
-
77949957365
-
Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
-
Sharma SV, Haber DA, Settleman J. Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat Rev. 2010;10:241-53.
-
(2010)
Nat Rev
, vol.10
, pp. 241-253
-
-
Sharma, S.V.1
Haber, D.A.2
Settleman, J.3
-
73
-
-
80555139776
-
Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC
-
suppl; abstr CRA7506
-
Kris MG, Johnson BE, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Aronson SL, et al. Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC). J Clin Oncol. 2011;29 (suppl; abstr CRA7506).
-
(2011)
J Clin Oncol
, pp. 29
-
-
Kris, M.G.1
Johnson, B.E.2
Kwiatkowski, D.J.3
Iafrate, A.J.4
Wistuba, I.I.5
Aronson, S.L.6
-
74
-
-
84866750638
-
Comprehensive genomic characterization of squamous cell carcinoma of the lung
-
suppl; abstr 7006
-
Govindan R, Hammerman PS, Hayes DN, Wilkerson MD, Baylin S, Meyerson M. Comprehensive genomic characterization of squamous cell carcinoma of the lung. J Clin Oncol. 2012;30 (suppl; abstr 7006).
-
(2012)
J Clin Oncol
, pp. 30
-
-
Govindan, R.1
Hammerman, P.S.2
Hayes, D.N.3
Wilkerson, M.D.4
Baylin, S.5
Meyerson, M.6
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