Local and systemic immune responses in pigs intramuscularly injected with an inactivated Mycoplasma hyopneumoniae vaccine

Vaccine

Volumn 31, Issue 9, 2013, Pages 1305-1311

  Marchioro, Silvana Beutinger ^a,b   Maes, Dominiek ^a   Flahou, Bram ^a   Pasmans, Frank ^a   Del Pozo Sacristán, Rubén ^a   Vranckx, Katleen ^a   Melkebeek, Vesna ^a   Cox, Eric ^a   Wuyts, Niels ^c   Haesebrouck, Freddy ^a  

^a GHENT UNIVERSITY   (Belgium)

^b FEDERAL UNIVERSITY OF PELOTAS   (Brazil)

^c PFIZER INC   (United States)

Author keywords

Enzootic pneumonia; Immune response; Mycoplasma hyopneumoniae; Vaccine

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL VACCINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12; MYCOPLASMA HYOPNEUMONIAE VACCINE; SODIUM CHLORIDE; SUVAXYN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; EUTHANASIA; FLOW CYTOMETRY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IN VITRO STUDY; LUNG; LUNG LAVAGE; LYMPH NODE; LYMPHOCYTE SUBPOPULATION; MYCOPLASMA HYOPNEUMONIAE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; SPLEEN; SWINE DISEASE; VACCINATION;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; BLOOD; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; ENZYME-LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INJECTIONS, INTRAMUSCULAR; LEUKOCYTES, MONONUCLEAR; MYCOPLASMA HYOPNEUMONIAE; PNEUMONIA OF SWINE, MYCOPLASMAL; SWINE; VACCINES, INACTIVATED;

EID: 84873415371     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.12.068     Document Type: Article

References (28)

1. Maes D., Segales J., Meyns T., Sibila M., Pieters M., Haesebrouck F. Control of Mycoplasma hyopneumoniae infections in pigs. Vet Microbiol 2008, 126(January (4)):297-309.
2. Lin J.H., Weng C.N., Liao C.W., Yeh K.S., Pan M.J. Protective effects of oral microencapsulated Mycoplasma hyopneumoniae vaccine prepared by co-spray drying method. J Vet Med Sci 2003, 65(January (1)):69-74.
3. Djordjevic S.P., Eamens G.J., Romalis L.F., Nicholls P.J., Taylor V., Chin J. Serum and mucosal antibody responses and protection in pigs vaccinated against Mycoplasma hyopneumoniae with vaccines containing a denatured membrane antigen pool and adjuvant. Aust Vet J 1997, 75(July (7)):504-511.
4. Thacker E.L., Thacker B.J., Kuhn M., Hawkins P.A., Waters W.R. Evaluation of local and systemic immune responses induced by intramuscular injection of a Mycoplasma hyopneumoniae bacterin to pigs. Am J Vet Res 2000, 61(November (11)):1384-1389.
5. Kick A.R., Tompkins M.B., Mark H.J., Routh P.A., Almond G.W. Evaluation of peripheral lymphocytes after weaning and vaccination for Mycoplasma hyopneumoniae. Res Vet Sci 2011, 91(December (3)):68-72.
6. Vraa-Andersen L., Christensen G. Mycoplasma induced pneumonia in pigs (enzootic pneumonia). A clinical trial of the vaccine Suvaxyn M. hyo. Dansk Vet Tidsskr 1993, 76:129-132.
7. Stark K.D., Nicolet J., Frey J. Detection of Mycoplasma hyopneumoniae by air sampling with a nested PCR assay. Appl Environ Microbiol 1998, 64(February (2)):543-548.
8. Marois C., Dory D., Fablet C., Madec F., Kobisch M. Development of a quantitative Real-Time TaqMan PCR assay for determination of the minimal dose of Mycoplasma hyopneumoniae strain 116 required to induce pneumonia in SPF pigs. J Appl Microbiol 2010, 108(May (5)):1523-1533.
9. Van den Broeck W., Cox E., Goddeeris B.M. Induction of immune responses in pigs following oral administration of purified F4 fimbriae. Vaccine 1999, 17:2020-2029.
10. Bereiter M., Young T.F., Joo H.S., Ross R.F. Evaluation of the elisa and comparison to the complement-fixation test and radial immunodiffusion enzyme assay for detection of antibodies against Mycoplasma-hyopneumoniae in swine serum. Vet Microbiol 1990, 25(November (2-3)):177-192.
11. Yang H., Oura C.A.L., Kirkham P.A., Parkhouse R.M.E. Preparation of monoclonal anti-porcine CD3 antibodies and preliminary characterization of porcine T lymphocytes. Immunology 1996, 88(August (4)):577-585.
12. Pescovitz M.D., Lunney J.K., Sachs D.H. Preparation and characterization of monoclonal-antibodies reactive with porcine Pbl. J Immunol 1984, 133(1):368-375.
13. Saalmuller A., Aasted B., Canals A., Dominguez J., Goldman T., Lunney J.K., et al. Analyses of Mab reactive with porcine Cd8. Vet Immunol Immunopathol 1994, 43(October (1-3)):249-254.
14. Sibila M., Nofrarias M., Lopez-Soria S., Segalés J., Valero O., Espinal A., et al. Chronological study of Mycoplasma hyopneumoniae infection, seroconversion and associated lung lesions in vaccinated and non-vaccinated pigs. Vet Microbiol 2007, 122(May (1-2)):97-107.
15. Villarreal I., Maes D., Vranckx K., Calus D., Pasmans F., Haesebrouck F. Effect of vaccination of pigs against experimental infection with high and low virulence Mycoplasma hyopneumoniae strains. Vaccine 2011, 29(February (9)):1731-1735.
16. Thacker E.L., Thacker B.J., Boettcher T.B., Jayappa H. Comparison of antibody production, lymphocyte stimulation, and protection induced by four commercial Mycoplasma hyopneumoniae bacterins. Swine Health Prod 1998, 6(May (3)):107-112.
17. Borghetti P., De Angelis E., Saleri R., Cavalli V., Cacchioli A., Corradi A., et al. Peripheral T lymphocyte changes in neonatal piglets: relationship with growth hormone (GH), prolactin (PRL) and cortisol changes. Vet Immunol Immunopathol 2006, 110(March (1-2)):17-25.
18. Stepanova H., Samankova P., Leva L., Sinkora J., Faldyna M. Early postnatal development of the immune system in piglets: the redistribution of T lymphocyte subsets. Cell Immunol 2007, 249(October (2)):73-79.
19. Jones H.P., Simecka J.W. T lymphocyte responses are critical determinants in the pathogenesis and resistance to Mycoplasma respiratory disease. Front Biosci 2003, 8(May):930-945.
20. Meyns T., Dewulf J., de K.A., Calus D., Haesebrouck F., Maes D. Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations. Vaccine 2006, 24(November (49-50)):7081-7086.
21. Conti P., Kempuraj D., Kandere K., Di Giocchino M., Barbace R.C., Castellani M.L., et al. IL-10, an inflammatory/inhibitory cytokine, but not always. Immunol Lett 2003, 86(April (2)):123-129.
22. Vranckx K., Maes D., Marchioro S.B., Villarreal I., Chiers K., Pasmans F., et al. Vaccination reduces macrophage infiltration in bronchus-associated lymphoid tissue in pigs infected with a highly virulent Mycoplasma hyopneumoniae strain. BMC Vet Res 2012, (March):8.
23. Yang J., Hooper W.C., Phillips D.J., Talkington D.F. Cytokines in Mycoplasma pneumoniae infections. Cytokine Growth Factor Rev 2004, 15(April (2-3)):157-168.
24. Park A.Y., Scott P.I.L-12. Keeping cell-mediated immunity alive. Scand J Immunol 2001, 53(June (6)):529-532.
25. Choi C., Kwon D., Jung K., Ha Y., Lee Y.H., Kim O., et al. Expression of inflammatory cytokines in pigs experimentally infected with Mycoplasma hyopneumoniae. J Comp Pathol 2006, 134(January (1)):40-46.
26. Asai T., Okada M., Ono M., Irisawa T., Mori Y., Yokomizo Y., et al. Increased Levels of tumor-necrosis-factor and interleukin-1 in bronchoalveolar lavage fluids from pigs infected with Mycoplasma-hyopneumoniae. Vet Immunol Immunopathol 1993, 38(October (3-4)):253-260.
27. Okada M., Asai T., Ono M., Sakano T., Sato S. Cytological and immunological changes in bronchoalveolar lavage fluid and histological observation of lung lesions in pigs immunized with Mycoplasma hyopneumoniae inactivated vaccine prepared from broth culture supernate. Vaccine 2000, 18(June (25)):2825-2831.
28. Sheldrake R.F., Gardner I.A., Saunders M.M., Romalis L.F. Serum antibody-response to Mycoplasma-hyopneumoniae measured by enzyme-linked-immunosorbent-assay after experimental and natural infection of pigs. Aust Vet J 1990, 67(February (2)):39-42.