Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using Drug Eluting Beads. Implications for clinical practice and trial design

Journal of Hepatology

Volumn 56, Issue 6, 2012, Pages 1330-1335

  Burrel, Marta ^a   Reig, María ^a,b   Forner, Alejandro ^a,b   Barrufet, Marta ^a   Lope, Carlos Rodríguez De ^a   Tremosini, Silvia ^a   Ayuso, Carmen ^a,b   Llovet, Josep M ^a,b,c,d   Real, María Isabel ^a   Bruix, Jordi ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Chemoembolization; Drug eluting beads (DEB); Hepatocellular carcinoma; Safety; Survival

Indexed keywords

DOXORUBICIN; SORAFENIB;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER SURVIVAL; CHEMOEMBOLIZATION; CONTROLLED STUDY; FEMALE; HUMAN; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PATIENT SAFETY; PRIORITY JOURNAL; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; BENZENESULFONATES; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; FEMALE; HEPATIC ARTERY; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PYRIDINES; RESEARCH DESIGN;

EID: 84861192547     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.01.008     Document Type: Article

References (24)

1. J. Bruix, and M. Sherman Management of hepatocellular carcinoma: an update Hepatology 53 2011 1020 1022
2. M. Varela, M.I. Real, M. Burrel, A. Forner, M. Sala, and M. Brunet Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics J Hepatol 46 2007 474 481 (Pubitemid 46201723)
3. R.T. Poon, W.K. Tso, R.W. Pang, K.K. Ng, R. Woo, and K.S. Tai A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead Clin Gastroenterol Hepatol 5 2007 1100 1108
4. K. Malagari, K. Chatzimichael, E. Alexopoulou, A. Kelekis, B. Hall, and S. Dourakis Transarterial chemoembolization of unresectable hepatocellular carcinoma with drug eluting beads: results of an open-label study of 62 patients Cardiovasc Intervent Radiol 31 2008 269 280
5. J. Lammer, K. Malagari, T. Vogl, F. Pilleul, A. Denys, and A. Watkinson Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the Precision V study Cardiovasc Intervent Radiol 33 2010 41 52
6. J.M. Llovet, M.I. Real, X. Montana, R. Planas, S. Coll, and J. Aponte Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial Lancet 359 2002 1734 1739 (Pubitemid 34607087)
7. C.M. Lo, H. Ngan, W.K. Tso, C.L. Liu, C.M. Lam, and R.T. Poon Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma Hepatology 35 2002 1164 1171 (Pubitemid 34454013)
8. J.L. Raoul, B. Sangro, A. Forner, V. Mazzaferro, F. Piscaglia, and L. Bolondi Evolving strategies for the management of intermediate-stage hepatocellular carcinoma: available evidence and expert opinion on the use of transarterial chemoembolization Cancer Treat Rev 37 2011 212 220
9. J. Luo, R.P. Guo, E.C. Lai, Y.J. Zhang, W.Y. Lau, and M.S. Chen Transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein tumor thrombosis: a prospective comparative study Ann Surg Oncol 18 2011 413 420
10. H.T. Hu, J.H. Kim, L.S. Lee, K.A. Kim, G.Y. Ko, and H.K. Yoon Chemoembolization for hepatocellular carcinoma: multivariate analysis of predicting factors for tumor response and survival in a 362-patient cohort J Vasc Interv Radiol 22 2011 917 923
11. J.M. Llovet, and J. Bruix Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival Hepatology 37 2003 429 442 (Pubitemid 36152543)
12. J. Bruix, and M. Sherman Management of hepatocellular carcinoma Hepatology 42 2005 1208 1236 (Pubitemid 43112690)
13. A. Forner, J.M. Llovet, and J. Bruix Hepatocellular carcinoma Lancet 2012 10.1016/S0140-6736(11)61347-0 PMID:22353262
14. R.N. Pugh, I.M. Murray-Lyon, J.L. Dawson, M.C. Pietroni, and R. Williams Transection of the oesophagus for bleeding oesophageal varices Br J Surg 60 1973 646 649
15. J.B. Sorensen, M. Klee, T. Palshof, and H.H. Hansen Performance status assessment in cancer patients. An inter-observer variability study Br J Cancer 67 1993 773 775 (Pubitemid 23101557)
16. J. Bruix, M. Reig, J. Rimola, A. Forner, M. Burrel, and R. Vilana Clinical decision making and research in hepatocellular carcinoma: Pivotal role of imaging techniques Hepatology 54 2011 2238 2244
17. Shelgikar CS, Loehle J, Scoggins CR, McMasters KM, Martin RC, 2nd. Empiric antibiotics for transarterial embolization in hepatocellular carcinoma: indicated? J Surg Res 2009;151:121-124.
18. Castells A, Bruix J, Ayuso C, Bru C, Montanya X, Boix L, et al. Transarterial embolization for hepatocellular carcinoma. Antibiotic prophylaxis and clinical meaning of postembolization fever. J Hepatol 1995;22:410-415.
19. K. Takayasu, S. Arii, I. Ikai, M. Kudo, Y. Matsuyama, and M. Kojiro Overall survival after transarterial lipiodol infusion chemotherapy with or without embolization for unresectable hepatocellular carcinoma: propensity score analysis AJR Am J Roentgenol 194 2010 830 837
20. K. Malagari, M. Pomoni, A. Kelekis, A. Pomoni, S. Dourakis, and T. Spyridopoulos Prospective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinoma Cardiovasc Intervent Radiol 33 2010 541 551
21. Bargellini I, Sacco R, Bozzi E, Bertini M, Ginanni B, Romano A, et al. Transarterial chemoembolization in very early and early-stage hepatocellular carcinoma patients excluded from curative treatment: a prospective cohort study. Eur J Radiol [3 April 2011, Epub ahead of print]. PMID:21466931.
22. K. Takayasu, S. Arii, I. Ikai, M. Omata, K. Okita, and T. Ichida Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients Gastroenterology 131 2006 461 469 (Pubitemid 44142456)
23. A. Nicolini, L. Martinetti, S. Crespi, M. Maggioni, and A. Sangiovanni Transarterial chemoembolization with epirubicin-eluting beads versus transarterial embolization before liver transplantation for hepatocellular carcinoma J Vasc Interv Radiol 21 2010 327 332
24. K. Malagari, M. Pomoni, T.N. Spyridopoulos, H. Moschouris, A. Kelekis, and S. Dourakis Safety profile of sequential transcatheter chemoembolization with DC Bead: results of 237 hepatocellular carcinoma (HCC) patients Cardiovasc Intervent Radiol 34 2011 774 785