Expression level of vascular endothelial growth factor in hippocampus is associated with cognitive impairment in patients with Alzheimer's disease

Neurobiology of Aging

Volumn 34, Issue 5, 2013, Pages 1412-1415

  Tang, Huidong ^a,b   Mao, XiaoOu ^b   Xie, Lin ^b   Greenberg, David A ^b   Jin, Kunlin ^b,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Alzheimer's disease; Brain; Expression; Human; VEGF

Indexed keywords

ISOPROTEIN; VASCULOTROPIN;

ALZHEIMER DISEASE; ARTICLE; ASTROCYTE; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DISEASE ASSOCIATION; DOWN REGULATION; ENTORHINAL CORTEX; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOLECULAR PATHOLOGY; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UPREGULATION; WESTERN BLOTTING;

ALZHEIMER DISEASE; COGNITION DISORDERS; HIPPOCAMPUS; HUMANS; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84873442078     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.10.029     Document Type: Article

References (12)

1. Cao L., Jiao X., Zuzga D.S., Liu Y., Fong D.M., Young D., During M.J. VEGF links hippocampal activity with neurogenesis, learning and memory. Nat. Genet. 2004, 36:827-835.
2. Chapuis J., Tian J., Shi J., Bensemain F., Cottel D., Lendon C., Amouyel P., Mann D., Lambert J.C. Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease. Neurobiol. Aging 2006, 27:1212-1215.
3. Corsi M.M., Licastro F., Porcellini E., Dogliotti G., Galliera E., Lamont J.L., Innocenzi P.J., Fitzgerald S.P. Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration. Biogerontology 2011, 12:451-454.
4. Cressey R., Wattananupong O., Lertprasertsuke N., Vinitketkumnuen U. Alteration of protein expression pattern of vascular endothelial growth factor (VEGF) from soluble to cell-associated isoform during tumourigenesis. BMC Cancer 2005, 5:128.
5. Del Bo R., Scarlato M., Ghezzi S., Martinelli Boneschi F., Fenoglio C., Galbiati S., Virgilio R., Galimberti D., Galimberti G., Crimi M., Ferrarese C., Scarpini E., Bresolin N., Comi G.P. Vascular endothelial growth factor gene variability is associated with increased risk for AD. Ann. Neurol. 2005, 57:373-380.
6. Gomez-Isla T., Price J.L., McKeel D.W., Morris J.C., Growdon J.H., Hyman B.T. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J. Neurosci. 1996, 16:4491-4500.
7. Isingrini E., Desmidt T., Belzung C., Camus V. Endothelial dysfunction: a potential therapeutic target for geriatric depression and brain amyloid deposition in Alzheimer's disease?. Curr. Opin. Investig. Drugs 2009, 10:46-55.
8. Jin K., Peel A.L., Mao X.O., Xie L., Cottrell B.A., Henshall D.C., Greenberg D.A. Increased hippocampal neurogenesis in Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:343-347.
9. Jin K., Zhu Y., Sun Y., Mao X., Xie L., Greenberg D. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:11946-11950.
10. Mateo I., Llorca J., Infante J., Rodriguez-Rodriguez E., Fernandez-Viadero C., Pena N., Berciano J., Combarros O. Low serum VEGF levels are associated with Alzheimer's disease. Acta Neurol. Scand. 2007, 116:56-58.
11. Patel N.S., Mathura V.S., Bachmeier C., Beaulieu-Abdelahad D., Laporte V., Weeks O., Mullan M., Paris D. Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2. J. Neurochem. 2010, 112:66-76.
12. Sun Y., Jin K., Xie L., Childs J., Mao X.O., Logvinova A., Greenberg D.A. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 2003, 111:1843-1851.