Elderly patients with colon cancer have unique tumor characteristics and poor survival

Cancer

Volumn 119, Issue 4, 2013, Pages 739-747

  Patel, Supriya S ^a   Nelson, Rebecca ^b   Sanchez, Julian ^b   Lee, Wendy ^b   Uyeno, Lori ^b   Garcia Aguilar, Julio ^b   Hurria, Arti ^b   Kim, Joseph ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

age; colon cancer; disparities; elderly; Los Angeles County

Indexed keywords

ADULT; AGE; AGE DISTRIBUTION; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER SURVIVAL; CLINICAL FEATURE; COLON CANCER; CONTROLLED STUDY; DISEASE SPECIFIC SURVIVAL; ELDERLY CARE; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PATIENT IDENTIFICATION; PRIORITY JOURNAL; TUMOR LOCALIZATION; TUMOR VOLUME;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; COLONIC NEOPLASMS; FEMALE; HUMANS; LOS ANGELES; MALE; MIDDLE AGED; SURVIVAL RATE; YOUNG ADULT;

EID: 84873406620     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27753     Document Type: Article

References (45)

1. Jemal A, Siegel R, Xu J, Ward E,. Cancer statistics, 2010. CA Cancer J Clin. 2010; 60: 277-300.
2. Rim SH, Seeff L, Ahmed F, King JB, Coughlin SS,. Colorectal cancer incidence in the United States, 1999-2004: an updated analysis of data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results Program. Cancer. 2009; 115: 1967-1976.
3. United States Census Bureau. U.S. Interim Projections by Age, Sex, Race, and Hispanic Origin: 2000-2050. http://www.census.gov/population/www/ projections/usinterimproj/ Accessed July 6, 2011.
4. Berger NA, Savvides P, Koroukian SM, et al. Cancer in the elderly. Trans Am Clin Climatol Assoc. 2006; 117: 147-155.
5. Ahuja N, Li Q, Mohan AL, Baylin SB, Issa JP,. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res. 1998; 58: 5489-5494.
6. Yancik R, Ries LA,. Cancer in older persons. Magnitude of the problem-how do we apply what we know? Cancer. 1994; 74: 1995-2003.
7. Jessup JM, McGinnis LS, Steele GD Jr, Menck HR, Winchester DP,. The National Cancer Data Base. Report on colon cancer. Cancer. 1996; 78: 918-926.
8. Kune GA, Kune S, Field B, et al. Survival in patients with large-bowel cancer. A population-based investigation from the Melbourne Colorectal Cancer Study. Dis Colon Rectum. 1990; 33: 938-946.
9. Dekker JW, van den Broek CB, Bastiaannet E, van de Geest LG, Tollenaar RA, Liefers GJ,. Importance of the first postoperative year in the prognosis of elderly colorectal cancer patients. Ann Surg Oncol. 2011; 18: 1533-1539.
10. Waldron RP, Donovan IA, Drumm J, Mottram SN, Tedman S,. Emergency presentation and mortality from colorectal cancer in the elderly. Br J Surg. 1986; 73: 214-216.
11. Kunitake H, Zingmond DS, Ryoo J, Ko CY,. Caring for octogenarian and nonagenarian patients with colorectal cancer: what should our standards and expectations be? Dis Colon Rectum. 2010; 53: 735-743.
12. Lemmens VE, Janssen-Heijnen ML, Houterman S, et al. Which comorbid conditions predict complications after surgery for colorectal cancer? World J Surg. 2007; 31: 192-199.
13. Mulcahy HE, Patchett SE, Daly L, O'Donoghue DP,. Prognosis of elderly patients with large bowel cancer. Br J Surg. 1994; 81: 736-738.
14. Irvin TT,. Prognosis of colorectal cancer in the elderly. Br J Surg. 1988; 75: 419-421.
15. Holt PR, Kozuch P, Mewar S,. Colon cancer and the elderly: from screening to treatment in management of GI disease in the elderly. Best Pract Res Clin Gastroenterol. 2009; 23: 889-907.
16. Wu X, Chen VW, Martin J, et al. Comparative Analysis of Incidence Rates Subcommittee, Data Evaluation and Publication Committee, North American Association of Central Cancer Registries. Subsite-specific colorectal cancer incidence rates and stage distributions among Asians and Pacific Islanders in the United States, 1995 to 1999. Cancer Epidemiol Biomarkers Prev. 2004; 13: 1215-1222.
17. Iacopetta B, Grieu F, Amanuel B,. Microsatellite instability in colorectal cancer. Asia Pac J Clin Oncol. 2010; 6: 260-269.
18. Turner NJ, Haward RA, Mulley GP, Selby PJ,. Cancer in old age-is it inadequately investigated and treated? BMJ. 1999; 319: 309-312.
19. Hodgson DC, Fuchs CS, Ayanian JZ,. Impact of patient and provider characteristics on the treatment and outcomes of colorectal cancer. J Natl Cancer Inst. 2001; 93: 501-515.
20. Kahn KL, Adams JL, Weeks JC, et al. Adjuvant chemotherapy use and adverse events among older patients with stage III colon cancer. JAMA. 2010; 303: 1037-1045.
21. Fata F, Mirza A, Craig G, et al. Efficacy and toxicity of adjuvant chemotherapy in elderly patients with colon carcinoma: a 10-year experience of the Geisinger Medical Center. Cancer. 2002; 94: 1931-1938.
22. Sundararajan V, Mitra N, Jacobson JS, Grann VR, Heitjan DF, Neugut AI,. Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with node-positive colon cancer. Ann Intern Med. 2002; 136: 349-357.
23. Sargent DJ, Goldberg RM, Jacobson SD, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med. 2001; 345: 1091-1097.
24. Popescu RA, Norman A, Ross PJ, Parikh B, Cunningham D,. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol. 1999; 17: 2412-2418.
25. Kim J, Sun CL, Mailey B, et al. Race and ethnicity correlate with survival in patients with gastric adenocarcinoma. Ann Oncol. 2010; 21: 152-160.
26. Kim J, Artinyan A, Mailey B, et al. An interaction of race and ethnicity with socioeconomic status in rectal cancer outcomes. Ann Surg. 2011; 253: 647-654.
27. Butcher D, Hassanein K, Dudgeon M, Rhodes J, Holmes FF,. Female gender is a major determinant of changing subsite distribution of colorectal cancer with age. Cancer. 1985; 56: 714-716.
28. Derwinger K, Gustavsson B,. Variations in demography and prognosis by colon cancer location. Anticancer Res. 2011; 31: 2347-2350.
29. Aldridge MC, Phillips RK, Hittinger R, Fry JS, Fielding LP,. Influence of tumour site on presentation, management and subsequent outcome in large bowel cancer. Br J Surg. 1986; 73: 663-670.
30. Snaebjornsson P, Jonasson L, Jonsson T, Möller PH, Theodors A, Jonasson JG,. Colon cancer in Iceland-a nationwide comparative study on various pathology parameters with respect to right and left tumor location and patients age. Int J Cancer. 2010; 127: 2645-2653.
31. Benedix F, Kube R, Meyer F, Schmidt U, Gastinger I, Lippert H,; Colon/Rectum Carcinomas (Primary Tumor) Study Group. Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival. Dis Colon Rectum. 2010; 53: 57-64.
32. Benatti P, Gafà R, Barana D, et al. Microsatellite instability and colorectal cancer prognosis. Clin Cancer Res. 2005; 11: 8332-8340.
33. Vilar E, Gruber SB,. Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010; 7: 153-162.
34. Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med. 2003; 349: 247-257.
35. Siegel RL, Ward EM, Jemal A,. Trends in colorectal cancer incidence rates in the United States by tumor location and stage, 1992-2008. Cancer Epidemiol Biomarkers Prev. 2012; 21: 411-416.
36. Manser CN, Bachmann LM, Brunner J, Hunold F, Bauerfeind P, Marbet UA,. Colonoscopy screening markedly reduces the occurrence of colon carcinomas and carcinoma-related death: a closed cohort study. Gastrointest Endosc. 2012; 76: 110-117.
37. Violi V, Pietra N, Grattarola M, et al. Curative surgery for colorectal cancer: long-term results and life expectancy in the elderly. Dis Colon Rectum. 1998; 41: 291-298.
38. Latkauskas T, Rudinskaite G, Kurtinaitis J, et al. The impact of age on post-operative outcomes of colorectal cancer patients undergoing surgical treatment. BMC Cancer. 2005; 5: 153.
39. Devon KM, Vergara-Fernandez O, Victor JC, McLeod RS,. Colorectal cancer surgery in elderly patients: presentation, treatment, and outcomes. Dis Colon Rectum. 2009; 52: 1272-1277.
40. McMillan DC, Hole DJ, McArdle CS,. The impact of old age on cancer-specific and non-cancer-related survival following elective potentially curative surgery for Dukes A/B colorectal cancer. Br J Cancer. 2008; 99: 1046-1049.
41. Widdison AL, Barnett SW, Betambeau N,. The impact of age on outcome after surgery for colorectal adenocarcinoma. Ann R Coll Surg Engl. 2011; 93: 445-450.
42. Kelder W, Inberg B, Schaapveld M, et al. Impact of the number of histologically examined lymph nodes on prognosis in colon cancer: a population-based study in the Netherlands. Dis Colon Rectum. 2009; 52: 260-267.
43. Landrum MB, Keating NL, Lamont EB, Bozeman SR, McNeil BJ,. Reasons for underuse of recommended therapies for colorectal and lung cancer in the Veterans Health Administration. Cancer. 2012; 118: 3345-3355.
44. Lewis JH, Kilgore ML, Goldman DP, et al. Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol. 2003; 21: 1383-1389.
45. Trimble EL, Carter CL, Cain D, Freidlin B, Ungerleider RS, Friedman MA,. Representation of older patients in cancer treatment trials. Cancer. 1994; 74 (7 suppl): 2208-2214.