Pegylated siRNA-loaded calcium phosphate nanoparticle-driven amplification of cancer cell internalization in vivo

Biomaterials

Volumn 34, Issue 12, 2013, Pages 2980-2990

  Tobin, Lisa A ^a   Xie, Yili ^a   Tsokos, Maria ^a,b   Chung, Su I ^a   Merz, Allison A ^a   Arnold, Michael A ^a,c   Li, Guang ^a   Malech, Harry L ^d   Kwong, King F ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Calcium phosphate; Cancer; Endocytosis; In vivo delivery; Nanoparticle; SiRNA

Indexed keywords

BIODISTRIBUTIONS; CALCIUM PHOSPHATE NANOPARTICLES; CANCER; CANCER CELLS; CAVEOLIN-1; DOXORUBICIN; ENDOCYTOSIS; EPITHELIAL CELLS; IN-VIVO; PAYLOAD DELIVERY; SIRNA; SYSTEMIC ADMINISTRATION; TUMOR GROWTH;

CALCIUM PHOSPHATE; CELL MEMBRANES; CYTOLOGY; MOLECULAR BIOLOGY; TUMORS;

NANOPARTICLES;

CALCIUM PHOSPHATE; CALCIUM PHOSPHATE NANOPARTICLE; CAVEOLIN; CAVEOLIN 1; DOXORUBICIN; MACROGOL; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENGINEERING; BYSTANDER EFFECT; CANCER CELL; CELL COUNT; CELL MEMBRANE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFECT; DRUG FORMULATION; ENDOCYTOSIS; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LUNG NON SMALL CELL CANCER; MEDIATOR; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR XENOGRAFT;

BASE SEQUENCE; CALCIUM PHOSPHATES; CELL LINE, TUMOR; CELLS, CULTURED; DNA PRIMERS; DOXORUBICIN; ENDOCYTOSIS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; NANOPARTICLES; NEOPLASMS; POLYETHYLENE GLYCOLS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING;

EID: 84873470295     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.01.046     Document Type: Article

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