Effect of thymoquinone on malformations and oxidative stress-induced diabetic mice

Pakistan Journal of Biological Sciences

Volumn 10, Issue 18, 2007, Pages 3115-3119

  Al Enazi, Maher M ^a  

^a JOUF UNIVERSITY   (Saudi Arabia)

Author keywords

Diabetes mellitus; Glutathione; Malondialdehyde; Streptozotocin; Thymoquinone

Indexed keywords

ANIMALIA; MUS; NIGELLA SATIVA;

EID: 35348872517     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2007.3115.3119     Document Type: Article

References (31)

1. Al-Shabanah, O.A., O.A. Badary, M.N. Nagi, M.N. Al-Gharably, A.C. Al-Rikabi and A.M. Al-Bekairi, 1998. Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity. J. Exp. Clin. Cancer Res., 17: 193-198.
2. Badary, O.A., M.N. Nagi, O.A. Al-Shabanah, H.A. Al-Sawaf, M.O. Al-Sohaibani and A.M. Al-Bekairi, 1997. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can. J. Physiol. Pharmacol., 75: 1356-1361.
3. Badary, O.A., R.A. Taha, A.M. Gamal El-Din and M.H. Abdel Wahab, 2003. Thymoquinone is a superoxide scavenger. Drug Chem. Toxicol., 26: 87-98.
4. Burns, N. and B. Gold, 2006. The effect of 3-methyladenine-DNA- glycosylase mediated DNA repair on the induction of toxicity and diabetes by the β-cell toxicant streptozotocin. Toxicol. Sci., 95: 391-400.
5. Cardinal, J.W., G.P. Margison, K.J. Mynett, A.P. Yates, D.P. Cameron and R.H. Elder, 2001. Increased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase- deficient mice. Mol. Cell Biol., 21: 5605-5613.
6. Cederberg, J., S. Basu and U.J. Eriksson, 2001. Increased rate of lipid peroxidation and protein carbonylation in experimental diabetic pregnancy. Diabetologi, 44: 766-774.
7. Damasceno, D.C., G.T. Volpato, M.P. Calderon I de and M.V.C. Rudge, 2002. Oxidative stress and diabetes in pregnant rats. Anim. Reprod. Sci., 72: 235-244.
8. El-Bassiouni, E.A., M.H. Helmy, Abou N. Rawash, S.M. El-Zoghby, M.A. Kamel and A.N. Abou Rayah, 2005. Embryopathy in experimental diabetic gestation: Assessment of oxidative stress and antioxidant defence. Br. J. Biomed. Sci., 62: 71-76.
9. El Gazzar, M., R. El Mezayen, J.C. Marecki, M.R. Nicolls, A. Canastar and S.C. Dreskin, 2006. Antiinflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int. Immunopharmacol., 6: 1135-1142.
10. El-Mahmoudy, A., H. Matsuyama, M.A. Borgan, Y. Shimizu, M.G. El-Sayed, M. Minamoto and T. Takewaki, 2002. Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int. Immunopharmacol., 2: 1603-1611.
11. Eriksson, U.J. and C.M. Siman, 1996. Pregnant diabetic rats fed the antioxidant butylated hydroxytoluene show decreased occurrence of malformations in offspring. Diabetes, 45: 1497-1502.
12. Fararh, K.M., Y. Shimizu, T. Shiina, H. Nikami, M.M. Ghanem and T. Takewaki, 2005. Thymoquinone reduces hepatic glucose production in diabetic hamsters. Res. Vet. Sci., 79: 219-223.
13. Fong, K.L., P.B. McCay, J.L. Poyer, B.B. Keele and H. Misra, 1973. Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity. J. Biol. Chem., 248: 7792-7797.
14. Gali-Muhtasib, H., A. Roessner and Shneider-Stock, 2006. Thymoquinone: A promising anti-cancer drug from natural sources. Int. J. Biochem. Cell Biol., 38: 1249-1253.
15. Galindo, A., A.G. Burguillo, S. Azriel and L. Fuente Pde, 2006. Outcome of fetuses in women with pregestational diabetes mellitus. J. Perinet Med., 34: 323-331.
16. Gosden, R.G. and R.E. Fowler, 1978. Corpus luteum function in aging inbred mice. Experimentia, 35: 128-130.
17. Harold, R.B., H.K. Pinar, L.P. Sandra and G. Shiping, 2001. Oxidative stress and ovary. J. Soc. Gynecol. Invest., 8: S40-S42.
18. Houghton, P.J., R. Zarka, B. de las Heras and J.R. Hoult, 1995. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med., 61: 33-36.
19. Nasrat, H., W. Fageeh, B. Abalkhail, T. Yamani and M.S. Ardawi, 1996. Determinants of pregnancy outcome in patients with gestational diabetes. Int. J. Gynaecol. Obstet., 53: 117-123.
20. Okomoto, H. and H. Yamamoto, 1983. DNA strands break and poly (ADP-ribose) synthetase activation in pancreatic islets: A new aspect of development of IDD and pancreatic β-cell tumors. Princess Takamatsu Symp., 13: 297-308.
21. Padmanabham, R., S. Mohammed and S. Singh, 2006. Beneficial effect of supplemental lipoic acid on diabetes-induced pregnancy loss in the mouse. Ann. N.Y. Acad Sci., 1084: 118-131.
22. Rosenn, B., M. Miodovnik, C.A. Corns, J. Khoury and T.A. Siddiqui. 1994. Glycemic thresholds for spontaneous abortion and congenital malformation in insulin-dependent diabetes mellitus. Obstet. Gynecol., 84: 515-520.
23. Sakami, H., S. Akazawa, M. Ishibashi, K. Izumino, H. Takino, H. Yamasaki, Y. Yamaguchi, S. Goto, Y. Urata, T. Condo and S. Nagataki., 1999. Significance of glutathione dependent anti-oxidant system in diabetes-induced embryonic malformations. Diabetes, 48: 1138-1144.
24. Salem, M.L., 2005. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int. Immunopharmacol., 5: 1749-1770.
25. Sedlak, J. and R.H. Lindsay, 1968. Estimation of total, protein-bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem., 25: 192-205.
26. Siman, C.M. and U.J. Eriksson, 1997. Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats. Diabetes, 46: 1054-1061.
27. Sivan, E., E.A. Reece, Y.K. Wu, C.J. Homko, M. Polansky and M. Borenstein, 1996. Dietary vitamin E prophylaxis and diabetic embropathy. Morphologic and biochemical analysis. Am. J. Obstet. Gynecol., 175: 793-799.
28. Viana, M., E. Herrera and B. Bonet, 1996. Teratogenic effects of diabetes mellitus in the rat. Prevention by vitamin E. Diabetologia, 39: 1041-1046.
29. Wentzel, P. and U.J. Eriksson, 1998. Antioxidants diminish developmental damage induced by high glucose and cyclooxygenase inhibitors in rat embryos in vitro. Diabetes, 47: 677-684.
30. West, I.C., 2000. Radicals and oxidative stress in diabetes. Diebet. Med., 17: 171-180.
31. Yang, J., E.A. Cummings, C. O'connell and K. Jangaard, 2006. Fetal and neonatal outcomes of diabetic pregnancies. Obstet. Gynecol., 108: 644-650.