Naturally occurring PD-1+ memory phenotype CD8 T cells belong to nonconventional CD8 T cells and are cyclophosphamide-sensitive regulatory T cells

Journal of Immunology

Volumn 190, Issue 4, 2013, Pages 1560-1566

  Sakuraba, Koji ^a   Shibata, Kensuke ^a   Iwamoto, Yukihide ^a   Yoshikai, Yasunobu ^a   Yamada, Hisakata ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CYCLOPHOSPHAMIDE; INTERLEUKIN 15; PROGRAMMED DEATH 1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD8+ T LYMPHOCYTE; CHIMERA; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; HEMATOPOIETIC CELL; IMMUNOSUPPRESSIVE TREATMENT; MEMORY T LYMPHOCYTE; MOLECULAR MODEL; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SENSITIVITY ANALYSIS; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANIMALS, NEWBORN; ANTIGENS, DIFFERENTIATION; CD8-POSITIVE T-LYMPHOCYTES; CYCLOPHOSPHAMIDE; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RADIATION CHIMERA; T-LYMPHOCYTES, REGULATORY;

EID: 84873550833     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202464     Document Type: Article

References (23)

1. Cho, B. K., V. P. Rao, Q. Ge, H. N. Eisen, and J. Chen. 2000. Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J. Exp. Med. 192: 549-556.
2. Goldrath, A. W., L. Y. Bogatzki, and M. J. Bevan. 2000. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J. Exp. Med. 192: 557-564.
3. Berg, L. J. 2007. Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development. Nat. Rev. Immunol. 7: 479-485.
4. + T cells contributes to the rapid production of IFNgamma in response to bacterial pathogens. J. Immunol. 166: 1097-1105.
5. + regulatory T cells in the maintenance of T cell homeostasis. J. Exp. Med. 200: 1123-1134.
6. + T cells as regulatory versus memory T cells. J. Immunol. 185: 803-807.
7. Barber, D. L., E. J. Wherry, D. Masopust, B. Zhu, J. P. Allison, A. H. Sharpe, G. J. Freeman, and R. Ahmed. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439: 682-687.
8. Lin, S. J., C. D. Peacock, K. Bahl, and R. M. Welsh. 2007. Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation. J. Exp. Med. 204: 2321-2333.
9. Kim, H. J., and H. Cantor. 2011. Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells. Semin. Immunol. 23: 446-452.
10. Mitsuoka, A., M. Baba, and S. Morikawa. 1976. Enhancement of delayed hypersensitivity by depletion of suppressor T cells with cyclophosphamide in mice. Nature 262: 77-78.
11. + Tregs in lupus, autoimmunity, and beyond. Autoimmun. Rev. 9: 560-568.
12. + molecule required for Ly2 suppressor cell activity. J. Exp. Med. 158: 1822-1835.
13. + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 105: 2862-2868.
14. Nishimura, H., T. Yajima, Y. Naiki, H. Tsunobuchi, M. Umemura, K. Itano, T. Matsuguchi, M. Suzuki, P. S. Ohashi, and Y. Yoshikai. 2000. Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo. J. Exp. Med. 191: 157-170.
15. + T cell exhaustion during chronic viral infection. Immunity 27: 670-684.
16. + cells. J. Exp. Med. 203: 1817-1825.
17. Sullivan, B. A., P. Kraj, D. A. Weber, L. Ignatowicz, and P. E. Jensen. 2002. Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. Immunity 17: 95-105.
18. + T cells in MHC class Ia-deficient mice. J. Immunol. 170: 5414-5420.
19. Kim, H. J., B. Verbinnen, X. Tang, L. Lu, and H. Cantor. 2010. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance. Nature 467: 328-332.
20. Kaufmann, S. H., H. Hahn, and T. Diamantstein. 1980. Relative susceptibilities of T cell subsets involved in delayed-type hypersensitivity to sheep red blood cells to the in vitro action of 4-hydroperoxycyclophosphamide. J. Immunol. 125: 1104-1108.
21. Chen, Y., C. J. Haines, I. Gutcher, K. Hochweller, W. M. Blumenschein, T. McClanahan, G. Hämmerling, M. O. Li, D. J. Cua, and M. J. McGeachy. 2011. Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2. Immunity 34: 409-421.
22. Sadlack, B., H. Merz, H. Schorle, A. Schimpl, A. C. Feller, and I. Horak. 1993. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261.
23. Shin, H., S. D. Blackburn, J. N. Blattman, and E. J. Wherry. 2007. Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection. J. Exp. Med. 204: 941-949.