TGF-β and TGF-β/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Wang, Junhua ^a,b   Zhang, Chuanshan ^a   Wei, Xufa ^a   Blagosklonov, Oleg ^b   Lv, Guodong ^a   Lu, Xiaomei ^a   Mantion, Georges ^b   Vuitton, Dominique A ^b   Wen, Hao ^a   Lin, Renyong ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

^b UNIVERSITÉ DE FRANCHE COMTÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; SMAD7 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4 CD8 RATIO; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ECHINOCOCCOSIS; ECHINOCOCCUS MULTILOCULARIS; FEMALE; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; HOST PARASITE INTERACTION; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL TOLERANCE; IN VIVO STUDY; LIVER CELL; LIVER FIBROSIS; LIVER PARENCHYMA; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; T LYMPHOCYTE SUBPOPULATION; ANIMAL; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DOWN REGULATION; FIBROSIS; GENETICS; LIVER; LIVER HYDATID CYST; METABOLISM; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COLLAGEN TYPE I; COLLAGEN TYPE III; DOWN-REGULATION; ECHINOCOCCOSIS, HEPATIC; ECHINOCOCCUS MULTILOCULARIS; FEMALE; FIBROSIS; HEPATOCYTES; HUMANS; LIVER; MICE; MICE, INBRED BALB C; SIGNAL TRANSDUCTION; SMAD PROTEINS; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84873558480     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055379     Document Type: Article

References (45)

1. Vuitton DA, Zhou H, Bresson-Hadni S, Wang Q, Piarroux M, et al. (2003) Epidemiology of alveolar echinococcosis with particular reference to China and Europe. Parasitology 127Suppl: S87-107.
2. Vuitton DA, Zhang SL, Yang Y, Godot V, Beurton I, et al. (2006) Survival strategy of Echinococcus multilocularis in the human host. Parasitol Int 55Suppl: S51-55.
3. Grenard P, Bresson-Hadni S, El Alaoui S, Chevallier M, Vuitton DA, et al. (2001) Transglutaminase-mediated cross-linking is involved in the stabilization of extracellular matrix in human liver fibrosis. J Hepatol 35: 367-375.
4. Guerret S, Vuitton DA, Liance M, Pater C, Carbillet JP, (1998) Echinococcus multilocularis: relationship between susceptibility/resistance and liver fibrogenesis in experimental mice. Parasitol Res 84: 657-667.
5. Ricard-Blum S, Bresson-Hadni S, Guerret S, Grenard P, Volle PJ, et al. (1996) Mechanism of collagen network stabilization in human irreversible granulomatous liver fibrosis. Gastroenterology 111: 172-182.
6. Ricard-Blum S, Bresson-Hadni S, Vuitton DA, Ville G, Grimaud JA, (1992) Hydroxypyridinium collagen cross-links in human liver fibrosis: study of alveolar echinococcosis. Hepatology 15: 599-602.
7. Vuitton DA, Guerret-Stocker S, Carbillet JP, Mantion G, Miguet JP, et al. (1986) Collagen immunotyping of the hepatic fibrosis in human alveolar echinococcosis. Z Parasitenkd 72: 97-104.
8. Ouellette MJ, Dubois CM, Bergeron D, Roy R, Lambert RD, (1997) TGF beta 2 in rabbit blastocoelic fluid regulates CD4 membrane expression: possible role in the success of gestation. Am J Reprod Immunol 37: 125-136.
9. Cufi S, Vazquez-Martin A, Oliveras-Ferraros C, Martin-Castillo B, Joven J, et al. (2010) Metformin against TGFbeta-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis. Cell Cycle 9: 4461-4468.
10. Feng M, Wang Q, Zhang F, Lu L, (2011) Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury. Int Immunopharmacol 12: 189-196.
11. Jetten AM, Shirley JE, Stoner G, (1986) Regulation of proliferation and differentiation of respiratory tract epithelial cells by TGF beta. Exp Cell Res 167: 539-549.
12. Harraga S, Godot V, Bresson-Hadni S, Mantion G, Vuitton DA, (2003) Profile of cytokine production within the periparasitic granuloma in human alveolar echinococcosis. Acta Trop 85: 231-236.
13. Vuitton DA, (2003) The ambiguous role of immunity in echinococcosis: protection of the host or of the parasite? Acta Trop 85: 119-132.
14. Zhang S, Hue S, Sene D, Penfornis A, Bresson-Hadni S, et al. (2008) Expression of major histocompatibility complex class I chain-related molecule A, NKG2D, and transforming growth factor-beta in the liver of humans with alveolar echinococcosis: new actors in the tolerance to parasites? J Infect Dis 197: 1341-1349.
15. Wu XW, Peng XY, Zhang SJ, Niu JH, Sun H, et al. (2004) [Formation mechanisms of the fibrous capsule around hepatic and splenic hydatid cyst]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 22: 1-4.
16. Mondragon-de-la-Pena C, Ramos-Solis S, Barbosa-Cisneros O, Rodriguez-Padilla C, Tavizon-Garcia P, et al. (2002) Echinococcus granulosus down regulates the hepatic expression of inflammatory cytokines IL-6 and TNF alpha in BALB/c mice. Parasite 9: 351-356.
17. Bartram U, Speer CP, (2004) The role of transforming growth factor beta in lung development and disease. Chest 125: 754-765.
18. Higashiyama H, Yoshimoto D, Okamoto Y, Kikkawa H, Asano S, et al. (2007) Receptor-activated Smad localisation in bleomycin-induced pulmonary fibrosis. J Clin Pathol 60: 283-289.
19. Banas MC, Parks WT, Hudkins KL, Banas B, Holdren M, et al. (2007) Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney. J Histochem Cytochem 55: 275-285.
20. Heldin CH, Miyazono K, ten Dijke P, (1997) TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471.
21. Zhou L, McMahon C, Bhagat T, Alencar C, Yu Y, et al. (2010) Reduced SMAD7 leads to overactivation of TGF-beta signaling in MDS that can be reversed by a specific inhibitor of TGF-beta receptor I kinase. Cancer Res 71: 955-963.
22. Sobral LM, Montan PF, Zecchin KG, Martelli-Junior H, Vargas PA, et al. (2010) Smad7 blocks transforming growth factor-beta1-induced gingival fibroblast-myofibroblast transition via inhibitory regulation of Smad2 and connective tissue growth factor. J Periodontol 82: 642-651.
23. Kamiya Y, Miyazono K, Miyazawa K, (2010) Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction. J Biol Chem 285: 30804-30813.
24. Chen HY, Huang XR, Wang W, Li JH, Heuchel RL, et al. (2010) The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential. Diabetes 60: 590-601.
25. Singh P, Wig JD, Srinivasan R, (2011) The Smad family and its role in pancreatic cancer. Indian J Cancer 48: 351-360.
26. Zhang C, Wang J, Lu G, Li J, Lu X, et al. (2012) Hepatocyte proliferation/growth arrest balance in the liver of mice during E. multilocularis infection: a coordinated 3-stage course. PLoS One 7: e30127.
27. Przybyszewska M, Miloszewska J, Rzonca S, Trembacz H, Pysniak K, et al. (2011) Soluble TNF-alpha receptor I encoded on plasmid vector and its application in experimental gene therapy of radiation-induced lung fibrosis. Arch Immunol Ther Exp (Warsz) 59: 315-326.
28. Maille E, Trinh NT, Prive A, Bilodeau C, Bissonnette E, et al. (2011) Regulation of normal and cystic fibrosis airway epithelial repair processes by TNF-alpha after injury. Am J Physiol Lung Cell Mol Physiol 301: L945-955.
29. Amiot F, Vuong P, Defontaines M, Pater C, Dautry F, et al. (1999) Secondary alveolar echinococcosis in lymphotoxin-alpha and tumour necrosis factor-alpha deficient mice: exacerbation of Echinococcus multilocularis larval growth is associated with cellular changes in the periparasitic granuloma. Parasite Immunol 21: 475-483.
30. Bresson-Hadni S, Petitjean O, Monnot-Jacquard B, Heyd B, Kantelip B, et al. (1994) Cellular localisations of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha mRNA in a parasitic granulomatous disease of the liver, alveolar echinococcosis. Eur Cytokine Netw 5: 461-468.
31. Emery I, Liance M, Deriaud E, Vuitton DA, Houin R, et al. (1996) Characterization of T-cell immune responses of Echinococcus multilocularis-infected C57BL/6J mice. Parasite Immunol 18: 463-472.
32. Wallace K, Burt AD, Wright MC, (2008) Liver fibrosis. Biochem J 411: 1-18.
33. Allen JT, Spiteri MA, (2002) Growth factors in idiopathic pulmonary fibrosis: relative roles. Respir Res 3: 13.
34. Anthony B, Mathieson W, de Castro-Borges W, Allen J, (2010) Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis. Exp Parasitol 124: 409-420.
35. Acharya SS, Dimichele DM, (2008) Rare inherited disorders of fibrinogen. Haemophilia 14: 1151-1158.
36. Itoh S, Taketomi A, Tanaka S, Harimoto N, Yamashita Y, et al. (2007) Role of growth factor receptor bound protein 7 in hepatocellular carcinoma. Mol Cancer Res 5: 667-673.
37. Schmierer B, Hill CS, (2007) TGF beta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 8: 970-982.
38. Del Pilar Alatorre-Carranza M, Miranda-Diaz A, Yanez-Sanchez I, Pizano-Martinez O, Hermosillo-Sandoval JM, et al. (2009) Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-beta and extracellular matrix proteins. BMC Gastroenterol 9: 81.
39. Moustakas A, Pardali K, Gaal A, Heldin CH, (2002) Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation. Immunol Lett 82: 85-91.
40. Spiliotis M, Konrad C, Gelmedin V, Tappe D, Bruckner S, et al. (2006) Characterisation of EmMPK1, an ERK-like MAP kinase from Echinococcus multilocularis which is activated in response to human epidermal growth factor. Int J Parasitol 36: 1097-1112.
41. Gelmedin V, Caballero-Gamiz R, Brehm K, (2008) Characterization and inhibition of a p38-like mitogen-activated protein kinase (MAPK) from Echinococcus multilocularis: antiparasitic activities of p38 MAPK inhibitors. Biochem Pharmacol 76: 1068-1081.
42. Brehm K, Spiliotis M, Zavala-Gongora R, Konrad C, Frosch M, (2006) The molecular mechanisms of larval cestode development: first steps into an unknown world. Parasitol Int 55Suppl: S15-21.
43. Lin RY, Wang JH, Lu XM, Zhou XT, Mantion G, et al. (2009) Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode. World J Gastroenterol 15: 2116-2124.
44. Nono JK, Pletinckx K, Lutz MB, Brehm K, (2012) Excretory/secretory-products of Echinococcus multilocularis larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro. PLoS Negl Trop Dis 6: e1516.
45. Liance M, Vuitton DA, Guerret-Stocker S, Carbillet JP, Grimaud JA, et al. (1984) Experimental alveolar echinococcosis. Suitability of a murine model of intrahepatic infection by Echinococcus multilocularis for immunological studies. Experientia 40: 1436-1439.