Synthesis and evaluation of 18F-FE-PEO in rodents: An 18F-labeled full agonist for opioid receptor imaging

Journal of Nuclear Medicine

Volumn 54, Issue 2, 2013, Pages 299-305

  Riss, Patrick J ^a,b,f   Hong, Young T ^a,b   Marton, János ^c   Caprioli, Daniele ^a,b   Williamson, David J ^a   Ferrari, Valentina ^a   Saigal, Neil ^a,b   Roth, Bryan L ^d   Henriksen, Gjermund ^e   Fryer, Tim D ^a,b   Dalley, Jeffrey W ^a,b   Aigbirhio, Franklin I ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c Biomedizinische Forschungsreagenzien GmbH   (Germany)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF OSLO   (Norway)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

18F; Agonist; FE PEO; Opioid receptor; PET

Indexed keywords

4,5 ALPHA EPOXY 6 (2 FLUOROETHOXY) 3 HYDROXY ALPHA 17 DIMETHYL ALPHA (2 PHENYLETH 1 YL) 6,14 ETHENOMORPHINAN 7 METHANOL F 18; DRUG METABOLITE; OPIATE RECEPTOR; TRACER; UNCLASSIFIED DRUG; 4,5-ALPHA-EPOXY-6-(2-FLUOROETHOXY)-3-HYDROXY-ALPHA,17-DIMETHYL-ALPHA-(2-PHENYLETH-1-YL)-6,14-ETHENOMORPHINAN-7-METHANOL; 4,5 ALPHA EPOXY 6 (2 FLUOROETHOXY) 3 HYDROXY ALPHA,17 DIMETHYL ALPHA (2 PHENYLETH 1 YL) 6,14 ETHENOMORPHINAN 7 METHANOL; FLUORINE; LIGAND; MORPHINAN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; BLOOD SAMPLING; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; ANIMAL; AUTOMATION; BRAIN; CHEMICAL MODEL; CHEMISTRY; DRUG POTENTIATION; KINETICS; METABOLISM; METHODOLOGY; PATHOLOGY; PROTEIN BINDING; REGRESSION ANALYSIS; SCINTISCANNING; TISSUE DISTRIBUTION;

ANIMALS; AUTOMATION; AUTORADIOGRAPHY; BRAIN; FLUORINE RADIOISOTOPES; KINETICS; LIGANDS; MODELS, CHEMICAL; MORPHINANS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; RATS; RECEPTORS, OPIOID; REGRESSION ANALYSIS; TISSUE DISTRIBUTION;

MLCS; MLOWN;

EID: 84873542587     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.112.108688     Document Type: Article

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