메뉴 건너뛰기




Volumn 74, Issue 3, 2012, Pages 195-200

The Effect of route of administration in thymoquinone toxicity in male and female rats

Author keywords

Acute pancreatitis; Acute toxicity; Adynamic ileus; Thymoquinone

Indexed keywords

AMYLASE; GLUCOSE; THYMOQUINONE; TRIACYLGLYCEROL;

EID: 84873432940     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.106060     Document Type: Article
Times cited : (74)

References (36)
  • 1
    • 84869844375 scopus 로고    scopus 로고
    • Mechanism of the pharmacological actions of a plant-derived active compound, thymoquinone
    • Shimizu Y, Takahiko S, El-Mahkoudy A, Hideki N, Tadashi T. Mechanism of the pharmacological actions of a plant-derived active compound, thymoquinone. Vet Biochem 2004;41:15-21
    • (2004) Vet Biochem , vol.41 , pp. 15-21
    • Shimizu, Y.1    Takahiko, S.2    El-Mahkoudy, A.3    Hideki, N.4    Tadashi, T.5
  • 5
    • 0035719313 scopus 로고    scopus 로고
    • Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats
    • Hawsawi ZA, Ali BA, Bamosa AO. Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats. Ann Saudi Med 2001;21:242-4
    • (2001) Ann Saudi Med , vol.21 , pp. 242-244
    • Hawsawi, Z.A.1    Ali, B.A.2    Bamosa, A.O.3
  • 6
    • 68349118245 scopus 로고    scopus 로고
    • Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats
    • Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA. Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. J Ayub Med Coll Abbottabad 2008;20:25-7
    • (2008) J Ayub Med Coll Abbottabad , vol.20 , pp. 25-27
    • Al-Ali, A.1    Alkhawajah, A.A.2    Randhawa, M.A.3    Shaikh, N.A.4
  • 9
    • 60849103071 scopus 로고    scopus 로고
    • Gender-selective toxicity of thimerosal
    • Branch DR. Gender-selective toxicity of thimerosal. Exp Toxicol Pathol 2009;61:133-6
    • (2009) Exp Toxicol Pathol , vol.61 , pp. 133-136
    • Branch, D.R.1
  • 10
    • 0034332111 scopus 로고    scopus 로고
    • Investigators perspective on the MTD
    • Cutler N, Sramek J. Investigators perspective on the MTD. J Clin Pharmacol 2000;40:1184-7
    • (2000) J Clin Pharmacol , vol.40 , pp. 1184-1187
    • Cutler, N.1    Sramek, J.2
  • 11
    • 0034331704 scopus 로고    scopus 로고
    • Regulators perspective on MTD: Is there a role for surrogate markers
    • Collins J. Regulators perspective on MTD: Is there a role for surrogate markers. J Clin Pharmacol 2000;40:1199-201
    • (2000) J Clin Pharmacol , vol.40 , pp. 1199-201
    • Collins, J.1
  • 12
    • 84873467628 scopus 로고    scopus 로고
    • internet]. Maryland: Borriston Labratories Inc Available from Last updated 2001 Dec 6; accessed 2011 Oct 20]
    • Tobaccodocuments.org [internet]. Maryland: Borriston Labratories, Inc.; 2001 Available from: Http://tobaccodocuments.org/lor/00953611.html. [Last updated 2001 Dec 6; accessed 2011 Oct 20]
    • (2001) Tobaccodocuments.org
  • 15
    • 84866241144 scopus 로고    scopus 로고
    • Thymoquinone: A promising antidiabetic agent
    • AbuKhader MM. Thymoquinone: A promising antidiabetic agent. Int J Diabetes Dev Ctries 2012;32:65-68
    • (2012) Int J Diabetes Dev Ctries , pp. 3265-3268
    • AbuKhader, M.M.1
  • 18
    • 0036273437 scopus 로고    scopus 로고
    • The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions
    • El-Dakhakhny M, Mady N, Lembert N, Ammon HP. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med 2002;68:465-6
    • (2002) Planta Med , vol.68 , pp. 465-466
    • El-dakhakhny, M.1    Mady, N.2    Lembert, N.3    Ammon, H.P.4
  • 19
    • 0024515852 scopus 로고
    • Oxidative fuel metabolism during mild hypoglycemia: Critical role of free fatty acids
    • Caprio S, Gelfand RA, Tamborlane WV, Sherwin RS. Oxidative fuel metabolism during mild hypoglycemia: Critical role of free fatty acids. Am J Physiol 1989;256:E413-9
    • (1989) Am J Physiol , vol.256
    • Caprio, S.1    Gelfand, R.A.2    Tamborlane, W.V.3    Sherwin, R.S.4
  • 20
    • 0033863049 scopus 로고    scopus 로고
    • Effect of hypoglycemia on amino acid and protein metabolism in healthy humans
    • Battezzati A, Benedini S, Fattorini A, Piceni Sereni L, Luzi L. Effect of hypoglycemia on amino acid and protein metabolism in healthy humans. Diabetes 2000;49:1543-51
    • (2000) Diabetes , vol.49 , pp. 1543-1551
    • Battezzati, A.1    Benedini, S.2    Fattorini, A.3    Piceni Sereni, L.4    Luzi, L.5
  • 21
    • 65649111745 scopus 로고    scopus 로고
    • Regulation of apolipoprotien A-1 and apolipoprotien B100 genes by thymoquinone rich fraction and thymoquinone in HepG2 cells
    • Al-Naqeeb G, Ismail M. Regulation of apolipoprotien A-1 and apolipoprotien B100 genes by thymoquinone rich fraction and thymoquinone in HepG2 cells. J Food Lipids 2009;16:245-58
    • (2009) J Food Lipids , vol.16 , pp. 245-58
    • Al-naqeeb, G.1    Ismail, M.2
  • 23
    • 0032460730 scopus 로고    scopus 로고
    • Acute pancreatitis, hyperlipidemia, and diabetic ketoacidosis: Who comes first?
    • Gianfrate L, Ferraris L. Acute pancreatitis, hyperlipidemia, and diabetic ketoacidosis: Who comes first? Am J Gastroenterol 1998;93:1393-4
    • (1998) Am J Gastroenterol , vol.93 , pp. 1393-1394
    • Gianfrate, L.1    Ferraris, L.2
  • 24
    • 39749187139 scopus 로고    scopus 로고
    • MDCT of acute mild (nonnecrotizing) pancreatitis: Abdominal complications and fate of fluid collections
    • Lenhart DK, Balthazar EJ. MDCT of acute mild (nonnecrotizing) pancreatitis: Abdominal complications and fate of fluid collections. Am J Roentgenol 2008;190:643-9
    • (2008) Am J Roentgenol , vol.190 , pp. 643-649
    • Lenhart, D.K.1    Balthazar, E.J.2
  • 25
    • 77953178795 scopus 로고    scopus 로고
    • Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: Role of reactive oxygen species
    • Koka PS, Mondal D, Schultz M, Abdel-Mageed AB, Agrawal KC. Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: Role of reactive oxygen species. Exp Biol Med (Maywood) 2010;235:751-60
    • (2010) Exp Biol Med (Maywood) , vol.235 , pp. 751-60
    • Koka, P.S.1    Mondal, D.2    Schultz, M.3    Abdel-mageed, A.B.4    Agrawal, K.C.5
  • 28
    • 84873452510 scopus 로고    scopus 로고
    • Small bowel obstruction
    • In Holzheimer RG, Mannick JA, editors Munich: Zuckschwerdt Verlag GmBH Available From Last accessed 2011 Oct 20
    • Kulaylat M, Doerr R. Small bowel obstruction. In: Holzheimer RG, Mannick JA, editors. Surgical Treatment: Evidence-Based and Problem-Oriented. Munich: Zuckschwerdt Verlag GmBH; 2001 Available from: Http://www.ncbi.nlm.nih.gov/ books/NBK6873/. [Last accessed 2011 Oct 20].
    • (2001) Surgical Treatment: Evidence-Based and Problem-Oriented
    • Kulaylat, M.1    Doerr, R.2
  • 29
    • 27744476617 scopus 로고    scopus 로고
    • Immunomodulatory and therapeutic properties of the Nigella sativa L. seed
    • Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005;5:1749-70
    • (2005) Int Immunopharmacol , vol.5 , pp. 1749-1770
    • Salem, M.L.1
  • 30
    • 33746190607 scopus 로고    scopus 로고
    • Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus
    • Al-Majed AA, Al-Omar FA, Nagi MN. Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. Eur J Pharmacol 2006;543:40-7
    • (2006) Eur J Pharmacol , vol.543 , pp. 40-47
    • Al-majed, A.A.1    Al-omar, F.A.2    Nagi, M.N.3
  • 31
    • 35348872517 scopus 로고    scopus 로고
    • Effect of thymoquinone on malformations and oxidative stress-induced diabetic mice
    • Al-Enazi MM. Effect of thymoquinone on malformations and oxidative stress-induced diabetic mice. Pak J Biol Sci 2007;10:3115-9
    • (2007) Pak J Biol Sci , vol.10 , pp. 3115-3119
    • Al-enazi, M.M.1
  • 32
    • 77955898256 scopus 로고    scopus 로고
    • Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats
    • Fararh KM, Ibrahim AK, Elsonosy YA. Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats. Res Vet Sci 2010;88:400-4
    • (2010) Res Vet Sci , vol.88 , pp. 400-404
    • Fararh, K.M.1    Ibrahim, A.K.2    Elsonosy, Y.A.3
  • 33
    • 38949116268 scopus 로고    scopus 로고
    • Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats
    • Kanter M. Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats. Neurochem Res 2008;33:579-88
    • (2008) Neurochem Res , vol.33 , pp. 579-88
    • Kanter, M.1
  • 34
    • 79957631258 scopus 로고    scopus 로고
    • Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats
    • Kanter M. Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats. Toxicol Ind Health 2011;27:387-95
    • (2011) Toxicol Ind Health , vol.27 , pp. 387-95
    • Kanter, M.1
  • 35
    • 0347318041 scopus 로고    scopus 로고
    • Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats
    • El-Saleh SC, Al-Sagair OA, Al-Khalaf MI. Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats. Int J Cardiol 2004;93:19-23
    • (2004) Int J Cardiol , vol.93 , pp. 19-23
    • El-Saleh, S.C.1    Al-Sagair, O.A.2    Al-Khalaf, M.I.3
  • 36
    • 0036090986 scopus 로고    scopus 로고
    • Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action
    • Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: A possible mechanism of action. Cell Biochem Funct 2002;20:143-51
    • (2002) Cell Biochem Funct , vol.20 , pp. 143-51
    • Mansour, M.A.1    Nagi, M.N.2    El-khatib, A.S.3    Al-bekairi, A.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.