Pharmacokinetics and clinical efficacy of phenobarbital in asphyxiated newborns treated with hypothermia: A thermopharmacological approach

Clinical Pharmacokinetics

Volumn 51, Issue 10, 2012, Pages 671-679

  Van Den Broek, M P H ^a   Groenendaal, F ^b   Toet, M C ^b   Van Straaten, H L M ^c   Van Hasselt, J G C ^d   Huitema, A D R ^d   De Vries, L S ^b   Egberts, A C G ^a,e   Rademaker, C M A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c ISALA HOSPITAL   (Netherlands)

^d SLOTERVAART HOSPITAL   (Netherlands)

^e UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LIDOCAINE; MIDAZOLAM; PHENOBARBITAL;

ADD ON THERAPY; ARTICLE; BODY TEMPERATURE; BRAIN DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPARTMENT MODEL; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; ELECTROENCEPHALOGRAM; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GESTATIONAL AGE; HUMAN; INDUCED HYPOTHERMIA; LOADING DRUG DOSE; MAINTENANCE DRUG DOSE; MALE; MONOTHERAPY; NEWBORN; NEWBORN HYPOXIA; NEWBORN INTENSIVE CARE; PERINATAL ASPHYXIA; PRIORITY JOURNAL; REPEATED DRUG DOSE; SEIZURE;

ANTICONVULSANTS; ASPHYXIA NEONATORUM; DRUG ADMINISTRATION SCHEDULE; ELECTROENCEPHALOGRAPHY; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA, BRAIN; INFANT, NEWBORN; INJECTIONS, INTRAVENOUS; INTENSIVE CARE UNITS, NEONATAL; INTENSIVE CARE, NEONATAL; MARKOV CHAINS; MODELS, BIOLOGICAL; NETHERLANDS; PHENOBARBITAL; PROSPECTIVE STUDIES; SEIZURES; TREATMENT OUTCOME;

EID: 84873400792     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-012-0004-y     Document Type: Article

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