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Volumn 20, Issue 1, 2013, Pages 48-61

Endocrine therapy for postmenopausal women with hormone receptor-positive her2-negative advanced breast cancer after progression or recurrence on nonsteroidal aromatase inhibitor therapy: A canadian consensus statement

Author keywords

Advanced breast cancer; Endocrine resistance; Endocrine therapy; Everolimus; Exemestane; Fulvestrant; Mtorinhibitor; Nonsteroidal aromatase inhibitor

Indexed keywords

ANASTROZOLE; AROMATASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; EXEMESTANE; FULVESTRANT; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PLACEBO; TAMOXIFEN;

EID: 84873444298     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: 10.3747/co.20.1316     Document Type: Article
Times cited : (25)

References (53)
  • 1
    • 84873428170 scopus 로고    scopus 로고
    • Canadian Cancer Society. Breast Cancer Statistics at a Glance [Web page]. Toronto, ON
    • Available at, cited September 27, 2012
    • Canadian Cancer Society. Breast Cancer Statistics at a Glance [Web page]. Toronto, ON: Canadian Cancer Society; 2012. [Available at: http://www.cancer.ca/Canada-wide/About%20 cancer/Cancer%20statistics/Stats%20at%20a%20glance/ Breast%20cancer.aspx?sc_lang=EN; cited September 27, 2012]
    • (2012) Canadian Cancer Society
  • 2
    • 33645963153 scopus 로고    scopus 로고
    • New guidelines for treatment of early hormone-positive breast cancer with tamoxifen and aromatase inhibitors
    • Kennecke HF, Ellard S, O'Reilly S, Gelmon KA. New guidelines for treatment of early hormone-positive breast cancer with tamoxifen and aromatase inhibitors. BC Med J 2006;48:121-6.
    • (2006) BC Med J , vol.48 , pp. 121-126
    • Kennecke, H.F.1    Ellard, S.2    O'Reilly, S.3    Gelmon, K.A.4
  • 3
    • 84867138398 scopus 로고    scopus 로고
    • Mtor inhibitors in the management of hormone receptor-positive breast cancer: The latest evidence and future directions
    • Villarreal-Garza C, Cortes J, Andre F, Verma S. mtor inhibitors in the management of hormone receptor-positive breast cancer: the latest evidence and future directions. Ann Oncol 2012;23:2526-35.
    • (2012) Ann Oncol , vol.23 , pp. 2526-2535
    • Villarreal-Garza, C.1    Cortes, J.2    Andre, F.3    Verma, S.4
  • 4
    • 20444505306 scopus 로고    scopus 로고
    • Association between tumour characteristics and her-2/neu by immunohistochemistry in 1362 women with primary operable breast cancer
    • Huang HJ, Neven P, Drijkoningen M, et al. Association between tumour characteristics and her-2/neu by immunohistochemistry in 1362 women with primary operable breast cancer. J Clin Pathol 2005;58:611-16.
    • (2005) J Clin Pathol , vol.58 , pp. 611-616
    • Huang, H.J.1    Neven, P.2    Drijkoningen, M.3
  • 5
    • 84873491548 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network (nccn)
    • Ver. 3.2012. Fort Washington, PA: nccn, Available online at, free registration required); cited September 16, 2012
    • National Comprehensive Cancer Network (nccn). Breast Cancer. NCCN Clinical Practice Guidelines in Oncology. Ver. 3.2012. Fort Washington, PA: nccn; 2012. [Available online at: http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf (free registration required); cited September 16, 2012]
    • (2012) Breast Cancer. NCCN Clinical Practice Guidelines In Oncology
  • 6
    • 84862544485 scopus 로고    scopus 로고
    • 1st International consensus guidelines for advanced breast cancer (abc 1)
    • Cardoso F, Costa A, Norton L, et al. 1st International consensus guidelines for advanced breast cancer (abc 1). Breast 2012;21:242-52.
    • (2012) Breast , vol.21 , pp. 242-252
    • Cardoso, F.1    Costa, A.2    Norton, L.3
  • 7
    • 0035498544 scopus 로고    scopus 로고
    • Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma
    • Bonneterre J, Buzdar A, Nabholtz JM, et al. Anastrozole is superior to tamoxifen as first-line therapy in hormone receptor positive advanced breast carcinoma. Cancer 2001;92:2247-58.
    • (2001) Cancer , vol.92 , pp. 2247-2258
    • Bonneterre, J.1    Buzdar, A.2    Nabholtz, J.M.3
  • 8
    • 0343584508 scopus 로고    scopus 로고
    • Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: Results of a phase iii study of the International Letrozole Breast Cancer Group
    • Mouridsen H, Gershanovich M, Sun Y, et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase iii study of the International Letrozole Breast Cancer Group. J Clin Oncol 2001;19:2596-606.
    • (2001) J Clin Oncol , vol.19 , pp. 2596-2606
    • Mouridsen, H.1    Gershanovich, M.2    Sun, Y.3
  • 9
    • 54449099359 scopus 로고    scopus 로고
    • Phase iii study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: The European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group
    • Paridaens RJ, Dirix LY, Beex LV, et al. Phase iii study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group. J Clin Oncol 2008;26:4883-90.
    • (2008) J Clin Oncol , vol.26 , pp. 4883-4890
    • Paridaens, R.J.1    Dirix, L.Y.2    Beex, L.V.3
  • 10
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase ii trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A gineco study
    • Bachelot T, Bourgier C, Cropet C, et al. Randomized phase ii trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a gineco study. J Clin Oncol 2012;30:2718-24.
    • (2012) J Clin Oncol , vol.30 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 11
    • 41149110156 scopus 로고    scopus 로고
    • Overcoming endocrine resistance in breast cancer: Are signal transduction inhibitors the answer?
    • Bedard PL, Freedman OC, Howell A, Clemons M. Overcoming endocrine resistance in breast cancer: are signal transduction inhibitors the answer? Breast Cancer Res Treat 2008;108:307-17.
    • (2008) Breast Cancer Res Treat , vol.108 , pp. 307-317
    • Bedard, P.L.1    Freedman, O.C.2    Howell, A.3    Clemons, M.4
  • 12
    • 79951814007 scopus 로고    scopus 로고
    • Tamrad: A gineco randomized phase ii trial of everolimus in combination with tamoxifen versus tamoxifen alone in patients (pts) with hormone-receptor positive, her2 negative metastatic breast cancer (mbc) with prior exposure to aromatase inhibitors (ai) [abstract S1-6]
    • December 8-12, San Antonio, TX. [Available online at, cited September 28, 2012
    • Bachelot T, Bourgier C, Cropet C, et al. tamrad: a gineco randomized phase ii trial of everolimus in combination with tamoxifen versus tamoxifen alone in patients (pts) with hormone-receptor positive, her2 negative metastatic breast cancer (mbc) with prior exposure to aromatase inhibitors (ai) [abstract S1-6]. Presented at the 33rd Annual San Antonio Breast Cancer Symposium; December 8-12, 2010; San Antonio, TX. [Available online at: http://www.abstracts2view.com/sabcs10/view.php?nu=SABCS10L_230&terms=; cited September 28, 2012]
    • (2010) Presented At the 33rd Annual San Antonio Breast Cancer Symposium
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3
  • 13
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase iii tandem study
    • Kaufman B, Mackey JR, Clemens MR, et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase iii tandem study. J Clin Oncol 2009;27:5529-37.
    • (2009) J Clin Oncol , vol.27 , pp. 5529-5537
    • Kaufman, B.1    Mackey, J.R.2    Clemens, M.R.3
  • 14
    • 77649100030 scopus 로고    scopus 로고
    • Lapatinib plus letrozole as first-line therapy for her-2+ hormone receptor-positive metastatic breast cancer
    • Schwartzberg LS, Franco SX, Florance A, O'Rourke L, Maltzman J, Johnston S. Lapatinib plus letrozole as first-line therapy for her-2+ hormone receptor-positive metastatic breast cancer. Oncologist 2010;15:122-9.
    • (2010) Oncologist , vol.15 , pp. 122-129
    • Schwartzberg, L.S.1    Franco, S.X.2    Florance, A.3    O'Rourke, L.4    Maltzman, J.5    Johnston, S.6
  • 15
    • 77949754385 scopus 로고    scopus 로고
    • Phase ii, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer
    • Cristofanilli M, Valero V, Mangalik A, et al. Phase ii, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer. Clin Cancer Res 2010;16:1904-14.
    • (2010) Clin Cancer Res , vol.16 , pp. 1904-1914
    • Cristofanilli, M.1    Valero, V.2    Mangalik, A.3
  • 16
    • 79952259688 scopus 로고    scopus 로고
    • Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: A randomized phase ii study
    • Osborne CK, Neven P, Dirix LY, et al. Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: a randomized phase ii study. Clin Cancer Res 2011;17:1147-59.
    • (2011) Clin Cancer Res , vol.17 , pp. 1147-1159
    • Osborne, C.K.1    Neven, P.2    Dirix, L.Y.3
  • 17
    • 0037102121 scopus 로고    scopus 로고
    • Fulvestrant, formerly ici 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment
    • Howell A, Robertson JF, Quaresma Albano J, et al. Fulvestrant, formerly ici 182,780, is as effective as anastrozole in postmenopausal women with advanced breast cancer progressing after prior endocrine treatment. J Clin Oncol 2002;20:3396-403.
    • (2002) J Clin Oncol , vol.20 , pp. 3396-3403
    • Howell, A.1    Robertson, J.F.2    Albano, J.Q.3
  • 18
    • 0019382847 scopus 로고
    • Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer
    • Ingle JN, Ahmann DL, Green SJ, et al. Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer. N Engl J Med 1981;304:16-21.
    • (1981) N Engl J Med , vol.304 , pp. 16-21
    • Ingle, J.N.1    Ahmann, D.L.2    Green, S.J.3
  • 19
    • 0022342348 scopus 로고
    • Metastatic breast cancer: Preliminary results with oral hormonal therapy
    • Allegra JC, Bertino J, Bonomi P, et al. Metastatic breast cancer: preliminary results with oral hormonal therapy. Semin Oncol 1985;12:61-4.
    • (1985) Semin Oncol , vol.12 , pp. 61-64
    • Allegra, J.C.1    Bertino, J.2    Bonomi, P.3
  • 20
    • 0027433430 scopus 로고
    • Randomized comparison of the effects of tamoxifen, megestrol acetate, or tamoxifen plus megestrol acetate on treatment response and survival in patients with metastatic breast cancer
    • Gill PG, Gebski V, Snyder R, et al. Randomized comparison of the effects of tamoxifen, megestrol acetate, or tamoxifen plus megestrol acetate on treatment response and survival in patients with metastatic breast cancer. Ann Oncol 1993;4:741-4.
    • (1993) Ann Oncol , vol.4 , pp. 741-744
    • Gill, P.G.1    Gebski, V.2    Snyder, R.3
  • 21
    • 0020472669 scopus 로고
    • Randomized clinical trial of megestrol acetate versus tamoxifen in paramenopausal or castrated women with advanced breast cancer
    • Ingle JN, Ahmann DL, Green SJ, et al. Randomized clinical trial of megestrol acetate versus tamoxifen in paramenopausal or castrated women with advanced breast cancer. Am J Clin Oncol 1982;5:155-60.
    • (1982) Am J Clin Oncol , vol.5 , pp. 155-160
    • Ingle, J.N.1    Ahmann, D.L.2    Green, S.J.3
  • 22
    • 0021978719 scopus 로고
    • Megestrol acetate v tamoxifen in advanced breast cancer in postmenopausal patients
    • Morgan LR. Megestrol acetate v tamoxifen in advanced breast cancer in postmenopausal patients. Semin Oncol 1985;12:43-7.
    • (1985) Semin Oncol , vol.12 , pp. 43-47
    • Morgan, L.R.1
  • 23
    • 0024041157 scopus 로고
    • Megestrol acetate versus tamoxifen in advanced breast cancer: 5-year analysis-a phase iii trial of the Piedmont Oncology Association
    • Muss HB, Wells HB, Paschold EH, et al. Megestrol acetate versus tamoxifen in advanced breast cancer: 5-year analysis-a phase iii trial of the Piedmont Oncology Association. J Clin Oncol 1988;6:1098-106.
    • (1988) J Clin Oncol , vol.6 , pp. 1098-1106
    • Muss, H.B.1    Wells, H.B.2    Paschold, E.H.3
  • 24
    • 0025686166 scopus 로고
    • Comparison of antiestrogen and progestogen therapy for initial treatment and consequences of their combination for second-line treatment of recurrent breast cancer
    • Paterson AH, Hanson J, Pritchard KI, et al. Comparison of antiestrogen and progestogen therapy for initial treatment and consequences of their combination for second-line treatment of recurrent breast cancer. Semin Oncol 1990;17:52-62.
    • (1990) Semin Oncol , vol.17 , pp. 52-62
    • Paterson, A.H.1    Hanson, J.2    Pritchard, K.I.3
  • 25
    • 50649113295 scopus 로고    scopus 로고
    • Aromatase inhibitors: Are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter?
    • Miller WR, Bartlett J, Brodie AM, et al. Aromatase inhibitors: are there differences between steroidal and nonsteroidal aromatase inhibitors and do they matter? Oncologist 2008;13:829-37.
    • (2008) Oncologist , vol.13 , pp. 829-837
    • Miller, W.R.1    Bartlett, J.2    Brodie, A.M.3
  • 26
    • 60349130840 scopus 로고    scopus 로고
    • Lack of complete cross-resistance between different aromatase inhibitors; a real finding in search for an explanation?
    • Lonning PE. Lack of complete cross-resistance between different aromatase inhibitors; a real finding in search for an explanation? Eur J Cancer 2009;45:527-35.
    • (2009) Eur J Cancer , vol.45 , pp. 527-535
    • Lonning, P.E.1
  • 27
    • 0026395885 scopus 로고
    • A potent specific pure antiestrogen with clinical potential
    • Wakeling AE, Dukes M, Bowler J. A potent specific pure antiestrogen with clinical potential. Cancer Res 1991;51:3867-73.
    • (1991) Cancer Res , vol.51 , pp. 3867-3873
    • Wakeling, A.E.1    Dukes, M.2    Bowler, J.3
  • 28
    • 0028084758 scopus 로고
    • Investigation of a new pure antiestrogen (ici 182780) in women with primary breast cancer
    • DeFriend DJ, Howell A, Nicholson RI, et al. Investigation of a new pure antiestrogen (ici 182780) in women with primary breast cancer. Cancer Res 1994;54:408-14.
    • (1994) Cancer Res , vol.54 , pp. 408-414
    • Defriend, D.J.1    Howell, A.2    Nicholson, R.I.3
  • 29
    • 0035884408 scopus 로고    scopus 로고
    • Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer
    • Robertson JF, Nicholson RI, Bundred NJ, et al. Comparison of the short-term biological effects of 7alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)-nonyl]estra-1,3,5, (10)-triene-3,17beta-diol (Faslodex) versus tamoxifen in postmenopausal women with primary breast cancer. Cancer Res 2001;61:6739-46.
    • (2001) Cancer Res , vol.61 , pp. 6739-6746
    • Robertson, J.F.1    Nicholson, R.I.2    Bundred, N.J.3
  • 30
    • 2442648038 scopus 로고    scopus 로고
    • Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: A multinational, double-blind, randomized trial
    • Howell A, Robertson JF, Abram P, et al. Comparison of fulvestrant versus tamoxifen for the treatment of advanced breast cancer in postmenopausal women previously untreated with endocrine therapy: a multinational, double-blind, randomized trial. J Clin Oncol 2004;22:1605-13.
    • (2004) J Clin Oncol , vol.22 , pp. 1605-1613
    • Howell, A.1    Robertson, J.F.2    Abram, P.3
  • 31
    • 43249130208 scopus 로고    scopus 로고
    • Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptorpositive, advanced breast cancer: Results from efect
    • Chia S, Gradishar W, Mauriac L, et al. Double-blind, randomized placebo controlled trial of fulvestrant compared with exemestane after prior nonsteroidal aromatase inhibitor therapy in postmenopausal women with hormone receptorpositive, advanced breast cancer: results from efect. J Clin Oncol 2008;26:1664-70.
    • (2008) J Clin Oncol , vol.26 , pp. 1664-1670
    • Chia, S.1    Gradishar, W.2    Mauriac, L.3
  • 32
    • 84872382609 scopus 로고    scopus 로고
    • Fulvestrant alone or with concomitant anastrozole vs. exemestane following progression on non-steroidal aromatase inhibitor-first results of the sofea trial (cruke/03/021 and cruk/09/007) (isrctn44195747) [abstract LBA2]
    • Johnston S, Kilburn LS, Ellis P, et al. Fulvestrant alone or with concomitant anastrozole vs. exemestane following progression on non-steroidal aromatase inhibitor-first results of the sofea trial (cruke/03/021 and cruk/09/007) (isrctn44195747) [abstract LBA2]. Eur J Cancer 2012;48(suppl3):S2.
    • (2012) Eur J Cancer , vol.48 , Issue.3 SUPPL.
    • Johnston, S.1    Kilburn, L.S.2    Ellis, P.3
  • 33
    • 78049523306 scopus 로고    scopus 로고
    • Results of the confirm phase iii trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer
    • Di Leo A, Jerusalem G, Petruzelka L, et al. Results of the confirm phase iii trial comparing fulvestrant 250 mg with fulvestrant 500 mg in postmenopausal women with estrogen receptor-positive advanced breast cancer. J Clin Oncol 2010;28:4594-600.
    • (2010) J Clin Oncol , vol.28 , pp. 4594-4600
    • Leo, A.D.1    Jerusalem, G.2    Petruzelka, L.3
  • 34
    • 77950633401 scopus 로고    scopus 로고
    • New strategies in estrogen receptor-positive breast cancer
    • Johnston SR. New strategies in estrogen receptor-positive breast cancer. Clin Cancer Res 2010;16:1979-87.
    • (2010) Clin Cancer Res , vol.16 , pp. 1979-1987
    • Johnston, S.R.1
  • 35
    • 79956195555 scopus 로고    scopus 로고
    • Novel agents and future directions for refractory breast cancer
    • Burstein HJ. Novel agents and future directions for refractory breast cancer. Semin Oncol 2011;38(suppl 2):S17-24.
    • (2011) Semin Oncol , vol.38 , Issue.2 SUPPL.
    • Burstein, H.J.1
  • 36
    • 32944466881 scopus 로고    scopus 로고
    • Clinical efforts to combine endocrine agents with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of rapamycin in breast cancer
    • Johnston SR. Clinical efforts to combine endocrine agents with targeted therapies against epidermal growth factor receptor/human epidermal growth factor receptor 2 and mammalian target of rapamycin in breast cancer. Clin Cancer Res 2006;12:1061s-8s.
    • (2006) Clin Cancer Res , vol.12
    • Johnston, S.R.1
  • 37
    • 9144256614 scopus 로고    scopus 로고
    • Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance
    • Schiff R, Massarweh SA, Shou J, Bharwani L, Mohsin SK, Osborne CK. Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clin Cancer Res 2004;10:331S-6S.
    • (2004) Clin Cancer Res , vol.10
    • Schiff, R.1    Massarweh, S.A.2    Shou, J.3    Bharwani, L.4    Mohsin, S.K.5    Osborne, C.K.6
  • 38
    • 34848885214 scopus 로고    scopus 로고
    • Treatment of postmenopausal women with locally advanced or metastatic breast cancer with letrozole alone or in combination with temsirolimus: A randomized, 3-arm, phase 2 study [abstract 1068]
    • Baselga J, Roche H, Fumoleau P. Treatment of postmenopausal women with locally advanced or metastatic breast cancer with letrozole alone or in combination with temsirolimus: a randomized, 3-arm, phase 2 study [abstract 1068]. Breast Cancer Res Treat 2005;94(suppl 1):S62.
    • (2005) Breast Cancer Res Treat , vol.94 , Issue.1 SUPPL.
    • Baselga, J.1    Roche, H.2    Fumoleau, P.3
  • 39
    • 84862573175 scopus 로고    scopus 로고
    • Reversal of tamoxifen resistance (hormone resistance) by addition of sirolimus (mtor inhibitor) in metastatic breast cancer [abstract 16LBA]
    • Bhattacharyya GS, Biswas J, Singh JK, et al. Reversal of tamoxifen resistance (hormone resistance) by addition of sirolimus (mtor inhibitor) in metastatic breast cancer [abstract 16LBA]. Eur J Cancer 2011;47(suppl 2):9.
    • (2011) Eur J Cancer , vol.47 , Issue.2 SUPPL. , pp. 9
    • Bhattacharyya, G.S.1    Biswas, J.2    Singh, J.K.3
  • 40
    • 34447106387 scopus 로고    scopus 로고
    • Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer [abstract 6091]
    • Chow L, Sun Y, Jassem J, et al. Phase 3 study of temsirolimus with letrozole or letrozole alone in postmenopausal women with locally advanced or metastatic breast cancer [abstract 6091]. Breast Cancer Res Treat 2006;100(suppl 1):S286.
    • (2006) Breast Cancer Res Treat , vol.100 , Issue.1 SUPPL.
    • Chow, L.1    Sun, Y.2    Jassem, J.3
  • 41
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012;366:520-9.
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 42
    • 84860470442 scopus 로고    scopus 로고
    • Everolimus for postmenopausal women with advanced breast cancer: Updated results of the bolero-2 phase iii trial [abstract S3-7]
    • San Antonio, TX; December 6-9, Available online at, cited November 15, 2012
    • Hortobagyi GN, Piccart M, Rugo H, et al. Everolimus for postmenopausal women with advanced breast cancer: updated results of the bolero-2 phase iii trial [abstract S3-7]. Presented at the 34th Annual San Antonio Breast Cancer Symposium; San Antonio, TX; December 6-9, 2011. [Available online at: http://www.abstracts2view.com/sabcs11/view.php?nu=SABCS11L_1653; cited November 15, 2012]
    • (2011) Presented At the 34th Annual San Antonio Breast Cancer Symposium
    • Hortobagyi, G.N.1    Piccart, M.2    Rugo, H.3
  • 43
    • 36849089023 scopus 로고    scopus 로고
    • Fulvestrant loading, tumor markers, and ongoing trials
    • Kaniklidis C. Fulvestrant loading, tumor markers, and ongoing trials. Comm Oncol 2007;4:649-50.
    • (2007) Comm Oncol , vol.4 , pp. 649-650
    • Kaniklidis, C.1
  • 44
    • 38749129651 scopus 로고    scopus 로고
    • Effects of fulvestrant 750 mg in premenopausal women with oestrogenreceptor-positive primary breast cancer
    • Young OE, Renshaw L, Macaskill EJ, et al. Effects of fulvestrant 750 mg in premenopausal women with oestrogenreceptor-positive primary breast cancer. Eur J Cancer 2008;44:391-9.
    • (2008) Eur J Cancer , vol.44 , pp. 391-399
    • Young, O.E.1    Renshaw, L.2    Macaskill, E.J.3
  • 45
    • 84873481273 scopus 로고    scopus 로고
    • Everolimus for postmenopausal women with advanced breast cancer: Updated results of the bolero-2 phase iii trial [abstract 559]
    • Available online at, cited November 1, 2012
    • Piccart M, Noguchi S, Pritchard K, et al. Everolimus for postmenopausal women with advanced breast cancer: updated results of the bolero-2 phase iii trial [abstract 559]. J Clin Oncol 2012;30:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=114&abstractID=101092; cited November 1, 2012]
    • (2012) J Clin Oncol , vol.30
    • Piccart, M.1    Noguchi, S.2    Pritchard, K.3
  • 46
    • 79952602636 scopus 로고    scopus 로고
    • In the end what matters most? A review of clinical endpoints in advanced breast cancer
    • Verma S, McLeod D, Batist G, Robidoux A, Martins IR, Mackey JR. In the end what matters most? A review of clinical endpoints in advanced breast cancer. Oncologist 2011;16:25-35.
    • (2011) Oncologist , vol.16 , pp. 25-35
    • Verma, S.1    McLeod, D.2    Batist, G.3    Robidoux, A.4    Martins, I.R.5    Mackey, J.R.6
  • 47
    • 84870644079 scopus 로고    scopus 로고
    • Effects of everolimus on disease progression in bone and bone markers in patients with bone metastases [abstract 512]
    • Available online at, cited December 20, 2012
    • Gnant M, Baselga J, Rugo HS, et al. Effects of everolimus on disease progression in bone and bone markers in patients with bone metastases [abstract 512]. J Clin Oncol 2012;30:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=114&abstractID=100783; cited December 20, 2012]
    • (2012) J Clin Oncol , vol.30
    • Gnant, M.1    Baselga, J.2    Rugo, H.S.3
  • 48
    • 84873478984 scopus 로고    scopus 로고
    • Bolero-2: Health-related quality-of-life in metastatic breast cancer patients treated with everolimus and exemestane versus exemestane [abstract 539]
    • Available online at, cited November 8, 2012
    • Beck JT, Rugo HS, Burris HA, et al. bolero-2: health-related quality-of-life in metastatic breast cancer patients treated with everolimus and exemestane versus exemestane [abstract 539]. J Clin Oncol 2012;30:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=114&abstractID=101451; cited November 8, 2012]
    • (2012) J Clin Oncol , vol.30
    • Beck, J.T.1    Rugo, H.S.2    Burris, H.A.3
  • 50
    • 47349113208 scopus 로고    scopus 로고
    • Nccn Task Force Report: Breast cancer in the older woman
    • Carlson RW, Moench S, Hurria A, et al. nccn Task Force Report: breast cancer in the older woman. J Natl Compr Canc Netw 2008;6(suppl 4):S1-25.
    • (2008) J Natl Compr Canc Netw , vol.6 , Issue.4 SUPPL.
    • Carlson, R.W.1    Moench, S.2    Hurria, A.3
  • 51
    • 84873414741 scopus 로고    scopus 로고
    • Safety of everolimus for women over 65 years of age with advanced breast cancer (bc): 12.5-mo follow-up of bolero-2 [abstract 551]
    • Available online at, cited November 15, 2012
    • Pritchard KI, Burris HA, Rugo HS, et al. Safety of everolimus for women over 65 years of age with advanced breast cancer (bc): 12.5-mo follow-up of bolero-2 [abstract 551]. J Clin Oncol 2012;30:. [Available online at: http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=114&abstractID=101036; cited November 15, 2012]
    • (2012) J Clin Oncol , vol.30
    • Pritchard, K.I.1    Burris, H.A.2    Rugo, H.S.3
  • 52
    • 84857568955 scopus 로고    scopus 로고
    • Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer
    • Amir E, Miller N, Geddie W, et al. Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer. J Clin Oncol 2012;30:587-92.
    • (2012) J Clin Oncol , vol.30 , pp. 587-592
    • Amir, E.1    Miller, N.2    Geddie, W.3
  • 53
    • 84864085607 scopus 로고    scopus 로고
    • Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression
    • Lindstrom LS, Karlsson E, Wilking UM, et al. Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression. J Clin Oncol 2012;30:2601-8.
    • (2012) J Clin Oncol , vol.30 , pp. 2601-2608
    • Lindstrom, L.S.1    Karlsson, E.2    Wilking, U.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.