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Volumn 779, Issue , 2013, Pages 145-164

Impact of genetic markers on treatment of non-small cell lung cancer

Author keywords

Affitinib; ALK; Bevacizumab; Cetuximab; Crizotinib; EGFR; Erlotinib; Gefitinib; MET; MetMab; Non small cell lung cancer; ROS1; Tivantinib; VEGF

Indexed keywords

AFATINIB; ANAPLASTIC LYMPHOMA KINASE; AP 26113; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; CRIZOTINIB; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; GEMCITABINE; IPILIMUMAB; MESENCHYMAL EPITHELIAL TRANSITION FACTOR; METMAB; MONOCLONAL ANTIBODY; NAVELBINE; NVP TAE 684; PACLITAXEL; PEMETREXED; PHOSPHOTRANSFERASE INHIBITOR; PLACEBO; PROTEIN ROS1; PROTEIN TYROSINE KINASE; TANESPIMYCIN; TIVANTINIB; UNCLASSIFIED DRUG;

EID: 84873591227     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-6176-0_6     Document Type: Review
Times cited : (10)

References (75)
  • 3
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat Rev. 2007;7:169-81.
    • (2007) Nat Rev , vol.7 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 6
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (iressa survival evaluation in lung cancer
    • Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J, Thongprasert S, Tan EH, Pemberton K, Archer V, Carroll K. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-37.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Rodrigues Pereira, J.4    Ciuleanu, T.5    Von Pawel, J.6    Thongprasert, S.7    Tan, E.H.8    Pemberton, K.9    Archer, V.10    Carroll, K.11
  • 12
    • 79960702788 scopus 로고    scopus 로고
    • Biomarker analyses andfinal overall survival results from a phase III, randomized, open-label,first-line study of gefitinib versus carboplatin/ paclitaxel in clinically selected patients with advanced non-smallcell lung cancer in Asia (IPASS
    • Fukuoka M, Wu YL, Thongprasert S, Sunpaweravong P, Leong SS, Sriuranpong V, Chao TY, Nakagawa K, Chu DT, Saijo N, Duffield EL, Rukazenkov Y, et al. Biomarker analyses andfinal overall survival results from a phase III, randomized, open-label,first-line study of gefitinib versus carboplatin/ paclitaxel in clinically selected patients with advanced non-smallcell lung cancer in Asia (IPASS). J Clin Oncol. 2011;29:2866-74.
    • (2011) J Clin Oncol , vol.29 , pp. 2866-2874
    • Fukuoka, M.1    Wu, Y.L.2    Thongprasert, S.3    Sunpaweravong, P.4    Leong, S.S.5    Sriuranpong, V.6    Chao, T.Y.7    Nakagawa, K.8    Chu, D.T.9    Saijo, N.10    Duffield, E.L.11    Rukazenkov, Y.12
  • 14
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
    • Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, Seto T, Satouchi M, Tada H, Hirashima T, Asami K, Katakami N, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial. Lancet Oncol. 2010;11:121-8.
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3    Negoro, S.4    Okamoto, I.5    Tsurutani, J.6    Seto, T.7    Satouchi, M.8    Tada, H.9    Hirashima, T.10    Asami, K.11    Katakami, N.12
  • 18
    • 84857501696 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study
    • Ciuleanu T, Stelmakh L, Cicenas S, Miliauskas S, Grigorescu AC, Hillenbach C, Johannsdottir HK, Klughammer B, Gonzalez EE. Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): A randomised multicentre, open-label, phase 3 study. Lancet Oncol. 2012;13(3):300-8.
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 300-308
    • Ciuleanu, T.1    Stelmakh, L.2    Cicenas, S.3    Miliauskas, S.4    Grigorescu, A.C.5    Hillenbach, C.6    Johannsdottir, H.K.7    Klughammer, B.8    Gonzalez, E.E.9
  • 21
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy asfirst-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, openlabel, randomised, phase 3 study
    • Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, Zhou S, Ren S, Lu S, Zhang L, et al. Erlotinib versus chemotherapy asfirst-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, openlabel, randomised, phase 3 study. Lancet Oncol. 2012;12(8):735-42.
    • (2012) Lancet Oncol , vol.12 , Issue.8 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3    Feng, J.4    Liu, X.Q.5    Wang, C.6    Zhou, S.7    Ren, S.8    Lu, S.9    Zhang, L.10
  • 23
    • 70349477817 scopus 로고    scopus 로고
    • for the ATLAS Investigators; Memorial Sloan-Kettering Cancer Center, New York, NY; Genentech, Inc., South San Francisco, CA; University Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer 161 of California, Los Angeles, Los Angeles, CA. A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B forfirst-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC. suppl; abstr LBA8002
    • Miller VA, O'Connor P, Soh C, Kabbinavar F, for the ATLAS Investigators; Memorial Sloan-Kettering Cancer Center, New York, NY; Genentech, Inc., South San Francisco, CA; University Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer 161 of California, Los Angeles, Los Angeles, CA. A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B forfirst-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27:18s. suppl; abstr LBA8002.
    • (2009) J Clin Oncol , vol.27
    • Miller, V.A.1    O'Connor, P.2    Soh, C.3    Kabbinavar, F.4
  • 24
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS medicine. 2005;2:e73.
    • (2005) PLoS medicine , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 25
    • 49649127657 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Engelman JA, Janne PA. Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res. 2008;14:2895-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 2895-2899
    • Engelman, J.A.1    Janne, P.A.2
  • 30
    • 84862785051 scopus 로고    scopus 로고
    • Afatinib versus placebo for patients with advanced, metastatic nonsmall-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
    • Miller VA, Hirsh V, Cadranel J, Chen YM, Park K, Kim SW, Zhou C, Su WC, Wang M, Sun Y, Heo DS, Crino L, et al. Afatinib versus placebo for patients with advanced, metastatic nonsmall-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial. Lancet Oncol. 2012;13:528-38.
    • (2012) Lancet Oncol , vol.13 , pp. 528-538
    • Miller, V.A.1    Hirsh, V.2    Cadranel, J.3    Chen, Y.M.4    Park, K.5    Kim, S.W.6    Zhou, C.7    Su, W.C.8    Wang, M.9    Sun, Y.10    Heo, D.S.11    Crino, L.12
  • 33
    • 37649022615 scopus 로고    scopus 로고
    • Randomized phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, asfirst-line therapy for patients with advanced or metastatic non small-cell lung cancer
    • Butts CA, Bodkin D, Middleman EL, Englund CW, Ellison D, Alam Y, Kreisman H, Graze P, Maher J, Ross HJ, Ellis PM, McNulty W, et al. Randomized phase II study of gemcitabine plus cisplatin or carboplatin [corrected], with or without cetuximab, asfirst-line therapy for patients with advanced or metastatic non small-cell lung cancer. J Clin Oncol. 2007;25:5777-84.
    • (2007) J Clin Oncol , vol.25 , pp. 5777-5784
    • Butts, C.A.1    Bodkin, D.2    Middleman, E.L.3    Englund, C.W.4    Ellison, D.5    Alam, Y.6    Kreisman, H.7    Graze, P.8    Maher, J.9    Ross, H.J.10    Ellis, P.M.11    McNulty, W.12
  • 34
    • 38849114239 scopus 로고    scopus 로고
    • Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone asfirst-line therapy in EGFR-expressing advanced non-small-cell lung cancer
    • Rosell R, Robinet G, Szczesna A, Ramlau R, Constenla M, Mennecier BC, Pfeifer W, O'Byrne KJ, Welte T, Kolb R, Pirker R, Chemaissani A, et al. Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone asfirst-line therapy in EGFR-expressing advanced non-small-cell lung cancer. Ann Oncol. 2008;19:362-9.
    • (2008) Ann Oncol , vol.19 , pp. 362-369
    • Rosell, R.1    Robinet, G.2    Szczesna, A.3    Ramlau, R.4    Constenla, M.5    Mennecier, B.C.6    Pfeifer, W.7    O'Byrne, K.J.8    Welte, T.9    Kolb, R.10    Pirker, R.11    Chemaissani, A.12
  • 41
    • 64849101672 scopus 로고    scopus 로고
    • Cell culture modeling of genotype-directed sensitivity to selective kinase inhibitors: Targeting the anaplastic lymphoma kinase (ALK
    • Settleman J. Cell culture modeling of genotype-directed sensitivity to selective kinase inhibitors: Targeting the anaplastic lymphoma kinase (ALK). Semin Oncol. 2009;36:S36-41.
    • (2009) Semin Oncol , vol.36
    • Settleman, J.1
  • 43
    • 70350140489 scopus 로고    scopus 로고
    • Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
    • suppl; abstr 3509
    • Kwak DRC EL, Clark J, Shapiro GI, Maki RG, Ratain MJ, Solomon B, Bang Y, S.Ou R, et al. Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol. 2009;27:15s (suppl; abstr 3509).
    • (2009) J Clin Oncol , vol.27
    • Kwak, D.R.C.E.L.1    Clark, J.2    Shapiro, G.I.3    Maki, R.G.4    Ratain, M.J.5    Solomon, B.6    Bang, Y.7    Ou, R.8
  • 49
    • 82555180241 scopus 로고    scopus 로고
    • An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC
    • suppl; abstr 7500
    • Wong K, Koczywas M, Goldman JW, Paschold EH, Horn L, Lufkin JM, Blackman F, Teofilovici G, Shapiro M. An open-label phase II study of the Hsp90 inhibitor ganetespib (STA-9090) as monotherapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2011;29 (suppl; abstr 7500).
    • (2011) J Clin Oncol , pp. 29
    • Wong, K.1    Koczywas, M.2    Goldman, J.W.3    Paschold, E.H.4    Horn, L.5    Lufkin, J.M.6    Blackman, F.7    Teofilovici, G.8    Shapiro, M.9
  • 51
    • 38549115197 scopus 로고    scopus 로고
    • The met tyrosine kinase receptor in development and cancer
    • Gentile A, Trusolino L, Comoglio PM. The met tyrosine kinase receptor in development and cancer. Cancer Metast Rev. 2008;27:85-94.
    • (2008) Cancer Metast Rev , vol.27 , pp. 85-94
    • Gentile, A.1    Trusolino, L.2    Comoglio, P.M.3
  • 52
    • 13944276728 scopus 로고    scopus 로고
    • Functional expression and Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer 163 mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer
    • Ma PC, Jagadeeswaran R, Jagadeesh S, Tretiakova MS, Nallasura V, Fox EA, Hansen M, Schaefer E, Naoki K, Lader A, Richards W, Sugarbaker D, et al. Functional expression and Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer 163 mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res. 2005;65:1479-88.
    • (2005) Cancer Res , vol.65 , pp. 1479-1488
    • Ma, P.C.1    Jagadeeswaran, R.2    Jagadeesh, S.3    Tretiakova, M.S.4    Nallasura, V.5    Fox, E.A.6    Hansen, M.7    Schaefer, E.8    Naoki, K.9    Lader, A.10    Richards, W.11    Sugarbaker, D.12
  • 54
    • 76749168413 scopus 로고    scopus 로고
    • Phase I dose escalation trial (ARQ 197-111) evaluating combination of selective c-Met inhibitor ARQ 197 and erlotinib
    • suppl; abstr 3549
    • I Laux JG, Just R, Brady K, Li J, Schwartz B, Savage R, et al. Phase I dose escalation trial (ARQ 197-111) evaluating combination of selective c-Met inhibitor ARQ 197 and erlotinib. J Clin Oncol. 2009;27:15s (suppl; abstr 3549).
    • (2009) J Clin Oncol , vol.27
    • I Laux, J.G.1    Just, R.2    Brady, K.3    Li, J.4    Schwartz, B.5    Savage, R.6
  • 55
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • Sequist LV, von Pawel J, Garmey EG, Akerley WL, Brugger W, Ferrari D, et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol. 2011;29(24):3307-15.
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3307-3315
    • Sequist, L.V.1    Von Pawel, J.2    Garmey, E.G.3    Akerley, W.L.4    Brugger, W.5    Ferrari, D.6
  • 56
    • 80052511675 scopus 로고    scopus 로고
    • Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
    • suppl; abstr 7505
    • Spigel DR, Ervin TJ, Ramlau R, Daniel DB, Goldschmidt JH, Blumenschein GR, et al. Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J Clin Oncol. 2011;29 (suppl; abstr 7505).
    • (2011) J Clin Oncol , pp. 29
    • Spigel, D.R.1    Ervin, T.J.2    Ramlau, R.3    Daniel, D.B.4    Goldschmidt, J.H.5    Blumenschein, G.R.6
  • 58
    • 33747887175 scopus 로고    scopus 로고
    • ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice
    • Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006;66:7473-81.
    • (2006) Cancer Res , vol.66 , pp. 7473-7481
    • Charest, A.1    Wilker, E.W.2    McLaughlin, M.E.3    Lane, K.4    Gowda, R.5    Coven, S.6    McMahon, K.7    Kovach, S.8    Feng, Y.9    Yaffe, M.B.10    Jacks, T.11    Housman, D.12
  • 61
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Bioph Res Co. 1989;161:851-8.
    • (1989) Biochem Bioph Res Co , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 62
    • 0031942430 scopus 로고    scopus 로고
    • High pre-Treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer
    • Salven P, Ruotsalainen T, Mattson K, Joensuu H. High pre-Treatment serum level of vascular endothelial growth factor (VEGF) is associated with poor outcome in small-cell lung cancer. Int J Cancer. 1998;79:144-6.
    • (1998) Int J Cancer , vol.79 , pp. 144-146
    • Salven, P.1    Ruotsalainen, T.2    Mattson, K.3    Joensuu, H.4
  • 66
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo asfirst-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL
    • Reck M, Von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Moore N, Manegold C. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo asfirst-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL). Ann Oncol. 2010;21:1804-9.
    • (2010) Ann Oncol , vol.21 , pp. 1804-1809
    • Reck, M.1    Von Pawel, J.2    Zatloukal, P.3    Ramlau, R.4    Gorbounova, V.5    Hirsh, V.6    Leighl, N.7    Mezger, J.8    Archer, V.9    Moore, N.10    Manegold, C.11
  • 69
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin asfirstline treatment in stage IIIb/IV non-small-cell lung cancer: Results from a randomized, doubleblind, multicenter phase II study
    • Lynch TJ, Bondarenko I, Luft A, Serwatowski P, Barlesi F, Chacko R, Sebastian M, Neal J, Lu H, Cuillerot JM, Reck M. Ipilimumab in combination with paclitaxel and carboplatin asfirstline treatment in stage IIIb/IV non-small-cell lung cancer: Results from a randomized, doubleblind, multicenter phase II study. J Clin Oncol. 2012;30:2046-54.
    • (2012) J Clin Oncol , vol.30 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3    Serwatowski, P.4    Barlesi, F.5    Chacko, R.6    Sebastian, M.7    Neal, J.8    Lu, H.9    Cuillerot, J.M.10    Reck, M.11
  • 72
    • 77949957365 scopus 로고    scopus 로고
    • Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
    • Sharma SV, Haber DA, Settleman J. Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat Rev. 2010;10:241-53.
    • (2010) Nat Rev , vol.10 , pp. 241-253
    • Sharma, S.V.1    Haber, D.A.2    Settleman, J.3
  • 73
    • 80555139776 scopus 로고    scopus 로고
    • Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC
    • suppl; abstr CRA7506
    • Kris MG, Johnson BE, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Aronson SL, et al. Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC). J Clin Oncol. 2011;29 (suppl; abstr CRA7506).
    • (2011) J Clin Oncol , pp. 29
    • Kris, M.G.1    Johnson, B.E.2    Kwiatkowski, D.J.3    Iafrate, A.J.4    Wistuba, I.I.5    Aronson, S.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.