Synthesis and evaluation of a full-agonist orvinol for PET-imaging of opioid receptors: [11C]PEO

Journal of Medicinal Chemistry

Volumn 52, Issue 18, 2009, Pages 5586-5589

  Marton, János ^a   Schoultz, Bent W ^b   Hjoernevik, Trine ^b   Drzezga, Alexander ^c   Yousefi, Behrooz H ^c   Wester, Hans Jurgen ^c   Willoch, Frode ^b,d   Henriksen, Gjermund ^b,c  

^a Biomedizinische Forschungsreagenzien GmbH   (Germany)

^b UNIVERSITY OF OSLO   (Norway)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

4,5 ALPHA EPOXY 17 METHYL 3 HYDROXY 6 METHOXY ALPHA 17 DIMETHYL ALPHA (2 PHENYLETHYL) 6,14 ETHENOMORPHINAN 7 METHANOL; CARBON 11; CYPRODIME; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; OPIATE AGONIST; OPIATE RECEPTOR; ORVINOL; RADIOLIGAND; SALVINORIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG SELECTIVITY; DRUG SYNTHESIS; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY; THALAMUS;

ANIMALS; BRAIN; CARBON RADIOISOTOPES; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; KINETICS; MALE; MORPHINANS; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, WISTAR; RECEPTORS, OPIOID; SUBSTRATE SPECIFICITY;

EID: 70349211757     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900892x     Document Type: Article

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