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Volumn 73, Issue 3, 2013, Pages 1156-1167

Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

5 (N ETHYL N ISOPROPYL)AMILORIDE; BCG VACCINE; CLATHRIN; CYTOCHALASIN; DYNAMIN; P21 ACTIVATED KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN CDC42; RAC1 PROTEIN; STAUROSPORINE;

EID: 84873452824     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-1882     Document Type: Article
Times cited : (81)

References (50)
  • 3
    • 74649087382 scopus 로고    scopus 로고
    • The role of bacillus Calmette-Guerin in the treatment of non-muscle-invasive bladder cancer
    • Gontero P, Bohle A, Malmstrom PU, O'Donnell MA, Oderda M, Sylvester R, et al. The role of bacillus Calmette-Guerin in the treatment of non-muscle-invasive bladder cancer. Eur Urol 2010; 57:410-29.
    • (2010) Eur Urol , vol.57 , pp. 410-429
    • Gontero, P.1    Bohle, A.2    Malmstrom, P.U.3    O'Donnell, M.A.4    Oderda, M.5    Sylvester, R.6
  • 4
    • 0041736386 scopus 로고    scopus 로고
    • Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer
    • Bohle A, Brandau S. Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer. J Urol 2003; 170:964-9.
    • (2003) J Urol , vol.170 , pp. 964-969
    • Bohle, A.1    Brandau, S.2
  • 5
    • 38449118811 scopus 로고    scopus 로고
    • Internalization of Mycobacterium bovis, Bacillus Calmette Guerin, by bladder cancer cells is cytotoxic
    • Pook SH, Rahmat JN, Esuvaranathan K, Mahendran R. Internalization of Mycobacterium bovis, Bacillus Calmette Guerin, by bladder cancer cells is cytotoxic. Oncol Rep 2007;18:1315-20.
    • (2007) Oncol Rep , vol.18 , pp. 1315-1320
    • Pook, S.H.1    Rahmat, J.N.2    Esuvaranathan, K.3    Mahendran, R.4
  • 6
    • 0025823180 scopus 로고
    • Internalization of bacille Calmette-Guerin by bladder tumor cells
    • Becich MJ, Carroll S, Ratliff TL. Internalization of bacille Calmette-Guerin by bladder tumor cells. J Urol 1991;145:1316-24.
    • (1991) J Urol , vol.145 , pp. 1316-1324
    • Becich, M.J.1    Carroll, S.2    Ratliff, T.L.3
  • 7
    • 0025101229 scopus 로고
    • Fibronectin-mediated Calmette-Guerin bacillus attachment to murine bladder mucosa. Requirement for the expression of an antitumor response
    • Kavoussi LR, Brown EJ, Ritchey JK, Ratliff TL. Fibronectin-mediated Calmette-Guerin bacillus attachment to murine bladder mucosa. Requirement for the expression of an antitumor response. J Clin Invest 1990;85:62-7.
    • (1990) J Clin Invest , vol.85 , pp. 62-67
    • Kavoussi, L.R.1    Brown, E.J.2    Ritchey, J.K.3    Ratliff, T.L.4
  • 8
    • 0036010617 scopus 로고    scopus 로고
    • Surface antigen expression on bladder tumor cells induced by bacillus Calmette-Guerin (BCG): A role of BCG internalization into tumor cells
    • Ikeda N, Toida I, Iwasaki A, Kawai K, Akaza H. Surface antigen expression on bladder tumor cells induced by bacillus Calmette-Guerin (BCG): a role of BCG internalization into tumor cells. Int J Urol 2002;9:29-35.
    • (2002) Int J Urol , vol.9 , pp. 29-35
    • Ikeda, N.1    Toida, I.2    Iwasaki, A.3    Kawai, K.4    Akaza, H.5
  • 9
    • 1842430006 scopus 로고    scopus 로고
    • Bacterial invasion: The paradigms of enteroinvasive pathogens
    • Cossart P, Sansonetti PJ. Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 2004;304:242-8.
    • (2004) Science , vol.304 , pp. 242-248
    • Cossart, P.1    Sansonetti, P.J.2
  • 11
    • 0026778387 scopus 로고
    • Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells
    • Ginocchio C, Pace J, Galan JE. Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells. Proc Natl Acad Sci U S A 1992;89:5976-80.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 5976-5980
    • Ginocchio, C.1    Pace, J.2    Galan, J.E.3
  • 13
    • 42549153337 scopus 로고    scopus 로고
    • Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells
    • Mercer J, Helenius A. Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Science 2008;320:531-5.
    • (2008) Science , vol.320 , pp. 531-535
    • Mercer, J.1    Helenius, A.2
  • 14
    • 77149129342 scopus 로고    scopus 로고
    • Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling
    • Koivusalo M, Welch C, Hayashi H, Scott CC, Kim M, Alexander T, et al. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol 2010;188: 547-63.
    • (2010) J Cell Biol , vol.188 , pp. 547-563
    • Koivusalo, M.1    Welch, C.2    Hayashi, H.3    Scott, C.C.4    Kim, M.5    Alexander, T.6
  • 15
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes CD, Hall A. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 1995;81:53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 16
    • 47749107873 scopus 로고    scopus 로고
    • Shaping cups into phagosomes and macropinosomes
    • Swanson JA. Shaping cups into phagosomes and macropinosomes. Nat Rev Mol Cell Biol 2008;9:639-49.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 639-649
    • Swanson, J.A.1
  • 18
    • 0033594123 scopus 로고    scopus 로고
    • Rho GTPases control polarity, protrusion, and adhesion during cell movement
    • Nobes CD, Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol 1999;144:1235-44.
    • (1999) J Cell Biol , vol.144 , pp. 1235-1244
    • Nobes, C.D.1    Hall, A.2
  • 20
    • 0036223236 scopus 로고    scopus 로고
    • P21-activated kinases: Three more join the Pak
    • Jaffer ZM, Chernoff J. p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol 2002;34:713-7.
    • (2002) Int J Biochem Cell Biol , vol.34 , pp. 713-717
    • Jaffer, Z.M.1    Chernoff, J.2
  • 21
    • 0028820587 scopus 로고
    • Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1
    • Zhang S, Han J, Sells MA, Chernoff J, Knaus UG, Ulevitch RJ, et al. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem 1995;270: 23934-6.
    • (1995) J Biol Chem , vol.270 , pp. 23934-23936
    • Zhang, S.1    Han, J.2    Sells, M.A.3    Chernoff, J.4    Knaus, U.G.5    Ulevitch, R.J.6
  • 22
    • 0037059807 scopus 로고    scopus 로고
    • P21-activated kinase links Rac/Cdc42 signaling to merlin
    • Xiao GH, Beeser A, Chernoff J, Testa JR. p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem 2002;277:883-6.
    • (2002) J Biol Chem , vol.277 , pp. 883-886
    • Xiao, G.H.1    Beeser, A.2    Chernoff, J.3    Testa, J.R.4
  • 23
    • 26944438047 scopus 로고    scopus 로고
    • Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells
    • Veiga E, Cossart P. Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells. Nat Cell Biol 2005;7: 894-900.
    • (2005) Nat Cell Biol , vol.7 , pp. 894-900
    • Veiga, E.1    Cossart, P.2
  • 27
    • 0021709743 scopus 로고
    • Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes
    • Hanover JA, Willingham MC, Pastan I. Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes. Cell 1984;39:283-93.
    • (1984) Cell , vol.39 , pp. 283-293
    • Hanover, J.A.1    Willingham, M.C.2    Pastan, I.3
  • 30
    • 23444440484 scopus 로고    scopus 로고
    • FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma
    • Jebar AH, Hurst CD, Tomlinson DC, Johnston C, Taylor CF, Knowles MA. FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma. Oncogene 2005;24:5218-25.
    • (2005) Oncogene , vol.24 , pp. 5218-5225
    • Jebar, A.H.1    Hurst, C.D.2    Tomlinson, D.C.3    Johnston, C.4    Taylor, C.F.5    Knowles, M.A.6
  • 32
    • 0033194037 scopus 로고    scopus 로고
    • Activation of LIMkinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
    • Edwards DC, Sanders LC, Bokoch GM, Gill GN. Activation of LIMkinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1999;1:253-9.
    • (1999) Nat Cell Biol , vol.1 , pp. 253-259
    • Edwards, D.C.1    Sanders, L.C.2    Bokoch, G.M.3    Gill, G.N.4
  • 33
    • 84856826293 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BKM120, an orally available pan-class i PI3-kinase inhibitor
    • Maira SM, Pecchi S, Huang A, Burger M, Knapp M, Sterker D, et al. Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor. Mol Cancer Ther 2012;11:317-28.
    • (2012) Mol Cancer Ther , vol.11 , pp. 317-328
    • Maira, S.M.1    Pecchi, S.2    Huang, A.3    Burger, M.4    Knapp, M.5    Sterker, D.6
  • 34
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate
    • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998;273:13375-8.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 37
    • 0032514903 scopus 로고    scopus 로고
    • Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation
    • Missy K, Van Poucke V, Raynal P, Viala C, Mauco G, Plantavid M, et al. Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation. J Biol Chem 1998;273: 30279-86.
    • (1998) J Biol Chem , vol.273 , pp. 30279-30286
    • Missy, K.1    Van Poucke, V.2    Raynal, P.3    Viala, C.4    Mauco, G.5    Plantavid, M.6
  • 38
    • 0028338545 scopus 로고
    • Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85
    • Zheng Y, Bagrodia S, Cerione RA. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J Biol Chem 1994;269: 18727-30.
    • (1994) J Biol Chem , vol.269 , pp. 18727-18730
    • Zheng, Y.1    Bagrodia, S.2    Cerione, R.A.3
  • 42
    • 38749088715 scopus 로고    scopus 로고
    • RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells
    • Wu F, Chen Y, Li Y, Ju J, Wang Z, Yan D. RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells. Biotechnol Appl Biochem 2008;49:121-8.
    • (2008) Biotechnol Appl Biochem , vol.49 , pp. 121-128
    • Wu, F.1    Chen, Y.2    Li, Y.3    Ju, J.4    Wang, Z.5    Yan, D.6
  • 43
    • 38549096026 scopus 로고    scopus 로고
    • The clinico-pathological significance of protein expression of PAK1 in bladder transitional cell carcinoma
    • Zhang YH, Xie D, Luo JH, Chen W, Chen LW, Xu QC, et al. [The clinico-pathological significance of protein expression of PAK1 in bladder transitional cell carcinoma]. Zhonghua Yi Xue Za Zhi 2007;87:2710-3.
    • (2007) Zhonghua Yi Xue Za Zhi , vol.87 , pp. 2710-2713
    • Zhang, Y.H.1    Xie, D.2    Luo, J.H.3    Chen, W.4    Chen, L.W.5    Xu, Q.C.6
  • 44
    • 34547753507 scopus 로고    scopus 로고
    • P21-activated kinase 1: A new molecular marker for intravesical recurrence after transurethral resection of bladder cancer
    • Ito M, Nishiyama H, Kawanishi H, Matsui S, Guilford P, Reeve A, et al. P21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer. J Urol 2007; 178:1073-9.
    • (2007) J Urol , vol.178 , pp. 1073-1079
    • Ito, M.1    Nishiyama, H.2    Kawanishi, H.3    Matsui, S.4    Guilford, P.5    Reeve, A.6
  • 45
    • 0032037616 scopus 로고    scopus 로고
    • Macrophage receptors for Mycobacterium tuberculosis
    • Ernst JD. Macrophage receptors for Mycobacterium tuberculosis. Infect Immun 1998;66:1277-81.
    • (1998) Infect Immun , vol.66 , pp. 1277-1281
    • Ernst, J.D.1
  • 47
    • 41949139871 scopus 로고    scopus 로고
    • Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3
    • Amstutz B, Gastaldelli M, Kalin S, Imelli N, Boucke K, Wandeler E, et al. Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3. EMBO J 2008;27:956-69.
    • (2008) EMBO J , vol.27 , pp. 956-969
    • Amstutz, B.1    Gastaldelli, M.2    Kalin, S.3    Imelli, N.4    Boucke, K.5    Wandeler, E.6
  • 48
    • 78149355646 scopus 로고    scopus 로고
    • Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner
    • Nanbo A, Imai M, Watanabe S, Noda T, Takahashi K, Neumann G, et al. Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog 2010;6:e1001121.
    • (2010) PLoS Pathog , vol.6
    • Nanbo, A.1    Imai, M.2    Watanabe, S.3    Noda, T.4    Takahashi, K.5    Neumann, G.6
  • 49
    • 79955118584 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells
    • Wu D, Tao J, Xu B, Qing W, Li P, Lu Q, et al. Phosphatidylinositol 3-kinase inhibitor LY294002 suppresses proliferation and sensitizes doxorubicin chemotherapy in bladder cancer cells. Urol Int 2011; 86:346-54.
    • (2011) Urol Int , vol.86 , pp. 346-354
    • Wu, D.1    Tao, J.2    Xu, B.3    Qing, W.4    Li, P.5    Lu, Q.6
  • 50
    • 70149124507 scopus 로고    scopus 로고
    • Phase 2 trial of sorafenib in patients with advanced urothelial cancer: A trial of the Eastern Cooperative Oncology Group
    • Dreicer R, Li H, Stein M, DiPaola R, Eleff M, Roth BJ, et al. Phase 2 trial of sorafenib in patients with advanced urothelial cancer: a trial of the Eastern Cooperative Oncology Group. Cancer 2009;115: 4090-5.
    • (2009) Cancer , vol.115 , pp. 4090-4095
    • Dreicer, R.1    Li, H.2    Stein, M.3    Dipaola, R.4    Eleff, M.5    Roth, B.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.