Synthesis of (Z) isomers of benzoheterocyclic derivatives of combretastatin A-4: A comparative study of several methods

Tetrahedron

Volumn 69, Issue 10, 2013, Pages 2336-2347

  Nguyen, Thi Thanh Binh ^a   Lomberget, Thierry ^a   Tran, Ngoc Chau ^a   Barret, Roland ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

Alkene; Diarylacetylene; Semi hydrogenation; Sonogashira coupling; Suzuki coupling

Indexed keywords

(2 FORMYL 4 METHOXY PHENYL) ESTER; (2 FORMYL 4 NITRO PHENYL) ESTER; 1 BENZENESULFONYL 2 (3,4,5 TRIMETHOXY PHENYL ETHYNYL) 1H INDOLE; 2 (3,4,5 TRIMETHOXY PHENYLETHYNYL) 1H INDOLE; 2 (3,4,5 TRIMETHOXY PHENYLETHYNYL) THIOPHENE; 2 (3,4,5 TRIMETHOXY PHENYLETHYNYL)BENZO[B]THIOPHENE; 2 [2 (3,4,5 TRIMETHOXY PHENYL) VINYL] BENZO[B]THIOPHENE; 2 [2 (3,4,5 TRIMETHOXY PHENYL) VINYL] BENZOFURAN; 2 [2 (3,4,5 TRIMETHOXY PHENYL) VINYL] INDOLE 1 CARBOXYLIC ACID TERT BUTYL ESTER; 2 [2 TRIETHYLSILANYL 2 (3,4,5 TRIMETHOXY PHENYL) VINYL] 1H INDOLE; 2 BROMO 5 METHOXYBENZALDEHYDE; 5 METHOXY 2 (3,4,5 TRIMETHOXY PHENYLETHYNYL) BENZO[B]THIOPHENE; 5 NITRO 2 (3,4,5 TRIMETHOXY PHENYLETHYNYL) BENZO[B]THIOPHENE; [2 (2,2 DIBROMO VINYL) 4METHOXY PHENYL] ESTER; [2 BENZOFURAN 2 YL 1 (3,4,5 TRIMETHOXY PHENYL) VINYL] ETHOXYDIMETHYLSILANE; [2 BENZOFURAN 2 YL 1 (3,4,5 TRIMETHOXY PHENYL) VINYL] TRIETHYLSILANE; ACETYLENE DERIVATIVE; ALKENE; BENZOFURAN DERIVATIVE; BENZOTHIOPHENE DERIVATIVE; COLCHICINE; COMBRETASTATIN A4; DIARYLACETYLENE DERIVATIVE; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; PALLADIUM ACETATE; SILANE DERIVATIVE; THIOPHENE DERIVATIVE; TRIMETHOXYSTYRENE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CYCLIZATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGENATION; HYDROLYSIS; HYDROSILYLATION; IC 50; ISOMER; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; SONOGASHIRA REACTION; STEREOCHEMISTRY; STEREOISOMERISM; SUZUKI REACTION; WITTIG REACTION;

EID: 84873410816     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2013.01.005     Document Type: Article

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