Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages

Neurobiology of Aging

Volumn 34, Issue 5, 2013, Pages 1451-1461

  Lee, Moonhee ^a   Guo, Jian Ping ^a   McGeer, Edith G ^a   McGeer, Patrick L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alzheimer disease; Factor B; Factor D; Macular degeneration; Membrane attack complex; Paroxysmal nocturnal hemoglobinemia; Properdin; Rheumatoid arthritis

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; AURINTRICARBOXYLIC ACID; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C9; COMPLEMENT FACTOR D;

ANIMAL CELL; ARTICLE; BINDING SITE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE MEMBRANE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

AURINTRICARBOXYLIC ACID; COMPLEMENT ACTIVATION; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; HUMANS; NEUROPROTECTIVE AGENTS; PROTEIN BINDING;

EID: 84873463342     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.10.023     Document Type: Article

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