Polyploidy in Spitz nevi: A not uncommon karyotypic abnormality identifiable by fluorescence in situ hybridization

American Journal of Dermatopathology

Volumn 32, Issue 2, 2010, Pages 144-148

  Isaac, Anjeli Krishnan ^a   Lertsburapa, Terakeith ^a   Pathria Mundi, Jyoti ^a   Martini, Mary ^a   Guitart, Joan ^a   Gerami, Pedram ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Fluorescence in situ hybridization; Melanoma; Polyploidy; Spitz nevi

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; JUVENILE MELANOMA; KARYOTYPE; MALE; PRIORITY JOURNAL; TETRAPLOIDY; TUMOR LOCALIZATION; X CHROMOSOME;

ADOLESCENT; ADULT; CELL AGING; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, X; EPITHELIOID CELLS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; KARYOTYPING; MALE; MIDDLE AGED; NEVUS, EPITHELIOID AND SPINDLE CELL; POLYPLOIDY; RETROSPECTIVE STUDIES; SKIN NEOPLASMS; YOUNG ADULT;

EID: 77949995505     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3181b72d6f     Document Type: Article

References (17)

1. Dahlstrom JE, Scolyer RA, Thompson JF, et al. Spitz naevus: diagnostic problems and their management implications. Pathology. 2004;36: 452-457.
2. Crotty KA, Scolyer RA, Li L, et al. Spitz naevus versus spitzoid melanoma: when and how can they be distinguished? Pathology. 2002;34: 6-12.
3. Busam KJ, Pulitzer M. Sentinel lymph node biopsy for patients with diagnostically controversial spitzoid melanocytic tumors? Adv Anat Pathol. 2008;15:253-262.
4. Barnhill RL. Childhood melanoma. Semin Diagn Pathol. 1998;15: 189-194.
5. Bastian BC, Wesselmann U, Pinkel D, et al. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol. 1999;113:1065-1069.
6. Wettengel GV, Draeger J, Kiesewetter F, et al. Differentiation between Spitz nevi and malignant melanomas by interphase fluorescent in situ hybridization. Int J Oncol. 1999;14:1177-1183.
7. Vogt T, Stolz W, Glässl A, et al. Multivariate DNA cytometry discriminates between Spitz nevi and malignant melanomas because large polymorphic nuclei in Spitz nevi are not aneuploid. Am J Dermatopathol. 1996;18:142-150.
8. Gerami P, Jewell SS, Morrison LE, et al. Fluorescence is situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma. Am J Surg Pathol. 2009;33:1146-1156.
9. Ganem NJ, Pellman D. Limiting the proliferation of polyploid cells. Cell. 2007;131:437-440.
10. Thorpe PH, Gonzalez-Barrera S, Rothstein R. More is not always better: the genetic constraints of polyploidy. Trends Genet. 2007;23: 263-266.
11. Gattuso P, Reddy V, Solans E, et al. Is DNA ploidy of prognostic significance in stage I cutaneous melanoma? Surgery. 1990;108:702-708.
12. Satoh S, Hashimoto-Tamaoki T, Furuyama J, et al. High frequency of tetraploidy detected in malignant melanoma of Japanese patients by fluorescence in situ hybridization. Int J Oncol. 2000;17:707-715.
13. Erenpreisa J, Cragg MS. Cancer: a matter of life cycle? Cell Biol Int. 2007; 31:1507-1510.
14. Andreassen PR, Martineau SN, Margolis RL. Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state. Mutat Res. 1996;372:181-194.
15. Andreassen PR, Lohez OD, Lacroix FB, et al. Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell. 2001;12:1315-1328.
16. Margolis RL. Tetraploidy and tumor development. Cancer Cell. 2005;8: 353-354.
17. Castedo M, Coquelle A, Vitale I, et al. Selective resistance of tetraploid cancer cells against DNA damage-induced apoptosis. Ann N Y Acad Sci. 2006;1090:35-49.