What Is the Contribution of Two Genetic Variants Regulating VEGF Levels to Type 2 Diabetes Risk and to Microvascular Complications?

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Bonnefond, Amélie ^a,h   Saulnier, Pierre Jean ^b,c   Stathopoulou, Maria G ^a   Grarup, Niels ^d,e,f   Ndiaye, Ndeye Coumba ^a   Roussel, Ronan ^g,h   Nezhad, Mohsen Azimi ^a   Dechaume, Aurélie ^i,j   Lantieri, Olivier ^k   Hercberg, Serge ^h,l   Lauritzen, Torsten ^m   Balkau, Beverley ^n,o   El Sayed Moustafa, Julia S ^p   Hansen, Torben ^d,e,f   Pedersen, Oluf ^d,e,f,q   Froguel, Philippe ^i,j,p   Charpentier, Guillaume ^r   Marre, Michel ^g,h   Hadjadj, Samy ^b,c,h   Visvikis Siest, Sophie ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b POITIERS UNIVERSITY HOSPITAL   (France)

^c Clinical investigation centre CIC0802   (France)

^d Capital Region   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f STENO DIABETES CENTER   (Denmark)

^g BICHAT HOSPITAL   (France)

^h INSERM   (France)

ⁱ CNRS   (France)

^j UNIV LILLE   (France)

^k Institut Inter Regional Pour la Santé IRSA   (France)

^l AVICENNE HOSPITAL   (France)

^m AARHUS UNIVERSITY   (Denmark)

ⁿ CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^o UNIVERSITÉ PARIS SACLAY   (France)

^p HAMMERSMITH HOSPITAL   (United Kingdom)

^q AARHUS UNIVERSITY   (Denmark)

^r CENTRE HOSPITALIER SUD FRANCILIEN   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C; VASCULOTROPIN;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DANISH; DIABETIC MICROANGIOPATHY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; ETHNIC GROUP; FALSE POSITIVE RESULT; FRENCH LANGUAGE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; QUANTITATIVE TRAIT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

CASE-CONTROL STUDIES; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIABETIC RETINOPATHY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84873542025     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055921     Document Type: Article

References (32)

1. Ferrara N, Gerber HP, LeCouter J, (2003) The biology of VEGF and its receptors. Nat Med 9: 669-676.
2. Ferrara N, Davis-Smyth T, (1997) The biology of vascular endothelial growth factor. Endocr Rev 18: 4-25.
3. Bates DO, Harper SJ, (2002) Regulation of vascular permeability by vascular endothelial growth factors. Vascul Pharmacol 39: 225-237.
4. Toi M, Hoshina S, Takayanagi T, Tominaga T, (1994) Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res 85: 1045-1049.
5. Hojo Y, Ikeda U, Zhu Y, Okada M, Ueno S, et al. (2000) Expression of vascular endothelial growth factor in patients with acute myocardial infarction. J Am Coll Cardiol 35: 968-973.
6. Slevin M, Krupinski J, Slowik A, Kumar P, Szczudlik A, et al. (2000) Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke. Stroke 31: 1863-1870.
7. Chin BS, Chung NA, Gibbs CR, Blann AD, Lip GY, (2002) Vascular endothelial growth factor and soluble P-selectin in acute and chronic congestive heart failure. Am J Cardiol 90: 1258-1260.
8. Wirostko B, Wong TY, Simo R, (2008) Vascular endothelial growth factor and diabetic complications. Prog Retin Eye Res 27: 608-621.
9. Lieb W, Safa R, Benjamin EJ, Xanthakis V, Yin X, et al. (2009) Vascular endothelial growth factor, its soluble receptor, and hepatocyte growth factor: clinical and genetic correlates and association with vascular function. Eur Heart J 30: 1121-1127.
10. Pantsulaia I, Trofimov S, Kobyliansky E, Livshits G, (2004) Heritability of circulating growth factors involved in the angiogenesis in healthy human population. Cytokine 27: 152-158.
11. Berrahmoune H, Herbeth B, Lamont JV, Masson C, Fitzgerald PS, et al. (2007) Heritability for plasma VEGF concentration in the Stanislas family study. Ann Hum Genet 71: 54-63.
12. Debette S, Visvikis-Siest S, Chen MH, Ndiaye NC, Song C, et al. (2011) Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. Circ Res 109: 554-563.
13. Sladek R, Rocheleau G, Rung J, Dina C, Shen L, et al. (2007) A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445: 881-885.
14. Hadjadj S, Fumeron F, Roussel R, Saulnier PJ, Gallois Y, et al. (2008) Prognostic value of the insertion/deletion polymorphism of the ACE gene in type 2 diabetic subjects: results from the Non-insulin-dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR), Diabete de type 2, Nephropathie et Genetique (DIAB2NEPHROGENE), and Survie, Diabete de type 2 et Genetique (SURDIAGENE) studies. Diabetes Care 31: 1847-1852.
15. Balkau B, (1996) [An epidemiologic survey from a network of French Health Examination Centres, (D.E.S.I.R.): epidemiologic data on the insulin resistance syndrome]. Rev Epidemiol Sante Publique 44: 373-375.
16. Hercberg S, Preziosi P, Briancon S, Galan P, Triol I, et al. (1998) A primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers in a general population: the SU.VI.MAX study-design, methods, and participant characteristics. SUpplementation en VItamines et Mineraux AntioXydants. Control Clin Trials 19: 336-351.
17. Sparso T, Bonnefond A, Andersson E, Bouatia-Naji N, Holmkvist J, et al. (2009) The G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans. Diabetes.
18. Jorgensen T, Borch-Johnsen K, Thomsen TF, Ibsen H, Glumer C, et al. (2003) A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur J Cardiovasc Prev Rehabil 10: 377-386.
19. Lauritzen T, Griffin S, Borch-Johnsen K, Wareham NJ, Wolffenbuttel BH, et al. (2000) The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening. Int J Obes Relat Metab Disord 24 Suppl 3: S6-11.
20. ADA (2008) Standards of medical care in diabetes. Diabetes Care 31 Suppl 1: S12-54.
21. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, et al. (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130: 461-470.
22. Wallace TM, Levy JC, Matthews DR, (2004) Use and abuse of HOMA modeling. Diabetes Care 27: 1487-1495.
23. Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, et al. (2010) Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42: 949-960.
24. Wasada T, Kawahara R, Katsumori K, Naruse M, Omori Y, (1998) Plasma concentration of immunoreactive vascular endothelial growth factor and its relation to smoking. Metabolism 47: 27-30.
25. Schrijvers BF, Flyvbjerg A, De Vriese AS, (2004) The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int 65: 2003-2017.
26. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, et al. (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42: 579-589.
27. Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, et al. (2010) Common variants at 10 genomic loci influence hemoglobin A(1)(C) levels via glycemic and nonglycemic pathways. Diabetes 59: 3229-3239.
28. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42: 105-116.
29. Boger CA, Chen MH, Tin A, Olden M, Kottgen A, et al. (2011) CUBN is a gene locus for albuminuria. J Am Soc Nephrol 22: 555-570.
30. Ellis JW, Chen MH, Foster MC, Liu CT, Larson MG, et al. (2012) Validated SNPs for eGFR and their associations with albuminuria. Hum Mol Genet 21: 3293-3298.
31. Kottgen A, Pattaro C, Boger CA, Fuchsberger C, Olden M, et al. (2010) New loci associated with kidney function and chronic kidney disease. Nat Genet 42: 376-384.
32. Antonetti DA, Klein R, Gardner TW, (2012) Diabetic retinopathy. N Engl J Med 366: 1227-1239.