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Volumn 15, Issue 1, 2013, Pages 43-54

Adenovector-mediated gene delivery to human umbilical cord mesenchymal stromal cells induces inner ear cell phenotype

Author keywords

[No Author keywords available]

Indexed keywords

ATOH1 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

EID: 84873378820     PISSN: 21524971     EISSN: 21524998     Source Type: Journal    
DOI: 10.1089/cell.2011.0097     Document Type: Article
Times cited : (20)

References (52)
  • 1
    • 67849101445 scopus 로고    scopus 로고
    • Adenovirus serotype 5 infects human dendritic cells via a CAR-independent receptor pathway mediated by lactoferrin and DC-SIGN
    • Adams, W.C., Bond, E., Havenga, M.J.E., Holterman, L., Goudsmit, J., Karlsson-Hedestam, G.B., Koup, R.A., and Lore, K. (2009). Adenovirus serotype 5 infects human dendritic cells via a CAR-independent receptor pathway mediated by lactoferrin and DC-SIGN. J. Gen. Virol. 90, 1600-1610.
    • (2009) J. Gen. Virol , vol.90 , pp. 1600-1610
    • Adams, W.C.1    Bond, E.2    Havenga, M.J.E.3    Holterman, L.4    Goudsmit, J.5    Karlsson-Hedestam, G.B.6    Koup, R.A.7    Lore, K.8
  • 2
    • 0030823167 scopus 로고    scopus 로고
    • LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors
    • Allay, J.A., Dennis, J.E., Haynesworth, S.E., Majumdar, M.K., Clapp, D.W., Shultz, L.D., Caplan, A.I., and Gerson, S.L. (1997). LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors. Hum. Gene Ther. 8, 1417-1427.
    • (1997) Hum. Gene Ther , vol.8 , pp. 1417-1427
    • Allay, J.A.1    Dennis, J.E.2    Haynesworth, S.E.3    Majumdar, M.K.4    Clapp, D.W.5    Shultz, L.D.6    Caplan, A.I.7    Gerson, S.L.8
  • 4
    • 20444429578 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells: Characterization, differentiation, and application in cell and gene therapy
    • Baksh, D., Song, L., and Tuan, R. (2007). Adult mesenchymal stem cells: Characterization, differentiation, and application in cell and gene therapy. J. Cell. Mol. Med. 8, 301-316.
    • (2007) J. Cell. Mol. Med. , vol.8 , pp. 301-316
    • Baksh, D.1    Song, L.2    Tuan, R.3
  • 6
    • 0032553686 scopus 로고    scopus 로고
    • Lipofectamine and related cationic lipids strongly improve adenoviral infection efficiency of primitive human hematopoietic cells
    • Byk, T., Haddada, H., Vainchenker, W., and Louache, F. (1998). Lipofectamine and related cationic lipids strongly improve adenoviral infection efficiency of primitive human hematopoietic cells. Hum. Gene Ther. 9, 2493-2502.
    • (1998) Hum. Gene Ther , vol.9 , pp. 2493-2502
    • Byk, T.1    Haddada, H.2    Vainchenker, W.3    Louache, F.4
  • 7
    • 39749171878 scopus 로고    scopus 로고
    • Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells
    • Campard, D., Lysy, P.A., Najimi, M., and Sokal, E.M. (2008). Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells. Gastroenterology. 134, 833-848.
    • (2008) Gastroenterology , vol.134 , pp. 833-848
    • Campard, D.1    Lysy, P.A.2    Najimi, M.3    Sokal, E.M.4
  • 8
    • 32944481724 scopus 로고    scopus 로고
    • Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: Results of a phase i clinical trial
    • Campochiaro, P.A., Nguyen, Q.D., Shah, S.M., Klein, M.L., Holz, E., Frank, R.N., Saperstein, D.A., Gupta, A., Stout, J.T., and Macko, J. (2006). Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: Results of a phase I clinical trial. Hum. Gene Ther. 17, 167-176.
    • (2006) Hum. Gene Ther , vol.17 , pp. 167-176
    • Campochiaro, P.A.1    Nguyen, Q.D.2    Shah, S.M.3    Klein, M.L.4    Holz, E.5    Frank, R.N.6    Saperstein, D.A.7    Gupta, A.8    Stout, J.T.9    MacKo, J.10
  • 9
    • 36249001191 scopus 로고    scopus 로고
    • Concise review: Human umbilical cord stroma with regard to the source of fetus derived stem cells
    • Can, A., and Karahuseyinoglu, S. (2007). Concise review: Human umbilical cord stroma with regard to the source of fetus derived stem cells. Stem Cells 25, 2886-2895.
    • (2007) Stem Cells , vol.25 , pp. 2886-2895
    • Can, A.1    Karahuseyinoglu, S.2
  • 10
    • 39049164672 scopus 로고    scopus 로고
    • Islet-like clusters derived from mesenchymal stem cells in Wharton's jelly of the human umbilical cord for transplantation to control type 1 diabetes
    • Chao, K.C., Chao, K.F., Fu, Y.S., and Liu, S.H. (2008). Islet-like clusters derived from mesenchymal stem cells in Wharton's jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS One. 3, e1451.
    • (2008) PLoS One , vol.3
    • Chao, K.C.1    Chao, K.F.2    Fu, Y.S.3    Liu, S.H.4
  • 11
    • 0033193044 scopus 로고    scopus 로고
    • Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells
    • Clark, P.R., Stopeck, A.T., Brailey, J.L., Wang, Q., McArthur, J., Finer, M.H., and Hersh, E.M. (1999). Polycations and cationic lipids enhance adenovirus transduction and transgene expression in tumor cells. Cancer Gene Ther. 6, 437-446.
    • (1999) Cancer Gene Ther , vol.6 , pp. 437-446
    • Clark, P.R.1    Stopeck, A.T.2    Brailey, J.L.3    Wang, Q.4    McArthur, J.5    Finer, M.H.6    Hersh, E.M.7
  • 12
    • 33846103060 scopus 로고    scopus 로고
    • Auditory hair cell explant co-cultures promote the differentiation of stem cells into bipolar neurons
    • Coleman, B., Fallon, J., Pettingill, L., de Silva, M., and Shepherd, R. (2007). Auditory hair cell explant co-cultures promote the differentiation of stem cells into bipolar neurons. Exp. Cell Res. 313, 232-243.
    • (2007) Exp. Cell Res , vol.313 , pp. 232-243
    • Coleman, B.1    Fallon, J.2    Pettingill, L.3    De Silva, M.4    Shepherd, R.5
  • 13
    • 0034006976 scopus 로고    scopus 로고
    • Adenoviral-mediated gene transfer into ex vivo expanded human bone marrow mesenchymal progenitor cells
    • Conget, P.A., and Minguell, J.J. (2000). Adenoviral-mediated gene transfer into ex vivo expanded human bone marrow mesenchymal progenitor cells. Exp. Hematol. 28, 382-390.
    • (2000) Exp. Hematol , vol.28 , pp. 382-390
    • Conget, P.A.1    Minguell, J.J.2
  • 14
    • 0024507950 scopus 로고
    • Protamine sulfate as an effective alternative to polybrene in retroviral-mediated genetransfer: Implications for human gene therapy
    • Cornetta, K., and Anderson, W.F. (1989). Protamine sulfate as an effective alternative to polybrene in retroviral-mediated genetransfer: Implications for human gene therapy. J. Virol Methods. 23, 187-194.
    • (1989) J. Virol Methods , vol.23 , pp. 187-194
    • Cornetta, K.1    Anderson, W.F.2
  • 15
    • 84873380050 scopus 로고    scopus 로고
    • Boston, MA: Massachusetts Eye & Ear Infirmary
    • Edge, A.B. (2009). Generation of Inner Ear Cells. Boston, MA: Massachusetts Eye & Ear Infirmary.
    • (2009) Generation of Inner Ear Cells
    • Edge, A.B.1
  • 16
    • 37349132289 scopus 로고    scopus 로고
    • Comparative growth behaviour and characterization of stem cells from human Wharton's jelly
    • Fong, C.Y., Richards, M., Manasi, N., Biswas, A., and Bongso, A. (2007). Comparative growth behaviour and characterization of stem cells from human Wharton's jelly. Reprod. Biomed. Online. 15, 708-718.
    • (2007) Reprod. Biomed. Online , vol.15 , pp. 708-718
    • Fong, C.Y.1    Richards, M.2    Manasi, N.3    Biswas, A.4    Bongso, A.5
  • 17
    • 0035884807 scopus 로고    scopus 로고
    • FM1-43 dye behaves as a permeant blocker of the haircell mechanotransducer channel
    • Gale, J., Marcotti, W., Kennedy, H., Kros, C., and Richardson, G. (2001). FM1-43 dye behaves as a permeant blocker of the haircell mechanotransducer channel. J. Neurosci. 21, 7013-7025.
    • (2001) J. Neurosci , vol.21 , pp. 7013-7025
    • Gale, J.1    Marcotti, W.2    Kennedy, H.3    Kros, C.4    Richardson, G.5
  • 18
    • 70349448090 scopus 로고    scopus 로고
    • Mechanotransduction by hair cells: Models, molecules, and mechanisms
    • Gillespie, P., and Mü ller, U. (2009). Mechanotransduction by hair cells: Models, molecules, and mechanisms. Cell. 139, 33-44.
    • (2009) Cell , vol.139 , pp. 33-44
    • Gillespie, P.1    Müller, U.2
  • 19
    • 0033231102 scopus 로고    scopus 로고
    • Transduction of bone marrow cells by the AdZF (pK7) modified adenovirus demonstrates preferential gene transfer in myeloma cells
    • Gonzalez, R., Vereecque, R., Wickham, T.J., Facon, T., Hetuin, D., Kovesdi, I., Bauters, F., Fenaux, P., and Quesnel, B. (1999). Transduction of bone marrow cells by the AdZ. F (pK7) modified adenovirus demonstrates preferential gene transfer in myeloma cells. Hum. Gene Ther. 10, 2709-2717.
    • (1999) Hum. Gene Ther , vol.10 , pp. 2709-2717
    • Gonzalez, R.1    Vereecque, R.2    Wickham, T.J.3    Facon, T.4    Hetuin, D.5    Kovesdi, I.6    Bauters, F.7    Fenaux, P.8    Quesnel, B.9
  • 20
    • 67349173143 scopus 로고    scopus 로고
    • New ectopic vestibular hair cell-like cells induced by Math1 gene transfer in postnatal rats
    • Huang, Y., Chi, F., Han, Z., Yang, J., Gao, W., and Li, Y. (2009). New ectopic vestibular hair cell-like cells induced by Math1 gene transfer in postnatal rats. Brain Res. 1276, 31-38.
    • (2009) Brain Res , vol.1276 , pp. 31-38
    • Huang, Y.1    Chi, F.2    Han, Z.3    Yang, J.4    Gao, W.5    Li, Y.6
  • 22
    • 33845865292 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells
    • Jeon, S., Oshima, K., Heller, S., and Edge, A. (2007). Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Mol. Cell. Neurosci. 34, 59-68.
    • (2007) Mol. Cell. Neurosci , vol.34 , pp. 59-68
    • Jeon, S.1    Oshima, K.2    Heller, S.3    Edge, A.4
  • 25
    • 0038118296 scopus 로고    scopus 로고
    • Math1 gene transfer generates newcochlear hair cells in mature guinea pigs in vivo
    • Kawamoto, K., Ishimoto, S.I., Minoda, R., Brough, D.E., and Raphael, Y. (2003).Math1 gene transfer generates newcochlear hair cells in mature guinea pigs in vivo. J. Neurosci. 23, 4395-4400.
    • (2003) J. Neurosci , vol.23 , pp. 4395-4400
    • Kawamoto, K.1    Ishimoto, S.I.2    Minoda, R.3    Brough, D.E.4    Raphael, Y.5
  • 27
    • 3042756199 scopus 로고    scopus 로고
    • Stem cells as therapy for hearing loss
    • Li, H., Corrales, C., Edge, A., and Heller, S. (2004). Stem cells as therapy for hearing loss. Trends Mol. Med. 10, 309-315.
    • (2004) Trends Mol. Med , vol.10 , pp. 309-315
    • Li, H.1    Corrales, C.2    Edge, A.3    Heller, S.4
  • 28
    • 3042825667 scopus 로고    scopus 로고
    • Enhancing adenovirus-mediated gene transfer in vitro and in vivo by addition of protamine and hydrocortisone
    • Lin, T., Gu, J., Zhang, L., Davis, J., Huang, X., Cabbini, G., Ji, L., and Fang, B. (2003). Enhancing adenovirus-mediated gene transfer in vitro and in vivo by addition of protamine and hydrocortisone. J. Gene Med. 5, 868-875.
    • (2003) J. Gene Med , vol.5 , pp. 868-875
    • Lin, T.1    Gu, J.2    Zhang, L.3    Davis, J.4    Huang, X.5    Cabbini, G.6    Ji, L.7    Fang, B.8
  • 29
    • 0033135776 scopus 로고    scopus 로고
    • Highefficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells
    • Marx, J.C., Allay, J.A., Persons, D.A., Nooner, S.A., Hargrove, P.W., Kelly, P.F., Vanin, E.F., and Horwitz, E.M. (1999). Highefficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells. Hum. Gene Ther. 10, 1163-1173.
    • (1999) Hum. Gene Ther , vol.10 , pp. 1163-1173
    • Marx, J.C.1    Allay, J.A.2    Persons, D.A.3    Nooner, S.A.4    Hargrove, P.W.5    Kelly, P.F.6    Vanin, E.F.7    Horwitz, E.M.8
  • 30
    • 55049118090 scopus 로고    scopus 로고
    • Lentiviral transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human disease
    • Meyerrose, T.E., Roberts, M., Ohlemiller, K.K., Vogler, C.A., Wirthlin, L., Nolta, J.A., and Sands, M.S. (2008). Lentiviral transduced human mesenchymal stem cells persistently express therapeutic levels of enzyme in a xenotransplantation model of human disease. Stem Cells. 26, 1713-1722.
    • (2008) Stem Cells , vol.26 , pp. 1713-1722
    • Meyerrose, T.E.1    Roberts, M.2    Ohlemiller, K.K.3    Vogler, C.A.4    Wirthlin, L.5    Nolta, J.A.6    Sands, M.S.7
  • 33
    • 58249083298 scopus 로고    scopus 로고
    • Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells
    • Pfannenstiel, S., Praetorius, M., Plinkert, P., Brough, D., and Staecker, H. (2009). Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells. Audiol. Neurotol. 14, 254-266.
    • (2009) Audiol. Neurotol , vol.14 , pp. 254-266
    • Pfannenstiel, S.1    Praetorius, M.2    Plinkert, P.3    Brough, D.4    Staecker, H.5
  • 37
    • 80053644229 scopus 로고    scopus 로고
    • The differentiation of mesenchymal stem cells into inner ear hair cell-like cells in vitro
    • Qin, H., Zhao, L.D., Sun, J.H., Ren, L.L., Guo, W.W., Liu, H.Z., Zhai, S.Q., and Yang, S.M. (2011). The differentiation of mesenchymal stem cells into inner ear hair cell-like cells in vitro. Acta Otolaryngol. 131, 1136-1141.
    • (2011) Acta Otolaryngol , vol.131 , pp. 1136-1141
    • Qin, H.1    Zhao, L.D.2    Sun, J.H.3    Ren, L.L.4    Guo, W.W.5    Liu, H.Z.6    Zhai, S.Q.7    Yang, S.M.8
  • 38
    • 34548621387 scopus 로고    scopus 로고
    • Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors
    • Rachakatla, R.S., Marini, F., Weiss, M.L., Tamura, M., and Troyer, D. (2007). Development of human umbilical cord matrix stem cell-based gene therapy for experimental lung tumors. Cancer Gene Ther. 14, 828-835.
    • (2007) Cancer Gene Ther , vol.14 , pp. 828-835
    • Rachakatla, R.S.1    Marini, F.2    Weiss, M.L.3    Tamura, M.4    Troyer, D.5
  • 39
    • 0037027340 scopus 로고    scopus 로고
    • Cell lines in inner ear research
    • Rivolta, M.N., and Holley, M.C. (2002). Cell lines in inner ear research. J. Neurobiol. 53, 306-318.
    • (2002) J. Neurobiol , vol.53 , pp. 306-318
    • Rivolta, M.N.1    Holley, M.C.2
  • 40
    • 0031666742 scopus 로고    scopus 로고
    • The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A C D, E, and F. J
    • Roelvink, P.W., Lizonova, A., Lee, J.G.M., Li, Y., Bergelson, J.M., Finberg, R.W., Brough, D.E., Kovesdi, I., and Wickham, T.J. (1998). The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J. Virol. 72, 7909-7915.
    • (1998) Virol , vol.72 , pp. 7909-7915
    • Roelvink, P.W.1    Lizonova, A.2    Lee, J.G.M.3    Li, Y.4    Bergelson, J.M.5    Finberg, R.W.6    Brough, D.E.7    Kovesdi, I.8    Wickham, T.J.9
  • 41
    • 13744254666 scopus 로고    scopus 로고
    • Human umbilical cord perivascular (HUCPV) cells: A source of mesenchymal progenitors
    • Sarugaser, R., Lickorish, D., Baksh, D., Hosseini, M.M., and Davies, J.E. (2005). Human umbilical cord perivascular (HUCPV) cells: A source of mesenchymal progenitors. Stem Cells 23, 220-229.
    • (2005) Stem Cells , vol.23 , pp. 220-229
    • Sarugaser, R.1    Lickorish, D.2    Baksh, D.3    Hosseini, M.M.4    Davies, J.E.5
  • 42
    • 80052595414 scopus 로고    scopus 로고
    • Selective atonal gene delivery improves balance function in a mouse model of vestibular disease
    • Schlecker, C., Praetorius, M., Brough, D., Presler, R., Hsu, C., Plinkert, P., and Staecker, H. (2011). Selective atonal gene delivery improves balance function in a mouse model of vestibular disease. Gene Ther. 18, 884-890.
    • (2011) Gene Ther , vol.18 , pp. 884-890
    • Schlecker, C.1    Praetorius, M.2    Brough, D.3    Presler, R.4    Hsu, C.5    Plinkert, P.6    Staecker, H.7
  • 43
    • 0033529954 scopus 로고    scopus 로고
    • Redirected infection of directly biotinylated recombinant adenovirus vectors through cell surface receptors and antigens
    • Smith, J.S., Keller, J.R., Lohrey, N.C., McCauslin, C.S., Ortiz, M., Cowan, K., and Spence, S.E. (1999). Redirected infection of directly biotinylated recombinant adenovirus vectors through cell surface receptors and antigens. Proc. Natl. Acad. Sci. U.S.A 96, 8855-8860.
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 8855-8860
    • Smith, J.S.1    Keller, J.R.2    Lohrey, N.C.3    McCauslin, C.S.4    Ortiz, M.5    Cowan, K.6    Spence, S.E.7
  • 44
    • 33846630878 scopus 로고    scopus 로고
    • Vestibular hair cell regeneration and restoration of balance function induced bymath1 gene transfer
    • Staecker, H., Praetorius, M., Baker, K., and Brough, D. (2007). Vestibular hair cell regeneration and restoration of balance function induced bymath1 gene transfer.Otol.Neurotol. 28, 223.
    • (2007) Otol.Neurotol , vol.28 , pp. 223
    • Staecker, H.1    Praetorius, M.2    Baker, K.3    Brough, D.4
  • 45
    • 19444370909 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated gene transfer to hair cells and support cells of the murine cochlea
    • Stone, I.M., Lurie, D.I., Kelley, M.W., and Poulsen, D.J. (2005). Adeno-associated virus-mediated gene transfer to hair cells and support cells of the murine cochlea. Mol. Ther. 11, 843-848.
    • (2005) Mol. Ther , vol.11 , pp. 843-848
    • Stone, I.M.1    Lurie, D.I.2    Kelley, M.W.3    Poulsen, D.J.4
  • 46
    • 77957582057 scopus 로고    scopus 로고
    • Hydrogen protects vestibular hair cells from free radicals
    • Taura, A., Kikkawa, Y.S., Nakagawa, T., and Ito, J. (2010). Hydrogen protects vestibular hair cells from free radicals. Acta Otolaryngol. 130, 95-100.
    • (2010) Acta Otolaryngol , vol.130 , pp. 95-100
    • Taura, A.1    Kikkawa, Y.S.2    Nakagawa, T.3    Ito, J.4
  • 49
    • 78650662132 scopus 로고    scopus 로고
    • Musculoskeletal tissue engineering with human umbilical cord mesenchymal stromal cells
    • Wang, L., Ott, L., Seshareddy, K.,Weiss,M.L., and Detamore, M.S. (2011). Musculoskeletal tissue engineering with human umbilical cord mesenchymal stromal cells. Regen. Med. 6, 95-109.
    • (2011) Regen. Med , vol.6 , pp. 95-109
    • Wang, L.1    Ott, L.2    Seshareddy, K.3    Weiss, M.L.4    Detamore, M.S.5
  • 50
    • 33744973827 scopus 로고    scopus 로고
    • Human umbilical cord matrix stem cells: Preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease
    • Weiss, M.L., Medicetty, S., Bledsoe, A.R., Rachakatla, R.S., Choi, M., Merchav, S., Luo, Y., Rao, M.S., Velagaleti, G., and Troyer, D. (2006). Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells. 24, 781-792.
    • (2006) Stem Cells , vol.24 , pp. 781-792
    • Weiss, M.L.1    Medicetty, S.2    Bledsoe, A.R.3    Rachakatla, R.S.4    Choi, M.5    Merchav, S.6    Luo, Y.7    Rao, M.S.8    Velagaleti, G.9    Troyer, D.10
  • 51
    • 0034860703 scopus 로고    scopus 로고
    • Protamine sulfate enhances the transduction efficiency of recombinant adeno-associated virus-mediated gene delivery
    • Yang, Y., and Hsieh, Y. (2001). Protamine sulfate enhances the transduction efficiency of recombinant adeno-associated virus-mediated gene delivery. Pharm. Res. 18, 922-927.
    • (2001) Pharm. Res , vol.18 , pp. 922-927
    • Yang, Y.1    Hsieh, Y.2
  • 52
    • 0034127584 scopus 로고    scopus 로고
    • Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears
    • Zheng, J., and Gao, W. (2000). Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat. Neurosci. 3, 580-586.
    • (2000) Nat. Neurosci , vol.3 , pp. 580-586
    • Zheng, J.1    Gao, W.2


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