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Volumn 32, Issue 4, 2012, Pages 348-359

Heterogeneity of patients with intermediate (BCLC B) hepatocellular carcinoma: Proposal for a subclassification to facilitate treatment decisions

Author keywords

Barcelona Clinic Liver Cancer; hepatocellular carcinoma; radioembolization; sorafenib; transarterial chemoembolization

Indexed keywords

SORAFENIB;

EID: 84873392306     PISSN: 02728087     EISSN: 10988971     Source Type: Journal    
DOI: 10.1055/s-0032-1329906     Document Type: Review
Times cited : (561)

References (82)
  • 1
    • 79952945610 scopus 로고    scopus 로고
    • National Cancer Institute Available at: http://seer.cancer.gov/statfacts/ html/livibd.html. Accessed August 24, 2012.
    • National Cancer Institute SEER Stat Fact Sheets: Liver and Intrahepatic Bile Duct. Available at: http://seer.cancer.gov/statfacts/html/livibd.html. Accessed August 24, 2012.
    • SEER Stat Fact Sheets: Liver and Intrahepatic Bile Duct
  • 2
    • 34548277030 scopus 로고    scopus 로고
    • Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: Results of the EUROCARE-4 study
    • DOI 10.1016/S1470-2045(07)70245-0, PII S1470204507702450
    • Berrino F., De Angelis R., Sant M., et al. EUROCARE Working group Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study. Lancet Oncol: 2007; 8 9 773 783 (Pubitemid 47321600)
    • (2007) Lancet Oncology , vol.8 , Issue.9 , pp. 773-783
    • Berrino, F.1    De Angelis, R.2    Sant, M.3    Rosso, S.4    Lasota, M.B.5    Coebergh, J.W.6    Santaquilani, M.7
  • 3
    • 34548232762 scopus 로고    scopus 로고
    • Recent cancer survival in Europe: A 2000-02 period analysis of EUROCARE-4 data
    • DOI 10.1016/S1470-2045(07)70246-2, PII S1470204507702462
    • Verdecchia A., Francisci S., Brenner H., et al. EUROCARE-4 Working Group Recent cancer survival in Europe: a 2000-02 period analysis of EUROCARE-4 data. Lancet Oncol: 2007; 8 9 784 796 (Pubitemid 47321601)
    • (2007) Lancet Oncology , vol.8 , Issue.9 , pp. 784-796
    • Verdecchia, A.1    Francisci, S.2    Brenner, H.3    Gatta, G.4    Micheli, A.5    Mangone, L.6    Kunkler, I.7
  • 4
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Forner A., Llovet J. M., Bruix J. Hepatocellular carcinoma. Lancet: 2012; 379 9822 1245 1255
    • (2012) Lancet , vol.379 , Issue.9822 , pp. 1245-1255
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 5
    • 16244369103 scopus 로고    scopus 로고
    • Prognosis of hepatocellular carcinoma: Comparison of 7 staging systems in an American cohort
    • DOI 10.1002/hep.20636
    • Marrero J. A., Fontana R. J., Barrat A., et al. Prognosis of hepatocellular carcinoma: comparison of 7 staging systems in an American cohort. Hepatology: 2005; 41 4 707 716 (Pubitemid 40462931)
    • (2005) Hepatology , vol.41 , Issue.4 , pp. 707-716
    • Marrero, J.A.1    Fontana, R.J.2    Barrat, A.3    Askari, F.4    Conjeevaram, H.S.5    Su, G.L.6    Lok, A.S.7
  • 6
    • 33644909117 scopus 로고    scopus 로고
    • Prospective validation of the Barcelona Clinic Liver Cancer staging system
    • Cillo U., Vitale A., Grigoletto F., et al. Prospective validation of the Barcelona Clinic Liver Cancer staging system. J Hepatol: 2006; 44 4 723 731
    • (2006) J Hepatol , vol.44 , Issue.4 , pp. 723-731
    • Cillo, U.1    Vitale, A.2    Grigoletto, F.3
  • 7
    • 40949127006 scopus 로고    scopus 로고
    • Comparison of seven staging systems in cirrhotic patients with hepatocellular carcinoma in a cohort of patients who underwent radiofrequency ablation with complete response
    • DOI 10.1111/j.1572-0241.2007.01604.x
    • Guglielmi A., Ruzzenente A., Pachera S., et al. Comparison of seven staging systems in cirrhotic patients with hepatocellular carcinoma in a cohort of patients who underwent radiofrequency ablation with complete response. Am J Gastroenterol: 2008; 103 3 597 604 (Pubitemid 351405970)
    • (2008) American Journal of Gastroenterology , vol.103 , Issue.3 , pp. 597-604
    • Guglielmi, A.1    Ruzzenente, A.2    Pachera, S.3    Valdegamberi, A.4    Sandri, M.5    D'Onofrio, M.6    Iacono, C.7
  • 8
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: An update
    • American Association for the Study of Liver Diseases
    • Bruix J., Sherman M. American Association for the Study of Liver Diseases Management of hepatocellular carcinoma: an update. Hepatology: 2011; 53 3 1020 1022
    • (2011) Hepatology , vol.53 , Issue.3 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 9
    • 84858658381 scopus 로고    scopus 로고
    • EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma
    • European Association For The Study Of The Liver; European Organisation For Research And Treatment Of Cancer
    • European Association For The Study Of The Liver; European Organisation For Research And Treatment Of Cancer EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol: 2012; 56 4 908 943
    • (2012) J Hepatol , vol.56 , Issue.4 , pp. 908-943
  • 10
    • 34447277896 scopus 로고    scopus 로고
    • Strategies for the management of hepatocellular carcinoma
    • DOI 10.1038/ncponc0844, PII NCPONC0844
    • Schwartz M., Roayaie S., Konstadoulakis M. Strategies for the management of hepatocellular carcinoma. Nat Clin Pract Oncol: 2007; 4 7 424 432 (Pubitemid 47039693)
    • (2007) Nature Clinical Practice Oncology , vol.4 , Issue.7 , pp. 424-432
    • Schwartz, M.1    Roayaie, S.2    Konstadoulakis, M.3
  • 11
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • DOI 10.1016/S0140-6736(03)14964-1
    • Llovet J. M., Burroughs A., Bruix J. Hepatocellular carcinoma. Lancet: 2003; 362 9399 1907 1917 (Pubitemid 37518510)
    • (2003) Lancet , vol.362 , Issue.9399 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 12
    • 28044465973 scopus 로고    scopus 로고
    • Staging and current treatment of hepatocellular carcinoma
    • DOI 10.1148/rg.25si055507
    • Clark H. P., Carson W. F., Kavanagh P. V., Ho C. P., Shen P., Zagoria R. J. Staging and current treatment of hepatocellular carcinoma. Radiographics: 2005; 25 01 S3 S23 (Pubitemid 41686059)
    • (2005) Radiographics , vol.25 , Issue.SPEC. ISSUE
    • Clark, H.P.1    Carson, W.F.2    Kavanagh, P.V.3    Ho, C.P.H.4    Shen, P.5    Zagoria, R.J.6
  • 14
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    • DOI 10.1053/jhep.2003.50047
    • Llovet J. M., Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology: 2003; 37 2 429 442 (Pubitemid 36152543)
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 15
    • 77953691839 scopus 로고    scopus 로고
    • The intermediate hepatocellular carcinoma stage: Should treatment be expanded
    • 03
    • Piscaglia F., Bolondi L. The intermediate hepatocellular carcinoma stage: Should treatment be expanded? Dig Liver Dis: 2010; 42 03 S258 S263
    • (2010) Dig Liver Dis , vol.42
    • Piscaglia, F.1    Bolondi, L.2
  • 16
    • 80051545416 scopus 로고    scopus 로고
    • Prognosis of hepatocellular carcinoma in relation to treatment across BCLC stages
    • D'Avola D., Iñarrairaegui M., Pardo F., et al. Prognosis of hepatocellular carcinoma in relation to treatment across BCLC stages. Ann Surg Oncol: 2011; 18 7 1964 1971
    • (2011) Ann Surg Oncol , vol.18 , Issue.7 , pp. 1964-1971
    • D'Avola, D.1    Iñarrairaegui, M.2    Pardo, F.3
  • 18
    • 77952349768 scopus 로고    scopus 로고
    • Transarterial chemoembolization, transarterial chemotherapy, and intra-arterial chemotherapy for hepatocellular carcinoma treatment
    • Tsochatzis E. A., Germani G., Burroughs A. K. Transarterial chemoembolization, transarterial chemotherapy, and intra-arterial chemotherapy for hepatocellular carcinoma treatment. Semin Oncol: 2010; 37 2 89 93
    • (2010) Semin Oncol , vol.37 , Issue.2 , pp. 89-93
    • Tsochatzis, E.A.1    Germani, G.2    Burroughs, A.K.3
  • 19
    • 84869231203 scopus 로고    scopus 로고
    • Response rate and clinical outcome of HCC after first and repeated cTACE performed "on demando"
    • Epub ahead of print
    • Terzi E., Golfieri R., Piscaglia F., et al. Response rate and clinical outcome of HCC after first and repeated cTACE performed "on demando" J Hepatol: 2012;; Epub ahead of print
    • (2012) J Hepatol
    • Terzi, E.1    Golfieri, R.2    Piscaglia, F.3
  • 20
    • 84858702846 scopus 로고    scopus 로고
    • Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines
    • Takayasu K., Arii S., Kudo M., et al. Superselective transarterial chemoembolization for hepatocellular carcinoma. Validation of treatment algorithm proposed by Japanese guidelines. J Hepatol: 2012; 56 4 886 892
    • (2012) J Hepatol , vol.56 , Issue.4 , pp. 886-892
    • Takayasu, K.1    Arii, S.2    Kudo, M.3
  • 21
    • 79953292241 scopus 로고    scopus 로고
    • Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma
    • Oliveri R. S., Wetterslev J., Gluud C. Transarterial (chemo)embolisation for unresectable hepatocellular carcinoma. Cochrane Database Syst Rev: 2011; 3 CD004787
    • (2011) Cochrane Database Syst Rev , Issue.3
    • Oliveri, R.S.1    Wetterslev, J.2    Gluud, C.3
  • 22
    • 77349102071 scopus 로고    scopus 로고
    • Modified RECIST (mRECIST) assessment for hepatocellular carcinoma
    • Lencioni R., Llovet J. M. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis: 2010; 30 1 52 60
    • (2010) Semin Liver Dis , vol.30 , Issue.1 , pp. 52-60
    • Lencioni, R.1    Llovet, J.M.2
  • 23
    • 81355147487 scopus 로고    scopus 로고
    • EASL and mRECIST responses are independent prognostic factors for survival in hepatocellular cancer patients treated with transarterial embolization
    • Gillmore R., Stuart S., Kirkwood A., et al. EASL and mRECIST responses are independent prognostic factors for survival in hepatocellular cancer patients treated with transarterial embolization. J Hepatol: 2011; 55 6 1309 1316
    • (2011) J Hepatol , vol.55 , Issue.6 , pp. 1309-1316
    • Gillmore, R.1    Stuart, S.2    Kirkwood, A.3
  • 25
    • 79952039170 scopus 로고    scopus 로고
    • Evolving strategies for the management of intermediate-stage hepatocellular carcinoma: Available evidence and expert opinion on the use of transarterial chemoembolization
    • Raoul J. L., Sangro B., Forner A., et al. Evolving strategies for the management of intermediate-stage hepatocellular carcinoma: available evidence and expert opinion on the use of transarterial chemoembolization. Cancer Treat Rev: 2011; 37 3 212 220
    • (2011) Cancer Treat Rev , vol.37 , Issue.3 , pp. 212-220
    • Raoul, J.L.1    Sangro, B.2    Forner, A.3
  • 26
    • 77955699976 scopus 로고    scopus 로고
    • Loco-regional treatment of hepatocellular carcinoma
    • Lencioni R. Loco-regional treatment of hepatocellular carcinoma. Hepatology: 2010; 52 2 762 773
    • (2010) Hepatology , vol.52 , Issue.2 , pp. 762-773
    • Lencioni, R.1
  • 27
    • 84868317583 scopus 로고    scopus 로고
    • A randomized phase II/III trial of three weekly cisplatin based transarterial chemoembolization (TACE) versus embolization (TAE) alone for hepatocellular cancer (HCC) [Abstract 4025]
    • Meyer T., Roughton M., Yu D., et al. A randomized phase II/III trial of three weekly cisplatin based transarterial chemoembolization (TACE) versus embolization (TAE) alone for hepatocellular cancer (HCC) [Abstract 4025]. J Clin Oncol: 2010; 28 (suppl): 15s
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL.
    • Meyer, T.1    Roughton, M.2    Yu, D.3
  • 28
    • 0037129704 scopus 로고    scopus 로고
    • Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: A randomised controlled trial
    • DOI 10.1016/S0140-6736(02)08649-X
    • Llovet J. M., Real M. I., Montaña X., et al. Barcelona Liver Cancer Group Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet: 2002; 359 9319 1734 1739 (Pubitemid 34607087)
    • (2002) Lancet , vol.359 , Issue.9319 , pp. 1734-1739
    • Llovet, J.M.1    Real, M.I.2    Montana, X.3    Planas, R.4    Coll, S.5    Aponte, J.6    Ayuso, C.7    Sala, M.8    Muchart, J.9    Sola, R.10    Rodes, J.11    Bruix, J.12
  • 29
    • 79955095871 scopus 로고    scopus 로고
    • Efficacy of selective transarterial chemoembolization in inducing tumor necrosis in small (<5 cm) hepatocellular carcinomas
    • Golfieri R., Cappelli A., Cucchetti A., et al. Efficacy of selective transarterial chemoembolization in inducing tumor necrosis in small (<5 cm) hepatocellular carcinomas. Hepatology: 2011; 53 5 1580 1589
    • (2011) Hepatology , vol.53 , Issue.5 , pp. 1580-1589
    • Golfieri, R.1    Cappelli, A.2    Cucchetti, A.3
  • 31
    • 77949264899 scopus 로고    scopus 로고
    • Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: Results of the PRECISION v study
    • PRECISION V Investigators
    • Lammer J., Malagari K., Vogl T., et al. PRECISION V Investigators Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study. Cardiovasc Intervent Radiol: 2010; 33 1 41 52
    • (2010) Cardiovasc Intervent Radiol , vol.33 , Issue.1 , pp. 41-52
    • Lammer, J.1    Malagari, K.2    Vogl, T.3
  • 32
    • 77953138048 scopus 로고    scopus 로고
    • Prospective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinoma
    • Malagari K., Pomoni M., Kelekis A., et al. Prospective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinoma. Cardiovasc Intervent Radiol: 2010; 33 3 541 551
    • (2010) Cardiovasc Intervent Radiol , vol.33 , Issue.3 , pp. 541-551
    • Malagari, K.1    Pomoni, M.2    Kelekis, A.3
  • 35
    • 0344099078 scopus 로고    scopus 로고
    • Transcatheter arterial chemoembolization for hepatocellular carcinoma in patients with cirrhosis: Evaluation of two kinds of dosages of anticancer drugs and analysis of prognostic factors
    • Lu W., Li Y., He X., Chen Y. Transcatheter arterial chemoembolization for hepatocellular carcinoma in patients with cirrhosis: evaluation of two kinds of dosages of anticancer drugs and analysis of prognostic factors. Hepatogastroenterology: 2003; 50 54 2079 2083 (Pubitemid 37467998)
    • (2003) Hepato-Gastroenterology , vol.50 , Issue.54 , pp. 2079-2083
    • Lu, W.1    Li, Y.2    He, X.3    Chen, Y.4
  • 36
    • 0026095001 scopus 로고
    • Effect of repeated transcatheter arterial embolization on the survival time in patients with hepatocellular carcinoma. An analysis by the Cox proportional hazard model
    • Ikeda K., Kumada H., Saitoh S., Arase Y., Chayama K. Effect of repeated transcatheter arterial embolization on the survival time in patients with hepatocellular carcinoma. An analysis by the Cox proportional hazard model. Cancer: 1991; 68 10 2150 2154
    • (1991) Cancer , vol.68 , Issue.10 , pp. 2150-2154
    • Ikeda, K.1    Kumada, H.2    Saitoh, S.3    Arase, Y.4    Chayama, K.5
  • 38
    • 0032905440 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma by transcatheter arterial chemoembolization: Comparison of planned periodic chemoembolization and chemoembolization based on tumor response
    • Ernst O., Sergent G., Mizrahi D., Delemazure O., Paris J. C., L'Herminé C. Treatment of hepatocellular carcinoma by transcatheter arterial chemoembolization: comparison of planned periodic chemoembolization and chemoembolization based on tumor response. AJR Am J Roentgenol: 1999; 172 1 59 64 (Pubitemid 29028431)
    • (1999) American Journal of Roentgenology , vol.172 , Issue.1 , pp. 59-64
    • Ernst, O.1    Sergent, G.2    Mizrahi, D.3    Delemazure, O.4    Paris, J.-C.5    L'Hermine, C.6
  • 39
    • 60049085346 scopus 로고    scopus 로고
    • Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma: Are response evaluation criteria in solid tumors reliable
    • Forner A., Ayuso C., Varela M., et al. Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma: are response evaluation criteria in solid tumors reliable? Cancer: 2009; 115 3 616 623
    • (2009) Cancer , vol.115 , Issue.3 , pp. 616-623
    • Forner, A.1    Ayuso, C.2    Varela, M.3
  • 40
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • SHARP Investigators Study Group
    • Llovet J. M., Ricci S., Mazzaferro V., et al. SHARP Investigators Study Group Sorafenib in advanced hepatocellular carcinoma. N Engl J Med: 2008; 359 4 378 390
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 42
    • 84862252896 scopus 로고    scopus 로고
    • Comparison of surgical resection and transarterial chemoembolization for hepatocellular carcinoma beyond the Milan criteria: A propensity score analysis
    • Hsu C. Y., Hsia C. Y., Huang Y. H., et al. Comparison of surgical resection and transarterial chemoembolization for hepatocellular carcinoma beyond the Milan criteria: a propensity score analysis. Ann Surg Oncol: 2012; 19 3 842 849
    • (2012) Ann Surg Oncol , vol.19 , Issue.3 , pp. 842-849
    • Hsu, C.Y.1    Hsia, C.Y.2    Huang, Y.H.3
  • 44
    • 80054749110 scopus 로고    scopus 로고
    • Criteria for liver transplantation for HCC: What should the limits be
    • Silva M. F., Sherman M. Criteria for liver transplantation for HCC: what should the limits be? J Hepatol: 2011; 55 5 1137 1147
    • (2011) J Hepatol , vol.55 , Issue.5 , pp. 1137-1147
    • Silva, M.F.1    Sherman, M.2
  • 45
    • 57749191711 scopus 로고    scopus 로고
    • Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: A retrospective, exploratory analysis
    • Metroticket Investigator Study Group
    • Mazzaferro V., Llovet J. M., Miceli R., et al. Metroticket Investigator Study Group Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol: 2009; 10 1 35 43
    • (2009) Lancet Oncol , vol.10 , Issue.1 , pp. 35-43
    • Mazzaferro, V.1    Llovet, J.M.2    Miceli, R.3
  • 46
    • 84855314307 scopus 로고    scopus 로고
    • Recommendations for liver transplantation for hepatocellular carcinoma: An international consensus conference report
    • OLT for HCC Consensus Group
    • Clavien P. A., Lesurtel M., Bossuyt P. M., Gores G. J., Langer B., Perrier A. OLT for HCC Consensus Group Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report. Lancet Oncol: 2012; 13 1 e11 e22
    • (2012) Lancet Oncol , vol.13 , Issue.1
    • Clavien, P.A.1    Lesurtel, M.2    Bossuyt, P.M.3    Gores, G.J.4    Langer, B.5    Perrier, A.6
  • 47
    • 77954333876 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • ESMO Guidelines Working Group 05
    • Jelic S., Sotiropoulos G. C. ESMO Guidelines Working Group Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol: 2010; 21 05 v59 v64
    • (2010) Ann Oncol , vol.21
    • Jelic, S.1    Sotiropoulos, G.C.2
  • 48
    • 55949123393 scopus 로고    scopus 로고
    • Liver transplantation for hepatocellular carcinoma: Results of down-staging in patients initially outside the Milan selection criteria
    • Ravaioli M., Grazi G. L., Piscaglia F., et al. Liver transplantation for hepatocellular carcinoma: results of down-staging in patients initially outside the Milan selection criteria. Am J Transplant: 2008; 8 12 2547 2557
    • (2008) Am J Transplant , vol.8 , Issue.12 , pp. 2547-2557
    • Ravaioli, M.1    Grazi, G.L.2    Piscaglia, F.3
  • 49
    • 72549115627 scopus 로고    scopus 로고
    • Progression of alphafetoprotein before liver transplantation for hepatocellular carcinoma in cirrhotic patients: A critical factor
    • Vibert E., Azoulay D., Hoti E., et al. Progression of alphafetoprotein before liver transplantation for hepatocellular carcinoma in cirrhotic patients: a critical factor. Am J Transplant: 2010; 10 1 129 137
    • (2010) Am J Transplant , vol.10 , Issue.1 , pp. 129-137
    • Vibert, E.1    Azoulay, D.2    Hoti, E.3
  • 50
    • 51349117878 scopus 로고    scopus 로고
    • Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: An intention-to-treat analysis
    • Yao F. Y., Kerlan R. K. Jr, Hirose R., et al. Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis. Hepatology: 2008; 48 3 819 827
    • (2008) Hepatology , vol.48 , Issue.3 , pp. 819-827
    • Yao, F.Y.1    Kerlan Jr., R.K.2    Hirose, R.3
  • 51
    • 84873734973 scopus 로고    scopus 로고
    • Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): Results of a Phase III randomized placebo-controlled trial (SHARP trial)
    • June 1-5, 2007; Chicago, IL
    • Llovet J. M., Ricci S., Mazzaferro V., et al. Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): results of a Phase III randomized placebo-controlled trial (SHARP trial). Paper presented at: American Society of Clinical Oncology Annual Meeting; June 1-5, 2007; Chicago, IL
    • Paper Presented At: American Society of Clinical Oncology Annual Meeting
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 52
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng A. L., Kang Y. K., Chen Z., et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol: 2009; 10 1 25 34
    • (2009) Lancet Oncol , vol.10 , Issue.1 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 53
    • 73449100910 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients with hepatocellular carcinoma (HCC): Subanalysis of SHARP trial based on Barcelona Clinic Liver Cancer (BCLC) stage
    • 01
    • Bruix J., Raoul J. L., Sherman M., et al. Efficacy and safety of sorafenib in patients with hepatocellular carcinoma (HCC): Subanalysis of SHARP trial based on Barcelona Clinic Liver Cancer (BCLC) stage. J Hepatol: 2009; 50 01 S28 S29
    • (2009) J Hepatol , vol.50
    • Bruix, J.1    Raoul, J.L.2    Sherman, M.3
  • 54
    • 84927612654 scopus 로고    scopus 로고
    • Second Interim Results of the GIDEON (Global Investigation of Therapeutic DEcisions in HCC and of Its Treatment with SorafeNib) Study - Barcelona-Clinic Liver Cancer (BCLC) Stage Subgroup Analysis. Abs 6500
    • Stockholm, Sweden
    • Lencioni R., Venook A. P., Marrero J. A., et al. Second Interim Results of the GIDEON (Global Investigation of Therapeutic DEcisions in HCC and of Its Treatment With SorafeNib) Study - Barcelona-Clinic Liver Cancer (BCLC) Stage Subgroup Analysis. Abs 6500. Abstract presented at: The European Multidisciplinary Cancer Congress; September 23-27, 2011; Stockholm, Sweden
    • (2011) Abstract Presented At: The European Multidisciplinary Cancer Congress; September 23-27
    • Lencioni, R.1    Venook, A.P.2    Marrero, J.A.3
  • 55
    • 82355192537 scopus 로고    scopus 로고
    • Global Investigation of Therapeutic Decisions in Hepatocellular Carcinoma and of its Treatment with Sorafenib (GIDEON) second interim analysis in more than 1,500 patients: Clinical findings in patients with liver dysfunction
    • Marrero J. A., Lencioni R., Kudo M., et al. Global Investigation of Therapeutic Decisions in Hepatocellular Carcinoma and of its Treatment with Sorafenib (GIDEON) second interim analysis in more than 1,500 patients: Clinical findings in patients with liver dysfunction. J Clin Oncol: 2011; 29 4001
    • (2011) J Clin Oncol , vol.29 , pp. 4001
    • Marrero, J.A.1    Lencioni, R.2    Kudo, M.3
  • 56
    • 82455162643 scopus 로고    scopus 로고
    • Field-practice study of sorafenib therapy for hepatocellular carcinoma: A prospective multicenter study in Italy
    • SOFIA (SOraFenib Italian Assessment) study group
    • Iavarone M., Cabibbo G., Piscaglia F., et al. SOFIA (SOraFenib Italian Assessment) study group Field-practice study of sorafenib therapy for hepatocellular carcinoma: a prospective multicenter study in Italy. Hepatology: 2011; 54 6 2055 2063
    • (2011) Hepatology , vol.54 , Issue.6 , pp. 2055-2063
    • Iavarone, M.1    Cabibbo, G.2    Piscaglia, F.3
  • 57
    • 84873721285 scopus 로고    scopus 로고
    • The rate of HCC patients in Child-Pugh B untreatable with effective strategies according to AASLD guidelines increases with the progression of specific Child-Pugh score
    • Piscaglia F., Trimarchi C., Terzi E., et al. The rate of HCC patients in Child-Pugh B untreatable with effective strategies according to AASLD guidelines increases with the progression of specific Child-Pugh score. Hepatology: 2010; 52 1168A
    • (2010) Hepatology , vol.52
    • Piscaglia, F.1    Trimarchi, C.2    Terzi, E.3
  • 58
    • 84861192547 scopus 로고    scopus 로고
    • Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using drug eluting beads. Implications for clinical practice and trial design
    • Burrel M., Reig M., Forner A., et al. Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using drug eluting beads. Implications for clinical practice and trial design. J Hepatol: 2012; 56 6 1330 1335
    • (2012) J Hepatol , vol.56 , Issue.6 , pp. 1330-1335
    • Burrel, M.1    Reig, M.2    Forner, A.3
  • 59
    • 72249087123 scopus 로고    scopus 로고
    • Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: A comprehensive report of long-term outcomes
    • Salem R., Lewandowski R. J., Mulcahy M. F., et al. Radioembolization for hepatocellular carcinoma using Yttrium-90 microspheres: a comprehensive report of long-term outcomes. Gastroenterology: 2010; 138 1 52 64
    • (2010) Gastroenterology , vol.138 , Issue.1 , pp. 52-64
    • Salem, R.1    Lewandowski, R.J.2    Mulcahy, M.F.3
  • 60
    • 78049487253 scopus 로고    scopus 로고
    • Radioembolization with yttrium-90 glass microspheres in hepatocellular carcinoma: European experience on safety and long-term survival
    • Hilgard P., Hamami M., Fouly A. E., et al. Radioembolization with yttrium-90 glass microspheres in hepatocellular carcinoma: European experience on safety and long-term survival. Hepatology: 2010; 52 5 1741 1749
    • (2010) Hepatology , vol.52 , Issue.5 , pp. 1741-1749
    • Hilgard, P.1    Hamami, M.2    Fouly, A.E.3
  • 61
    • 80052023374 scopus 로고    scopus 로고
    • Survival after yttrium-90 resin microsphere radioembolization of hepatocellular carcinoma across Barcelona clinic liver cancer stages: A European evaluation
    • European Network on Radioembolization with Yttrium-90 Resin Microspheres (ENRY)
    • Sangro B., Carpanese L., Cianni R., et al. European Network on Radioembolization with Yttrium-90 Resin Microspheres (ENRY) Survival after yttrium-90 resin microsphere radioembolization of hepatocellular carcinoma across Barcelona clinic liver cancer stages: a European evaluation. Hepatology: 2011; 54 3 868 878
    • (2011) Hepatology , vol.54 , Issue.3 , pp. 868-878
    • Sangro, B.1    Carpanese, L.2    Cianni, R.3
  • 62
    • 84855982021 scopus 로고    scopus 로고
    • Radioembolization for hepatocellular carcinoma
    • Sangro B., Iñarrairaegui M., Bilbao J. I. Radioembolization for hepatocellular carcinoma. J Hepatol: 2012; 56 2 464 473
    • (2012) J Hepatol , vol.56 , Issue.2 , pp. 464-473
    • Sangro, B.1    Iñarrairaegui, M.2    Bilbao, J.I.3
  • 63
    • 84861717788 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma (HCC) by intra-arterial infusion of radio-emitter compounds: Trans-arterial radio-embolisation of HCC
    • Andreana L., Isgrò G., Marelli L., et al. Treatment of hepatocellular carcinoma (HCC) by intra-arterial infusion of radio-emitter compounds: trans-arterial radio-embolisation of HCC. Cancer Treat Rev: 2012; 38 6 641 649
    • (2012) Cancer Treat Rev , vol.38 , Issue.6 , pp. 641-649
    • Andreana, L.1    Isgrò, G.2    Marelli, L.3
  • 64
    • 84862171820 scopus 로고    scopus 로고
    • Response to radioembolization with yttrium-90 resin microspheres may allow surgical treatment with curative intent and prolonged survival in previously unresectable hepatocellular carcinoma
    • Iñarrairaegui M., Pardo F., Bilbao J. I., et al. Response to radioembolization with yttrium-90 resin microspheres may allow surgical treatment with curative intent and prolonged survival in previously unresectable hepatocellular carcinoma. Eur J Surg Oncol: 2012; 38 7 594 601
    • (2012) Eur J Surg Oncol , vol.38 , Issue.7 , pp. 594-601
    • Iñarrairaegui, M.1    Pardo, F.2    Bilbao, J.I.3
  • 65
    • 67650938388 scopus 로고    scopus 로고
    • A comparative analysis of transarterial downstaging for hepatocellular carcinoma: Chemoembolization versus radioembolization
    • Lewandowski R. J., Kulik L. M., Riaz A., et al. A comparative analysis of transarterial downstaging for hepatocellular carcinoma: chemoembolization versus radioembolization. Am J Transplant: 2009; 9 8 1920 1928
    • (2009) Am J Transplant , vol.9 , Issue.8 , pp. 1920-1928
    • Lewandowski, R.J.1    Kulik, L.M.2    Riaz, A.3
  • 66
    • 84864052036 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma with transarterial chemoembolization in the era of systemic targeted therapy
    • Lencioni R. Management of hepatocellular carcinoma with transarterial chemoembolization in the era of systemic targeted therapy. Crit Rev Oncol Hematol: 2012; 83 2 216 224
    • (2012) Crit Rev Oncol Hematol , vol.83 , Issue.2 , pp. 216-224
    • Lencioni, R.1
  • 67
    • 4644289324 scopus 로고    scopus 로고
    • Expression of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma and effect of transcatheter arterial chemoembolization therapy on plasma vascular endothelial growth factor level
    • Li X., Feng G. S., Zheng C. S., Zhuo C. K., Liu X. Expression of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma and effect of transcatheter arterial chemoembolization therapy on plasma vascular endothelial growth factor level. World J Gastroenterol: 2004; 10 19 2878 2882 (Pubitemid 39303010)
    • (2004) World Journal of Gastroenterology , vol.10 , Issue.19 , pp. 2878-2882
    • Li, X.1    Feng, G.-S.2    Zheng, C.-S.3    Zhuo, C.-K.4    Liu, X.5
  • 68
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P., Jain R. K. Angiogenesis in cancer and other diseases. Nature: 2000; 407 6801 249 257
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 69
    • 78649972858 scopus 로고    scopus 로고
    • Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: Results of a phase i study
    • Dufour J. F., Hoppe H., Heim M. H., et al. Continuous administration of sorafenib in combination with transarterial chemoembolization in patients with hepatocellular carcinoma: results of a phase I study. Oncologist: 2010; 15 11 1198 1204
    • (2010) Oncologist , vol.15 , Issue.11 , pp. 1198-1204
    • Dufour, J.F.1    Hoppe, H.2    Heim, M.H.3
  • 70
    • 79958797450 scopus 로고    scopus 로고
    • Study in Asia of the combination of transcatheter arterial chemoembolization (TACE) with sorafenib in patients with hepatocellular carcinoma (HCC) trial (START): Second interim safety and efficacy analysis
    • Chung Y., Kim B., Chen C., et al. Study in Asia of the combination of transcatheter arterial chemoembolization (TACE) with sorafenib in patients with hepatocellular carcinoma (HCC) trial (START): Second interim safety and efficacy analysis. J Clin Oncol: 2010; 28 4026
    • (2010) J Clin Oncol , vol.28 , pp. 4026
    • Chung, Y.1    Kim, B.2    Chen, C.3
  • 71
    • 84860261590 scopus 로고    scopus 로고
    • Sorafenib or placebo in combination with transarterial chemoembolization (TACE) with doxorubicin-eluting beads (DEBDOX) for intermediate-stage hepatocellular carcinoma (HCC): Phase II, randomized, double-blind SPACE trial
    • [Abstract LBA154]
    • Lencioni R., Llovet J. M., Han G., et al. Sorafenib or placebo in combination with transarterial chemoembolization (TACE) with doxorubicin-eluting beads (DEBDOX) for intermediate-stage hepatocellular carcinoma (HCC): Phase II, randomized, double-blind SPACE trial. [Abstract LBA154] J Clin Oncol: 2012; 30 (suppl)
    • (2012) J Clin Oncol , Issue.SUPPL. , pp. 30
    • Lencioni, R.1    Llovet, J.M.2    Han, G.3
  • 72
    • 19944372023 scopus 로고    scopus 로고
    • Evaluation of transcatheter arterial embolization prior to percutaneous tumor ablation in patients with hepatocellular carcinoma: A randomized controlled trial
    • Akamatsu M., Yoshida H., Obi S., et al. Evaluation of transcatheter arterial embolization prior to percutaneous tumor ablation in patients with hepatocellular carcinoma: a randomized controlled trial. Liver Int: 2004; 24 6 625 629
    • (2004) Liver Int , vol.24 , Issue.6 , pp. 625-629
    • Akamatsu, M.1    Yoshida, H.2    Obi, S.3
  • 73
    • 0028861999 scopus 로고
    • Treatment of large HCC: Transcatheter arterial chemoembolization combined with percutaneous ethanol injection versus repeated transcatheter arterial chemoembolization
    • Bartolozzi C., Lencioni R., Caramella D., et al. Treatment of large HCC: transcatheter arterial chemoembolization combined with percutaneous ethanol injection versus repeated transcatheter arterial chemoembolization. Radiology: 1995; 197 3 812 818
    • (1995) Radiology , vol.197 , Issue.3 , pp. 812-818
    • Bartolozzi, C.1    Lencioni, R.2    Caramella, D.3
  • 76
    • 77954558611 scopus 로고    scopus 로고
    • Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes
    • Cheung T. T., Ng K. K., Chok K. S., et al. Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: prognosis and outcomes. World J Gastroenterol: 2010; 16 24 3056 3062
    • (2010) World J Gastroenterol , vol.16 , Issue.24 , pp. 3056-3062
    • Cheung, T.T.1    Ng, K.K.2    Chok, K.S.3
  • 78
    • 80051758429 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma in Japan: Consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version
    • HCC Expert Panel of Japan Society of Hepatology
    • Kudo M., Izumi N., Kokudo N., et al. HCC Expert Panel of Japan Society of Hepatology Management of hepatocellular carcinoma in Japan: consensus-based clinical practice guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version. Dig Dis: 2011; 29 3 339 364
    • (2011) Dig Dis , vol.29 , Issue.3 , pp. 339-364
    • Kudo, M.1    Izumi, N.2    Kokudo, N.3
  • 79
    • 84984586846 scopus 로고    scopus 로고
    • Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma
    • Omata M., Lesmana L. A., Tateishi R., et al. Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma. Hepatol Int: 2010; 4 2 439 474
    • (2010) Hepatol Int , vol.4 , Issue.2 , pp. 439-474
    • Omata, M.1    Lesmana, L.A.2    Tateishi, R.3
  • 80
    • 78649630146 scopus 로고    scopus 로고
    • Development and validation of a new prognostic score of death for patients with hepatocellular carcinoma in palliative setting
    • Tournoux-Facon C., Paoletti X., Barbare J. C., et al. Development and validation of a new prognostic score of death for patients with hepatocellular carcinoma in palliative setting. J Hepatol: 2011; 54 1 108 114
    • (2011) J Hepatol , vol.54 , Issue.1 , pp. 108-114
    • Tournoux-Facon, C.1    Paoletti, X.2    Barbare, J.C.3
  • 81
    • 0032898237 scopus 로고    scopus 로고
    • Natural history of untreated nonsurgical hepatocellular carcinoma: Rationale for the design and evaluation of therapeutic trials
    • DOI 10.1002/hep.510290145
    • Llovet J. M., Bustamante J., Castells A., et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials. Hepatology: 1999; 29 1 62 67 (Pubitemid 29023987)
    • (1999) Hepatology , vol.29 , Issue.1 , pp. 62-67
    • Llovet, J.M.1    Bustamante, J.2    Castells, A.3    Vilana, R.4    Del Carmen Avuso, M.5    Sala, M.6    Bru, C.7    Rodes, J.8    Bruix, J.9
  • 82
    • 7044229703 scopus 로고    scopus 로고
    • Chemoembolization for hepatocellular carcinoma
    • DOI 10.1053/j.gastro.2004.09.032, PII S0016508504016117
    • Bruix J., Sala M., Llovet J. M. Chemoembolization for hepatocellular carcinoma. Gastroenterology: 2004; 127 5 01 S179 S188 (Pubitemid 39423386)
    • (2004) Gastroenterology , vol.127 , Issue.SUPPL.
    • Bruix, J.1    Sala, M.2    Llovet, J.M.3


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