Control of Mycoplasma hyopneumoniae infections in pigs

Veterinary Microbiology

Volumn 126, Issue 4, 2008, Pages 297-309

  Maes, D ^a   Segales, J ^b   Meyns, T ^a   Sibila, M ^b   Pieters, M ^c   Haesebrouck, F ^a  

^a GHENT UNIVERSITY   (Belgium)

^b CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Control; Eradication; Medication; Mycoplasma hyopneumoniae; Vaccination

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BACTERIAL VACCINE; BACTERIN; CEPHALOSPORIN DERIVATIVE; CHLORTETRACYCLINE; DNA VACCINE; FLORFENICOL; LINCOSAMIDE DERIVATIVE; MACROLIDE; PENICILLIN G; PLEUROMUTILIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULFADIMIDINE; TETRACYCLINE; TIAMULIN; TYLOSIN;

CELLULAR IMMUNITY; CLIMATE CHANGE; DRUG EFFICACY; ERADICATION THERAPY; HERD; IMMUNITY; INFECTION RISK; LUNG INJURY; MYCOPLASMA HYOPNEUMONIAE; MYCOPLASMAL PNEUMONIA OF SWINE; NONHUMAN; PIG FARMING; PNEUMONIA; RESPIRATORY TRACT DISEASE; REVIEW; SWINE; VACCINATION;

ANIMAL HUSBANDRY; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL VACCINES; HOUSING, ANIMAL; MYCOPLASMA HYOPNEUMONIAE; PNEUMONIA OF SWINE, MYCOPLASMAL; SWINE; VACCINATION; WEIGHT GAIN;

MYCOPLASMA HYOPNEUMONIAE; SUIDAE;

EID: 36549032157     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2007.09.008     Document Type: Review

References (81)

1. Amass S., and Baysinger A. Swine disease transmission and prevention. In: Straw B.E., Zimmerman J.J., D'Allaire S., and Taylor D.J. (Eds). Diseases of Swine. 9th ed. (2006), Blacwell Publishing Ltd., Oxford, UK 1075-1098
2. Baccaro M., Hirose F., Umehara O., Gonçalves L., Doto D., Paixão R., Shinya L., and Moreno A. Comparative efficacy of two single-dose bacterins in the control of Mycoplasma hyopneumoniae in swine raised under commercial conditions in Brazil. Vet. J. 172 (2006) 526-531
3. Bandrick M., Pieters M., Pijoan C., and Molitor T. Cellular immune response in piglets following sow vaccination wit Mycoplasma hyopneumoniae. Proceedings of the Allen D. Leman Swine Conference, vol. 33, Supplement (2006), College of Veterinary Medicine, University of Minnesota, Minneapolis MN, USA 11
4. Bargen L. A system response to an outbreak of enzootic pneumonia in grow/finish pigs. Can. Vet. J. 45 (2004) 856-859
5. Batista L., Pijoan C., Ruiz A., Utrera V., and Dee S. Assessment of transmission of Mycoplasma hyopneumoniae by personnel. J. Swine Health Prod. 12 (2004) 75-77
6. Blanchard B., Vena M., Cavalier A., Lannic J., Gouranton J., Kobisch M., and Le-Lannic J. Electron microscopic observation of the respiratory tract of SPF piglets inoculated with Mycoplasma hyopneumoniae. Vet. Microbiol. 30 (1992) 329-341
7. Boettcher T., Thacker B., Halbur P., Waters W., Nutsch R., and Thacker E. Vaccine efficacy and immune response to Mycoplasma hyopneumoniae challenge in pigs vaccinated against porcine reproductive and respiratory syndrome virus and M. hyopneumoniae. J. Swine Health Prod. 10 (2002) 259-264
8. Burnett T., Dinkla K., Rohde M., Chatwal G., Uphoff C., Srivastava M., Cordwell S., Geary S., Liao X., Minion C., Walker M., and Djordjevic S. P159 is a proteolytic processed surface adhesin of Mycoplasma hyopneumoniae: defined domains of P159 bind heparin and promote adherence to eukaryote cells. Mol. Microbiol. 60 (2006) 669-686
9. Calsamiglia M., Pijoan C., and Trigo A. Application of a nested polymerase chain reaction assay to detect Mycoplasma hyopneumoniae from nasal swabs. J. Vet. Diagn. Invest. 11 (1999) 246-251
10. Calus D., Baele M., Meyns T., de Kruif A., Butaye P., Decostere A., Haesebrouck F., and Maes D. Protein variability among Mycoplasma hyopneumoniae isolates. Vet. Microbiol. 120 (2007) 284-291
11. Chen A., Fry S., Forbes-Faulkner J., Daggard G., and Mukkur T. Comparative immunogenicity of Mycoplasma hyopneumoniae NrdF encoded in different expression systems delivered orally via attenuated S. Typhimurium aroA in mice. Vet. Microbiol. 114 (2006) 252-259
12. Chen J.R., Lin L.H., Weng C.N., and Lai S.S. Identification of a novel adhesin-like glycoprotein from Mycoplasma hyopneumoniae. Vet. Microbiol. 62 (1998) 97-110
13. Chen Y.L., Wang S.N., Yang W., Chen Y.J., Lin H.H., and Shiuan D. Expression and immunogenicity of Mycoplasma hyopneumoniae heat shock protein antigen P42 by DNA vaccination. Infect. Immun. 71 (2003) 1155-1160
14. Clark L., Freeman M., Scheidt A., and Knox K. Investigating the transmission of Mycoplasma hyopneumoniae in a swine herd with enzootic pneumonia. Vet. Med. 86 (1991) 543-550
15. Clark L., Hill M., Kniffen T., VanAlstine W., Stevenson G., Meyer K., Wu C., Scheidt A., Knox K., and Albregts S. An evaluation of the components of medicated early weaning. Swine Health Prod. 2 (1994) 5-11
16. Djordjevic S., Eamens G., Romalis L., Nicholls P., Taylor V., and Chin J. Serum and mucosal antibody responses and protection in pigs vaccinated against Mycoplasma hyopneumoniae with vaccines containing a denatured membrane antigen pool and adjuvant. Aust. Vet. J. 75 (1997) 504-511
17. Fagan P., Walker M., Chin J., Eamens G., and Djordjevic S. Oral immunization of swine with attenuated Salmonella Typhimurium aroA SL3261 expressing a recombinant antigen of Mycoplasma hyopneumoniae (NrdF) primes the immune system for a NrDF specific secretory IgA response in the lungs. Microb. Pathogenesis 30 (2001) 101-110
18. Flesja K., and Solberg I. Pathological lesions in swine at slaughter. Acta Vet. Scand. 22 (1981) 272-282
19. Gardner A., Willeberg P., and Mousing J. Empirical and theoretical evidence for herd size as a risk factor for swine diseases. Anim. Health Res. Rev. 3 (2002) 43-55
20. Geary S., and Walczak E. Isolation of a cytopathic factor from Mycoplasma hyopneumoniae. Infect. Immun. 48 (1985) 576-578
21. Gonyou H., Lemay S., and Zhang Y. Effects of the environment on productivity and disease. In: Straw B.E., Zimmerman J.J., D'Allaire S., and Taylor D.J. (Eds). Diseases of Swine. 9th ed. (2006), Blacwell Publishing Ltd., Oxford, UK 1027-1038
22. Goodwin R. Apparent reinfection of enzootic-pneumonia-free pig herds: search for possible causes. Vet. Rec. 116 (1985) 690-694
23. Haesebrouck F., Pasmans F., Chiers K., Maes D., Ducatelle R., and Decostere A. Efficacy of vaccines against bacterial diseases in swine: what can we expect?. Vet. Microbiol. 100 (2004) 255-268
24. Harris H., and Alexander T. Methods of disease control. In: Straw B., D'Allaire S., Mengeling W., and Taylor D. (Eds). Diseases of Swine. 8th ed. (1999), Iowa State University Press, Ames 1077-1110
25. Haruna J., Hanna P., Hurnik D., Ikede B., Miller L., and Yason C. The role of immunostimulation in the development of postweaning multisystemic wasting syndrome in pigs under field conditions. Can. J. Vet. Res. 70 (2006) 269-276
26. Hodgins D., Shewen P., and Dewey C. Influence of age and maternal antibodies on antibody responses of neonatal piglets vaccinated against Mycoplasma hyopneumoniae. J. Swine Health Prod. 12 (2004) 10-16
27. Hoy S., Mehlhorn G., Hörügel K., Dorn W., Eulenberger K., and Johannsen U. Der Einfluss ausgewählter endogener Faktoren auf das Auftreten entzündlicher Lungenveränderungen bei Schweinen. Mh. Vet. Med. 41 (1986) 397-400
28. Inamoto T., Takahashi H., Yamamoto K., Nakai Y., and Ogimoto K. Antibiotic susceptibility of Mycoplasma hyopneumoniae isolated from swine. J. Vet. Med. Sci. 56 (1994) 393-394
29. Jayappa H., Davis B., Rapp-Gabrielson V., Wasmoen T., and Thacker E. Evaluation of the efficacy of Mycoplasma hyopneumoniae bacterin follwoing immunization of young pigs in the presence of varying levels of maternal antibodies. Proceedings of the 32nd Annual Meeting. Am. Assoc. Swine Vet., Nashville, Tennessee (2001) 237-241
30. Jensen D., Ersboll A., and Nielsen J. A meta-analysis comparing the effect of vaccines against Mycoplasma hyopneumoniae on daily weight gain in pigs. Prev. Vet. Med. 54 (2002) 265-278
31. Jones G., Rapp-Gabrielson V., Wilke R., Thacker E., Thacker B., Gergen L., Sweeney D., and Wasmoen T. Intradermal vaccination for Mycoplasma hyopneumoniae. J. Swine Health Prod. 13 (2004) 19-27
32. Joo H.S. Segregated parity production: a potential method to improve production and health. Int. Pigletter 23 (2003) 5-6
33. King K., Faulds D., Rosey E., and Yancey R. Characterization of the gene encoding Mhp1 from Mycoplasma hyopneumoniae and examination of Mhp1's vaccine potential. Vaccine 15 (1996) 25-35
34. Le Grand A., and Kobisch M. Comparaison de l'utilisation d'un vaccin et d'un traitement antibiotique séquentiel dans un élevage infecté par Mycoplasma hyopneumoniae. Vet. Med. 27 (1996) 241-253
35. Lin J., Weng C., Liao C., Yeh K., and Pan M. Protective effects of oral microencapsulated Mycoplasma hyopneumoniae vaccine prepared by co-spray drying method. J. Vet. Med. Sci. 65 (2003) 69-74
36. Madec F. The risk factors of respiratory diseases on fatteners in intensive breeding-finishing units. Proceedings of the 8th IPVS Congress. Ghent, Belgium (1984) 349
37. Maes D., Deluyker H., Verdonck M., Castryck F., Miry C., Lein A., Vrijens B., and de Kruif A. Effect of vaccination against Mycoplasma hyopneumoniae in pig herds with a continuous production system. J. Vet. Med. B 45 (1998) 495-505
38. Maes D., Deluyker H., Verdonck M., Castryck F., Miry C., Vrijens B., Verbeke W., Viaene J., and de Kruif A. Effect of vaccination against Mycoplasma hyopneumoniae in pig herds with an all-in/all-out production system. Vaccine 17 (1999) 1024-1034
39. Maes D., Deluyker H., Verdonck M., Castryck F., Miry C., Vrijens B., and de Kruif A. Risk indicators for the seroprevalences of Mycoplasma hyopneumoniae, porcine infuenza viruses and Aujeszky's disease virus in slaughter pigs from fattening pig herds. J. Vet. Med. B 46 (1999) 341-352
40. Maes D., Deluyker H., Verdonck M., Castryck F., Miry C., Vrijens B., and de Kruif A. Risk indicators for the seroprevalences of Mycoplasma hyopneumoniae, porcine influenza viruses and Aujeszky's disease virus in slaughter pigs from farrow-to-finish pig herds in Belgium. Vet. Res. 31 (2000) 313-327
41. Maes D., Deluyker H., Verdonck M., Castryck F., Miry C., Vrijens B., Ducatelle R., and de Kruif A. Non-infectious herd factors associated with macroscopic and microscopic lung lesions in slaughter pigs from farrow-to-finish pig herds. Vet. Rec. 148 (2001) 41-46
42. Maes D., Verbeke W., Vicca J., Verdonck M., and de Kruif A. Benefit to cost of vaccination against Mycoplasma hyopneumoniae in pig herds under Belgian market conditions from 1996 to 2000. Livest. Prod. Sci. 83 (2003) 85-93
43. Martelli P., Terreni M., Guazzetti S., and Cavirani S. Antibody response to Mycoplasma hyopneumoniae infection in vaccinated pigs with or without maternal antibodies induced by sow vaccination. J. Vet. Med. B 53 (2006) 229-233
44. Mateusen B., Maes D., Van Goubergen M., Verdonck M., and de Kruif A. Effectiveness of treatment with lincomycin hydrochloride and/or vaccination against Mycoplasma hyopneumoniae for controlling chronic respiratory disease in a herd of pigs. Vet. Rec. 151 (2002) 135-140
45. Meyns T., Dewulf J., de Kruif A., Calus D., Haesebrouck F., and Maes D. Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations. Vaccine 24 (2006) 7081-7086
46. Meyns T., Maes D., Calus D., Ribbens S., Dewulf J., Chiers K., de Kruif A., Cox E., Decostere A., and Haesebrouck F. Interactions of highly and low virulent Mycoplasma hyopneumoniae isolates with the respiratory tract of pigs. Vet. Microbiol. 120 (2007) 87-95
47. Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., and Mahairas G.G. The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis. J. Bacteriol. 186 (2004) 7123-7133
48. Murphy D., Van Alstine W., Clark K., Albregts S., and Knox K. Aerosol vaccination of pigs against Mycoplasma hyopneumoniae infection. Am. J. Vet. Res. 54 (1993) 1874-1880
49. Okamba F., Moreau E., Bouh C., Gagnon C., Massie B., and Arella M. Immune responses induced by replication-defective andenovirus expressing the C-terminal portion of Mycoplasma hyopneumoniae-P97 adhesin. Clin. Vaccine Immunol. 14 (2007) 767-774
50. Opriessnig T., Halbur P., Yu S., Thacker E., Fenaux M., and Meng X. Effects of the timing of Mycoplasma hyopneumoniae bacterin on the development of lesions associated with porcine circovirus type 2. Vet. Rec. 158 (2006) 149-154
51. Opriessnig T., Yu S., Gallup J., Evans R., Fenaux M., Pallares F., Thacker E., Brockus C., Ackermann M., Thomas P., Meng X., and Halbur P. Effect of vaccination with selective bacterins on conventional pigs infected with type 2 porcine circovirus. Vet. Pathol. 41 (2003) 624-640
52. Park S.C., Yibchok-Anun S., Cheng H., Young T.F., Tacker E.L., Minion F.C., Ross R.F., and Hsu W.H. Mycoplasma hyopneumoniae increased intracellular calcium release in porcine ciliated tracheal cells. Infect. Immun. 70 (2002) 2502-2506
53. Pointon A., Heap P., and McCloud P. Enzootic pneumonia of pigs in South Australia-factors relating to incidence of disease. Aust. Vet. J. 62 (1985) 98-100
54. Razin S., Yogev D., and Naot Y. Molecular biology and pathogenicity of Mycoplasmas. Microbiol. Mol. Biol. Rev. 62 (1998) 1094-1156
55. Sørensen V., Ahrens P., Barfod K., Feenstra A., Feld N., Friis N., Bille-Hansen V., Jensen N., and Pedersen M. Mycoplasma hyopneumoniae infection in pigs: duration of the disease and evaluation of four diagnostic assays. Vet. Microbiol. 54 (1997) 23-34
56. Shimoji Y., Oishi E., Muneta Y., Nosaka H., and Mori Y. Vaccine efficacy of the attenuated Erysipelothrix rhusiopathiae YS-19 expressing a recombinant protein of Mycoplasma hyopneumoniae P97 adhesin against mycoplasmal pneumonia of swine. Vaccine 21 (2003) 532-537
57. Sibila M., Bernal R., Torrent D., March R., Llopart D., Riera P., and Calsamiglia M. Effect of Mycoplasma hyopneumoniae sow vaccination on colonization, seroconversion and presence of enzootic pneumonia compatible lung lesions. Proceedings of the 19th IPVS congress. Copenhagen, Denmark (2006) 103
58. Sibila M., Calsamiglia M., Nofrarías M., López-Soria S., Espinal A., Segalés J., Riera P., Llopart D., and Artigas C. Longitudinal study of Mycoplasma hyopneumonicae infection in naturally infected pigs. Proceedings of the 18th IPVS congress. Hamburg, Germany (2004) 169
59. Sibila M., Calsamiglia M., Vidal D., Badiella Ll., Aldaz A., and Jensen J.D. Dynamics of Mycoplasma hyopneumonicae infection in twelve farms with different production systems. Can. J. Vet. Res. 68 (2004) 12-18
60. Sibila M., Nofrari{dotless}as M., Lopez-Soria S., Segales J., Riera P., Llopart D., and Calsamiglia M. Exploratory field study on Mycoplasma hyopneumoniae infection in suckling pigs. Vet. Microbiol. 121 (2007) 352-356
61. Sibila M., Nofrarías M., López-Soria S., Segalés J., Valero O., Espinalm A., and Calsamiglia M. Chronological study of Mycoplasma hyopneumoniae infection, seroconversion and associated lung lesions in vaccinated and non-vaccinated pigs. Vet. Microbiol. 122 (2007) 97-107
62. Stakenborg T., Vicca J., Maes D., Peeters J., de Kruif A., Haesebrouck F., and Butaye P. Comparison of molecular techniques for the typing of Mycoplasma hyopneumoniae isolates. J. Microbiol. Methods 66 (2006) 263-275
63. Stärk K. Epidemiological investigation of the influence of environmental risk factors on respiratory diseases in swine-a literature review. Vet. J. 159 (2000) 37-56
64. Tajima M., Yagihashi T., Nunoya T., Takeuchi A., and Ohashi F. Mycoplasma hyopneumoniae infection in pigs immunosuppressed by thymectomy and treatment with antithymocyte serum. Am. J. Vet. Res. 45 (1984) 1928-1932
65. Thacker B., Thacker E., Halbur P., Minion C., Young T., Erickson B., and Thanawonguwech T. The influence of maternally-derived antibodies on Mycoplasma hyopneumoniae infection. Proceedings of the 16th IPVS Congress. Melbourne, Australia (2000) 454
66. Thacker E. Diagnosis of Mycoplasma hyopneumoniae. Anim. Health Res. Rev. 5 (2004) 317-320
67. Thacker E. Mycoplasmal diseases. In: Straw B.E., Zimmerman J.J., D'Allaire S., and Taylor D.J. (Eds). Diseases of Swine. 9th ed. (2006), Blacwell Publishing Ltd., Oxford, UK 701-717
68. Thacker E., Halbur P., Ross R., Thanawongnuwech R., and Thacker B. Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia. J. Clin. Microbiol. 37 (1999) 620-627
69. ® chlortetracycline (CTC) granulated premix in decreasing the potentiation of PRRSV pneumonia by Mycoplasma hyopneumoniae. Proceedings of the 37th Annual Meeting. Am. Assoc. Swine Vet., Kansas City, Missouri (2006) 153-155
70. Thacker E., Thacker B., Boettcher T., and Jayappa H. Comparison of antibody production, lymphocyte stimulation, and protection induced by four commercial Mycoplasma hyopneumoniae bacterins. J. Swine Health Prod. 6 (1998) 107-112
71. Thacker E., Thacker B., Kuhn M., Hawkins P., and Waters W. Evaluation of local and systemic immune responses induced by intramuscular injection of a Mycoplasma hyopneumoniae bacterin to pigs. Am. J. Vet. Res. 61 (2000) 1384-1389
72. Thacker E., Thacker B., and Wolff T. Efficacy of a chlortetracycline feed additive in reducing pneumonia and clinical signs induced by experimental Mycoplasma hyopneumoniae challenge. J. Swine Health Prod. 14 (2004) 140-144
73. Thacker E., Thacker B., Young Th., and Halbur P. Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae. Vaccine 18 (2000) 1244-1252
74. Vasconcelos A.T., Ferreira H.B., Bizarro C.V., Bonatto S.L., Carvalho M.O., Pinto P.M., Almeida D.F., Almeida R., ALves-Filho L., Assunçao E.N., Azevedo V.A., Bogo M.R., Brigido M.M., Brocchi M., Helio A.B., Camargo A.A., Camargo S.S., Carepo M.S., Carraro D.C., de Mattos Cascardo J.C., Castro L.A., Cavalcanti G., Chemale G., Collevatti R.G., Cunha C.W., Dallagiovanna B., Dambrós B.P., Dellagostin O.A., Falcão C., Fantinatti-Garboggini F., Felipe M.S.S., Fiorentin L., Franco G.R., Freitas N.S.A., Frías D., Grangeiro T.B., Grisard E.C., Guimarães C.T., Hungria M., Jardim S.N., Krieger M.A., Laurino J.P., Lima L.F.A., Lopes M.I., Loreto E.L.S., Madeira H.M.F., Manfio G.P., Maranhão A.Q., Martinkovics C.T., Medeiros S.R.B., Moreira M.A.M., Neiva M., Ramalho-Neto C.O., Nicolás M.F., Oliveira S.C., Paixão R.F.C., Pedrosa F.O., Pena S.D.J., Pereira M., Pereira-Ferrari L., Piffer I., Pinto L.S., Potrich D.P., Salim A.C.M., Santos F.R., Schmitt R., Schneider M.P.C., Schrank A., Schrank I.S., Schuck A.F., Seuanez H.N., Silva D.W., Silva R., Silva S.C., Soares C.M.A., Souza K.R.L., Souza R.C., Staats C.C., Steffens M.B.R., Teixeira S.M.R., Urmenyi T.P., Vainstein M.H., Zuccherato L.W., Simpson A.J.H., and Zaha A. Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae. J. Bacteriol. 187 (2005) 5568-5577
75. Vicca J., Maes D., Jonker L., de Kruif A., and Haesebrouck F. The efficacy of tylosin premix for the treatment and control of Mycoplasma hyopneumoniae infections. Vet. Rec. 156 (2005) 606-610
76. Vicca, J., 2005. Virulence and antimicrobial susceptibility of Mycoplasma hyopneumoniae isolates from pigs. PhD thesis, Faculty of Veterinary Medicine, Ghent University, ISBN 90-5864-086-8, 219 pp.
77. Vicca J., Stakenborg T., Maes D., Butaye P., Peeters J., de Kruif A., and Haesebrouck F. In vitro susceptibilities of Mycoplasma hyopneumoniae field isolates. Antimicrob. Agents Chemother. 48 (2004) 4470-4472
78. Vicca J., Thermote L., Maes D., D'Hooghe I., Peeters J., Haesebrouck F., and de Kruif A. Patterns of Mycoplasma hyopneumoniae infection in closed pig herds using serology and nested PCR on nasal samples. J. Vet. Med. B 49 (2002) 349-353
79. Whittlestone P. Control of Enzootic Pneumonia Infection in Pigs. Zentralblatt (Suppl.) 20 (1990), Gustav Fischer Verlag, Stuttgart, New York pp. 254-259
80. Zhang Q., Young T.F., and Ross R.F. Identification and characterization of Mycoplasma hyopneumoniae adhesins. Infect. Immun. 62 (1995) 1616-1622
81. Zimmerman W., Odermatt W., and Tschudi P. Enzootische Pneumonie (EP): die Teilsanierung EP-reinfizierter Schweinezuchtbetriebe als Alternative zur Totalsanierung. Schweiz. Arch. Tierheilk. 131 (1989) 179-191