Vitamin D insufficiency may impair CD4 recovery among Women's Interagency HIV Study participants with advanced disease on HAART

AIDS

Volumn 27, Issue 4, 2013, Pages 573-578

  Aziz, Mariam ^a,b   Livak, Britt ^b   Burke Miller, Jane ^b   French, Audrey L ^a,b   Glesby, Marshall J ^c   Sharma, Anjali ^d   Young, Mary ^e   Villacres, Maria C ^f   Tien, Phyllis C ^g,h   Golub, Elizabeth T ⁱ   Cohen, Mardge H ^a,b   Adeyemi, Oluwatoyin M ^a,b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Jr Hospital of Cook County   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d SUNY DOWNSTATE MEDICAL CENTER   (United States)

^e GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

antiretroviral therapy; HIV; immune reconstitution; vitamin D; women

Indexed keywords

25 HYDROXYVITAMIN D;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONVALESCENCE; DISEASE ASSOCIATION; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTOPOIESIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; VIRUS LOAD; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; FEMALE; HIV SEROPOSITIVITY; HUMANS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; MIDDLE AGED; PROSPECTIVE STUDIES; RNA, VIRAL; UNITED STATES; VIRAL LOAD; VITAMIN D DEFICIENCY; WOMEN'S HEALTH;

EID: 84873406560     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32835b9ba1     Document Type: Article

References (34)

1. Melamed ML, Michos ED, Post W, Astor B. 25-hydroxy vitamin D levels and the risk of mortality in the general population. Arch Intern Med 2008; 168:1629-1637.
2. Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-281.
3. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001; 22: 477-501.
4. Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyVitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 2007; 167:1159-1165.
5. Tsoukas CD, Provvedini DM, Manolagas SC. 1,25-dihydroxy vitamin D3: a novel immunoregulatory hormone. Science 1984; 224:1438-1440.
6. Aranow C. Vitamin D and the immune system. J Investig Med 2011; 59:881-886.
7. French AL, Adeyemi OM, Agniel DM, Evans CT, Yin MT, Anastos K, Cohen MH. The association of HIV status with bacterial vaginosis and vitamin D in the United States. J Womens Health (Larchmt) 2011; 20:1497-1503.
8. Vescini F, Cozzi-Lepri A, Borderi M, Re MC, Maggiolo F, De Luca A, et al. Prevalence of hypoVitaminosis D and factors associated with vitamin D deficiency and morbidity among HIV-infected patients enrolled in a large Italian cohort. J Acquir Immune Defic Syndr 2011; 58:163-172.
9. Mueller NJ, Fux CA, Ledergerber B, Elzi L, Schmid P, Dang T, et al. High prevalence of severe vitamin D deficiency in combined antiretroviral therapy-naive and successfully treated Swiss HIV patients. AIDS 2011; 24:1127-1134.
10. Mehta S, Giovannucci E, Mugusi FM, Spiegelman D, Aboud S, Hertzmark E, et al. Vitamin D status of HIV-infected women and its association with HIV disease progression, anemia, and mortality. PLoS One 2011; 5:e8770.
11. Adeyemi OM, Agniel D, French AL, Tien PC, Weber K, Glesby MJ, et al. Vitamin D deficiency in HIV-infected and HIVuninfected women in the United States. J Acquir Immune Defic Syndr 2011; 57:197-204.
12. Haug CJ, Aukrust P, Lien E, Muller F, Espevik T, Froland SS. Disseminated mycobacterium avium complex infection in AIDS: immunopathogenic significance of an activated tumor necrosis factor system and depressed serum levels of 1,25 dihydroxy vitamin D. J Infect Dis 1996; 173: 259-262.
13. Haug C, Muller F, Aukrust P, Froland SS. Subnormal serum concentration of 1,25-Vitamin D in human immunodeficiency virus infection: correlation with degree of immune deficiency and survival. J Infect Dis 1994; 169:889- 893.
14. Ross AC, Judd S, Kumari M, Hileman C, Storer N, Labbato D, et al. Vitamin D is linked to carotid intima-media thickness and immune reconstitution in HIV-positive individuals. Antivir Ther 2011; 16:555-563.
15. Barkan SE, Melnick SL, Preston-Martin S, Weber K, Kalish LA, Miotti P, et al. The Women's Interagency HIV Study. WIHS Collaborative Study Group. Epidemiology 1998; 9: 117-125.
16. Teixeira L, Valdez H, McCune JM, Koup RA, Badley AD, Hellerstein MK, et al. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 2001; 15:1749-1756.
17. Tuboi SH, Brinkhof MW, Egger M, Stone RA, Braitstein P, Nash D, et al. Discordant responses to potent antiretroviral treatment in previously naive HIV-1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaboration. J Acquir Immune Defic Syndr 2007; 45:52-59.
18. Nakanjako D, Kiragga A, Ibrahim F, Castelnuovo B, Kamya MR, Easterbrook PJ. Sub-optimal CD4 reconstitution despite viral suppression in an urban cohort on antiretroviral therapy (ART) in sub-Saharan Africa: frequency and clinical significance. AIDS Res Ther 2008; 5:23.
19. Gazzola L, Tincati C, Bellistri GM, Monforte A, Marchetti G. The absence of CD4R T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options. Clin Infect Dis 2009; 48:328-337.
20. Grabar S, Le Moing V, Goujard C, Leport C, Kazatchkine MD, Costagliola D, Weiss L. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy. Ann Intern Med 2000; 133:401-410.
21. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004; 80:1689S-1696S.
22. Chiu KC, Chu A, Go VL, Saad MF. HypoVitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 2004; 79:820-825.
23. Chandra G, Selvaraj P, Jawahar MS, Banurekha VV, Narayanan PR. Effect of vitamin D3 on phagocytic potential of macrophages with live Mycobacterium tuberculosis and lymphoproliferative response in pulmonary tuberculosis. J Clin Immunol 2004; 24:249-257.
24. Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001; 358:1500-1503.
25. Karnchanasorn R, Ou HY, Chiu KC. Plasma 25-hydroxy vitamin D levels are favorably associated with beta-cell function. Pancreas 2011:863-868.
26. Choi AI, Lo JC, Mulligan K, Schnell A, Kalapus SC, Li Y, et al. Association of vitamin D insufficiency with carotid intimamedia thickness in HIV-infected persons. Clin Infect Dis 2011; 52:941-944.
27. McGreevy C, Williams D. New insights about vitamin D and cardiovascular disease: a narrative review. Ann Intern Med 2011; 155:820-826.
28. Pelajo CF, Lopez-Benitez JM, Kent DM, Price LL, Miller LC, Dawson-Hughes B. 25-HydroxyVitamin D levels and juvenile idiopathic arthritis: is there an association with disease activity? Rheumatol Int 2011.
29. von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation ofhuman Tcells.Nat Immunol 2010; 11:344-349.
30. Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med (Berl) 2010; 88:441-450.
31. Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology 2011; 134: 123-139.
32. Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxy vitamin Dand risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008; 168:1174-1180.
33. Fiscella K, Franks P. Vitamin D, race, and cardiovascular mortality: findings from a national US sample. Ann Fam Med 2011; 8:11-18.
34. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008; 117:503-511.