Regulation of calcium influx and signaling pathway in cancer cells via TRPV6-Numb1 interaction

Cell Calcium

Volumn 53, Issue 2, 2013, Pages 102-111

  Kim, Sung Young ^a   Yang, Dongki ^b   Myeong, Jongyoun ^a   Ha, Kotdaji ^a   Kim, Su Hwa ^a   Park, Eun Jung ^a   Kim, In Gyu ^a   Cho, Nam Hyuk ^a   Lee, Kyu Pil ^c   Jeon, Ju Hong ^a   So, Insuk ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Gachon University College of Medicine   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

Calcium; Numb; Protein protein interaction; TRPV6

Indexed keywords

AMINO ACID; ASPARTIC ACID; CALCIUM; ISOPROTEIN; NUMB1 PROTEIN; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 6;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CANCER CELL; CELL FATE; CELL FUNCTION; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); DELETION MUTANT; DOWN REGULATION; ENDOCYTOSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SMALL INTESTINE; WESTERN BLOTTING;

EID: 84873523415     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2012.10.005     Document Type: Article

References (42)

1. Prevarskaya N., Skryma R., Shuba Y. Calcium in tumour metastasis: new roles for known actors. Nature Reviews Cancer 2011, 11:609-618.
2. 2+ transport. Nature Reviews Cancer 2007, 7:519-530.
3. Vig M., Kinet J.-P. Calcium signaling in immune cells. Nature Immunology 2009, 10:21-27.
4. 2+ channel expression. Biochemical and Biophysical Research Communications 2004, 322:1359-1363.
5. 2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 2003, 22:7858-7861.
6. Tsavaler L., Shapero M.H., Morkowski S., Laus R. Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Research 2001, 61:3760-3769.
7. Gélébart P., Kovács T., Brouland J.P., van Gorp R., Grossmann J., Rivard N., Panis Y., Martin V., Bredoux R., Enouf J., Papp B. Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation. Journal of Biological Chemistry 2002, 277:26310-26320.
8. Montell C., Birnbaumer L., Flockerzi V. The TRP channels, a remarkably functional family. Cell 2002, 108:595-598.
9. Clapham D.E. TRP channels as cellular sensors. Nature 2003, 426:517-524.
10. Owsianik G., Talavera K., Voets T., Nilius B. Permeation and selectivity of TRP channels. Annual Review of Physiology 2006, 68:685-717.
11. den Dekker E., Hoenderop J.G., Nilius B., Bindels R.J. The epithelial calcium channels, TRPV5 & TRPV6: from identification towards regulation. Cell Calcium 2003, 33:497-507.
12. Nijenhuis T., Hoenderop J.G., Bindels R.J. TRPV5 and TRPV6 in Ca(2+) (re)absorption: regulating Ca(2+) entry at the gate. Pflugers Archiv 2005, 451:181-192.
13. Hoenderop J.G., Vennekens R., Müller D., Prenen J., Droogmans G., Bindels R.J., Nilius B. Function and expression of the epithelial Ca(2+) channel family: comparison of mammalian ECaC1 and 2. Journal of Physiology 2001, 537:747-761.
14. Yee N.S., Zhou W., Lee M. Transient receptor potential channel trpm8 is overexpressed and required for cellular proliferation in pancreatic adenocarcinoma. Cancer Letters 2010, 297:49-55.
15. 2+-sensitive socs3a signaling in development and cancer. Disease Models & Mechanisms 2011, 4:240-254.
16. Cai R., Ding X., Zhou K., Shi Y., Ge R., Ren G., Jin Y., Wang Y. Blockade of trpc6 channels induced g2/m phase arrest and suppressed growth in human gastric cancer cells. International Journal of Cancer 2009, 125:2281-2287.
17. Ding X., He Z., Zhou K., Cheng J., Yao H., Lu D., Cai R., Jin Y., Dong B., Xu Y., Wang Y. Essential role of trpc6 channels in g2/m phase transition and development of human glioma. Journal of the National Cancer Institute 2010, 102:1052-1068.
18. El Boustany C., Bidaux G., Enfissi A., Delcourt P., Prevarskaya N., Capiod T. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology 2008, 47:2068-2077.
19. Shi Y., Ding X., He Z.H., Zhou K.C., Wang Q., Wang Y.Z. Critical role of trpc6 channels in g2 phase transition and the development of human oesophageal cancer. Gut 2009, 58:1443-1450.
20. Wissenbach U., Niemeyer B.A., Fixemer T., Schneidewind A., Trost C., Cavalie A., Reus K., Meese E., Bonkhoff H., Flockerzi V. Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. Journal of Biological Chemistry 2001, 276:19461-19468.
21. Peng J.B., Zhuang L., Berger U.V., Adam R.M., Williams B.J., Brown E.M., Hediger M.A., Freeman M.R. CaT1 expression correlates with tumor grade in prostate cancer. Biochemical and Biophysical Research Communications 2001, 282:729-734.
22. Lehen'kyi V., Flourakis M., Skryma R., Prevarskaya N. TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways. Oncogene 2007, 26:7380-7385.
23. Uemura T., Shepherd S., Ackerman L., Jan L.Y., Jan Y.N. Numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos. Cell 1989, 58:349-360.
24. Cayouette M., Raff M. Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals. Nature Neuroscience 2002, 5:1265-1269.
25. Gulino A., Di Marcotullio L., Screpanti I. The multiple functions of Numb. Experimental Cell Research 2010, 316:900-906.
26. Colaluca I.N., Tosoni D., Nuciforo P., Senic-Matuglia F., Galimberti V., Viale G., Pece S., Di Fiore P.P. NUMB controls p53 tumour suppressor activity. Nature 2008, 451:76-80.
27. Pece S., Serresi M., Santolini E., Capra M., Hulleman E., Galimberti V., Zurrida S., Maisonneuve P., Viale G., Di Fiore P.P. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. Journal of Cell Biology 2004, 167:215-221.
28. Westhoff B., Colaluca I.N., 'D'Ario G., Donzelli M., Tosoni D., Volorio S., Pelosi G., Spaggiari L., Mazzarol G., Viale G., Pece S., Di Fiore P.P. Alterations of the Notch pathway in lung cancer. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:22293-22298.
29. Erickson M.G., Alseikhan B.A., Peterson B.Z., Yue D.T. Preassociation of calmodulin with voltage-gated Ca(2+) channels revealed by FRET in single living cells. Neuron 2001, 31:973-985.
30. Kim H.J., Yang D.K., So I. PDZ domain-containing protein as a physiological modulator of TRPV6. Biochemical and Biophysical Research Communications 2007, 361:433-438.
31. Lu P., Boros S., Chang Q., Bindels R.J., Hoenderop J.G. The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6. Nephrology Dialysis Transplantation 2008, 23:3397-3402.
32. Hellwig N., Albrecht N., Harteneck C., Schultz G., Schaefer M. Homo- and heteromeric assembly of TRPV channel subunits. Journal of Cell Science 2005, 118:917-928.
33. Spehr J., Gelis L., Osterloh M., Oberland S., Hatt H., Spehr M., Neuhaus E.M. G protein-coupled receptor signaling via Src kinase induces endogenous human transient receptor potential vanilloid type 6 (TRPV6) channel activation. Journal of Biological Chemistry 2011, 286:13184-13192.
34. Haenfler J.M., Kuang C., Lee C.Y. Cortical aPKC kinase activity distinguishes neural stem cells from progenitor cells by ensuring asymmetric segregation of Numb. Developmental Biology 2012, 365:219-228.
35. Ouyang Y., Petritsch C., Wen H., Jan L., Jan Y.N., Lu B. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development 2011, 138:2185-2196.
36. Smith C.A., Lau K.M., Rahmani Z., Dho S.E., Brothers G., She Y.M., Berry D.M., Bonneil E., Thibault P., Schweisguth F., Le Borgne R., McGlade C.J. aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb. EMBO Journal 2007, 26:468-480.
37. Tokumitsu H., Hatano N., Yokokura S., Sueyoshi Y., Nozaki N., Kobayashi R. Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2. FEBS Letters 2006, 580:5797-5801.
38. Dhennin-Duthille I., Gautier M., Faouzi M., Guilbert A., Brevet M., Vaudry D., Ahidouch A., Sevestre H., Ouadid-Ahidouch High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters. Cellular Physiology and Biochemistry 2011, 28:813-822.
39. Shin Y.C., Shin S.Y., So I., Kwon D., Jeon J.H. TRIP database: a manually curated database of protein-protein interactions for mammalian TRP channels. Nucleic Acids Research 2011, 39:356-361.
40. Kyriazis G.A., Belal C., Madan M., Taylor D.G., Wang J., Wei Z., Pattisapu J.V., Chan S.L. Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. Journal of Biological Chemistry 2010, 285:6811-6825.
41. Nakamura H. Roles of electrostatic interaction in proteins. Quarterly Reviews of Biophysics 1996, 29:1-90.
42. Toriya M., Tokunaga A., Sawamoto K., Nakao K., Okano H. Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain. Developmental Neuroscience 2006, 28:142-155.