Adherence to adjuvant hormonal therapy among breast cancer survivors in clinical practice: A systematic review

Breast Cancer Research and Treatment

Volumn 134, Issue 2, 2012, Pages 459-478

  Murphy, Caitlin C ^a   Bartholomew, L Kay ^a   Carpentier, Melissa Y ^a   Bluethmann, Shirley M ^a   Vernon, Sally W ^a  

^a UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Adherence; Adjuvant hormonal therapy; Survivorship; Systematic review

Indexed keywords

AROMATASE INHIBITOR; CYTOCHROME P450 2D6; TAMOXIFEN;

BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER HORMONE THERAPY; CANCER SURVIVOR; CLINICAL PRACTICE; DECISION MAKING; DRUG SAFETY; DRUG SUBSTITUTION; ENZYME ACTIVITY; GENERAL PRACTITIONER; HUMAN; PATIENT COMPLIANCE; PATIENT REFERRAL; PREVALENCE; PRIORITY JOURNAL; REVIEW; SOCIAL SUPPORT; SYSTEMATIC REVIEW; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CHEMOTHERAPY, ADJUVANT; CLINICAL TRIALS AS TOPIC; FEMALE; HUMANS; MEDICATION ADHERENCE; NEOPLASMS, HORMONE-DEPENDENT; SURVIVORS;

EID: 84868204335     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2114-5     Document Type: Review

References (83)

1. Fisher B, Dignam J, Bryant J, De Cillis A, Wickerham DL, Wolmark N, Costantino J, Redmond C, Fisher ER, Bowman DM, Deschenes L, Dimitrov NV, Margolese RG, Robidoux A, Shibata H, Terz J, Paterson AH, Feldman MI, Farrar W, Evans J, Lickley HL (1996) Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors. J Natl Cancer Inst 88:1529-1542
2. The Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trialists' Group (2005) Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 365:60-62. doi:10.1016/s0140-6736 (04) 17666-6
3. The Arimidex, Tamoxifen, Alone or in Combination (ATAC) Trialists' Group (2008) Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer:100-month analysis of the ATAC trial. Lancet Oncol 9:45-53. doi:10.1016/s1470-2045 (07) 70385-6
4. Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Tu D, Shepherd LE, Pritchard KI, Livingston RB, Davidson NE, Norton L, Perez EA, Abrams JS, Therasse P, Palmer MJ, Pater JL (2003) A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Eng J Med 349:1793-1802
5. Coombes RC, Hall E, Gibson LJ, Paridaens R, Jassem J, Delozier T, Jones SE, Alvarez I, Bertelli G, Ortmann O, Coates AS, Bajetta E, Dodwell D, Coleman RE, Fallowfield LJ, Mickiewicz E, Andersen J, Lonning PE, Cocconi G, Stewart A, Stuart N, Snowdon CF, Carpentieri M, Massimini G, Bliss JM, Intergroup Exemestane Study (2004) A randomized trial of exemestane after two or three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Engl J Med 350:1081-1092
6. Early Breast Cancer Trialists' Collaborative Group (2011) Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 378:771-784. doi:10.1016/s0140-6736 (11) 60993-8
7. National Comprehensive Cancer Network (2012) NCCN clinical practice guidelines in oncology: breast cancer. Version 1.012 http://www.nccn.org/ professionals/physician-gls/pdf/breast.pdf. Accessed 23 Jan 2012
8. Burstein HJ, Griggs JJ, Prestrud AA, Temin S (2010) American Society of Clinical Oncology clinical practice guideline update on adjuvant endocrine therapy for women with hormone receptorpositive breast cancer. J Oncol Pract 6(5):243-246. doi:10.1200/jop. 000082
9. McCowan C, Shearer J, Donnan PT, Dewar JA, Crilly M, Thompson AM, Fahey TP (2008) Cohort study examining tamoxifen adherence and its relationship to mortality in women with breast cancer. Br J Cancer 99:1763-1768. doi:10.1038/sj. bjc.6604758
10. Dezentje VO, Van Blijderveen NJC, Gelderblom H, Putter H, Van Herk-Sukel MPP, Casparie MK, Egberts ACG, Nortier JWR, Guchelaar H (2010) Effect of concomitant CYP2D6 inhibitor use and tamoxifen adherence on breast cancer recurrence in earlystage breast cancer. J Clin Oncol 28(14):2423-2429. doi:10.1200/jco.2009.25.0894
11. Hershman DL, Shao T, Kushi LH, Buono D, Tsai WT, Fehrenbacher L, Kwan M, Gomez SL, Neugut AI (2011) Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer. Breast Cancer Res Treat 126:529-537. doi:10.1007/s10549-010-1132-4
12. Van De Water W, Bastiaannet E, Hille ETM, Kranenbarg EMM, Putter H, Seynaeve CM, Paridaens R, De Craen AJM, Westendorp RGJ, Liefers G, Van De Velde CJH (2012) Age-specific nonpersistence of endocrine therapy in postmenopausal patients diagnosed with hormone receptor-positive breast cancer: a TEAM study analysis. Oncologist 17:55-63. doi:10.1634/theoncologist. 2011-0037
13. Chlebowski RT, Geller ML (2006) Adherence to endocrine therapy for breast cancer. Oncol 71:1-9. doi:10.1159/000100444
14. Hadji P (2010) Improving compliance and persistence to adjuvant tamoxifen and aromatase inhibitor therapy. Critic Rev Oncol Hematol 73:156-166. doi:10.1016/j.critrevonc.2009.02.001
15. Dogrell SA (2011) Adherence to oral endocrine treatments in women with breast cancer: can it be improved? Breast Cancer Res Treat 129:299-308. doi:10.1007/s10549-011-1578-z
16. Gotay C, Dunn J (2011) Adherence to long-term adjuvant hormonal therapy for breast cancer. Expert Rev Pharmacoeconomics Outcomes Res 11(6):709-715. doi:10.1586/erp. 11.80
17. Verma S, Madarnas Y, Sehdev S, Martin G, Bajcar J (2011) Patient adherence to aromatase inhibitor treatment in the adjuvant setting. Curr Oncol 18(Suppl 1):S3-S9
18. Banning M (2012) Adherence to adjuvant therapy in post-menopausal breast cancer patients: a review. Eur J Cancer Care 21:10-19. doi:10.1111/j.1365-2354. 2011.01295.x
19. Moher D, Liberati A, Tetzlaff J, Altman DG, PRSIMA Group (2009) Preferred reporting items for systematic reviews and metaanalyses: the PRISMA statement. J Clin Epidemiol 62(10):1006-1012. doi:10.1016/j.jclinepi.2009.06.006
20. Early Breast Cancer Trialists' Collaborative Group (1998) Tamoxifen for early breast cancer: an overview of randomized trials. Lancet 351:1451-1467. doi:10.1016/s0140-6736 (97) 11423-4
21. Ruddy K, Mayer E, Partridge A (2009) Patient adherence and persistence with oral anticancer treatment. CA Cancer J Clin 59:56-66. doi:10.3322/caac. 20004
22. Peterson AM, Nau DP, Cramer JA, Benner J, Gwadry-Sridhar F, Nichol M (2007) A checklist for medication compliance and persistence studies using retrospective databases. Value Health 10(1):3-12. doi:10.1111/j.1524-4733.2006. 00139.x
23. Partridge AH, Wang PS, Winer EP, Avorn J (2003) Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer. J Clin Oncol 21(4):602-606. doi:10.1200/jco.2003.07.071
24. Grunfeld EA, Hunter MS, Sikka P, Mittal S (2005) Adherence beliefs among breast cancer patients taking tamoxifen. Patient Educ Couns 59:97-102. doi:10.1016/j.pec.2004.10.005
25. Ma AMT, Barone J, Wallis AE, Wu NJ, Garcia LB, Estabrook A, Rosenbaum-Smith SM, Tartter PI (2008) Noncompliance with adjuvant radiation, chemotherapy, or hormonal therapy in breast cancer patients. Am J Surg 196:500-504. doi:10.1016/j.amjsurg. 2008.06.027
26. Guth U, Huang DJ, Schotzau A, Zanetti-Dallenback R, Holzgreve W, Bitzer J, Wight E (2008) Target and reality of adjuvant endocrine therapy in postmenopausal patients with invasive breast cancer. Br J Cancer 99:428-433. doi:10.1038/sj.bjc. 6604525
27. Ziller V, Kalder M, Albert US, Hozhauer W, Ziller M, Wagner U, Hadji P (2009) Adherence to adjuvant endocrine therapy in postmenopausal women with breast cancer. Ann Oncol 20:431-436. doi:10.1093/annonc/mdn646
28. Sedjo RL, Devine S (2011) Predictors of non-adherence to aromatase inhibitors among commercially insured women with breast cancer. Breast Cancer Res Treat 125:191-200. doi:10.1007/s10549-010-0952-6
29. Thompson AM, Johnson A, Quinlan P, Hillman G, Fontecha M, Bray SE, Purdie CA, Jordan LB, Ferraldeschi R, Latif A, Hadfield KD, Clarke RB, Ashcroft L, Evans DG, Howell A, Nikoloff M, Lawrence J, Newman WG (2011) Comprehensive CYP256 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy. Breast Cancer Res Treat 125:279-287. doi:10.1007/s10549-010-1139-x
30. Dittmer C, Roeder K, Hoellen F, Salehin D, Thill M, Fischer D (2011) Compliance to adjuvant therapy in breast cancer patients. Eur J Gynecol Oncol 32(3):280-282
31. Riley GF, Warren JL, Harlan LC, Blackwell SA (2011) Endocrine therapy use among elderly hormone receptor-positive breast cancer patients enrolled in Medicare Part D. Medicare Medicaid Res Rev 1(4):E1-E21. doi:10.5600/mmrr.001.04. a04
32. Wigertz A, Ahlgren J, Holmqvist M, Fornander T, Adolfsson J, Lindman H, Bergkvist L, Lambe M (2012) Adherence and discontinuation of adjuvant hormonal therapy in breast cancer patients: a population-based study. Breast Cancer Res Treat 133:367-373. doi:10.1007/s10549-012-1961-4
33. Demissie S, Silliman RA, Lash TL (2001) Adjuvant tamoxifen: predictors of use, side effects, and discontinuation in older women. J Clin Oncol 19(2):322-328
34. Fink AK, Gurwitz J, Rakowski W, Guadagnoli E, Silliman RA (2004) Patient beliefs and tamoxifen discontinuance in older women with estrogen receptor-positive breast cancer. J Clin Oncol 22(16):3309-3315. doi:10.1200/jco.2004.11.064
35. Lash TL, Fox MP, Westrup JL, Fink AK, Silliman RA (2006) Adherence to tamoxifen over the five-year course. Breast Cancer Res Treat 99:215-220. doi:10.1007/s10549-006-9193-0
36. Kahn KL, Schneider EC, Malin JL, Adams JL, Epstein AM (2007) Patient centered experiences in breast cancer: predicting long-term adherence to tamoxifen use. Med Care 45(5):431-439
37. Owusu C, Buist DSM, Field TS, Lash TL, Thwin SS, Geiger AM, Quinn VP, Frost F, Prout M, Yood MU, Wei F, Silliman RA (2008) Predictors of tamoxifen discontinuation among older women with estrogen receptor-positive breast cancer. J Clin Oncol 26(4):549-555. doi:10.1200/jco.2006.10.1022
38. Schwartzberg LS, Cobb P, Senecal F, Henry D, Kulig K, Walker MS, Houts AC, Stepanski EJ (2009) Initial treatment and changes in adjuvant endocrine therapy for early stage breast cancer. Breast 18:78-83. doi:10.1016/j.breast. 2009.01.002
39. Rae JM, Sikora MJ, Henry NL, Li L, Kim S, Oesterreich S, Skaar T, Nguyen AT, Desta Z, Storniolo AM, Flockhart DA, Hayes DF, Stearns V (2009) Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients. Pharmacogenomics 9(4):258-264. doi:10.1038/tpj.2009.14
40. Van Herk-Sukel MPP, Van Del Poll-Franse LV, Voogd AC, Nieuwenhuijzen GAP, Coebergh JWW, Herings RMC (2010) Half of breast cancer patients discontinue tamoxifen and any endocrine treatment before the end of the recommended treatment period of 5 years: a population-based analysis. Breast Cancer Res Treat 122:843-851. doi:10.1007/s10549-009-0724-3
41. Guth U, Myrick ME, Schotzau A, Kilic N, Schmid SM (2011) Drug switch because of treatment-related adverse side effects in endocrine adjuvant breast cancer therapy: how often and how often does it work? Breast Cancer Res Treat 129:799-807. doi:10.1007/s10549-011-1668-y
42. Partridge AH, La Fountain A, Mayer E, Taylor BS, Winer E, Asnis-Alibozek A (2008) Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer. J Clin Oncol 26(4):556-562. doi:10.1200/JCO.2007.11. 5451
43. Kimmick G, Anderson R, Camacho F, Bhosle M, Hwang W, Balkrishman R (2009) Adjuvant hormonal therapy use among insured, low-income women with breast cancer. J Clin Oncol 27(21):3445-3451. doi:10.1200/jco.2008.19.2419
44. Neugut AI, Subar M, Wilde ET, Stratton S, Brouse CH, Hillyer GC, Grann VR, Hershman DL (2011) Association between prescription co-payment amount and compliance with adjuvant hormonal therapy in women with early-stage breast cancer. J Clin Oncol 29(18):2534-2542. doi:10.1200/jco.2010.33.3179
45. Huiart L, Dell'Aniello S, Suissa S (2011) Use of tamoxifen and aromatase inhibitors in a large population-based cohort of women with breast cancer. Br J Cancer 104:1558-1563. doi:10.1038/bjc. 2011.140
46. Nekhlyudov L, Lingling L, Ross-Degnan D, Wagner AK (2011) Five-year patterns of adjuvant hormonal therapy use, persistence, and adherence among insured women with early-stage breast cancer. Breast Cancer Res Treat 130:681-689. doi:10.1007/s 10549-011-1703-z
47. Weaver KE, Camacho F, Hwang W, Anderson R, Kimmick G (2012) Adherence to adjuvant hormonal therapy and its relationship to breast cancer recurrence and survival among lowincome women. Am J Clin Oncol. doi:10.1097/coc.0b013e31 82436ec1
48. Huiart L, Bouknik A, Rey D, Tarpin C, Cluze C, Bendiane MK, Viens P, Giorgi R (2012) Early discontinuation of tamoxifen intake in younger women with breast cancer: is it time to rethink the way it is prescribed? Eur J Cancer. doi:10.1016/j.ejca. 2012.03.004
49. Hewitt ME, Greenfield S, Stovall E (eds) (2005) From cancer patient to cancer survivor: lost in transition. National Academies Press, Washington, DC
50. Centers for Disease Control and Prevention (2012) Surveillance or demographic characteristics and health behaviors among adult cancer survivors-behavioral risk factor surveillance system, United States, 2009. MMWR: Morbidity and Mortality Weekly Report 61:1. http://www.cdc.gov/mmwr. Accessed 19 Jan 2012
51. Potosky AL, Han PKJ, Rowland J, Klabunde CN, Smith T, Aziz N, Earle C, Ayanian JZ, Ganz PA, Stefanek M (2011) Difference between primary care physicians' and oncologists' knowledge, attitudes and practices regarding the care of cancer survivors. J Gen Intern Med 26(12):1403-1410. doi:10.1007/s11606-011-1808-4
52. Lin JH, Zhang SM, Manson JE (2011) Predicting adherence to tamoxifen for breast cancer adjuvant therapy and prevention. Cancer Prev Res 4:1360-1365. doi:10.1158/1940-6207.capr-11-0380
53. Neugut AI, Hillyer GC, Kushi LH, Lamerato L, Leoce N, Nathanson SD, Ambrosone CB, Bovbjerg DH, Mandelblatt JS, Magai C, Tsai W, Jacobson JS, Hershman DL (2012) Non-initiation of adjuvant hormonal therapy in women with hormone receptor-positive breast cancer: The Breast Cancer Quality of Care Study (BQUAL). Breast Cancer Res Treat. doi:10.1007/s 10549-012-2066-9
54. Cluze C, Rey D, Huiart L, Ben Diane MK, Bouhnik AD, Berenger C, Carrieri MP, Giorgi R (2012) Adjuvant endocrine therapy with tamoxifen in young women with breast cancer: determinants of interruptions vary over time. Ann Oncol 23:882-890. doi:10.1093/annonc/mdr330
55. Garreau JR, De La Melena T, Walts D, Karamlou K, Johnson N (2006) Side effects of aromatase inhibitors versus tamoxifen: the patients' perspective. Am J Surg 192:496-498. doi:10.1016/j. amjsurg.2006.06.018
56. Cella D, Fallowfield LJ (2008) Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy. Breast Cancer Res Treat 107:167-180. doi:10.1007/s10549-007- 9548-1
57. Fellowes D, Fallowfield LJ, Saunder CM, Haughton J (2001) Tolerability of hormone therapies for breast cancer: how informative are documented symptom profiles in medical notes for 'well-tolerated' treatments? Breast Cancer Res Treat 66:73-81
58. Salgado BA, Zivian MT (2006) Aromatase inhibitors: side effects reported by 622 women. Breast Cancer Res Treat 100:S1618
59. Henry NL, Giles JT, Ang D, Mohan M, Dadabhoy D, Robarge J, Hayden J, Lemler S, Shahverdi K, Powers P, Li L, Flockhart D, Stearns V, Hayes DF, Storniolo AM, Clauw DJ (2008) Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors. Breast Cancer Res Treat 111:365-372. doi:10.1007/s10549-007-9774-6
60. Presant CA, Bosserman L, Young T, Vakil M, Horns R, Upadhyaya G, Ebrahimi B, Yeon C, Howard F (2007) Aromatase inhibitor-associated arthralgia and/or bone pain: frequency and characterization in non-clinical trial patients. Clin Breast Cancer 7(10):775-778
61. Pellegrini I, Sarradon-Eck A, Soussan PB, Lacour AC, Largillier R, Tallet A, Tarpin C, Julian-Reynier C (2010) Women's perception and experience of adjuvant tamoxifen therapy account for their adherence: breast cancer patients' point of view. Pyscho-Oncology 19:472-479. doi:10.1002/pon. 1593
62. Henry NL, Azzouz F, Desta Z, Li L, Nguyen AT, Lemler S, Hayden J, Tarpinian K, Yakim E, Flockhart DA, Stearns V, Hayes DF, Storniolo AM (2012) Predictors of aromatase inhibitor discontinuation as a result of treatment-emergent symptoms in early-stage breast cancer. J Clin Oncol 30(9):936-942. doi:10.1200/jco.2011.38.0261
63. Gallicchio L, MacDonald R, Wood B, Rushovich E, Helzlsouer KJ (2011) Menopausal-type symptoms among breast cancer patients on aromatase inhibitor therapy. Climacteric. doi:10.3109/13697137.2011.620658
64. Boonstra A, Van Zadelhoff J, Timmer-Bonte A, Ottevanger PB, Beurskens CH, Van Laarhoven HW (2012) Arthralgia during aromatase inhibitor treatment in early breast cancer patients: prevalence, impact, and recognition by healthcare providers. Cancer Nurs. doi:10.1097/ncc.0b013e31824a7e18
65. Nedrow A, Miller J, Walker M, Nygren P, Huffman LH, Nelson HD (2006) Complementary and alternative therapies for the management of menopause-related symptoms: a systematic evidence review. Arch Intern Med 166:1453-1465
66. Nelson HD, Vesco KK, Haney E, Fu R, Nedrow A, Miller J, Nicolaidis C, Walker M, Humphrey L (2006) Nonhomronal therapies for menopausal hot f35es: systematic review and metaanalysis. J Am Med Assoc 295(17):2057-2071
67. Hickey M, Saunders CM, Stuckey BGA (2005) Management of menopausal symptoms in patients with breast cancer: an evidence-based approach. Lancet Oncol 6:687-695
68. Cimprich B, Janz NA, Northouse L, Wren PA, Given B, Given CW (2005) Taking charge: a self-management program for women following breast cancer treatment. Psycho-Oncology 14:704-717. doi:10.1002/pon. 891
69. Ganz PA, Kwan L, Stanton AL, Krupnick JL, Rowland JH, Meyerowitz BE, Bower JE, Belin TR (2004) Quality of life at the end of primary treatment of breast cancer: first results from the moving beyond cancer randomized trial. J Natl Cancer Inst 96(5):376-387
70. Ganz PA, Greendale GA, Petersen L, Zibecchi L, Kahn B, Belin TR (2000) Managing menopausal symptoms in breast cancer survivors: results of a randomized controlled trial. J Natl Cancer Inst 92(13):1054-1064
71. Hunter MS, Conventry S, Hamed H, Fentiman I, Grunfeld EA (2009) Evaluation of a group cognitive behavioral intervention for women suffering from menopausal symptoms following breast cancer treatment. Psycho-Oncology 18:560-563. doi:10.1002/pon. 1414
72. Meneses KD, McNees P, Loerzel VW, Su X, Zhang Y, Hassey LA (2007) Transition from treatment to survivorship: effects of a psychoeducational intervention on quality of life in breast cancer survivors. Oncol Nurs Forum 34(5):1007-1016. doi:10.1188/07. onf.1007-1016
73. Mishel MH, Germino BB, Gil KM, Belyea M, Laney IC, Stewart J, Porter L, Clayton M (2005) Benefits from an uncertainty management intervention for African-American and Caucasian older long-term breast cancer survivors. Psycho-Oncology 14:962-972. doi:10.1002/pon. 909
74. Mann E, Smith MJ, Hellier J, Balabanovic JA, Hamed H, Grunfeld EA, Hunter MS (2012) Cognitive behavioral treatment for women who have menopausal symptoms after breast cancer treatment (MENOS 1): a randomised controlled trial. Lancet Oncol 13:309-318. doi:10.1186/1471-2407-11-44
75. Mortimer JE (2010) Managing the toxicities of aromatase inhibitors. Curr Opin Obstet Gynecol 22(1):56-60. doi:10.1097/gco.0b013e328334e44e
76. Wengstrom Y (2008) Effectively nursing patients receiving aromatase inhibitor therapy. Breast 17(3):227-238. doi:10.1016/j. breast.2007.11.001
77. Miaskowski C, Shockney L, Chlebowski RT (2008) Adherence to endocrine therapy for breast cancer: a nursing perspective. Clin J Oncol Nurs 12(2):213-221. doi:10.1188/08.cjon. 213-221
78. Kelly A, Agius CR (2006) Improving adherence to endocrine therapies: the role of advanced practice nurses. Oncol 20(10):50-54
79. Albert US, Zemlin C, Hadji P, Ziller V, Kuhler B, Frank-Hahn B, Wagner U, Kalder M (2011) The impact of breast care nurses on patients' satisfaction, understanding of the disease, and adherence to adjuvant endocrine therapy. Breast Care 6(3):221-226. doi:10.1159/000329006
80. Wu X, Lund MJ, Kimmick GC, Richardson LC, Sabatino SA, Chen VW, Fleming ST, Morris CR, Huang B, Trentham-Dietz A, Lipscomb J (2012) Influence of race, insurance, socioeconomic status, and hospital type on receipt of guideline-concordant adjuvant systemic therapy for locoregional breast cancers. J Clin Oncol 30(2):142-150. doi:10.1200/jco.2011.36.8399
81. Livaudais JC, Hershman DL, Habel L, Kushi L, Gomez SL, Li CI, Neugut AI, Fehrenbacher L, Thompson B, Coronado GD (2012) Racial/ethnic differences in initiation of adjuvant hormonal therapy among women with hormone receptor-positive breast cancer. Breast Cancer Res Treat 131:607-617. doi:10.1007/s10549-011-1762-1
82. Rothman KJ (2002) Epidemiology: an introduction. Oxford University Press, New York
83. Hershman DL, Kushi LH, Shao T, Buono D, Kershenbaum A, Tsai W, Fehrenbacher L, Gomez SL, Miles S, Neugut AI (2010) Early discontinuation and nonadherence to adjuvant hormonal therapy in a cohort of 8, 769 early-stage breast cancer patients. J Clin Oncol 28(27):4120-4128. doi:10.1200/jco.2009.25. 9655