Targeting FOXM1 in cancer

Biochemical Pharmacology

Volumn 85, Issue 5, 2013, Pages 644-652

  Halasi, Marianna ^a   Gartel, Andrei L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Apoptosis; ARF; FOXM1; NPM; Proteasome inhibitors; RNAi

Indexed keywords

2,3,4 TRIBROMO 3 METHYL 1 PHENYLPHOSPHOLANE 1 OXIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 3,3 DIINDOLYLMETHANE; 9D; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CENTROMERE PROTEIN A; CENTROMERE PROTEIN B; CISPLATIN; DOCETAXEL; EPIRUBICIN; FULVESTRANT; GEFITINIB; GENISTEIN; LAPATINIB; MG 115; NATURA ALPHA; PACLITAXEL; POLO LIKE KINASE 1; PROTEASOME INHIBITOR; SIOMYCIN A; SMALL INTERFERING RNA; TAMOXIFEN; THIAZOLE; THIOSTREPTON; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXM1; TRANSCRIPTION FACTOR FOXM1 INHIBITOR; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BASAL CELL NEVUS SYNDROME; BREAST CANCER; CANCER CELL; CANCER INVASION; CANCER PROGNOSIS; CELL CYCLE PROGRESSION; CELL MIGRATION; CHROMOSOME SEGREGATION; CYTOKINESIS; DNA BINDING; DNA REPLICATION; DOWN REGULATION; DRUG TARGETING; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GAMMA IRRADIATION; GENE OVEREXPRESSION; GLIOMA; HUMAN; LARGE CELL LYMPHOMA; LARYNX CARCINOMA; LEUKEMIA; LIVER CELL CARCINOMA; MELANOMA; METASTASIS; MICROARRAY ANALYSIS; MOUTH SQUAMOUS CELL CARCINOMA; NASOPHARYNX CARCINOMA; NEOPLASM; NEUROBLASTOMA; NONHUMAN; OROPHARYNX CARCINOMA; OSTEOSARCOMA; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; THYROID CARCINOMA; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; DRUG DESIGN; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; RNA INTERFERENCE;

EID: 84873408961     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.10.013     Document Type: Review

References (124)

1. W. Korver, J. Roose, K. Heinen, D.O. Weghuis, D. de Bruijn, and A.G. van Kessel The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization Genomics 46 1997 435 442
2. K.M. Yao, M. Sha, Z. Lu, and G.G. Wong Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain J Biol Chem 272 1997 19827 19836
3. H. Ye, T.F. Kelly, U. Samadani, L. Lim, S. Rubio, and D.G. Overdier Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues Mol Cell Biol 17 1997 1626 1641
4. J. Laoukili, M. Stahl, and R.H. Medema FoxM1. At the crossroads of ageing and cancer Biochim Biophys Acta 1775 2007 92 102
5. W. Korver, J. Roose, and H. Clevers The winged-helix transcription factor Trident is expressed in cycling cells Nucleic Acids Res 25 1997 1715 1719
6. J.M. Luscher-Firzlaff, J.M. Westendorf, J. Zwicker, H. Burkhardt, M. Henriksson, and R. Muller Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation Oncogene 18 1999 5620 5630
7. I. Wierstra, and J. Alves FOXM1 a typical proliferation-associated transcription factor Biol Chem 388 2007 1257 1274
8. Z. Fu, L. Malureanu, J. Huang, W. Wang, H. Li, and J.M. van Deursen Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression Nat Cell Biol 2008
9. Y.J. Chen, C. Dominguez-Brauer, Z. Wang, J.M. Asara, R.H. Costa, and A.L. Tyner A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1 J Biol Chem 284 2009 30695 30707
10. L. Anders, N. Ke, P. Hydbring, Y.J. Choi, H.R. Widlund, and J.M. Chick A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells Cancer Cell 20 2011 620 634
11. X. Wang, H. Kiyokawa, M.B. Dennewitz, and R.H. Costa The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration Proceedings of the National Academy of Sciences of the United States of America 99 2002 16881 16886
12. I.C. Wang, Y.J. Chen, D.E. Hughes, T. Ackerson, M.L. Major, and V.V. Kalinichenko FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness J Biol Chem 283 2008 20770 20778
13. I.C. Wang, Y.J. Chen, D. Hughes, V. Petrovic, M.L. Major, and H.J. Park Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase Mol Cell Biol 25 2005 10875 10894
14. X. Wang, H. Kiyokawa, M.B. Dennewitz, and R.H. Costa The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration Proceedings of the National Academy of Sciences of the United States of America 99 2002 16881 16886
15. X. Wang, E. Quail, N.J. Hung, Y. Tan, H. Ye, and R.H. Costa Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver Proceedings of the National Academy of Sciences of the United States of America 98 2001 11468 11473
16. J. Laoukili, M.R. Kooistra, A. Bras, J. Kauw, R.M. Kerkhoven, and A. Morrison FoxM1 is required for execution of the mitotic programme and chromosome stability Nat Cell Biol 7 2005 126 136
17. D.R. Wonsey, and M.T. Follettie Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe Cancer Res 65 2005 5181 5189
18. R.H. Costa FoxM1 dances with mitosis Nat Cell Biol 7 2005 108 110
19. M.T. Teh, S.T. Wong, G.W. Neill, L.R. Ghali, M.P. Philpott, and A.G. Quinn FOXM1 is a downstream target of Gli1 in basal cell carcinomas Cancer Res 62 2002 4773 4780
20. C. Pilarsky, M. Wenzig, T. Specht, H.D. Saeger, and R. Grutzmann Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data Neoplasia (New York, NY) 6 2004 744 750
21. D.W. Chan, S.Y. Yu, P.M. Chiu, K.M. Yao, V.W. Liu, and A.N. Cheung Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis J Pathol 215 2008 245 252
22. S. Romagnoli, E. Fasoli, V. Vaira, M. Falleni, C. Pellegrini, and A. Catania Identification of potential therapeutic targets in malignant mesothelioma using cell-cycle gene expression analysis Am J Pathol 174 2009 762 770
23. M. Liu, B. Dai, S.H. Kang, K. Ban, F.J. Huang, and F.F. Lang FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells Cancer Res 66 2006 3593 3602
24. J.G. Hodgson, R.F. Yeh, A. Ray, N.J. Wang, I. Smirnov, and M. Yu Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts Neuro-oncol 11 2009 477 487
25. J. Yu, H. Deshmukh, J.E. Payton, C. Dunham, B.W. Scheithauer, and T. Tihan Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor Clin Cancer Res 17 2011 1924 1934
26. M. Priller, J. Poschl, L. Abrao, A.O. von Bueren, Y.J. Cho, and S. Rutkowski Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients Clin Cancer Res 17 2011 6791 6801
27. E. Gemenetzidis, A. Bose, A.M. Riaz, T. Chaplin, B.D. Young, and M. Ali FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation PLoS One 4 2009 e4849
28. C.H. Chen, C.Y. Chien, C.C. Huang, C.F. Hwang, H.C. Chuang, and F.M. Fang Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity Oncogene 28 2009 2723 2737
29. J.R. Janus, R.R. Laborde, A.J. Greenberg, V.W. Wang, W. Wei, and A. Trier Linking expression of FOXM1, CEP55 and HELLS to tumorigenesis in oropharyngeal squamous cell carcinoma Laryngoscope 121 2011 2598 2603
30. M. Ahmed, S. Uddin, A.R. Hussain, A. Alyan, Z. Jehan, and F. Al-Dayel FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma J Clin Endocrinol Metabol 97 2012 E1 E13
31. M.K. Hui, K.W. Chan, J.M. Luk, N.P. Lee, Y. Chung, and L.C. Cheung Cytoplasmic Forkhead box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage World J Surg 36 2012 90 97
32. L.Z. Jiang, P. Wang, B. Deng, C. Huang, W.X. Tang, and H.Y. Lu Overexpression of Forkhead Box M1 transcription factor and nuclear factor-kappaB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis Hum Pathol 42 2011 1185 1193
33. H. Chen, C. Yang, L. Yu, L. Xie, J. Hu, and L. Zeng Adenovirus-mediated RNA interference targeting FOXM1 transcription factor suppresses cell proliferation and tumor growth of nasopharyngeal carcinoma J Gene Med 14 2012 231 240
34. I. Laurendeau, M. Ferrer, D. Garrido, N. D'Haene, P. Ciavarelli, and A. Basso Gene expression profiling of the hedgehog signaling pathway in human meningiomas Mol Med (Cambridge, Mass) 16 2010 262 270
35. S. Nakamura, I. Hirano, K. Okinaka, T. Takemura, D. Yokota, and T. Ono The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia Carcinogenesis 31 2010 2012 2021
36. D. Bell, A. Berchuck, M. Birrer, J. Chien, D. Cramer, and F. Dao Integrated genomic analyses of ovarian carcinoma Nature 474 2011 609 615
37. D.R. Rhodes, J. Yu, K. Shanker, N. Deshpande, R. Varambally, and D. Ghosh Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression Proceedings of the National Academy of Sciences of the United States of America 101 2004 9309 9314
38. D.K. Yang, C.H. Son, S.K. Lee, P.J. Choi, K.E. Lee, and M.S. Roh Forkhead box M1 expression in pulmonary squamous cell carcinoma: correlation with clinicopathologic features and its prognostic significance Hum Pathol 40 2009 464 470
39. N. Bektas, A. Haaf, J. Veeck, P.J. Wild, J. Luscher-Firzlaff, and A. Hartmann Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer BMC Cancer 8 2008 42
40. Q. Li, N. Zhang, Z. Jia, X. Le, B. Dai, and D. Wei Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression Cancer Res 69 2009 3501 3509
41. H.C. Sun, M. Li, J.L. Lu, D.W. Yan, C.Z. Zhou, and J.W. Fan Overexpression of Forkhead box M1 protein associates with aggressive tumor features and poor prognosis of hepatocellular carcinoma Oncol Rep 25 2011 1533 1539
42. J.T. Xia, H. Wang, L.J. Liang, B.G. Peng, Z.F. Wu, and L.Z. Chen Overexpression of FOXM1 is associated with poor prognosis and clinicopathologic stage of pancreatic ductal adenocarcinoma Pancreas 41 2012 629 635
43. K.J. Martin, D.R. Patrick, M.J. Bissell, and M.V. Fournier Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets PLoS One 3 2008 e2994
44. C. Kretschmer, A. Sterner-Kock, F. Siedentopf, W. Schoenegg, P.M. Schlag, and W. Kemmner Identification of early molecular markers for breast cancer Mol Cancer 10 2011 15
45. T.V. Kalin, V. Ustiyan, and V.V. Kalinichenko Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models Cell Cycle (Georgetown, Tex) 10 2011 396 405
46. P. Raychaudhuri, and Park H.J. FoxM1. A Master Regulator of Tumor Metastasis Cancer Res 71 2011 4329 4333
47. E. Gemenetzidis, D. Elena-Costea, E.K. Parkinson, A. Waseem, H. Wan, and M.T. Teh Induction of human epithelial stem/progenitor expansion by FOXM1 Cancer Res 70 2010 9515 9526
48. K. Krupczak-Hollis, X. Wang, V.V. Kalinichenko, G.A. Gusarova, I.C. Wang, and M.B. Dennewitz The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis Dev Biol 276 2004 74 88
49. I.M. Kim, S. Ramakrishna, G.A. Gusarova, H.M. Yoder, R.H. Costa, and V.V. Kalinichenko The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature J Biol Chem 280 2005 22278 22286
50. W. Korver, M.W. Schilham, P. Moerer, M.J. van den Hoff, K. Dam, and W.H. Lamers Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident Curr Biol 8 1998 1327 1330
51. S. Ramakrishna, I.M. Kim, V. Petrovic, D. Malin, I.C. Wang, and T.V. Kalin Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor Dev Dyn 236 2007 1000 1013
52. T.V. Kalin, I.C. Wang, T.J. Ackerson, M.L. Major, C.J. Detrisac, and V.V. Kalinichenko Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Progression of Prostate Carcinomas in both TRAMP and LADY Transgenic Mice Cancer Res 66 2006 1712 1720
53. Y. Yoshida, I.C. Wang, H.M. Yoder, N.O. Davidson, and R.H. Costa The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer Gastroenterology 132 2007 1420 1431
54. I.M. Kim, T. Ackerson, S. Ramakrishna, M. Tretiakova, I.C. Wang, and T.V. Kalin The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer Cancer Res 66 2006 2153 2161
55. Z. Wang, S. Banerjee, D. Kong, Y. Li, and F.H. Sarkar Down-regulation of Forkhead Box M1 Transcription Factor Leads to the Inhibition of Invasion and Angiogenesis of Pancreatic Cancer Cells Cancer Res 67 2007 8293 8300
56. J. Zeng, L. Wang, Q. Li, W. Li, M. Bjorkholm, and J. Jia FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1 J Pathol 218 2009 419 427
57. H.J. Park, J.R. Carr, Z. Wang, V. Nogueira, N. Hay, and A.L. Tyner FoxM1, a critical regulator of oxidative stress during oncogenesis EMBO J 28 2009 2908 2918
58. A. Ahmad, Z. Wang, D. Kong, S. Ali, Y. Li, and S. Banerjee FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors Breast Cancer Res Treat 2010
59. X.Y. Chu, Z.M. Zhu, L.B. Chen, J.H. Wang, Q.S. Su, and J.R. Yang FOXM1 expression correlates with tumor invasion and a poor prognosis of colorectal cancer Acta Histochem 2012
60. B. Dai, S.H. Kang, W. Gong, M. Liu, K.D. Aldape, and R. Sawaya Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells Oncogene 26 2007 6212 6219
61. Y. Zhang, N. Zhang, B. Dai, M. Liu, R. Sawaya, and K. Xie FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells Cancer Res 68 2008 8733 8742
62. U.G. Bhat, R. Jagadeeswaran, M. Halasi, and A.L. Gartel Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells J Biol Chem 286 2011 41425 41433
63. Z. Wang, H.J. Park, J.R. Carr, Y.J. Chen, Y. Zheng, and J. Li FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors Cancer Res 71 2011 4292 4302
64. M. Wang, and A.L. Gartel The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA Oncotarget 2 2011 1218 1226
65. Y.Y. Park, S.Y. Jung, N. Jennings, C. Rodriguez-Aguayo, G. Peng, and S.R. Lee FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair Carcinogenesis 2012
66. S.K. Radhakrishnan, U.G. Bhat, D.E. Hughes, I.C. Wang, R.H. Costa, and A.L. Gartel Identification of a Chemical Inhibitor of the Oncogenic Transcription Factor Forkhead Box M1 Cancer Res 66 2006 9731 9735
67. U.G. Bhat, P.A. Zipfel, D.S. Tyler, and A.L. Gartel Novel anticancer compounds induce apoptosis in melanoma cells Cell Cycle (Georgetown, Tex) 7 2008 1851 1855
68. U.G. Bhat, M. Halasi, and A.L. Gartel Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells PLoS One 4 2009 e5592
69. J.M. Kwok, S.S. Myatt, C.M. Marson, R.C. Coombes, D. Constantinidou, and E.W. Lam Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression Mol Cancer Therap 7 2008 2022 2032
70. G.H. Nesbitt, and P.R. Fox Clinical evaluation of Panolog Cream used to treat canine and feline dermatoses Vet Med Small Anim Clin 76 1981 535 538
71. G. Lentzen, R. Klinck, N. Matassova, F. Aboul-ela, and A.I. Murchie Structural basis for contrasting activities of ribosome binding thiazole antibiotics Chem Biol 10 2003 769 778
72. T. Uchiumi, A. Wada, and R. Kominami A base substitution within the GTPase-associated domain of mammalian 28 S ribosomal RNA causes high thiostrepton accessibility J Biol Chem 270 1995 29889 29893
73. M. Halasi, and A.L. Gartel A novel mode of FoxM1 regulation: positive auto-regulatory loop Cell Cycle (Georgetown, Tex) 8 2009 1966 1967
74. U.G. Bhat, M. Halasi, and A.L. Gartel FoxM1 is a general target for proteasome inhibitors PLoS One 4 2009 e6593
75. A. Sors, F. Jean-Louis, C. Pellet, L. Laroche, L. Dubertret, and G. Courtois Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis Blood 107 2006 2354 2363
76. C. Nakanishi, and M. Toi Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs Nat Rev Cancer 5 2005 297 309
77. A. Nencioni, F. Grunebach, F. Patrone, A. Ballestrero, and P. Brossart Proteasome inhibitors: antitumor effects and beyond Leukemia 21 2007 30 36
78. A.L. Gartel A new target for proteasome inhibitors: FoxM1 Expert Opin Invest Drugs 19 2010 235 242
79. N.S. Hegde, D.A. Sanders, R. Rodriguez, and S. Balasubramanian The transcription factor FOXM1 is a cellular target of the natural product thiostrepton Nat Chem 3 2011 725 731
80. A.L. Gartel Thiostrepton, proteasome inhibitors and FOXM1 Cell Cycle (Georgetown, Tex) 10 2011 4341 4342
81. S. Uddin, A.R. Hussain, M. Ahmed, K. Siddiqui, F. Al-Dayel, and P. Bavi Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma Haematologica 97 2012 1092 1100
82. M. Halasi, H. Zhao, H. Dahari, U.G. Bhat, E.B. Gonzalez, and A.V. Lyubimov Thiazole antibiotics against breast cancer Cell Cycle (Georgetown, Tex) 2010 9
83. B. Pandit, and A.L. Gartel New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer Prostate 70 2010 825 833
84. S. Uddin, M. Ahmed, A. Hussain, J. Abubaker, N. Al-Sanea, and A. AbdulJabbar Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy Am J Pathol 178 2011 537 547
85. M. Wang, and A.L. Gartel Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts Mol Cancer Therap 10 2011 2287 2297
86. L.J. Crawford, B. Walker, and A.E. Irvine Proteasome inhibitors in cancer therapy J Cell Commun Signal 5 2011 101 110
87. A.F. Kisselev, W.A. van der Linden, and H.S. Overkleeft Proteasome inhibitors: an expanding army attacking a unique target Chem Biol 19 2012 99 115
88. B. Pandit, U.G. Bhat, and A. Gartel Proteasome inhibitory activity of thiazole antibiotics Cancer Biol Therapy 11 2011 36 40
89. E.S. Kandel NFkappaB inhibition and more: a side-by-side comparison of the inhibitors of IKK and proteasome Cell Cycle (Georgetown, Tex) 8 2009 1819 1820
90. B. Pandit, and A.L. Gartel FoxM1 knockdown sensitizes human cancer cells to proteasome inhibitor-induced apoptosis but not to autophagy Cell Cycle (Georgetown, Tex) 10 2011 3269 3273
91. J.R. Carr, H.J. Park, Z. Wang, M.M. Kiefer, and P. Raychaudhuri FoxM1 mediates resistance to herceptin and paclitaxel Cancer Res 70 2010 5054 5063
92. A. Ahmad, S. Ali, Z. Wang, A.S. Ali, S. Sethi, and W.A. Sakr 3,3'-Diindolylmethane enhances taxotere-induced growth inhibition of breast cancer cells through downregulation of FoxM1 Int J Cancer 129 2011 1781 1791
93. J.M. Kwok, B. Peck, L.J. Monteiro, H.D. Schwenen, J. Millour, and R.C. Coombes FOXM1 confers acquired cisplatin resistance in breast cancer cells Mol Cancer Res 8 2010 24 34
94. J. Millour, D. Constantinidou, A.V. Stavropoulou, M.S. Wilson, S.S. Myatt, and J.M. Kwok FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance Oncogene 29 2010 2983 2995
95. Z. Wang, A. Ahmad, S. Banerjee, A. Azmi, D. Kong, and Y. Li FoxM1 is a novel target of a natural agent in pancreatic cancer Pharm Res 27 2010 1159 1168
96. N. Xu, X. Zhang, X. Wang, H.Y. Ge, X.Y. Wang, and D. Garfield FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells Acta Pharmacol Sin 33 2012 675 681
97. M. Halasi, and A.L. Gartel Suppression of FOXM1 Sensitizes Human Cancer Cells to Cell Death Induced by DNA-Damage PLoS One 7 2012 e31761
98. R.B. Shirley, I. Kaddour-Djebbar, D.M. Patel, V. Lakshmikanthan, R.W. Lewis, and M.V. Kumar Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells Neoplasia (New York, NY) 7 2005 1104 1111
99. J. Park, V. Ayyappan, E.K. Bae, C. Lee, B.S. Kim, and B.K. Kim Curcumin in combination with bortezomib synergistically induced apoptosis in human multiple myeloma U266 cells Mol Oncol 2 2008 317 326
100. B. Pandit, and A.L. Gartel Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells PLoS One 6 2011 e17110
101. M. Wang, and A.L. Gartel Combination with bortezomib enhances the antitumor effects of nanoparticle-encapsulated thiostrepton Cancer Biol Therapy 13 2012 184 189
102. Z. Wang, Y. Li, A. Ahmad, S. Banerjee, A.S. Azmi, and D. Kong Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells J Cell Biochem 112 2011 78 88
103. B. Bao, Z. Wang, S. Ali, D. Kong, S. Banerjee, and A. Ahmad Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells J Cell Biochem 2011
104. Y. Li, M. Ligr, J.P. McCarron, G. Daniels, D. Zhang, and X. Zhao Natura-alpha targets forkhead box m1 and inhibits androgen-dependent and -independent prostate cancer growth and invasion Clin Cancer Res 17 2011 4414 4424
105. U.B. McGovern, R.E. Francis, B. Peck, S.K. Guest, J. Wang, and S.S. Myatt Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer Mol Cancer Therap 8 2009 582 591
106. R.E. Francis, S.S. Myatt, J. Krol, J. Hartman, B. Peck, and U.B. McGovern FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer Int J Oncol 35 2009 57 68
107. C.T. Karadedou, A.R. Gomes, J. Chen, M. Petkovic, K.K. Ho, and A.K. Zwolinska FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer Oncogene 31 2011 1845 1858
108. P.A. Madureira, R. Varshochi, D. Constantinidou, R.E. Francis, R.C. Coombes, and K.M. Yao The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells J Biol Chem 281 2006 25167 25176
109. B. Pandit, M. Halasi, and A.L. Gartel p53 negatively regulates expression of FoxM1 Cell Cycle (Georgetown, Tex) 8 2009 3425 3427
110. A.M. Barsotti, and C. Prives Pro-proliferative FoxM1 is a target of p53-mediated repression Oncogene 28 2009 4295 4305
111. Y. Tan, P. Raychaudhuri, and R.H. Costa Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes Mol Cell Biol 27 2007 1007 1016
112. J. Millour, N. de Olano, Y. Horimoto, L.J. Monteiro, J.K. Langer, and R. Aligue ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance Mol Cancer Therap 10 2011 1046 1058
113. Y. Li, X. Li, M. Hussain, and F.H. Sarkar Regulation of microtubule, apoptosis, and cell cycle-related genes by taxotere in prostate cancer cells analyzed by microarray Neoplasia (New York, NY) 6 2004 158 167
114. Y. Li, X. Hong, M. Hussain, S.H. Sarkar, R. Li, and F.H. Sarkar Gene expression profiling revealed novel molecular targets of docetaxel and estramustine combination treatment in prostate cancer cells Mol Cancer Therap 4 2005 389 398
115. V. Petrovic, R.H. Costa, L.F. Lau, P. Raychaudhuri, and A.L. Tyner Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin Cancer Biol Therapy 9 2010 1008 1016
116. S. Nakamura, M. Yamashita, D. Yokota, I. Hirano, T. Ono, and M. Fujie Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity Invest New Drugs 28 2009 381 391
117. S.A. Caldwell, S.R. Jackson, K.S. Shahriari, T.P. Lynch, G. Sethi, and S. Walker Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1 Oncogene 29 2010 2831 2842
118. V.V. Kalinichenko, M.L. Major, X. Wang, V. Petrovic, J. Kuechle, and H.M. Yoder Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor Genes Dev 18 2004 830 850
119. R.H. Costa, V.V. Kalinichenko, M.L. Major, and P. Raychaudhuri New and unexpected: forkhead meets ARF Curr Opin Genetics Dev 15 2005 42 48
120. G.A. Gusarova, I.C. Wang, M.L. Major, V.V. Kalinichenko, T. Ackerson, and V. Petrovic A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment J Clin Invest 117 2007 99 111
121. H.J. Park, G. Gusarova, Z. Wang, J.R. Carr, J. Li, and K.H. Kim Deregulation of FoxM1b leads to tumour metastasis EMBO Mol Med 3 2011 21 34
122. E.S. Kandel, T. Lu, Y. Wan, M.K. Agarwal, M.W. Jackson, and G.R. Stark Mutagenesis by reversible promoter insertion to study the activation of NF-kappaB Proceedings of the National Academy of Sciences of the United States of America 102 2005 6425 6430
123. A.L. Gartel, and E.S. Kandel RNA interference in cancer Biomol Eng 2006
124. S.K. Radhakrishnan, and A.L. Gartel FOXM1: the Achilles' heel of cancer? Nat Rev Cancer 8 2008 c1 [author reply c2]