Neural stem cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar medulloblastoma

Gene Therapy

Volumn 20, Issue 2, 2013, Pages 143-150

  Gutova, M ^a   Shackleford, G M ^b   Khankaldyyan, V ^b   Herrmann, K A ^a   Shi, X H ^b,c   Mittelholtz, K ^b   Abramyants, Y ^a   Blanchard, M S ^a   Kim, S U ^d   Annala, A J ^a   Najbauer, J ^a   Synold, T W ^a   D'apuzzo, M ^a   Barish, M E ^a   Moats, R A ^b   Aboody, K S ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c Chung Ang University College of Medicine   (South Korea)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Carboxylesterase; CPT 11; Irinotecan; Medulloblastoma; MRI; Neural stem cells

Indexed keywords

CARBOXYLESTERASE; FIRTECAN; IRINOTECAN; SONIC HEDGEHOG PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; CANCER GROWTH; CANCER SIZE; CELL KILLING; CELL MIGRATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME PRODRUG THERAPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEDULLOBLASTOMA; MOUSE; NEURAL STEM CELL; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CARBOXYLESTERASE; CELL LINE, TUMOR; CEREBELLAR NEOPLASMS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HUMANS; MEDULLOBLASTOMA; MICE; MICE, NUDE; MICE, TRANSGENIC; NEURAL STEM CELLS; PRODRUGS; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME;

MUS; MUS MUSCULUS;

EID: 84873566310     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2012.12     Document Type: Article

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