Validation and quantification of 18 Faltanserin binding in the rat brain using blood input and reference tissue modeling

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 12, 2011, Pages 2334-2342

  Riss, Patrick J ^a,b,c   Hong, Young T ^a,b   Williamson, David ^a,b   Caprioli, Daniele ^b,d   Sitnikov, Sergey ^a   Ferrari, Valentina ^a,b   Sawiak, Steve J ^a,b,c   Baron, Jean Claude ^a,c,e   Dalley, Jeffrey W ^a,c,d   Fryer, Tim D ^a,b,c   Aigbirhio, Franklin I ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d University of Cambridge   (United Kingdom)

^e CENTRE DE PSYCHIATRIE ET NEUROSCIENCES   (France)

Author keywords

5 HT2A; 18F altanserin; animal; brain; modeling; PET

Indexed keywords

ALTANSERIN F 18; SEROTONIN 2A RECEPTOR; TRACER; UNCLASSIFIED DRUG; ALTANSERIN; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE; KETANSERIN; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN TISSUE; CEREBELLUM; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; MICRO POSITRON EMISSION TOMOGRAPHY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; ANIMAL; BIOLOGICAL MODEL; BLOOD; BRAIN; BRAIN CIRCULATION; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; QUALITY CONTROL; SCINTISCANNING; STANDARD; SYNTHESIS;

ANIMALS; BRAIN; CEREBELLUM; CEREBROVASCULAR CIRCULATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; KETANSERIN; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; QUALITY CONTROL; RADIOPHARMACEUTICALS; RATS; RECEPTOR, SEROTONIN, 5-HT2A; REFERENCE STANDARDS;

EID: 82555172480     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.94     Document Type: Article

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