Pattern formation of Rho GTPases in single cell wound healing

Molecular Biology of the Cell

Volumn 24, Issue 3, 2013, Pages 421-432

  Simon, Cory M ^a   Vaughan, Emily M ^a   Bement, William M ^b,c,d   Edelstein Keshet, Leah ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Cell and Molecular Biology Program   (United States)

^c Department of Zoology ^*  (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PROTEIN ABR; PROTEIN CDC42; RAC PROTEIN; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; IN VIVO STUDY; MATHEMATICAL MODEL; NONHUMAN; OOCYTE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN STABILITY; SIMULATION; WOUND HEALING; XENOPUS;

ANIMALS; BODY PATTERNING; CELLS, CULTURED; COMPUTER SIMULATION; ENZYME STABILITY; GTPASE-ACTIVATING PROTEINS; KINETICS; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MONOMERIC GTP-BINDING PROTEINS; OOCYTES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; RHOA GTP-BINDING PROTEIN; SINGLE-CELL ANALYSIS; TIME-LAPSE IMAGING; WOUND HEALING; XENOPUS LAEVIS; XENOPUS PROTEINS;

EID: 84873382745     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-08-0634     Document Type: Article

References (29)

1. Artavanis-Tsakonas S, Rand MD, Lake RJ (1999). Notch signaling: cell fate control and signal integration in development. Science 284, 770-776.
2. Bement WM, Benink HA, von Dassow G (2005). A microtubule-dependent zone of active RhoA during cleavage plane specification. J Cell Biol 170, 91-101.
3. Bement WM, Miller AL, von Dassow G (2006). Rho GTPase activity zones and transient contractile arrays. Bioessays 28, 983-992.
4. Benink HA, Bement WM (2005). Concentric zones of active RhoA and Cdc42 around single cell wounds. J Cell Biol 168, 429-439.
5. Bravo-Cordero JJ, Oser M, Chen X, Eddy R, Hodgson L, Condeelis J (2011). A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol 21, 635-644.
6. Burkel BM, Benink HA, Vaughan EM, von Dassow G, Bement WM (2012). A Rho GTPase signal treadmill backs a contractile array. Dev Cell 23, 384-396.
7. Chuang TH, Xu X, Kaartinen V, Heisterkamp N, Groffen J, Bokoch GM (1995). Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci USA 92, 10282-10286.
8. Clark AG, Miller AL, Vaughan E, Yu HY, Penkert R, Bement WM (2009). Integration of single and multicellular wound responses. Curr Biol 19, 1389-1395.
9. Craciun G, Tang Y, Feinberg M (2006). Understanding bistability in complex enzyme-driven reaction networks. Proc Natl Acad Sci USA 103, 8697-8702.
10. Ferrell J Jr., Xiong W (2001). Bistability in cell signaling: how to make continuous processes discontinuous, and reversible processes irreversible. Chaos 11, 227-236.
11. Goehring NW, Trong PK, Bois JS, Chowdhury D, Nicola EM, Hyman AA, Grill SW (2011). Polarization of PAR proteins by advective triggering of a pattern-forming system. Science 334, 1137-1141.
12. Goryachev A (2011). A common mechanism for protein cluster formation. Small GTPases 2, 143-147.
13. Guyer JE, Wheeler D, Warren JA (2009). FiPy: partial differential equations with Python. Comp Sci Eng 11, 6-15.
14. Jaffe AB, Hall A (2005). Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21, 247-269.
15. Jilkine A, Marèe AFM, Edelstein-Keshet L (2007). Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk. Bull Math Biol 69, 1943-1978.
16. Kholodenko B (2006). Cell-signaling dynamics in time and space. Nat Rev Mol Cell Biol 7, 165-176.
17. Ma C, Benink HA, Cheng D, Montplaisir V, Wang L, Xi Y, Zheng PP, Bement WM, Liu XJ (2006). Cdc42 activation couples spindle positioning to first polar body formation in oocyte maturation. Curr Biol 16, 214-220.
18. Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P, Abell A, Johnson GL, Hahn KM, Danuser G (2009). Coordination of Rho GTPase activities during cell protrusion. Nature 461, 99-102.
19. Mandato CA, Bement WM (2001). Contraction and polymerization cooperate to assemble and close actomyosin rings around Xenopus oocyte wounds. J Cell Biol 154, 785-797.
20. Miller AL, Bement WM (2009). Regulation of cytokinesis by Rho GTPase flux. Nat Cell Biol 11, 71-77.
21. Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM (2012). Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit. Cell 148, 803-815.
22. Pertz O (2010). Spatio-temporal Rho GTPase signaling -where are we now? J Cell Sci 123, 1841-1850.
23. Postma M, Bosgraaf L, Loovers H, Van Haastert P (2004). Chemotaxis: signalling modules join hands at front and tail. EMBO Rep 5, 35-40.
24. Umulis DM, Serpe M, O'Connor MB, Othmer HG (2006). Robust, bistable patterning of the dorsal surface of the Drosophila embryo. Proc Natl Acad Sci USA 103, 11613-11618.
25. Vaughan EM, Miller AL, Yu HY, Bement WM (2011). Control of local Rho GTPase crosstalk by Abr. Curr Biol 21, 270-277.
26. Wang YC, Ferguson EL (2005). Spatial bistability of Dpp-receptor interactions during Drosophila dorsal-ventral patterning. Nature 434, 229-234.
27. Wang H, Yang C, Leskow FC, Sun J, Canagarajah B, Hurley JH, Kazanietz MG (2006). Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling. EMBO J 25, 2062-2074.
28. Yoshida S, Bartolini S, Pellman D (2009). Mechanisms for concentrating Rho1 during cytokinesis. Genes Dev 23, 810-822.
29. Zhang X, Ma C, Miller AL, Katbi HA, Bement WM, Liu XJ (2008). Polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion. Dev Cell 15, 386-400.