Mitotically active proliferative nodule arising in a giant congenital melanocytic nevus: A diagnostic pitfall

American Journal of Dermatopathology

Volumn 35, Issue 1, 2013, Pages

  Nguyen, Thuy L T ^a   Theos, Amy ^b   Kelly, David R ^a   Busam, Klaus ^c   Andea, Aleodor A ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Congenital melanocytic nevus; Fluorescence in situ hybridization; Molecular inversion probe technology; Polyploidy; Proliferative nodule

Indexed keywords

DNA; KI 67 ANTIGEN;

ARTICLE; CASE REPORT; CLINICAL FEATURE; CONGENITAL MELANOCYTIC NEVI; DNA DETERMINATION; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE DOSAGE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MELANOCYTIC NEVUS; NEWBORN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SKIN BIOPSY; SKIN NODULE;

BIOPSY; CELL PROLIFERATION; COMPARATIVE GENOMIC HYBRIDIZATION; DIAGNOSIS, DIFFERENTIAL; DNA COPY NUMBER VARIATIONS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT, NEWBORN; KI-67 ANTIGEN; MALE; MELANOMA; MITOSIS; NEVUS, PIGMENTED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYPLOIDY; PREDICTIVE VALUE OF TESTS; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84873391896     PISSN: 01931091     EISSN: 15330311     Source Type: Journal    
DOI: 10.1097/DAD.0b013e318265fe12     Document Type: Article

References (62)

1. Herron MD, Vanderhooft SL, Smock K, et al. Proliferative nodules in congenital melanocytic nevi: A clinicopathologic and immunohistochemical analysis. Am J Surg Pathol. 2004;28:1017-1025.
2. Leech SN, Bell H, Leonard N, et al. Neonatal giant congenital nevi with proliferative nodules: A clinicopathologic study and literature review of neonatal melanoma. Arch Dermatol. 2004;140:83-88.
3. Borbujo J, Jara M, Cortes L, et al. A newborn with nodular ulcerated lesion on a giant congenital nevus. Pediatr Dermatol. 2000;17:299-301.
4. Phadke PA, Rakheja D, Le LP, et al. Proliferative nodules arising within congenital melanocytic nevi: A histologic, immunohistochemical, and molecular analyses of 43 cases. Am J Surg Pathol. 2011;35:656-669.
5. Bett BJ. Large or multiple congenital melanocytic nevi: Occurrence of cutaneous melanoma in 1008 persons. J Am Acad Dermatol. 2005;52: 793-797.
6. Krengel S, Hauschild A, Schafer T. Melanoma risk in congenital melanocytic naevi: A systematic review. Br J Dermatol. 2006;155:1-8.
7. Paradela S, Fonseca E, Prieto VG. Melanoma in children. Arch Pathol Lab Med. 2011;135:307-316.
8. Schneiderman H, Wu AY, Campbell WA, et al. Congenital melanoma with multiple prenatal metastases. Cancer. 1987;60:1371-1377.
9. Koyama T, Murakami M, Nishihara O, et al. Congenital melanoma: A case suggesting rhabdomyogenic differentiation. Pediatr Dermatol. 1996;13:389-393.
10. Baader W, Kropp R, Tapper D. Congenital malignant melanoma. Plast Reconstr Surg. 1992;90:53-56.
11. Song KY, Song HG, Chi JG, et al. Congenital malignant melanoma -
12. a case report. J Korean Med Sci. 1990;5:91-95.
13. Murphy MJ, Jen M, Chang MW, et al. Molecular diagnosis of a benign proliferative nodule developing in a congenital melanocytic nevus in a 3-month-old infant. J Am Acad Dermatol. 2008;59:518-523.
14. Vergier B, Prochazkova-Carlotti M, de la Fouchardiere A, et al. Fluorescence hybridization, a diagnostic aid in ambiguous melanocytic tumors: European study of 113 cases. Mod Pathol. 2011;24:613-623.
15. Bastian BC, Xiong J, Frieden IJ, et al. Genetic changes in neoplasms arising in congenital melanocytic nevi: Differences between nodular proliferations and melanomas. Am J Pathol. 2002;161:1163-1169.
16. Gerami P, Jewell SS, Morrison LE, et al. Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am J Surg Pathol. 2009;33:1146-1156.
17. Feito-Rodriguez M, de Lucas-Laguna R, Bastian BC, et al. Nodular lesions arising in a large congenital melanocytic naevus in a newborn with eruptive disseminated Spitz naevi. Br J Dermatol. 2011;165:1138-1142.
18. Bauer J, Bastian BC. Distinguishing melanocytic nevi from melanoma by DNA copy number changes: Comparative genomic hybridization as a research and diagnostic tool. Dermatol Ther. 2006;19:40-49.
19. Bastian BC, Wesselmann U, Pinkel D, et al. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol. 1999;113:1065-1069.
20. Busam KJ, Fang Y, Jhanwar SC, et al. Distinction of conjunctival melanocytic nevi from melanomas by fluorescence in situ hybridization. J Cutan Pathol. 2010;37:196-203.
21. Gaiser T, Kutzner H, Palmedo G, et al. Classifying ambiguous melanocytic lesions with FISH and correlation with clinical long-term follow up. Mod Pathol. 2010;23:413-419.
22. Gerami P, Mafee M, Lurtsbarapa T, et al. Sensitivity of fluorescence in situ hybridization for melanoma diagnosis using RREB1, MYB, Cep6, and 11q13 probes in melanoma subtypes. Arch Dermatol. 2010;146:273-278.
23. Morey AL, Murali R, McCarthy SW, et al. Diagnosis of cutaneous melanocytic tumours by four-colour fluorescence in situ hybridisation. Pathology. 2009;41:383-387.
24. Clemente C, Bettio D, Venci A, et al. A fluorescence in situ hybridization (FISH) procedure to assist in differentiating benign from malignant melanocytic lesions. Pathologica. 2009;101:169-174.
25. Moore MW, Gasparini R. FISH as an effective diagnostic tool for the management of challenging melanocytic lesions. Diagn Pathol. 2011;6:76.
26. Boi S, Leonardi E, Fasanella S, et al. The Four-color FISH probe in the diagnosis of melanocytic lesions. J Eur Acad Dermatol Venereol. 2010; 24:1235-1236.
27. North JP, Vetto JT, Murali R, et al. Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognostic information in primary melanoma. Am J Surg Pathol. 2011;35:1146-1150.
28. Kutzner H, Metzler G, Argenyi Z, et al. Histological and genetic evidence for a variant of superficial spreading melanoma composed predominantly of large nests. Mod Pathol. 2012;25(6):838-845.
29. Affymetrix. Oncoscan FFPE 2.0 express services. Oncoscan FFPE 2. 0 express services [Affymetrix Web site]. Available at: Http://www. affymetrix.com/estore/browse/products.jsp?productId=prod150008#1-3. Accessed July 22, 2012.
30. Wang Y, Carlton VE, Karlin-Neumann G, et al. High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays. BMC Med Genomics. 2009;2:8.
31. Wang Y, Moorhead M, Karlin-Neumann G, et al. Analysis of molecular inversion probe performance for allele copy number determination. Genome Biol. 2007;8:R246.
32. Wang Y, Moorhead M, Karlin-Neumann G, et al. Allele quantification using molecular inversion probes. Nucleic Acids Res. 2005;33:e183.
33. Kopf AW, Bart RS, Hennessey P. Congenital nevocytic nevi and malignant melanomas. J Am Acad Dermatol. 1979;1:123-130.
34. Alper JC, Holmes LB. The incidence and significance of birthmarks in a cohort of 4,641 newborns. Pediatr Dermatol. 1983;1:58-68.
35. Weedon D. Lentigines, nevi, and melanomas. In: Weedon D, ed. Weedon's Skin Pathology. Philadelphia, Pennsylvania, United States: Churchill Livingstone; 2010:710-756.
36. Bostjan L, Boris CB, Calonje E. Melanocytic nevi. In: Calonje JE, Brenn T, Lazar AJ, et al, eds. McKee's Pathology of the Skin: Philadelphia, Pennsylvania, United States: Elsevier; 2011:1150-1217.
37. Hurwitz RM, Buckel LJ. Superficial congenital compound melanocytic nevus. Another pitfall in the diagnosis of malignant melanoma. Dermatol Surg. 1997;23:897-900.
38. Silvers DN, Helwig EB. Melanocytic nevi in neonates. J Am Acad Dermatol. 1981;4:166-175.
39. Barnhill R. Congenital melanocytic nevi and associated neoplasms, congenital and childhood melanoma. In: Barnhill R, Piepkorn M, Busam K, eds. Pathology of Melanocytic Nevi and Malignant Melanoma. New York, NY: Springer Science and Business Media; 2004:111-147.
40. Hendrickson MR, Ross JC. Neoplasms arising in congenital giant nevi: Morphologic study of seven cases and a review of the literature. Am J Surg Pathol. 1981;5:109-135.
41. Tate PS, Ronan SG, Feucht KA, et al. Melanoma in childhood and adolescence: Clinical and pathological features of 48 cases. J Pediatr Surg. 1993;28:217-222.
42. Boris CB, Lazar A. Melanoma in children. In: Calonje JE, Brenn T, Lazar AJ, et al, eds. McKee's Pathology of the Skin: Philadelphia, Pennsylvania, United States: Elsevier; 2011:1257-1259.
43. Huynh PM, Grant-Kels JM, Grin CM. Childhood melanoma: Update and treatment. Int J Dermatol. 2005;44:715-723.
44. Richardson SK, Tannous ZS, Mihm MC Jr. Congenital and infantile melanoma: Review of the literature and report of an uncommon variant, pigment-synthesizing melanoma. J Am Acad Dermatol. 2002;47:77-90.
45. Bittencourt FV, Marghoob AA, Kopf AW, et al. Large congenital melanocytic nevi and the risk for development of malignant melanoma and neurocutaneous melanocytosis. Pediatrics. 2000;106:736-741.
46. Spatz A, Ruiter D, Hardmeier T, et al. Melanoma in childhood: An EORTC-MCG multicenter study on the clinico-pathological aspects. Int J Cancer. 1996;68:317-324.
47. Xu X, Bellucci KS, Elenitsas R, et al. Cellular nodules in congenital pattern nevi. J Cutan Pathol. 2004;31:153-159.
48. Hoang MP, Rakheja D, Amirkhan RH. Rosette formation within a proliferative nodule of an atypical combined melanocytic nevus in an adult. Am J Dermatopathol. 2003;25:35-39.
49. McKee P, Calonje E. Congenital nevus. In: McKee P, Calonje E, eds. Diagnostic Atlas of Melanocytic Pathology: Philadelphia, Pennsylvania, United States: Mosby Elsevier; 2009:65-75.
50. McGowan JW, Smith MK, Ryan M, et al. Proliferative nodules with balloon-cell change in a large congenital melanocytic nevus. J Cutan Pathol. 2006;33:253-255.
51. Cerroni L, Barnhill R, Elder D, et al. Melanocytic tumors of uncertain malignant potential: Results of a tutorial held at the XXIX Symposium of the International Society of Dermatopathology in Graz, October 2008. Am J Surg Pathol. 2010;34:314-326.
52. van Houten AH, van Dijk MC, Schuttelaar ML. Proliferative nodules in a giant congenital melanocytic nevus-case report and review of the literature. J Cutan Pathol. 2010;37:764-776.
53. de Vooght A, Vanwijck R, Gosseye S, et al. Pseudo-tumoral proliferative nodule in a giant congenital naevus. Br J Plast Surg. 2003;56:164-167.
54. Angelucci D, Natali PG, Amerio PL, et al. Rapid perinatal growth mimicking malignant transformation in a giant congenital melanocytic nevus. Hum Pathol. 1991;22:297-301.
55. Flux K, Hartschuh W. Congenital spindle cell naevus with unusual transformation: Proliferative nodule or melanomä Acta Derm Venereol. 2012;92:152-155.
56. Bastian BC, LeBoit P, Hamm H, et al. Chromosomal gains and losses in primary cutaneous melanoma detected by comparative genomic hybridization. Cancer Res. 1998;58:2170-2175.
57. Bastian BC, Olshen AB, LeBoit PE, et al. Classifying melanocytic tumors based on DNA copy number changes. Am J Pathol. 2003;163:1765-1770.
58. Boone SL, Busam KJ, Marghoob AA, et al. Two cases of multiple spitz nevi: Correlating clinical, histologic, and fluorescence in situ hybridization findings. Arch Dermatol. 2011;147:227-231.
59. Isaac AK, Lertsburapa T, Pathria Mundi J, et al. Polyploidy in spitz nevi: A not uncommon karyotypic abnormality identifiable by fluorescence in situ hybridization. Am J Dermatopathol. 2010;32:144-148.
60. Vogt T, Stolz W, Glassl A, et al. Multivariate DNA cytometry discriminates between Spitz nevi and malignant melanomas because large polymorphic nuclei in Spitz nevi are not aneuploid. Am J Dermatopathol. 1996;18:142-150.
61. Pouryazdanparast P, Haghighat Z, Beilfuss BA, et al. Melanocytic nevi with an atypical epithelioid cell component: Clinical, histopathologic, and fluorescence in situ hybridization findings. Am J Surg Pathol. 2011;35:1405-1412.
62. Mancianti ML, Clark WH, Hayes FA, et al. Malignant melanoma simulants arising in congenital melanocytic nevi do not show experimental evidence for a malignant phenotype. Am J Pathol. 1990;136:817-829.